Evaluation of the combined expression of chemokine SDF-1α and its receptor CXCR4 as a prognostic marker for gastric cancer

Experimental and Therapeutic Medicine

Volumn 2, Issue 3, 2011, Pages 499-504

  Lee, Hyo Jin ^a   Huang, Song Mei ^a   Kim, Ha Yon ^a   Oh, Yoon Suk ^a   Hwang, Ji Young ^a   Liang, Zhe Long ^a   Min, Jeong Ki ^b   Yun, Hwan Jung ^a   Sul, Ji Young ^a   Kim, Samyong ^a   Jo, Deog Yeon ^a   Kim, Jin Man ^a  

^a Chungnam National University   (South Korea)

^b Korea Research Institute of Bioscience and Biotechnology (KRIBB)   (South Korea)

Author keywords

CXC chemokine receptor 4; Gastric cancer; Prognosis; Stromal cell derived factor 1

Indexed keywords

CHEMOKINE RECEPTOR CXCR4; STROMAL CELL DERIVED FACTOR 1ALPHA;

ADULT; AGED; ARTICLE; CANCER GROWTH; CANCER INVASION; CANCER SURVIVAL; FEMALE; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MAJOR CLINICAL STUDY; MALE; PROGNOSIS; PROTEIN EXPRESSION; STOMACH CANCER; TUMOR CELL; TUMOR LOCALIZATION; TUMOR VOLUME;

EID: 79953282812     PISSN: 17920981     EISSN: 17921015     Source Type: Journal    
DOI: 10.3892/etm.2011.228     Document Type: Article

References (28)

1. Kamangar F, Dores GM and Anderson WF: Patterns of cancer incidence, mortality, and prevalence across five continents: defining priorities to reduce cancer disparities in different geographic regions of the world. J Clin Oncol 24: 2137-2150, 2006.
2. Parkin DM, Bray F, Ferlay J and Pisani P: Global cancer statistics. 2002. CA Cancer J Clin 55: 74-108, 2005.
3. Hermans J, Bonenkamp JJ, Boon MC, et al: Adjuvant therapy after curative resection for gastric cancer: meta-analysis of randomized trials. J Clin Oncol 11: 1441-1447, 1993.
4. Jackson CB and Giraud AS: STAT3 as a prognostic marker in human gastric cancer. J Gastroenterol Hepatol 24: 505-507, 2009.
5. Arya M, Patel HR and Williamson M: Chemokines: key players in cancer. Curr Med Res Opin 19: 557-564, 2003.
6. Burger JA and Kipps TJ: CXCR4: a key receptor in the crosstalk between tumor cells and their microenvironment. Blood 107: 1761-1767, 2006.
7. Scotton CJ, Wilson JL, Scott K, et al: Multiple actions of the chemokine CXCL12 on epithelial tumor cells in human ovarian cancer. Cancer Res 62: 5930-5938, 2002.
8. Barbieri F, Bajetto A, Stumm R, et al: Overexpression of stromal cell-derived factor 1 and its receptor CXCR4 induces autocrine/ paracrine cell proliferation in human pituitary adenomas. Clin Cancer Res 14: 5022-5032, 2008.
9. Koshiba T, Hosotani R, Miyamoto Y, et al: Expression of stromal cell-derived factor 1 and CXCR4 ligand receptor system in pancreatic cancer: a possible role for tumor progression. Clin Cancer Res 6: 3530-3535, 2000.
10. Muller A, Homey B, Soto H, et al: Involvement of chemokine receptors in breast cancer metastasis. Nature 410: 50-56, 2001.
11. Ganju RK, Brubaker SA, Meyer J, et al: The alpha-chemokine, stromal cell-derived factor-1, binds to the transmembrane G-protein-coupled CXCR-4 receptor and activates multiple signal transduction pathways. J Biol Chem 273: 23169-23175, 1998.
12. Oh JW, Drabik K, Kutsch O, Choi C, Tousson A and Benveniste EN CXC chemokine receptor 4 expression and function in human astroglioma cells. J Immunol 166: 2695-2704, 2001.
13. Orimo A, Gupta PB, Sgroi DC, et al: Stromal fibroblasts present in invasive human breast carcinomas promote tumor growth and angiogenesis through elevated SDF-1/CXCL12 secretion. Cell 121: 335-348, 2005.
14. Mirisola V, Zuccarino A, Bachmeier BE, et al: CXCL12/SDF1 expression by breast cancers is an independent prognostic marker of disease-free and overall survival. Eur J Cancer 45: 2579-2587, 2009.
15. Yoshitake N, Fukui H, Yamagishi H, et al: Expression of SDF-1 alpha and nuclear CXCR4 predicts lymph node metastasis in colorectal cancer. Br J Cancer 98: 1682-1689, 2008.
16. Schimanski CC, Schwald S, Simiantonaki N, et al: Effect of chemokine receptors CXCR4 and CCR7 on the metastatic behavior of human colorectal cancer. Clin Cancer Res 11: 1743-1750, 2005.
17. Arigami T, Natsugoe S, Uenosono Y, et al: CCR7 and CXCR4 expression predicts lymph node status including micrometastasis in gastric cancer. Int J Oncol 35: 19-24, 2009.
18. Yasumoto K, Koizumi K, Kawashima A, et al: Role of the CXCL12/CXCR4 axis in peritoneal carcinomatosis of gastric cancer. Cancer Res 66: 2181-2187, 2006.
19. Hashimoto I, Koizumi K, Tatematsu M, et al: Blocking on the CXCR4/mTOR signalling pathway induces the anti-metastatic properties and autophagic cell death in peritoneal disseminated gastric cancer cells. Eur J Cancer 44: 1022-1029, 2008.
20. Zieker D, Königsrainer I, Traub F, et al: PGK1 a potential marker for peritoneal dissemination in gastric cancer. Cell Physiol Biochem 21: 429-436, 2008.
21. Lee HJ, Kim SW, Kim HY, et al: Chemokine receptor CXCR4 expression, function, and clinical implications in gastric cancer. Int J Oncol 34: 473-480, 2009.
22. Ishigami S, Natsugoe S, Okumura H, et al: Clinical implication of CXCL12 expression in gastric cancer. Ann Surg Oncol 14: 3154-3158, 2007.
23. Japanese Gastric Cancer Association: Japanese Classification of Gastric Carcinoma. 2nd English edition. Gastric Cancer 1: 10-24, 1998.
24. Kim SW, Kim HY, Lee HJ, Yun HJ, Kim S and Jo DY: Stromal cell-derived factor-1 promotes myeloma cell growth in both aurocrine and paracrine manners. Korean J Hematol 43: 127-137, 2008.
25. Guleng B, Tateishi K, Ohta M, et al: Blockade of the stromal cell-derived factor-1/CXCR4 axis attenuates in vivo tumor growth by inhibiting angiogenesis in a vascular endothelial growth factor-independent manner. Cancer Res 65: 5864-5871, 2005.
26. Schimanski CC, Galle PR and Moehler M: Chemokine receptor CXCR4-prognostic factor for gastrointestinal tumors. World J Gastroenterol 14: 4721-4724, 2008.
27. Iwasa S, Yanagawa T, Fan J and Katoh R: Expression of CXCR4 and its ligand SDF-1 in intestinal-type gastric cancer is associated with lymph node and liver metastasis. Anticancer Res 29: 4751-4758, 2009.
28. Tsuboi K, Kodera Y, Nakanishi H, et al: Expression of CXCL12 and CXCR4 in pT3-stage gastric cancer does not correlate with peritoneal metastasis. Oncol Rep 20: 1117-1123, 2008.