Phosphatidylinositol phosphates directly bind to neurofilament light chain (NF-L) for the regulation of NF-L self assembly

Experimental and Molecular Medicine

Volumn 43, Issue 3, 2011, Pages 153-160

  Kim, Sung Kuk ^a   Kim, Ho ^a   Yang, Yong Ryoul ^b   Suh, Pann Ghill ^b   Chang, Jong Soo ^a  

^a Daejin University   (South Korea)

^b Ulsan National Institute of Science and Technology   (South Korea)

Author keywords

Neurofilament protein L; Phosphatidylino sitol phosphates; Phospholipase C

Indexed keywords

ARGININE; NEUROFILAMENT LIGHT CHAIN; NEUROFILAMENT PROTEIN; PHOSPHATIDYLINOSITOL 4,5 BISPHOSPHATE; POLYPHOSPHOINOSITIDE; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; CELL DIFFERENTIATION; CONTROLLED STUDY; HUMAN; HUMAN CELL; IN VITRO STUDY; NEUROFILAMENT; PROTEIN ASSEMBLY; PROTEIN FUNCTION; PROTEIN LIPID INTERACTION; PROTEIN PHOSPHORYLATION; REGULATORY MECHANISM;

MURINAE;

EID: 79953282106     PISSN: 12263613     EISSN: 20926413     Source Type: Journal    
DOI: 10.3858/emm.2011.43.3.019     Document Type: Article

References (44)

1. Al-Chalabi A, Miller CC. Neurofilaments and neurological disease. Bioessays 2003; 25:346-55
2. Balla T. Inositol-lipid binding motifs: signal integrators through protein-lipid and protein-protein interactions. J Cell Sci 2005; 118:2093-104
3. Berridge MJ. Inositol trisphosphate and calcium signalling. Nature 1993; 361:315-25
4. Carlton JG, Cullen PJ. Coincidence detection in phos-phoinositide signaling. Trends Cell Biol 2005; 15:540-7
5. Carter JE, Gallo JM, Anderson VE, Anderton BH, Robertson J. Aggregation of neurofilaments in NF-L transfected neuronal cells: regeneration of the filamentous network by a protein kinase C inhibitor. J Neurochem 1996; 67:1997-2004
6. Chang JS, Noh DY, Park IA, Kim MJ, Song H, Ryu SH, Suh P-G. Overexpression of phospholipase C-gamma1 in rat 3Y1 fibroblast cells leads to malignant transformation. Cancer Res 1997; 57:5465-8
7. Chang JS, Seok H, Kwon T-K, Min DS, Ahn BH, Lee YH, Suh JW, Kim JW, Iwashita S, Omori A, Ichinose S, Numata O, Seo J-K, Oh YS, Suh P-G. Interaction of elongation factor-1alpha and pleckstrin homology domain of phospholipase C-gamma 1 with activating its activity. J Biol Chem 2002; 277:19697-702
8. Ching GY, Liem RK. Assembly of type IV neuronal intermediate filaments in nonneuronal cells in the absence of preexisting cytoplasmic intermediate filaments. J Cell Biol 1993; 122:1323-35
9. Chung SH, Kim S-K, Kim JK, Yang Y-R, Suh P-H, Chang J-S. A double point mutation in PLC-gamma1 (Y509A/F510A) enhances Y783 phosphorylation and inositol phospholipid-hydrolyzing activity upon EGF stimulation. Exp Mol Med 2010; 42:216-27
10. Collard J F, Cote F, Julien J P. Deffective axonal transport in a transgenic mouse model of amyotrophic lateral sclerosis. Nature 1995; 375:61-4
11. Cote F, Collard JF, Julien JP. Progressive neuronopathy in transgenic mice expressing the human neurofilament heavy gene: a mouse model of amyotrophic lateral sclerosis. Cell 1993; 73:35-46
12. Cozier GE, Carlton J, Bouyoucef D, Cullen PJ. Membrane targeting by pleckstrin homology domains. Curr Top Micro-biol Immunol 2004; 282:49-88
13. Fabrizi GM, Cavallaro T, Angiari C, Bertolasi L, Cabrini I, Ferrarini M, Rizzuto N. Giant axon and neurofilament accumulation in Charcot-Marie-Tooth disease type 2E. Neurology 2004; 62:1429-31
14. Falasca M, Logan SK, Lehto VP, Baccante G, Lemmon MA, Schlessinger J. Activation of phospholipase C gamma by PI 3-kinase-induced PH domain-mediated membrane targeting. EMBO J 1998; 17:414-22
15. Fuchs E, Weber K. Intermediate filaments: structure, dynamics, function, and disease. Annu Rev Biochem 1994; 63: 345-82
16. 55 mutants in transfected mammalian cells. J Neurochem 1996; 66:1306-11
17. Gibson TJ, Hyvonen M, Musacchio A, Saraste M, Birney E. PH domain: the first anniversary. Trends Biochem Sci 1994; 19:349-53
18. Grant P, Pant HC. Neurofilament protein synthesis and phosphorylation. J Neurocytol 2000; 29:843-72
19. Guan RJ, Hall FL, Cohlberg JA. Proline-directed protein kinase (p34cdc2/p58cyclinA) phosphorylates bovine neuro-filaments. J Neurochem 1992; 58:1365-71
20. Hirano A, Donnenfeld H, Sasaki S, Nakano I. Fine structural observations of neurofilamentous changes in amyotrophic lateral sclerosis. J Neuropathol Exp Neurol 1984; 43:461-70
21. Hisanaga S, Hirokawa N. Molecular architecture of the neurofilament. II. Reassembly process of neurofilament L protein in vitro. J Mol Biol 1990; 211:871-82
22. Hisanaga S, Matsuoka Y, Nishizawa K, Saito T, Inagaki M, Hirokawa N. Phosphorylation of native and reassembled neurofilaments composed of NF-L, NF-M, and NF-H by the catalytic subunit of cAMP-dependent protein kinase. Mol Biol Cell 1994; 5:161-72
23. Kim SK, Choi JH, Suh P-G, Chang J-S. Pleckstrin homology domain of phospholipase C-gamma1 directly binds to 68-kDa neurofilament light chain. Exp Mol Med 2006; 38: 265-72
24. Klopfenstein DR, Tomishige M, Stuurman N, Vale RD. Role of phosphatidylinositol (4,5) bisphosphate organization in membrane transport by the Unc104 kinesin motor. Cell 2002; 109:347-58
25. Klopfenstein DR, Vale RD. The lipid binding pleckstrin homology domain in UNC-104 kinesin is necessary for synaptic vesicle transport in Caenorhabditis elegans. Mol Biol Cell 2004; 15:3729-39
26. Lee IB, Kim S-K, Chung S-H, Kim H, Kwon T-K, Min DS, Chang J-S. The effect of rod domain A148V mutation of neurofilament light chain on filament formation. BMB Rep 2008; 41:868-74
27. Lee MK, Xu Z, Wong PC, Cleveland DW. Neurofilaments are obligate heteropolymers in vivo. J Cell Biol 1993; 122: 1337-50
28. Lemmon MA, Ferguson KM, Schlessinger J. PH domains: diverse sequences with a common fold recruit signaling molecules to the cell surface. Cell 1996; 85:621-4
29. Lemmon MA, Ferguson KM. Signal-dependent membrane targeting by pleckstrin homology (PH) domains. Biochem J 2000; 350:1-18
30. 2+ binding to C2 domain of synaptotagmin 1. J Biol Chem 2006; 281:15845-52
31. Mathieu JF, Ma D, Descarries L, Vallee A, Parent A, Julien JP, Doucet G. CNS distribution and overexpression of neurofilament light proteins (NF-L) in mice transgenic for the human NF-L: aberrant accumulation in thalamic perikarya. Exp Neurol 1995; 132:134-46
32. Mukai H, Toshimori M, Shibata H, Kitagawa M, Shimakawa M, Miyahara M, Sunakawa H, Ono Y. PKN associates and phosphorylates the head-rod domain of neurofilament protein. J Biol Chem 1996; 271:9816-22
33. Nakagawa T, Chen J, Zhang Z, Kanai Y, Hirokawa N. Two distinct functions of the carboxyl-terminal tail domain of NF-M upon neurofilament assembly: cross-bridge formation and longitudinal elongation of filaments. J Cell Biol 1995; 129: 411-29
34. Nakamura Y, Hashimoto R, Kashiwagi Y, Aimoto S, Fukusho E, Matsumoto N, Kudo T, Takeda M. Major phosphorylation site (Ser55) of neurofilament L by cyclic AMP-dependent protein kinase in rat primary neuronal culture. J Neurochem 2000; 74:949-59
35. Nishizuka Y. Protein kinase C and lipid signaling for sustained cellular responses. FASEB J 1995; 9:484-96
36. Norgren N, Rosengren L, Stigbrand T. Elevated neurofila-ment levels in neurological diseases. Brain Res 2003; 987: 25-31
37. Rhee SG. Regulation of phosphoinositide-specific phospho-lipase C. Annu Rev Biochem 2001; 70:281-312
38. Shepherd CE, McCann H, Thiel E, Halliday GM. Neuro-filament-immunoreactive neurons in Alzheimer's disease and dementia with Lewy bodies. Neurobiol Dis 2002; 9: 249-57
39. Shin SY, Yoon SC, Kim YH, Kim YS, Lee YH. Phosphorylation of glycogen synthase kinase-3beta at serine-9 by phospholipase Cgamma1 through protein kinase C in rat 3Y1 fibroblasts. Exp Mol Med 2002; 34:444-50
40. Sihag RK, Nixon RA. Identification of Ser-55 as a major protein kinase A phosphorylation site on the 70-kDa subunit of neurofilaments. Early turnover during axonal transport. J Biol Chem 1991; 266:18861-7
41. Suh PG, Ryu SH, Moon KH, Suh HW, Rhee SG. Inositol phospholipid-specific phospholipase C: complete cDNA and protein sequences and sequence homology to tyrosine kinase-related oncogene products. Proc Natl Acad Sci USA 1988; 85:5419-23
42. Watson DF, Nachtman FN, Kuncl RW, Griffin JW. Altered neurofilament phosphorylation and beta tubulin isotypes in Charcot-Marie-Tooth disease type 1. Neurology 1994; 44: 2383-7
43. Xu Z, Cork LC, Griffin JW, Cleveland DW. Increased expression of neurofilament subunit NF-L produces morphological alterations that resemble the pathology of human motor neuron disease. Cell 1993; 73:23-33
44. Yates DM, Manser C, De Vos KJ, Shaw CE, McLoughlin DM, Miller CC. Neurofilament subunit (NFL) head domain phosphorylation regulates axonal transport of neurofila-ments. Eur J Cell Biol 2009; 88:193-202