Genetic variation of TLR-4, TLR-9 and TIRAP genes in Iranian malaria patients

Malaria Journal

Volumn 10, Issue , 2011, Pages

  Zakeri, Sedigheh ^a   Pirahmadi, Sakineh ^a,b   Mehrizi, Akram A ^a   Djadid, Navid D ^a  

^a PASTEUR INSTITUTE OF IRAN   (Iran)

^b Khatam University   (Iran)

Author keywords

[No Author keywords available]

Indexed keywords

TOLL INTERLEUKIN 1 RECEPTOR DOMAIN CONTAINING ADAPTOR PROTEIN; TOLL LIKE RECEPTOR; TOLL LIKE RECEPTOR 4; TOLL LIKE RECEPTOR 9; UNCLASSIFIED DRUG; INTERLEUKIN 1 RECEPTOR; MEMBRANE PROTEIN; TIRAP PROTEIN, HUMAN; TLR4 PROTEIN, HUMAN; TLR9 PROTEIN, HUMAN;

ADULT; ARTICLE; GENE FREQUENCY; GENETIC ANALYSIS; GENETIC VARIABILITY; GENOTYPE; HUMAN; IMMUNOGENETICS; IRAN; MAJOR CLINICAL STUDY; MALARIA; OUTCOME ASSESSMENT; PLASMODIUM FALCIPARUM; POLYMERASE CHAIN REACTION; POPULATION RESEARCH; RESTRICTION FRAGMENT LENGTH POLYMORPHISM; SINGLE NUCLEOTIDE POLYMORPHISM; DNA SEQUENCE; FEMALE; GENETIC POLYMORPHISM; GENETIC PREDISPOSITION; GENETICS; IMMUNOLOGY; INNATE IMMUNITY; ISOLATION AND PURIFICATION; MALARIA FALCIPARUM; MALE; NUCLEOTIDE SEQUENCE;

ADULT; BASE SEQUENCE; FEMALE; GENE FREQUENCY; GENETIC PREDISPOSITION TO DISEASE; HUMANS; IMMUNITY, INNATE; IRAN; MALARIA, FALCIPARUM; MALE; MEMBRANE GLYCOPROTEINS; PLASMODIUM FALCIPARUM; POLYMERASE CHAIN REACTION; POLYMORPHISM, GENETIC; POLYMORPHISM, RESTRICTION FRAGMENT LENGTH; POLYMORPHISM, SINGLE NUCLEOTIDE; RECEPTORS, INTERLEUKIN-1; SEQUENCE ANALYSIS, DNA; TOLL-LIKE RECEPTOR 4; TOLL-LIKE RECEPTOR 9;

EID: 79953256938     PISSN: None     EISSN: 14752875     Source Type: Journal    
DOI: 10.1186/1475-2875-10-77     Document Type: Article

References (26)

1. TLR4 mutations are associated with endotoxin hyporesponsiveness in humans. NC Arbour E Lorenz BC Schutte J Zabner JN Kline M Jones K Frees JL Watt Schwartz, Nat Genet 2000 25 187 191 10.1038/76048 10835634 (Pubitemid 30394990)
2. Toll-like receptors and innate immunity. R Medzhitov, Nat Rev Immunol 2001 1 135 145 10.1038/35100529 11905821 (Pubitemid 33741967)
3. Toll-like receptor signaling. S Akira K Takeda, Nat Rev Immunol 2004 4 499 511 10.1038/nri1391 15229469
4. Role of the Toll/interleukin-1 receptor signaling pathway in host resistance and pathogenesis during infection with protozoan parasites. RT Gazzinelli C Ropert MA Campos, Immunol Rev 2004 201 9 25 10.1111/j.0105-2896. 2004.00174.x 15361229 (Pubitemid 39318440)
5. The interface between innate and adaptive immunity. K Hoebe E Janssen B Beutler, Nat Immunol 2004 5 971 974 10.1038/ni1004-971 15454919 (Pubitemid 41057712)
6. Induction of proinflammatory responses in macrophages by the glycosylphosphatidylinositols of Plasmodium falciparum: cell signaling receptors, glycosylphosphatidylinositol (GPI) structural requirement, and regulation of GPI activity. G Krishnegowda AM Hajjar J Zhu EJ Douglass S Uematsu S Akira AS Woods DC Gowda, J Biol Chem 2005 280 8606 8616 10.1074/jbc. M413541200 15623512 (Pubitemid 40349765)
7. Toll-like receptor (TLR) polymorphisms in African children: Common TLR-4 variants predispose to severe malaria. FP Mockenhaupt JP Cramer L Hamann MS Stegemann J Eckert NR Oh RN Otchwemah E Dietz S Ehrhardt NW Schröder U Bienzle RR Schumann, J Commun Dis 2006 38 230 245 17373355
8. Common polymorphisms of toll-like receptors 4 and 9 are associated with the clinical manifestation of malaria during pregnancy. FP Mockenhaupt L Hamann C von Gaertner G Bedu-Addo C von Kleinsorgen RR Schumann U Bienzle, J Infect Dis 2006 194 184 188 10.1086/505152 16779724 (Pubitemid 44087189)
9. Pathological role of Toll-like receptor signaling in cerebral malaria. C Coban KJ Ishii S Uematsu N Arisue S Sato M Yamamoto T Kawai O Takeuchi H Hisaeda T Horii S Akira, Int Immunol 2007 19 67 79 10.1093/intimm/dxl123 17135446 (Pubitemid 46017889)
10. Plasmodium falciparum infection causes proinflammatory priming of human TLR responses. MB McCall MG Netea CC Hermsen T Jansen L Jacobs D Golenbock AJ van der Ven RW Sauerwein, J Immunol 2007 179 162 171 17579034 (Pubitemid 46986530)
11. Malaria hemozoin is immunologically inert but radically enhances innate responses by presenting malaria DNA to Toll-like receptor 9. P Parroche FN Lauw N Goutagny E Latz BG Monks A Visintin KA Halmen M Lamphier M Olivier DC Bartholomeu RT Gazzinelli DT Golenbock, Proc Natl Acad Sci USA 2007 104 1919 1924 10.1073/pnas.0608745104 17261807 (Pubitemid 46239879)
12. Malarial fever: hemozoin is involved but Toll-free. RR Schumann, Proc Natl Acad Sci USA 2007 104 1743 1744 10.1073/pnas.0610874104 17272492 (Pubitemid 46239849)
13. Essential role for TIRAP in activation of the signaling cascade shared by TLR2 and TLR4. M Yamamoto S Sato H Hemmi H Sanjo S Uematsu T Kaisho K Hoshino O Takeuchi M Kobayashi T Fujita K Takeda S Akira, Nature 2002 420 324 329 10.1038/nature01182 12447441 (Pubitemid 35398188)
14. Single nucleotide polymorphisms of Toll-like receptors and susceptibility to infectious disease. NW Schroder RR Schumann, Lancet Infect Dis 2005 5 156 164 15766650 (Pubitemid 40568671)
15. Analysis of TLR4 polymorphic variants: new insights into TLR4/MD-2/CD14 stoichiometry, structure, and signaling. P Rallabhandi J Bell MS Boukhvalova A Medvedev E Lorenz M Arditi VG Hemming JC Blanco DM Segal SN Vogel, J Immunol 2006 177 322 332 16785528 (Pubitemid 43939144)
16. Single-nucleotide polymorphisms in the Toll-like receptor 9 gene (TLR9): frequencies, pairwise linkage disequilibrium, and haplotypes in three U.S. ethnic groups and exploratory case-control disease association studies. R Lazarus WT Klimecki BA Raby D Vercelli LJ Palmer DJ Kwiatkowski EK Silverman F Martinez ST Weiss, Genomics 2003 81 85 91 10.1016/S0888-7543(02)00022-8 12573264 (Pubitemid 36263362)
17. A Mal functional variant is associated with protection against invasive pneumococcal disease, bacteremia, malaria and tuberculosis. CC Khor SJ Chapman FO Vannberg A Dunne C Murphy EY Ling AJ Frodsham AJ Walley O Kyrieleis A Khan C Aucan S Segal CE Moore K Knox SJ Campbell C Lienhardt A Scott P Aaby OY Sow RT Grignani J Sillah G Sirugo N Peshu TN Williams K Maitland RJ Davies DP Kwiatkowski NP Day D Yala DW Crook K Marsh JA Berkley LA O'Neill AV Hill, Nat Genet 2007 39 523 528 10.1038/ng1976 17322885 (Pubitemid 46514767)
18. High sensitivity of detection of human malaria parasites by the use of nested polymerase chain reaction. G Snounou S Viriyakosol XP Zhu W Jarra L Pinheiro VE do Rosario S Thaithong KN Brown, Mol Biochem Parasitol 1993 61 315 320 10.1016/0166-6851(93)90077-B 8264734
19. Open Source Epidemiologic Statistics for Public Health, Version. AG Dean KM Sullivan MM Soe, http://www.openepi.com Updated 2009/20/05, accessed 2010/06/16
20. A simple calculator to determine whether observed genotype frequencies are consistent with Hardy-Weinberg equilibrium. C Michael, 2008 http://www.tufts.edu/∼mcourt01/Documents/Court lab - HW calculator.xls
21. Malaria transmission and morbidity. K Marsh RW Snow, Parassitologia 1999 41 241 246 10697862 (Pubitemid 129640259)
22. Disease and evolution. JBS Haldane, Ric Sci 1949 19 68 76
23. Pathogen recognition and innate immunity. S Akira S Uematsu O Takeuchi, Cell 2006 124 783 801 10.1016/j.cell.2006.02.015 16497588 (Pubitemid 43261452)
24. Variants in the Toll-like receptor signaling pathway and clinical outcomes of malaria. FM Leoratti L Farias FP Alves MC Suarez-Mtis JR Coura J Kalil EP Camargo SL Moraes R Ramasawmy, J Infect Dis 2008 198 772 780 10.1086/590440 18662133
25. Low frequency of the TIRAP S180L polymorphism in Africa, and its potential role in malaria, sepsis, and leprosy. L Hamann O Kumpf RP Schuring E Alpsoy G Bedu-Addo U Bienzle L Oskam FP Mockenhaupt RR Schumann, BMC Med Genet 2009 10 65 70 10.1186/1471-2350-10-65 19602285
26. Toll-like receptor 4 Asp299Gly/Thr399Ile polymorphisms are a risk factor for Candida bloodstream infection. CA Van der Graaf MG Netea SA Morré MD Heijer PE Verweij JW Van der Meer BJ Kullberg, Eur Cytokine Netw 2006 17 29 34 16613760