Drug product development and pharmacological evaluation of a sparingly soluble novel camptothecin analog for peroral administration

Drug Delivery

Volumn 18, Issue 4, 2011, Pages 294-303

  Nekkanti, Vijaykumar ^a   Karatgi, Pradeep ^a   Paruchuri, Srinivasarao ^a   Pillai, Raviraj ^a  

^a DR REDDY'S LABORATORIES LTD   (India)

Author keywords

2 hydroxypropyl cyclodextrin (HP CD); camptothecin analog; complexation; low bioavailability; poor solubility

Indexed keywords

2 HYDROXYPROPYL BETA CYCLODEXTRIN; ARGININE; CAMPTOTHECIN DERIVATIVE; DODECYL SULFATE SODIUM; MANNITOL; NANOPARTICLE; WATER;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CANCER INHIBITION; CONTROLLED STUDY; DIFFERENTIAL SCANNING CALORIMETRY; DRUG FORMULATION; HUMAN; HUMAN CELL; INFRARED SPECTROSCOPY; MALE; NONHUMAN; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE; RAT; SOLUBILITY; X RAY POWDER DIFFRACTION;

ANIMALS; BETA-CYCLODEXTRINS; CALORIMETRY, DIFFERENTIAL SCANNING; CAMPTOTHECIN; CHEMISTRY, PHARMACEUTICAL; EXCIPIENTS; FREEZE DRYING; MAGNETIC RESONANCE SPECTROSCOPY; MICE; MICE, NUDE; NANOPARTICLES; PARTICLE SIZE; POWDERS; RATS; RATS, WISTAR; SOLUBILITY; SPECTROSCOPY, FOURIER TRANSFORM INFRARED; X-RAY DIFFRACTION;

EID: 79953252044     PISSN: 10717544     EISSN: 15210464     Source Type: Journal    
DOI: 10.3109/10717544.2010.544689     Document Type: Article

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