Association analysis of thromboxane A synthase 1 gene polymorphisms with aspirin intolerance in asthmatic patients

Pharmacogenomics

Volumn 12, Issue 3, 2011, Pages 351-363

  Oh, Sun Hee ^a   Kim, Yong Hoon ^a   Park, Se Min ^a   Cho, Sung Hwan ^a   Park, Jong Sook ^a   Jang, An Soo ^a   Park, Sung Woo ^a   Uh, Soo Taek ^a   Lee, Youg Mok ^a   Kim, Mi Kyeong ^b   Choi, Inseon S ^c   Cho, Sang Heon ^d   Hong, Chein Soo ^e   Lee, Yong Won ^e   Lee, Jae Young ^f   Choi, Byoung Whui ^g   Park, Byung Lae ^h   Shin, Hyoung Doo ^h,i   Park, Choon Sik ^a  

^a Soonchunhyang University   (South Korea)

^b Chungbuk National University College of Medicine   (South Korea)

^c Chonnam National University Medical School   (South Korea)

^d Seoul National University College of Medicine   (South Korea)

^e Yonsei University College of Medicine   (South Korea)

^f Hallym University College of Medicine   (South Korea)

^g Chung Ang University   (South Korea)

^h SNP Genetics Inc   (South Korea)

ⁱ Sogang University   (South Korea)

Author keywords

aspirin; asthma; gene; isoform; SNP; thromboxane A synthase 1

Indexed keywords

ACETYLSALICYLIC ACID; MESSENGER RNA; THROMBOXANE A SYNTHASE 1; THROMBOXANE B2; THROMBOXANE SYNTHASE; UNCLASSIFIED DRUG;

ADOLESCENT; ADULT; AGED; ARTICLE; ASPIRIN EXACERBATED RESPIRATORY DISEASE; ASTHMA; CATALYSIS; COHORT ANALYSIS; CONTROLLED STUDY; DRUG HYPERSENSITIVITY; DRUG TOLERANCE; ENZYME LINKED IMMUNOSORBENT ASSAY; EXON; FEMALE; FORCED EXPIRATORY VOLUME; GENE; GENE ACTIVITY; GENE DELETION; GENE EXPRESSION; GENE FREQUENCY; GENE LINKAGE DISEQUILIBRIUM; GENETIC ASSOCIATION; GENOTYPE; HETEROZYGOTE; HOMOZYGOTE; HUMAN; HUMAN CELL; INTRON; MAJOR CLINICAL STUDY; MALE; MUTATIONAL ANALYSIS; PERIPHERAL BLOOD MONONUCLEAR CELL; PROTECTION; PROTEIN BLOOD LEVEL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SINGLE NUCLEOTIDE POLYMORPHISM; SPLICING DEFECT; THROMBOXANE A SYNTHASE 1 GENE; WILD TYPE;

NASO;

EID: 79953248832     PISSN: 14622416     EISSN: 17448042     Source Type: Journal    
DOI: 10.2217/pgs.10.181     Document Type: Article

References (51)

1. Samter M, Beers Rf Jr: Concerning the nature of intolerance to aspirin. Allergy 40(5), 281-293 (1967).
2. Stevenson DD, Sanchez-Borges M, Szczeklik A: Classification of allergic and pseudoallele reactions to drugs that inhibit cyclooxygenase enzymes. Ann. Allergy Asthma Immunol. 87(3), 177-180 (2001). (Pubitemid 32879888)
3. Szczeklik A, Stevenson DD: Aspirin-induced asthma: advances in pathogenesis, diagnosis, and management. Allergy Clin. Immunol. 111(5), 913-921; quiz 922 (2003). (Pubitemid 36570845)
4. Nusing R, Ullrich V: Immunoquanthation of thromboxane synthase in human tissues. Eicosanoids30), 175-180 (1990).
5. Shen RF, Tai HH: Thromboxanes: synthase and receptors. Biomed. Sci. 5(3), 153-172 (1998).
6. Shen Rf, Tai Hh: Immunoaffinity purification and characterization of thromboxane synthase from porcine lung. Biol. Chem. 261(25), 11592-11599 (1986).
7. Haurand M, Ullrich V: Isolation and characterization of thromboxane synthase from human platelets as a cytochrome p-450 enzyme. Biol. Chem. 260(28), 15059-15067(1985). (Pubitemid 16147992)
8. Hamberg M, Svensson J, Samuelsson B: Thromboxanes: a new group of biologically active compounds derived from prostaglandin endoperoxides. Proc. Natl Acad. Sci. USA 72(8), 2994-2998 (1975).
9. Higgs GA, Moncada S, Salmon JA, Seager K: The source of thromboxane and prostaglandins in experimental inflammation. Br. J. Pharmacol. 79(4), 863-868 (1983). (Pubitemid 13025887)
10. Hopkins NK, Sun FF, Gorman RR: Thromboxane a2 biosynthesis in human lung fibroblasts wi-38. Biochem. biophys. Res. Comm. 85(2), 827-836 (1978). (Pubitemid 9068194)
11. Nusing R, Lesch R, Ullrich V: Immunohistochemical localization of thromboxane synthase in human tissues. Eicosanoids 3(1), 53-58 (1990).
12. Needleman P, Turk J, Jakschik BA, Morrison AR, Lefkowith JB: Arachidonic acid metabolism. Annu. Rev. Biochem. 55, 69-102 (1986). (Pubitemid 16070764)
13. Hanasaki K, Nakano T, Arka H: Receptor-mediated mkogenic effect of thromboxane A2 in vascular smooth muscle cells. Biochem. Pharmacol. 40(11), 2535-2542 (1990).
14. Ushikubi F, Aiba Y, Nakamura K et al. Thromboxane A2 receptor is highly expressed in mouse immature thymocytes and mediates DNA fragmentation and apoptosis. Exp. Med. 178(5), 1825-1830 (1993).
15. Ogletree Ml: Overview of physiological and pathophysiological effects of thromboxane a2. Fed. Proc. 46(1), 133-138 (1987).
16. Shephard EG, Malan L, Macfarlane CM, Mouton W, Joubert JR: Lung function and plasma levels of thromboxane B2, 6-ketoprostaglandin Fl a and p-thromboglobulin in antigen-induced asthma before and after indomethacin pretreatment. Br. J. Clin. Pharmacol. 19(4), 459-470 (1985). (Pubitemid 16254587)
17. FujimuraM, Sasaki F, Nakatsumi X et al. Effects of a thromboxane synthetase inhibitor (OKY-046) and a lipoxygenase inhibitor (AA-861) on bronchial responsiveness to acetylcholine in asthmatic subjects. Thorax 41(12), 955-959 (1986).
18. Gresele P, DottoriniM, Selli Ml et al.: Altered platelet function associated with the bronchial hyperresponsiveness accompanying nocturnal asthma. Allergy Clin. Immunol. 91(4), 894-902(1993). (Pubitemid 23118506)
19. Christie PE, Tagari P, Ford-Hutchinson AW et al.: Urinary leukotriene e4 concentrations increase after aspirin challenge in aspirin-sensitive asthmatic subjects. Am. Rev. Respir. Dis. 143(5 Pt 1), 1025-1029 (1991).
20. Smith CM, Hawksworth RJ, Thien FC, Christie PE, Lee TH: Urinary leukotriene E4 in bronchial asthma. Eur. Respir. J. 5(6), 693-699 (1992).
21. Kumlin M, Dahlen B, Bjorck T, Zetterstrom O, Granstrom E, Dahlen SE: Urinary excretion of leukotriene E4 and 11-dehydro-thromboxane B2 in response to bronchial provocations with allergen, aspirin, leukotriene D4, and histamine in asthmatics. Am. Rev. Respir. Dis. 146(1), 96-103 (1992).
22. Sladek K, Dworski R, SojaJ et al.: Eicosanoids in bronchoalveolar lavage fluid of aspirin-intolerant patients with asthma after aspirin challenge. Am. J. Respir. Cnt. Care Med. 149(4 Pt 1), 940-946 (1994). (Pubitemid 24108486)
23. Szczeklik A, Sladek K, Dworski R et al.: Bronchial aspirin challenge causes specific eicosanoid response in aspirin-sensitive asthmatics. Am. J. Respir. Crit. Care Med. 154(6 Pt 1), 1608-1614 (1996). (Pubitemid 26424923)
24. Oosaki R, Mizushima Y, Mita H, Shida T, Akiyama K, Kobayashi M: Urinary leukotriene E4 and 11-dehydrothromboxane B2 in patients with aspirin-sensitive asthma. Allergy 52(4), 470-473 (1997). (Pubitemid 27244165)
25. Obase Y, Shimoda T, Tomarl SY, et al.: Effects of pranlukast on chemical mediators in induced sputum on provocation tests in atopic and aspirin-intolerant asthmatic patients. Chest 121(1), 143-150 (2002). (Pubitemid 34114239)
26. Juergens UR, Christiansen SC, Stevenson DD, Zuraw BL: Arachidonic acid metabolism in monocytes of aspirin-sensitive asthmatic patients before and after oral aspirin challenge. Allergy Clin. Immunol. 90(4 Pt 1), 636-645 (1992).
27. Menzies D, Nair A, Meldrum Kt, Hopkinson P, Lipworth BJ: Effect of aspirin on airway inflammation and pulmonary function in patients with persistent asthma. J. Allergy Clin. Immunol. 121(5), 1184-1189. e4 (2008).
28. Genevieve D, Proulle V, Isidor B et al.: Thromboxane synthase mutations in an increased bone density disorder (ghosal syndrome). Nat. Genet. 40(3), 284-286 (2008). (Pubitemid 351311762)
29. Chase MB, Baek SJ, Purtell DC, Schwartz S, Shen RF: Mapping of the human thromboxane synthase gene (TBXASl) to chromosome 7q34-q35 by two-color fluorescence in situ hybridization. Genomics 16(3), 111-113 (1993).
30. Miyata A, Yokoyama C, Ihara H et al.: Characterization of the human gene (TBXASl) encoding thromboxane synthase. Eur. J. Biochem. 224(2), 273-279 (1994). (Pubitemid 24282809)
31. Wang LH, Tazawa R, Lang AQ, Wu KK: Alternate splicing of human thromboxane synthase mrna. Arch. Biochem. Biophys 315(2), 273-278(1994). (Pubitemid 24381544)
32. Bateman ED, Hurd SS, Barnes PJ et al.: Global strategy for asthma management and prevention: GINA executive summary. Eur. Respir. J. 31(1), 143-178 (2008).
33. Kim TH, Chang HS, Park SM et al.: Association of angiotensin I-converting enzyme gene polymorphisms with aspirin intolerance in asthmatics. Clin. Exp. Allergy 38(11), 1727-1737(2008).
34. Cormican LJ, Farooque S, Altmann DR, Lee TH: Improvements in an oral aspirin challenge protocol for the diagnosis of aspirin hypersensitivity. Clin. Exp. Allergy 35 (6), 717-722 (2005). (Pubitemid 40961342)
35. Vreeland WN, Meagher RJ, Barron AE: Multiplexed, high-throughput genotyping by single-base extension and end-labeled free-solution electrophoresis. Anal. Chem. 14(11), 4328-4333 (2002). (Pubitemid 35006418)
36. Chomczynski P, Sacchi N: Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal. Biochem. 162(1), 156-159 (1987). (Pubitemid 17064313)
37. T method. Methods 25(4), 402-408 (2001). (Pubitemid 34164012)
38. Hedrick PW: Gametic disequilibrium measures: proceed with caution. Genetics 117(2), 331-341 (1987).
39. Stephens M, Smith NJ, Donnelly P: A new statistical method for haplotype reconstruction from population data. Am. J. Hum. Genet. 68(4), 978-989 (2001). (Pubitemid 32289743)
40. Nyholt DR: A simple correction for multiple testing for single-nucleotide polymorphisms in linkage disequilibrium with each other. Am. J. Hum. Genet. 74(4), 765-769 (2004). (Pubitemid 38420107)
41. Saha S, Chant D, Welham J, Mcgrath J: A systematic review of the prevalence of schizophrenia. PLoSMed. 2(5),el4l (2005).
42. Menashe I, Rosenberg PS, Chen BE: PGA: power calculator for case-control genetic association analyses. BMC Genet. 9, 36 (2008).
43. Jinnai N, Sakagami T, Sekigawa T et al.: Polymorphisms in the prostaglandin E2 receptor subtype 2 gene confer susceptibility to aspirin-intolerant asthma: a candidate gene approach. Hum. Mol. Genet. 13(24), 3203-3217(2004). (Pubitemid 40045272)
44. Pitchford SC, Riffo-Vasquez Y, Sousa A et al.: Platelets are necessary for airway wall remodeling in a murine model of chronic allergic inflammation. Blood 103(2), 639-647 (2004). (Pubitemid 38140099)
45. Pagan F, Baralle FE: Genomic variants in exons and introns: identifying the splicing spoilers. Nat. Rev. Genet. 5 (5), 389-3 (2004).
46. Knight JC: Regulatory polymorphisms underlying complex disease traits. Mol. Med. 83(2), 97-109 (2005). (Pubitemid 40379298)
47. Kalnina Z, Zayakin P, Silina K, Line A: Alterations of pre-mRNA splicing in cancer. Genes Chromosomes Cancer 42(4), 342-357 (2005). (Pubitemid 40271278)
48. Choi JH, Park HS, Oh HB et al.: Leukotriene-related gene polymorphisms in ASA-intolerant asthma: an association with a haplotype of 5-lipoxygenase. Hum. Genet. 114(4), 337-344 (2004).
49. Kim SH, Choi JH, Park HS et al.: Association of thromboxane A2 receptor gene polymorphism with the phenotype of acetyl salicylic acid-intolerant asthma. Clin. Exp. Allergy 35(5), 585-590 (2005).
50. ParkJS, Chang HS, Park CS et al.: Association analysis of cysteinyl-leukotriene receptor 2 (CYSLTR2) polymorphisms with aspirin intolerance in asthmatics. Pharmacogenet. Genomics 15(7), 483-492 (2005).
51. Oh SH, Park SM, ParkJS et al.: Association analysis of peroxisome proliferator-activated receptors y gene polymorphisms with aspirin hypersensitivity in asthmatics. Allergy Asthma Immunol. Res. 1, 30-35 (2009).