-
1
-
-
77955665655
-
Overlapping and distinct mechanisms of action of multiple sclerosis therapies
-
Graber JJ, McGraw CA, Kimbrough D et al.: Overlapping and distinct mechanisms of action of multiple sclerosis therapies. Clin. Neurol. Neurosurg. 112(7), 583-591 (2010).
-
(2010)
Clin. Neurol. Neurosurg.
, vol.112
, Issue.7
, pp. 583-591
-
-
Graber, J.J.1
McGraw, C.A.2
Kimbrough, D.3
-
2
-
-
77649290565
-
Neuroprotection, regeneration and immunomodulation: Broadening the therapeutic repertoire in multiple sclerosis
-
Aktas O, Kieseier B, Hartung HP: Neuroprotection, regeneration and immunomodulation: broadening the therapeutic repertoire in multiple sclerosis. Trends Neurosci. 33(3), 140-152 (2010).
-
(2010)
Trends Neurosci.
, vol.33
, Issue.3
, pp. 140-152
-
-
Aktas, O.1
Kieseier, B.2
Hartung, H.P.3
-
3
-
-
70349745515
-
Predicting responders to therapies for multiple sclerosis
-
Río J, Comabella M, Montalban X: Predicting responders to therapies for multiple sclerosis. Nat. Rev. Neurol. 5(10), 553-560 (2009).
-
(2009)
Nat. Rev. Neurol.
, vol.5
, Issue.10
, pp. 553-560
-
-
Río, J.1
Comabella, M.2
Montalban, X.3
-
4
-
-
65549108709
-
Current approaches to the identifcation and management of breakthrough disease in patients with multiple sclerosis
-
Rudick RA, Polman CH: Current approaches to the identifcation and management of breakthrough disease in patients with multiple sclerosis. Lancet Neurol. 8(6), 545-559 (2009).
-
(2009)
Lancet Neurol.
, vol.8
, Issue.6
, pp. 545-559
-
-
Rudick, R.A.1
Polman, C.H.2
-
5
-
-
5644273987
-
What do we know about the mechanism of action of disease-modifying treatments in MS?
-
Hartung HP, Bar-Or A, Zoukos Y: What do we know about the mechanism of action of disease-modifying treatments in MS? J. Neurol. 251(Suppl. 5), v12-v29 (2004).
-
(2004)
J. Neurol.
, vol.251
, Issue.SUPPL. 5
-
-
Hartung, H.P.1
Bar-Or, A.2
Zoukos, Y.3
-
6
-
-
74249112995
-
Interferon-b mechanisms of action in multiple sclerosis
-
Dhib-Jalbut S, Marks S: Interferon-b mechanisms of action in multiple sclerosis. Neurology 74(Suppl. 1), S17-S24 (2010).
-
(2010)
Neurology
, vol.74
, Issue.SUPPL. 1
-
-
Dhib-Jalbut, S.1
Marks, S.2
-
7
-
-
74249111385
-
The mechanism of action of glatiramer acetate treatment in multiple sclerosis
-
Racke MK, Lovett-Racke AE, Karandikar NJ: The mechanism of action of glatiramer acetate treatment in multiple sclerosis. Neurology 74(Suppl. 1), S25-S30 (2010).
-
(2010)
Neurology
, vol.74
, Issue.SUPPL. 1
-
-
Racke, M.K.1
Lovett-Racke, A.E.2
Karandikar, N.J.3
-
8
-
-
66849106883
-
United Europeans for development of pharmacogenomics in multiple sclerosis network
-
Vandenbroeck K, Comabella M, Tolosa E et al.: United Europeans for development of pharmacogenomics in multiple sclerosis network. Pharmacogenomics 10(5), 885-894 (2009).
-
(2009)
Pharmacogenomics
, vol.10
, Issue.5
, pp. 885-894
-
-
Vandenbroeck, K.1
Comabella, M.2
Tolosa, E.3
-
9
-
-
3142556134
-
Development of biomarkers in multiple sclerosis
-
DOI 10.1093/brain/awh176
-
Bielekova B, Martin R: Development of biomarkers in multiple sclerosis. Brain 127(Pt 7), 1463-1478 (2004). (Pubitemid 38899400)
-
(2004)
Brain
, vol.127
, Issue.7
, pp. 1463-1478
-
-
Bielekova, B.1
Martin, R.2
-
10
-
-
64149102326
-
Monitoring of multiple sclerosis immunotherapy: From single candidates to biomarker networks
-
Goertsches RH, Hecker M, Zettl UK: Monitoring of multiple sclerosis immunotherapy: from single candidates to biomarker networks. J. Neurol. 255(Suppl. 6), 48-57 (2008).
-
(2008)
J. Neurol.
, vol.255
, Issue.SUPPL. 6
, pp. 48-57
-
-
Goertsches, R.H.1
Hecker, M.2
Zettl, U.K.3
-
12
-
-
54149084585
-
Multiple sclerosis
-
Compston A, Coles A: Multiple sclerosis. Lancet 372(9648), 1502-1517 (2008).
-
(2008)
Lancet
, vol.372
, Issue.9648
, pp. 1502-1517
-
-
Compston, A.1
Coles, A.2
-
13
-
-
67349216357
-
Autoimmune T cell responses in the central nervous system
-
Goverman J: Autoimmune T cell responses in the central nervous system. Nat. Rev. Immunol. 9(6), 393-407 (2009).
-
(2009)
Nat. Rev. Immunol.
, vol.9
, Issue.6
, pp. 393-407
-
-
Goverman, J.1
-
14
-
-
45549092100
-
The genetics of multiple sclerosis: SNPs to pathways to pathogenesis
-
DOI 10.1038/nrg2395, PII NRG2395
-
Oksenberg JR, Baranzini SE, Sawcer S, Hauser SL: The genetics of multiple sclerosis: SNPs to pathways to pathogenesis. Nat. Rev. Genet. 9(7), 516-526 (2008). (Pubitemid 351861542)
-
(2008)
Nature Reviews Genetics
, vol.9
, Issue.7
, pp. 516-526
-
-
Oksenberg, J.R.1
Baranzini, S.E.2
Sawcer, S.3
Hauser, S.L.4
-
15
-
-
34548133584
-
Multiple sclerosis: A complicated picture of autoimmunity
-
DOI 10.1038/ni1507, PII NI1507
-
McFarland HF, Martin R: Multiple sclerosis: a complicated picture of autoimmunity. Nat. Immunol. 8(9), 913-919 (2007). (Pubitemid 47300005)
-
(2007)
Nature Immunology
, vol.8
, Issue.9
, pp. 913-919
-
-
McFarland, H.F.1
Martin, R.2
-
16
-
-
77951214891
-
Role of the innate immune system in the pathogenesis of multiple sclerosis
-
Gandhi R, Laroni A, Weiner HL: Role of the innate immune system in the pathogenesis of multiple sclerosis. J. Neuroimmunol. 221(1-2), 7-14 (2010).
-
(2010)
J. Neuroimmunol.
, vol.221
, Issue.1-2
, pp. 7-14
-
-
Gandhi, R.1
Laroni, A.2
Weiner, H.L.3
-
17
-
-
38449121963
-
Interleukin-17: A novel inflammatory cytokine that bridges innate and adaptive immunity
-
DOI 10.2741/2667
-
Yu JJ, Gaffen SL: Interleukin-17: A novel infammatory cytokine that bridges innate and adaptive immunity. Front. Biosci. 13, 170-177 (2008). (Pubitemid 351594768)
-
(2008)
Frontiers in Bioscience
, vol.13
, Issue.1
, pp. 170-177
-
-
Yu, J.J.1
Gaffen, S.L.2
-
18
-
-
34948909646
-
H17 lymphocytes promote blood-brain barrier disruption and central nervous system inflammation
-
DOI 10.1038/nm1651, PII NM1651
-
Kebir H, Kreymborg K, Ifergan I et al.: Human TH17 lymphocytes promote blood-brain barrier disruption and central nervous system infammation. Nat. Med. 13(10), 1173-1175 (2007). (Pubitemid 47530640)
-
(2007)
Nature Medicine
, vol.13
, Issue.10
, pp. 1173-1175
-
-
Kebir, H.1
Kreymborg, K.2
Ifergan, I.3
Dodelet-Devillers, A.4
Cayrol, R.5
Bernard, M.6
Giuliani, F.7
Arbour, N.8
Becher, B.9
Prat, A.10
-
19
-
-
70449716915
-
MicroRNA miR-326 regulates TH-17 differentiation and is associated with the pathogenesis of multiple sclerosis
-
Du C, Liu C, Kang J et al.: MicroRNA miR-326 regulates TH-17 differentiation and is associated with the pathogenesis of multiple sclerosis. Nat. Immunol. 10(12), 1252-1259 (2009).
-
(2009)
Nat. Immunol.
, vol.10
, Issue.12
, pp. 1252-1259
-
-
Du, C.1
Liu, C.2
Kang, J.3
-
20
-
-
67249090787
-
T-helper 17 cells expand in multiple sclerosis and are inhibited by interferon-b
-
Durelli L, Conti L, Clerico M et al.: T-helper 17 cells expand in multiple sclerosis and are inhibited by interferon-b. Ann. Neurol. 65(5), 499-509 (2009).
-
(2009)
Ann. Neurol.
, vol.65
, Issue.5
, pp. 499-509
-
-
Durelli, L.1
Conti, L.2
Clerico, M.3
-
21
-
-
77950526192
-
IFN-b inhibits human Th17 cell differentiation
-
Ramgolam VS, Sha Y, Jin J, Zhang X, Markovic-Plese S: IFN-b inhibits human Th17 cell differentiation. J. Immunol. 183(8), 5418-5427 (2009).
-
(2009)
J. Immunol.
, vol.183
, Issue.8
, pp. 5418-5427
-
-
Ramgolam, V.S.1
Sha, Y.2
Jin, J.3
Zhang, X.4
Markovic-Plese, S.5
-
22
-
-
77950534540
-
T helper type 1 and 17 cells determine effcacy of interferon-b in multiple sclerosis and experimental encephalomyelitis
-
Axtell RC, de Jong BA, Boniface K et al.: T helper type 1 and 17 cells determine effcacy of interferon-b in multiple sclerosis and experimental encephalomyelitis. Nat. Med. 16(4), 406-412 (2010).
-
(2010)
Nat. Med.
, vol.16
, Issue.4
, pp. 406-412
-
-
Axtell, R.C.1
De Jong, B.A.2
Boniface, K.3
-
23
-
-
77950538845
-
Molecular oracles for multiple sclerosis therapy
-
Wekerle H, Hohlfeld R: Molecular oracles for multiple sclerosis therapy. Nat. Med. 16(4), 376-377 (2010).
-
(2010)
Nat. Med.
, vol.16
, Issue.4
, pp. 376-377
-
-
Wekerle, H.1
Hohlfeld, R.2
-
24
-
-
34447323888
-
Pharmacogenetics of glatiramer acetate therapy for multiple sclerosis reveals drug-response markers
-
DOI 10.1097/FPC.0b013e3281299169, PII 0121301120070800000010
-
Grossman I, Avidan N, Singer C et al.: Pharmacogenetics of glatiramer acetate therapy for multiple sclerosis reveals drug-response markers. Pharmacogenet. Genomics 17(8), 657-666 (2007). (Pubitemid 47057715)
-
(2007)
Pharmacogenetics and Genomics
, vol.17
, Issue.8
, pp. 657-666
-
-
Grossman, I.1
Avidan, N.2
Singer, C.3
Goldstaub, D.4
Hayardeny, L.5
Eyal, E.6
Ben-Asher, E.7
Paperna, T.8
Pe'er, I.9
Lancet, D.10
Beckmann, J.S.11
Miller, A.12
-
25
-
-
40849094272
-
Genome-wide pharmacogenomic analysis of the response to interferon beta therapy in multiple sclerosis
-
DOI 10.1001/archneurol.2008.47
-
Byun E, Caillier SJ, Montalban X et al.: Genome-wide pharmacogenomic ana lysis of the response to interferon b therapy in multiple sclerosis. Arch. Neurol. 65(3), 337-344 (2008). (Pubitemid 351398518)
-
(2008)
Archives of Neurology
, vol.65
, Issue.3
, pp. 337-344
-
-
Byun, E.1
Caillier, S.J.2
Montalban, X.3
Villoslada, P.4
Fernandez, O.5
Brassat, D.6
Comabella, M.7
Wang, J.8
Barcellos, L.F.9
Baranzini, S.E.10
Oksenberg, J.R.11
-
26
-
-
70449504564
-
Genetic polymorphisms, their allele combinations and IFN-b treatment response in Irish multiple sclerosis patients
-
O'Doherty C, Favorov A, Heggarty S et al.: Genetic polymorphisms, their allele combinations and IFN-b treatment response in Irish multiple sclerosis patients. Pharmacogenomics 10(7), 1177-1186 (2009).
-
(2009)
Pharmacogenomics
, vol.10
, Issue.7
, pp. 1177-1186
-
-
O'Doherty, C.1
Favorov, A.2
Heggarty, S.3
-
27
-
-
71549134054
-
ABC-transporter gene-polymorphisms are potential pharmacogenetic markers for mitoxantrone response in multiple sclerosis
-
Cotte S, von Ahsen N, Kruse N et al.: ABC-transporter gene-polymorphisms are potential pharmacogenetic markers for mitoxantrone response in multiple sclerosis. Brain 132(Pt 9), 2517-2530 (2009).
-
(2009)
Brain
, vol.132
, Issue.PART 9
, pp. 2517-2530
-
-
Cotte, S.1
Von Ahsen, N.2
Kruse, N.3
-
28
-
-
68549085471
-
Genome-wide scan of 500,000 single-nucleotide polymorphisms among responders and nonresponders to interferon b therapy in multiple sclerosis
-
Comabella M, Craig DW, Morcillo-Suárez C et al.: Genome-wide scan of 500,000 single-nucleotide polymorphisms among responders and nonresponders to interferon b therapy in multiple sclerosis. Arch. Neurol. 66(8), 972-978 (2009).
-
(2009)
Arch. Neurol.
, vol.66
, Issue.8
, pp. 972-978
-
-
Comabella, M.1
Craig, D.W.2
Morcillo-Suárez, C.3
-
29
-
-
44849128066
-
Pharmacogenomics of interferon-b therapy in multiple sclerosis: Baseline IFN signature determines pharmacological differences between patients
-
Van Baarsen LG, Vosslamber S, Tijssen M et al.: Pharmacogenomics of interferon-b therapy in multiple sclerosis: baseline IFN signature determines pharmacological differences between patients. PLoS ONE 3(4), e1927 (2008).
-
(2008)
PLoS ONE
, vol.3
, Issue.4
-
-
Van Baarsen, L.G.1
Vosslamber, S.2
Tijssen, M.3
-
30
-
-
74049156448
-
Molecular profling of glatiramer acetate early treatment effects in multiple sclerosis
-
Achiron A, Feldman A, Gurevich M: Molecular profling of glatiramer acetate early treatment effects in multiple sclerosis. Dis. Markers 27(2), 63-73 (2009).
-
(2009)
Dis. Markers
, vol.27
, Issue.2
, pp. 63-73
-
-
Achiron, A.1
Feldman, A.2
Gurevich, M.3
-
31
-
-
77949639406
-
Long-term genome-wide blood RNA expression profles yield novel molecular response candidates for IFN-b-1b treatment in relapsing remitting MS
-
Goertsches R, Hecker M, Koczan D et al.: Long-term genome-wide blood RNA expression profles yield novel molecular response candidates for IFN-b-1b treatment in relapsing remitting MS. Pharmacogenomics 11(2), 147-161 (2010).
-
(2010)
Pharmacogenomics
, vol.11
, Issue.2
, pp. 147-161
-
-
Goertsches, R.1
Hecker, M.2
Koczan, D.3
-
32
-
-
20044373640
-
Transcription-based prediction of response to IFNb using supervised computational methods
-
Baranzini SE, Mousavi P, Rio J et al.: Transcription-based prediction of response to IFNb using supervised computational methods. PLoS Biol. 3(1), e2 (2005).
-
(2005)
PLoS Biol.
, vol.3
, Issue.1
-
-
Baranzini, S.E.1
Mousavi, P.2
Rio, J.3
-
33
-
-
34447341975
-
Zinc-ion binding and cytokine activity regulation pathways predicts outcome in relapsing-remitting multiple sclerosis
-
DOI 10.1111/j.1365-2249.2007.03405.x
-
Achiron A, Gurevich M, Snir Y et al.: Zinc-ion binding and cytokine activity regulation pathways predicts outcome in relapsing-remitting multiple sclerosis. Clin. Exp. Immunol. 149(2), 235-242 (2007). (Pubitemid 47063046)
-
(2007)
Clinical and Experimental Immunology
, vol.149
, Issue.2
, pp. 235-242
-
-
Achiron, A.1
Gurevich, M.2
Snir, Y.3
Segal, E.4
Mandel, M.5
-
34
-
-
56349127789
-
Genomic effects of once-weekly, intramuscular interferon-b1 treatment after the frst dose and on chronic dosing: Relationships to 5-year clinical outcomes in multiple sclerosis patients
-
Weinstock-Guttman B, Bhasi K, Badgett D et al.: Genomic effects of once-weekly, intramuscular interferon-b1 treatment after the frst dose and on chronic dosing: relationships to 5-year clinical outcomes in multiple sclerosis patients. J. Neuroimmunol. 205(1-2), 113-125 (2008).
-
(2008)
J. Neuroimmunol.
, vol.205
, Issue.1-2
, pp. 113-125
-
-
Weinstock-Guttman, B.1
Bhasi, K.2
Badgett, D.3
-
35
-
-
69049102091
-
Prediction of acute multiple sclerosis relapses by transcription levels of peripheral blood cells
-
Gurevich M, Tuller T, Rubinstein U et al.: Prediction of acute multiple sclerosis relapses by transcription levels of peripheral blood cells. BMC Med. Genomics 2, 46 (2009).
-
(2009)
BMC Med. Genomics
, vol.2
, pp. 46
-
-
Gurevich, M.1
Tuller, T.2
Rubinstein, U.3
-
36
-
-
72649106903
-
A type i interferon signature in monocytes is associated with poor response to interferon-b in multiple sclerosis
-
Comabella M, Lünemann JD, Río J et al.: A type I interferon signature in monocytes is associated with poor response to interferon-b in multiple sclerosis. Brain 132(Pt 12), 3353-3365 (2009).
-
(2009)
Brain
, vol.132
, Issue.PART 12
, pp. 3353-3365
-
-
Comabella, M.1
Lünemann, J.D.2
Río, J.3
-
37
-
-
69549086810
-
Clinical trials of multiple sclerosis therapies: Improvements to demonstrate long-term patient beneft
-
Carroll WM: Clinical trials of multiple sclerosis therapies: improvements to demonstrate long-term patient beneft. Mult. Scler. 15(8), 951-958 (2009).
-
(2009)
Mult. Scler.
, vol.15
, Issue.8
, pp. 951-958
-
-
Carroll, W.M.1
-
38
-
-
77953353229
-
Cross-sectional study assessing long-term safety of interferon-b-1b for relapsing-remitting MS
-
Reder AT, Ebers GC, Traboulsee A et al.: Cross-sectional study assessing long-term safety of interferon-b-1b for relapsing-remitting MS. Neurology 74(23), 1877-1885 (2010).
-
(2010)
Neurology
, vol.74
, Issue.23
, pp. 1877-1885
-
-
Reder, A.T.1
Ebers, G.C.2
Traboulsee, A.3
-
39
-
-
77950876430
-
Clinical effect of neutralizing antibodies to interferon b that persist long after cessation of therapy for multiple sclerosis
-
Van Der Voort LF, Gilli F, Bertolotto A et al.: Clinical effect of neutralizing antibodies to interferon b that persist long after cessation of therapy for multiple sclerosis. Arch. Neurol. 67(4), 402-407 (2010).
-
(2010)
Arch. Neurol.
, vol.67
, Issue.4
, pp. 402-407
-
-
Van Der Voort, L.F.1
Gilli, F.2
Bertolotto, A.3
-
40
-
-
33846966636
-
A brief history of T(H) 17, the frst major revision in the T(H)1/T(H)2 hypothesis of T cell-mediated tissue damage
-
Steinman L: A brief history of T(H)17, the frst major revision in the T(H)1/T(H)2 hypothesis of T cell-mediated tissue damage. Nat. Med. 13(2), 139-145 (2007).
-
(2007)
Nat. Med.
, vol.13
, Issue.2
, pp. 139-145
-
-
Steinman, L.1
-
41
-
-
78650173034
-
The blood-brain barrier, chemokines and multiple sclerosis
-
Holman DW, Klein RS, Ransohoff RM: The blood-brain barrier, chemokines and multiple sclerosis. Biochim. Biophys. Acta. 1812(2), 220-230 (2011).
-
(2011)
Biochim. Biophys. Acta.
, vol.1812
, Issue.2
, pp. 220-230
-
-
Holman, D.W.1
Klein, R.S.2
Ransohoff, R.M.3
-
42
-
-
0036975338
-
A comparison of the biologic activity of two recombinant IFN-β preparations used in the treatment of relapsing-remitting multiple sclerosis
-
DOI 10.1089/10799900260475696
-
Antonetti F, Finocchiaro O, Mascia M et al.: A comparison of the biologic activity of two recombinant IFN-b preparations used in the treatment of relapsing-remitting multiple sclerosis. J. Interferon Cytokine Res. 22(12), 1181-1184 (2002). (Pubitemid 36432854)
-
(2002)
Journal of Interferon and Cytokine Research
, vol.22
, Issue.12
, pp. 1181-1184
-
-
Antonetti, F.1
Finocchiaro, O.2
Mascia, M.3
Terlizzese, M.G.4
Jaber, A.5
-
43
-
-
34250159112
-
Interferon-beta: Mechanism of action and dosing issues
-
DOI 10.1212/01.wnl.0000277703.74115.d2, PII 0000611420070612400003
-
Markowitz CE: Interferon-b: mechanism of action and dosing issues. Neurology 68(Suppl. 4), S8-S11 (2007). (Pubitemid 46897272)
-
(2007)
Neurology
, vol.68
, Issue.24 SUPPL. 4
-
-
Markowitz, C.E.1
-
44
-
-
10344243508
-
Biological responsiveness to first injections of interferon-beta in patients with multiple sclerosis
-
DOI 10.1016/j.jneuroim.2004.08.006, PII S016557280400284X
-
Gilli F, Marnetto F, Caldano M et al.: Biological responsiveness to frst injections of interferon-b in patients with multiple sclerosis. J. Neuroimmunol. 158(1-2), 195-203 (2005). (Pubitemid 39626087)
-
(2005)
Journal of Neuroimmunology
, vol.158
, Issue.1-2
, pp. 195-203
-
-
Gilli, F.1
Marnetto, F.2
Caldano, M.3
Sala, A.4
Malucchi, S.5
Di Sapio, A.6
Capobianco, M.7
Bertolotto, A.8
-
45
-
-
44249102808
-
IFN-β1b induces transient and variable gene expression in relapsing-remitting multiple sclerosis patients independent of neutralizing antibodies or changes in IFN receptor RNA expression
-
DOI 10.1089/jir.2007.0131
-
Reder AT, Velichko S, Yamaguchi KD et al.: IFN-b1b induces transient and variable gene expression in relapsing-remitting multiple sclerosis patients independent of neutralizing antibodies or changes in IFN receptor RNA expression. J. Interferon Cytokine Res. 28(5), 317-331 (2008). (Pubitemid 351725305)
-
(2008)
Journal of Interferon and Cytokine Research
, vol.28
, Issue.5
, pp. 317-331
-
-
Reder, A.T.1
Velichko, S.2
Yamaguchi, K.D.3
Hamamcioglu, K.4
Ku, K.5
Beekman, J.6
Wagner, T.C.7
Perez, H.D.8
Salamon, H.9
Croze, E.10
-
46
-
-
0031678450
-
Comparative study of the pharmacodynamic and pharmacologic effects of Betaseron® and AVONEX(TM)
-
Williams GJ, Witt PL: Comparative study of the pharmacodynamic and pharmacologic effects of Betaseron and AVONEX. J. Interferon Cytokine Res. 18(11), 967-975 (1998). (Pubitemid 28565800)
-
(1998)
Journal of Interferon and Cytokine Research
, vol.18
, Issue.11
, pp. 967-975
-
-
Williams, G.J.1
Witt, P.L.2
-
47
-
-
31644440262
-
Biological markers of interferon-beta therapy: Comparison among interferon-stimulated genes MxA, TRAIL and XAF-1
-
DOI 10.1191/135248506ms1245oa
-
Gilli F, Marnetto F, Caldano M H et al.: Biological markers of interferon-b therapy: comparison among interferon-stimulated genes MxA, TRAIL and XAF-1. Mult. Scler. 12(1), 47-57 (2006). (Pubitemid 43169237)
-
(2006)
Multiple Sclerosis
, vol.12
, Issue.1
, pp. 47-57
-
-
Gilli, F.1
Marnetto, F.2
Caldano, M.3
Sala, A.4
Malucchi, S.5
Capobianco, M.6
Bertolotto, A.7
-
48
-
-
34547699396
-
Type II monocytes modulate T cell-mediated central nervous system autoimmune disease
-
DOI 10.1038/nm1620, PII NM1620
-
Weber MS, Prod'homme T, Youssef S et al.: Type II monocytes modulate T cell-mediated central nervous system autoimmune disease. Nat. Med. 13(8), 935-943 (2007). (Pubitemid 47222047)
-
(2007)
Nature Medicine
, vol.13
, Issue.8
, pp. 935-943
-
-
Weber, M.S.1
Prod'homme, T.2
Youssef, S.3
Dunn, S.E.4
Rundle, C.D.5
Lee, L.6
Patarroyo, J.C.7
Stuve, O.8
Sobel, R.A.9
Steinman, L.10
Zamvil, S.S.11
-
49
-
-
79953232973
-
Dynamic ex vivo monocyte specifc and T cell relevant RNA signatures after glatiramer acetate administration in multiple sclerosis
-
P539
-
Goertsches R, Hecker M, Thamilarasan M et al.: Dynamic ex vivo monocyte specifc and T cell relevant RNA signatures after glatiramer acetate administration in multiple sclerosis. J. Neuroimmunol. 228(1-2), 90; P539 (2010).
-
(2010)
J. Neuroimmunol.
, vol.228
, Issue.1-2
, pp. 90
-
-
Goertsches, R.1
Hecker, M.2
Thamilarasan, M.3
-
50
-
-
36749069393
-
Interferons at age 50: Past, current and future impact on biomedicine
-
DOI 10.1038/nrd2422, PII NRD2422
-
Borden EC, Sen GC, Uze G et al.: Interferons at age 50: past, current and future impact on biomedicine. Nat. Rev. Drug. Discov. 6(12), 975-990 (2007). (Pubitemid 350201788)
-
(2007)
Nature Reviews Drug Discovery
, vol.6
, Issue.12
, pp. 975-990
-
-
Borden, E.C.1
Sen, G.C.2
Uze, G.3
Silverman, R.H.4
Ransohoff, R.M.5
Foster, G.R.6
Stark, G.R.7
-
51
-
-
70450162691
-
Identification of new sensitive biomarkers for the in vivo response to interferon-p treatment in multiple sclerosis using DNA-array evaluation
-
Sellebjerg F, Krakauer M, Hesse D et al. Identification of new sensitive biomarkers for the in vivo response to interferon-p treatment in multiple sclerosis using DNA-array evaluation. Eur. J. Neurol. 16(12), 1291-1298 (2009).
-
(2009)
Eur. J. Neurol.
, vol.16
, Issue.12
, pp. 1291-1298
-
-
Sellebjerg, F.1
Krakauer, M.2
Hesse, D.3
-
52
-
-
68249162126
-
Absence of MxA induction by interferon p in patients with MS reflects complete loss of bioactivky
-
Hesse D, Sellebjerg F, Sorensen PS: Absence of MxA induction by interferon p in patients with MS reflects complete loss of bioactivky. Neurology 73(5), 372-377 (2009).
-
(2009)
Neurology
, vol.73
, Issue.5
, pp. 372-377
-
-
Hesse, D.1
Sellebjerg, F.2
Sorensen, P.S.3
-
53
-
-
84859006684
-
Network analysis of transcriptional regulation in response to intramuscular interferon p-la multiple sclerosis treatment
-
Epub ahead of print
-
Hecker M, Goertsches R, Fatum C et al. Network analysis of transcriptional regulation in response to intramuscular interferon p-la multiple sclerosis treatment. Pharmacogenomics J. (2010) (Epub ahead of print).
-
(2010)
Pharmacogenomics J.
-
-
Hecker, M.1
Goertsches, R.2
Fatum, C.3
-
54
-
-
77955175014
-
Results of a phase I/II study of ocrelizumab, a fully humanized anti-CD20 mAb, in patients with relapsed/refractory follicular lymphoma
-
Morschhauser F, Marlton P, Vitolo U et al. Results of a phase I/II study of ocrelizumab, a fully humanized anti-CD20 mAb, in patients with relapsed/refractory follicular lymphoma. Ann. Oncol. 21(9), 1870-1876 (2010).
-
(2010)
Ann. Oncol.
, vol.21
, Issue.9
, pp. 1870-1876
-
-
Morschhauser, F.1
Marlton, P.2
Vitolo, U.3
-
55
-
-
34249891600
-
Gene expression changes in peripheral blood mononuclear cells from multiple sclerosis patients undergoing β-interferon therapy
-
DOI 10.1016/j.jns.2007.02.034, PII S0022510X07001785
-
Singh MK, Scott TF, La Framboise WAet al.: Gene expression changes in peripheral blood mononuclear cells from multiple sclerosis patients undergoing p-interferon therapy. Neurol. Sa. 258(1-2), 52-59 (2007). (Pubitemid 46874477)
-
(2007)
Journal of the Neurological Sciences
, vol.258
, Issue.1-2
, pp. 52-59
-
-
Singh, M.K.1
Scott, T.F.2
LaFramboise, W.A.3
Hu, F.Z.4
Post, J.C.5
Ehrlich, G.D.6
-
56
-
-
0034855936
-
Complex immunomodulatory effects of interferon-β in multiple sclerosis include the upregulation of T helper 1-associated marker genes
-
DOI 10.1002/ana.1096
-
Wandinger KP, Sturzebecher CS, Bielekova B et al.: Complex immunomodulatory effects of interferon-p in multiple sclerosis include the upregulation of T helper 1-associated marker genes. Ann. Neurol. 50(3), 349-357 (2001). (Pubitemid 32848737)
-
(2001)
Annals of Neurology
, vol.50
, Issue.3
, pp. 349-357
-
-
Wandinger, K.-P.1
Sturzebecher, C.-S.2
Bielekova, B.3
Detore, G.4
Rosenwald, A.5
Staudt, L.M.6
McFarland, H.F.7
Martin, R.8
-
57
-
-
1842687455
-
Microarray detection of E2F pathway activation and other targets in multiple sclerosis peripheral blood mononuclear cells
-
DOI 10.1016/j.jneuroim.2004.01.017, PII S0165572804000396
-
Iglesias AH, Camelo S, Hwang D, Villanueva R, Stephanopoulos G, Dangond F: Microarray detection of E2F pathway activation and other targets in multiple sclerosis peripheral blood mononuclear cells. J. Neuroimmunol. 150(1-2), 163-177(2004). (Pubitemid 38481661)
-
(2004)
Journal of Neuroimmunology
, vol.150
, Issue.1-2
, pp. 163-177
-
-
Iglesias, A.H.1
Camelo, S.2
Hwang, D.3
Villanueva, R.4
Stephanopoulos, G.5
Dangond, F.6
-
58
-
-
0038015502
-
Gelatinase B/matrix metalloproteinase-9 cleaves interferon-β and is a target for immunotherapy
-
DOI 10.1093/brain/awg129
-
Nelissen I, Martens E, Van den Steen PE et al. Gelatinase B/matrix met al.loproteinase-9 cleaves interferon-p and is a target for immunotherapy. Brain 126(Pt 6), 1371-1381 (2003). (Pubitemid 36644382)
-
(2003)
Brain
, vol.126
, Issue.6
, pp. 1371-1381
-
-
Nelissen, I.1
Martens, E.2
Van den Steen, P.E.3
Proost, P.4
Ronsse, I.5
Opdenakker, G.6
-
59
-
-
33744811943
-
Cerebrospinal fluid and serum levels and intrathecal production of active matrix metalloproteinase-9 (MMP-9) as markers of disease activity in patients with multiple sclerosis
-
DOI 10.1191/135248506ms1274oa
-
Fainardi E, Castellazzi M, Bellini T et al. Cerebrospinal fluid and serum levels and intrathecal production of active matrix met al.loproteinase-9 (MMP-9) as markers of disease activity in patients with multiple sclerosis. Mult. Scler. 12(3), 294-301 (2006). (Pubitemid 43827184)
-
(2006)
Multiple Sclerosis
, vol.12
, Issue.3
, pp. 294-301
-
-
Fainardi, E.1
Castellazzi, M.2
Bellini, T.3
Manfrinato, M.C.4
Baldi, E.5
Casetta, I.6
Paolino, E.7
Granieri, E.8
Dallocchio, F.9
-
60
-
-
77951868853
-
Breakthrough disease during interferon-p therapy in MS: No signs of impaired biologic response
-
Hesse D, Krakauer M, Lund H et al.Breakthrough disease during interferon-p therapy in MS: no signs of impaired biologic response. Neurology 74(18), 1455-1462 (2010).
-
(2010)
Neurology
, vol.74
, Issue.18
, pp. 1455-1462
-
-
Hesse, D.1
Krakauer, M.2
Lund, H.3
-
61
-
-
44949253997
-
Interferon-β increases BAFF levels in multiple sclerosis: Implications for B cell autoimmunity
-
DOI 10.1093/brain/awn077
-
KrumbholzM, Faber H, Steinmeyer F et al. Interferon-p increases BAFF levels in multiple sclerosis: implications for B cell autoimmunity. Brain 131(Pt6), 1455-1463 (2008). (Pubitemid 351806460)
-
(2008)
Brain
, vol.131
, Issue.6
, pp. 1455-1463
-
-
Krumbholz, M.1
Faber, H.2
Steinmeyer, F.3
Hoffmann, L.-A.4
Kumpfel, T.5
Pellkofer, H.6
Derfuss, T.7
Ionescu, C.8
Starck, M.9
Hafner, C.10
Hohlfeld, R.11
Meinl, E.12
-
62
-
-
51349090494
-
BAFF is a biological response marker to IFN-p treatment in multiple sclerosis
-
Gandhi KS, McKay FC, Schibeci SD et al. BAFF is a biological response marker to IFN-p treatment in multiple sclerosis. Interferon CytokineRes. 28(9), 529-539 (2008).
-
(2008)
Interferon Cytokine Res.
, vol.28
, Issue.9
, pp. 529-539
-
-
Gandhi, K.S.1
McKay, F.C.2
Schibeci, S.D.3
-
63
-
-
68849107852
-
Longitudinal system-based analysis of transcriptional responses to type i interferons
-
Pappas DJ, Coppola G, Gabatto PA et al. Longitudinal system-based analysis of transcriptional responses to type I interferons. Physiol. Genomics 38(3), 362-371 (2009).
-
(2009)
Physiol. Genomics
, vol.38
, Issue.3
, pp. 362-371
-
-
Pappas, D.J.1
Coppola, G.2
Gabatto, P.A.3
-
64
-
-
0034041863
-
Glatiramer acetate (Copaxone®) induces degenerate, Th2-polarized immune responses in patients with multiple sclerosis
-
Duda PW, Schmied MC, Cook SL et al. Glatiramer acetate (Copaxone®) induces degenerate, Th2-polarized immune responses in patients with multiple sclerosis. Clin. Invest. 105(7), 967-976 (2000). (Pubitemid 30203069)
-
(2000)
Journal of Clinical Investigation
, vol.105
, Issue.7
, pp. 967-976
-
-
Duda, P.W.1
Schmied, M.C.2
Cook, S.L.3
Krieger, J.I.4
Hafler, D.A.5
-
65
-
-
62549088294
-
Systems biology and its application to the understanding of neurological diseases
-
Villoslada P, Steinman L, Baranzini SE: Systems biology and its application to the understanding of neurological diseases. Ann. Neurol. 65(2), 124-139 (2009).
-
(2009)
Ann. Neurol.
, vol.65
, Issue.2
, pp. 124-139
-
-
Villoslada, P.1
Steinman, L.2
Baranzini, S.E.3
-
66
-
-
34247104189
-
Genome-wide network analysis reveals the global properties of IFN-β immediate transcriptional effects in humans
-
Fernald GH, Knott S, Pachner A et al.: Genome-wide network analysis reveals the global properties of IFN-p immediate transcriptional effects in humans. Immunol. 178(8), 5076-5085 (2007). (Pubitemid 46595291)
-
(2007)
Journal of Immunology
, vol.178
, Issue.8
, pp. 5076-5085
-
-
Fernald, G.H.1
Knott, S.2
Pachner, A.3
Caillier, S.J.4
Narayan, K.5
Oksenberg, J.R.6
Mousavi, P.7
Baranzini, S.E.8
-
67
-
-
43549125744
-
Martinez-Forero i et al.: A network analysis of the human T-cell activation gene network identifies JAGGEDl as a therapeutic target for autoimmune diseases
-
Palacios R, Goni J, Martinez-Forero I et al.: A network analysis of the human T-cell activation gene network identifies JAGGEDl as a therapeutic target for autoimmune diseases. PLoS ONE 2, 222 (2007).
-
(2007)
PLoS ONE
, vol.2
, pp. 222
-
-
Palacios, R.1
Goni, J.2
-
68
-
-
42049094003
-
IFN-p-regulated genes show abnormal expression in therapy-naive relapsing-remkting MS mononuclear cells: Gene expression analysis employing all reported protein-protein interactions
-
Yamaguchi KD, Ruderman DL, Croze E et al. IFN-p-regulated genes show abnormal expression in therapy-naive relapsing-remkting MS mononuclear cells: gene expression analysis employing all reported protein-protein interactions. Neuroimmunol. 195(1-2), 116-120 (2008).
-
(2008)
Neuroimmunol.
, vol.195
, Issue.1-2
, pp. 116-120
-
-
Yamaguchi, K.D.1
Ruderman, D.L.2
Croze, E.3
-
69
-
-
47649124124
-
A global view of gene activity and alternative splicing by deep sequencing of the human transcriptome
-
Sultan M, Schulz MH, Richard H et al.: A global view of gene activity and alternative splicing by deep sequencing of the human transcriptome. Science321(5891), 956-960 (2008).
-
(2008)
Science
, vol.321
, Issue.5891
, pp. 956-960
-
-
Sultan, M.1
Schulz, M.H.2
Richard, H.3
-
70
-
-
62649151993
-
Pharmacogenomics of IFN-p in multiple sclerosis: Towards a personalized medicine approach
-
Vosslamber S, Van Baarsen LG, Verweij CL: Pharmacogenomics of IFN-p in multiple sclerosis: towards a personalized medicine approach. Pharmacogenomics 10(1), 97-108 (2009).
-
(2009)
Pharmacogenomics
, vol.10
, Issue.1
, pp. 97-108
-
-
Vosslamber, S.1
Van Baarsen, L.G.2
Verweij, C.L.3
-
71
-
-
77954399739
-
Sex and sensitivity: The continued need for sex-based biomedical research and implementation
-
Tingen CM, Kim AM, Wu PH, Woodruff TK: Sex and sensitivity: the continued need for sex-based biomedical research and implementation. Womens Health 6(4), 511-516 (2010).
-
(2010)
Womens Health
, vol.6
, Issue.4
, pp. 511-516
-
-
Tingen, C.M.1
Kim, A.M.2
Wu, P.H.3
Woodruff, T.K.4
-
72
-
-
77956287071
-
Novel approaches to detect serum biomarkers for clinical response to interferon-p treatment in multiple sclerosis
-
Gandhi KS, McKay FC, Diefenbach E et al.: Novel approaches to detect serum biomarkers for clinical response to interferon-p treatment in multiple sclerosis. PLoS ONE 5 (5), e 10484 (2010).
-
(2010)
PLoS ONE
, vol.5
, Issue.5
-
-
Gandhi, K.S.1
McKay, F.C.2
Diefenbach, E.3
-
73
-
-
79953246243
-
Gender effects on intramuscular interferon p-la in relapsing-remkting multiple sclerosis: Analysis of 1406 patients
-
Epub ahead of print
-
Rudick R, Kappos L, Kinkel R et al.: Gender effects on intramuscular interferon p-la in relapsing-remkting multiple sclerosis: analysis of 1406 patients. Mult. Scler. (2010) (Epub ahead of print).
-
(2010)
Mult. Scler.
-
-
Rudick, R.1
Kappos, L.2
Kinkel, R.3
-
74
-
-
0042930859
-
Genomic effects of IFN-β in multiple sclerosis patients
-
Weinstock-Guttman B, Badgett D, Patrick K et al.: Genomic effects of IFN-p in multiple sclerosis patients. Immunol. 171(5), 2694-2702 (2003). (Pubitemid 37025583)
-
(2003)
Journal of Immunology
, vol.171
, Issue.5
, pp. 2694-2702
-
-
Weinstock-Guttman, B.1
Badgett, D.2
Patrick, K.3
Hartrich, L.4
Santos, R.5
Hall, D.6
Baier, M.7
Feichter, J.8
Ramanathan, M.9
-
75
-
-
33746078848
-
Dynamics of interferon-β modulated mRNA biomarkers in multiple sclerosis patients with anti-interferon-β neutralizing antibodies
-
DOI 10.1016/j.jneuroim.2006.03.019, PII S0165572806001226
-
Santos R, Weinstock-Guttman B, Tamano-Blanco M et al.: Dynamics of interferon-p modulated mRNA biomarkers in multiple sclerosis patients with anti-interferon-p neutralizing antibodies. Neuroimmunol. 176(1-2), 125-133 (2006). (Pubitemid 44080329)
-
(2006)
Journal of Neuroimmunology
, vol.176
, Issue.1-2
, pp. 125-133
-
-
Santos, R.1
Weinstock-Guttman, B.2
Tamano-Blanco, M.3
Badgett, D.4
Zivadinov, R.5
Justinger, T.6
Munschauer III, F.7
Ramanathan, M.8
-
76
-
-
78751522947
-
Disease protection and interleukin-10 induction by endogenous interferon-p in multiple sclerosis?
-
Epub ahead of print
-
Hesse D, Krakauer M, Lund H et al.: Disease protection and interleukin-10 induction by endogenous interferon-p in multiple sclerosis? Eur. J. Neurol, doi: 18, 266-272 (2010) (Epub ahead of print).
-
(2010)
Eur. J. Neurol Doi
, vol.18
, pp. 266-272
-
-
Hesse, D.1
Krakauer, M.2
Lund, H.3
-
77
-
-
46849085156
-
Gene expression analysis of interferon-β treatment in multiple sclerosis
-
DOI 10.1177/1352458507085976
-
Sellebjerg F, Datta P, Larsen J et al.: Gene expression analysis of interferon-p treatment in multiple sclerosis. Mult. Scler. 14(5), 615-621 (2008). (Pubitemid 351954403)
-
(2008)
Multiple Sclerosis
, vol.14
, Issue.5
, pp. 615-621
-
-
Sellebjerg, F.1
Datta, P.2
Larsen, J.3
Rieneck, K.4
Alsing, I.5
Oturai, A.6
Svejgaard, A.7
Sorensen, P.S.8
Ryder, L.P.9
-
78
-
-
33646107167
-
T cell gene expression profiling identifies distinct subgroups of Japanese multiple sclerosis patients
-
Satoh J, Nakanishi M, Koike F et al.: T cell gene expression profiling identifies distinct subgroups of Japanese multiple sclerosis patients. Neuroimmunol. 174(1-2), 108-118 (2006).
-
(2006)
Neuroimmunol.
, vol.174
, Issue.1-2
, pp. 108-118
-
-
Satoh, J.1
Nakanishi, M.2
Koike, F.3
-
79
-
-
0038546727
-
Microarray analysis identifies interferon β-regulated genes in multiple sclerosis
-
DOI 10.1016/S0165-5728(03)00155-3
-
Koike F, Satoh J, Miyake S et al.: Microarray analysis identifies interferon p-regulated genes in multiple sclerosis. Neuroimmunol. 139(1-2), 109-118 (2003). (Pubitemid 36694397)
-
(2003)
Journal of Neuroimmunology
, vol.139
, Issue.1-2
, pp. 109-118
-
-
Koike, F.1
Satoh, J.-I.2
Miyake, S.3
Yamamoto, T.4
Kawai, M.5
Kikuchi, S.6
Nomura, K.7
Yokoyama, K.8
Ota, K.9
Kanda, T.10
Fukazawa, T.11
Yamamura, T.12
-
80
-
-
0038692013
-
Expression profiling identifies responder and non-responder phenotypes to interferon-β in multiple sclerosis
-
DOI 10.1093/brain/awg147
-
Sturzebecher S, Wandinger KP, Rosenwald A et al.: Expression profiling identifies responder and non-responder phenotypes to interferon-p in multiple sclerosis. Brain 126(6), 1419-1429 (2003). (Pubitemid 36644386)
-
(2003)
Brain
, vol.126
, Issue.6
, pp. 1419-1429
-
-
Sturzebecher, S.1
Wandinger, K.P.2
Rosenwald, A.3
Sathyamoorthy, M.4
Tzou, A.5
Mattar, P.6
Frank, J.A.7
Staudt, L.8
Martin, R.9
McFarland, H.F.10
-
81
-
-
33847377610
-
Gene expression profiles reveal homeostatic dynamics during interferon-β therapy in multiple sclerosis
-
DOI 10.1080/08916930601135241, PII 771299014
-
Annibali V, Di Giavanni S, Cannoni S et al.: Gene expression profiles reveal homeostatic dynamics during interferon-p therapy in multiple sclerosis. Autoimmunity 40(1), 16-22 (2007). (Pubitemid 46332418)
-
(2007)
Autoimmunity
, vol.40
, Issue.1
, pp. 16-22
-
-
Annibali, V.1
Di Giovanni, S.2
Cannoni, S.3
Giugni, E.4
Bomprezzi, R.5
Mattei, C.6
Elkahloun, A.7
Coccia, E.M.8
Alfo, M.9
Orzi, F.10
Ristori, G.11
Salvetti, M.12
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