Intrathecal IgM synthesis in pediatric MS is not a negative prognostic marker of disease progression: Quantitative versus qualitative IgM analysis

Multiple Sclerosis Journal

Volumn 17, Issue 3, 2011, Pages 327-334

  Stauch, C ^a   Reiber, H ^a   Rauchenzauner, M ^b   Strasak, A ^b   Pohl, D ^c   Hanefeld, F ^a   Gartner J ^a   Rostasy K M ^b  

^a UNIVERSITY OF GÖTTINGEN   (Germany)

^b INNSBRUCK MEDICAL UNIVERSITY   (Austria)

^c CHILDREN S HOSPITAL OF EASTERN ONTARIO   (Canada)

Author keywords

cerebrospinal fluid; children; IgM; multiple sclerosis

Indexed keywords

AZATHIOPRINE; GLATIRAMER; IMMUNOGLOBULIN M; INTERFERON; METHYLPREDNISOLONE;

ADOLESCENT; ARTICLE; CEREBROSPINAL FLUID ANALYSIS; CHILDHOOD DISEASE; CONTROLLED STUDY; DISABILITY SEVERITY; DISEASE ASSOCIATION; DISEASE COURSE; FEMALE; HUMAN; MAJOR CLINICAL STUDY; MALE; MULTIPLE SCLEROSIS; PREDICTIVE VALUE; PROGNOSIS; QUALITATIVE ANALYSIS; QUANTITATIVE ANALYSIS; RECURRENT DISEASE;

EID: 79953216039     PISSN: 13524585     EISSN: None     Source Type: Journal    
DOI: 10.1177/1352458510388543     Document Type: Article

References (21)

1. Reiber H., Teut M., Pohl D., Rostasy KM and Hanefeld F. Pediatric Multiple sclerosis: Age related differences and time course of the neuroimmunological reponse in CSF. Mult Scler 2009 ; 15: 1466-1480.
2. Reiber H. and Albaum W. Statistical evaluation of intrathecal protein synthesis in CSF/Serum quotient diagrams. Acta Neuropsychiatrica 2008 ; 20: 48-49.
3. CSF Statistics Tool, free download from http://www.comed-com.de/ ( CoMed, Soest, Germany).
4. Wildemann B, Oschmann P, Reiber H (eds) (2010). Laboratory diagnosis in Neurology. Thieme, Stuttgart, Germany.
5. Reiber H. and Peter JB Cerebrospinal fluid analysis - disease-related data patterns and evaluation programs. J Neurol Sci 2001 ; 184: 101-122. (Pubitemid 32178265)
6. Villar LM, Masjuan J., Gonzalez-Porque P., et al. Intrathecal IgM synthesis predicts the onset of new relapses and a worse disease course in MS. Neurology 2002 ; 59: 555-559. (Pubitemid 34919989)
7. Sharief MK and Thompson EJ Intrathecal immunglobulin M synthesis in multiple sclerosis. Brain 1991 ; 114: 181-195.
8. Villar LM, Masjuan J., Gonzalez-Porque P., Plaza J., et al. Intrathecal IgM Synthesis in neurologic diseases: Relationship with disability in MS. Neurology 2002 ; 58: 824-826. (Pubitemid 34211568)
9. Villar LM, Sadaba MC, Roldan E., et al. Intrathecal synthesis of oligoclonal IgM against myelin basic protein predicts an aggressive disease course in MS. J Clin Invest 2005 ; 115: 187-194. (Pubitemid 40385520)
10. Poser CM, Paty DW, Scheinberg LC, et al. New diagnostic criteria for multiple sclerosis: guidelines for research protocols. Ann Neurol 1983 ; 13: 227-231. (Pubitemid 13158528)
11. McDonald WI, Compston A., Edan G., et al. Recommended diagnostic criteria for multiple sclerosis: Guidelines from the international panel on the diagnosis of multiple sclerosis. Ann Neurol 2001 ; 50: 121-127.
12. Lechner-Scott J., Kappos L., Hofman M., et al. Can the Expanded Disability Status Scale be assessed by telephone? Mult Scler 2003 ; 9: 154-159. (Pubitemid 36426990)
13. Reiber H., Ungefehr S. and Jacobi C. The intrathecal, polyspecific and oligoclonal immune response in multiple sclerosis. Mult Scler 1998 ; 4: 111-117. (Pubitemid 28410034)
14. Pohl D., Rostasy K., Reiber H. and Hanefeld F. CSF characteristics in early-onset multiple sclerosis: A tool for early diagnosis. Neurology 2004 ; 63: 1966-1967. (Pubitemid 39532406)
15. Franciotta D., Salvetti M., Lolli F., Serafini B. and Aloisi F. B cells and multiple sclerosis. Lancet Neurology 2008 ; 7: 852-858.
16. Meinl E., Krumbholz M. and Hohlfeld R. B lineage cells in the inflammatory central nervous system environment: Migration, maintenance, local antibody production and therapeutic modulation. Ann Neurol 2006 ; 59: 880-892. (Pubitemid 43830920)
17. Schneider R., Euler B. and Rauer S. Intrathecal IgM-synthesis does not correlate with the risk of relapse in patients with a primary demyelinating event. Euro J Neurol 2007 ; 14: 907-911. (Pubitemid 47106779)
18. Mikaeloff Y., Suissa S., Vallee L., Lubetzki C., Ponsot G., Confavreux C., et al. KIDMUS Study Group. First episode of acute inflammatory demyelinisation in childhood: prognostic factors for multiple sclerosis. J Pediatr 2004 ; 144: 246-252. (Pubitemid 38869403)
19. Mikaeloff Y., Caridade G., Assi S., Suissa S. and Tardieu M. Prognostic factors forearly severity in a childhood multiple sclerosis cohort. Pediatrics 2006 ; 118: 1133-1139. (Pubitemid 46090056)
20. Simone IL, Carrara D., Tortorella C., et al. Course and prognosis in early-onset MS. Comparison with adult-onset forms. Neurology 2002 ; 59: 1922-1928. (Pubitemid 36076565)
21. Reiber H. Flow rate of cerebrospinal fluid (CSF) - a concept common to normal blood-CSF barrier function and to dysfunction in neurological diseases. J Neurol Sci 1994 ; 122: 189-203. (Pubitemid 24097269)