Plasmid-mediated penicillin and tetracycline resistance among neisseria gonorrhoeae isolates in South Africa: Prevalence, detection and typing using a novel molecular assay

Sexually Transmitted Diseases

Volumn 38, Issue 4, 2011, Pages 329-333

  Fayemiwo, Samuel A ^a   Müller, Etienne E ^b   Gumede, Lindy ^b   Lewis, David A ^b,c,d  

^a UNIVERSITY OF IBADAN   (Nigeria)

^b NATIONAL INSTITUTE FOR COMMUNICABLE DISEASES   (South Africa)

^c UNIVERSITY OF THE WITWATERSRAND   (South Africa)

^d UNIVERSITY OF CAPE TOWN   (South Africa)

Author keywords

[No Author keywords available]

Indexed keywords

BETA LACTAMASE; NITROCEFIN; PENICILLIN G; PENICILLINASE; TETRACYCLINE;

AMPLICON; ANTIBIOTIC RESISTANCE; ARTICLE; BACTERIUM DETECTION; BACTERIUM ISOLATE; BIOASSAY; CONTROLLED STUDY; DISEASE ASSOCIATION; EPSILOMETER TEST; HUMAN; MALE; MINIMUM INHIBITORY CONCENTRATION; MOLECULAR TYPING; NEISSERIA GONORRHOEAE; NONHUMAN; PLASMID; POLYMERASE CHAIN REACTION; PREVALENCE; SOUTH AFRICA;

ANTI-BACTERIAL AGENTS; BETA-LACTAMASES; DNA, BACTERIAL; GONORRHEA; HUMANS; MALE; MICROBIAL SENSITIVITY TESTS; MOLECULAR TYPING; NEISSERIA GONORRHOEAE; PENICILLIN RESISTANCE; PENICILLINS; POLYMERASE CHAIN REACTION; PREVALENCE; R FACTORS; SOUTH AFRICA; TETRACYCLINE; TETRACYCLINE RESISTANCE; URETHRA;

EID: 79953214377     PISSN: 01485717     EISSN: None     Source Type: Journal    
DOI: 10.1097/OLQ.0b013e3181fc695a     Document Type: Article

References (27)

1. Romoren M, Sundby J, Velauthapillai M, et al. Chlamydia and gonorrhoea in pregnant Batswana women: time to discard the syndromic approach? BMC Infect Dis 2007; 7:27.
2. Pepin J, Sobela F, Deslandes S, et al. Etiology of urethral discharge in West Africa: The role of Mycoplasma genitalium and Trichomonas vaginalis. Bull World Health Organ 2001; 79:118-126. (Pubitemid 32187792)
3. Lewis DA. The gonococcus fights back: is this time a knock out? Sex Trasm Infect 2010; 86:415-421.
4. Tapsall JW, Ndowa F, Lewis DA, et al. Meeting the public health challenge of multidrug-and extensively drug-resistant Neisseria gonorrhoeae. Expert Rev Anti Infect Ther 2009; 7:821-834.
5. Viberg N, Mujinja P, Kalala W, et al. STI management in Tanzanian private drugstores: Practices and roles of drug sellers. Sex Transm Infect 2009; 85:300-307.
6. Unemo M, Fasth O, Fredlund H, et al. Phenotypic and genetic characterization of the 2008 WHO Neisseria gonorrhoeae reference strain panel intended for global quality assurance and quality control of gonococcal antimicrobial resistance surveillance for public health purposes. J Antimicrob Chemother 2009; 63:1142-1151.
7. Van Dyck E, Rossau R, Duhamel M, et al. Antimicrobial susceptibility of Neisseria gonorrhoeae in Zaire: High level plasmidmediated tetracycline resistance in central Africa. Genitourin Med 1992; 68:111-116.
8. Bogaerts J, Van Dyck E, Mukantabana B, et al. Auxotypes, serovars, and trends of antimicrobial resistance of Neisseria gonorrhoeae in Kigali, Rwanda (1985-93). Sex Transm Infect 1998; 74:205-209.
9. West B, Changalucha J, Grosskurth H, et al. Antimicrobial susceptibility, auxotype and plasmid content of Neisseria gonorrhoeae in northern Tanzania: emergence of high level plasmid mediated tetracycline resistance. Genitourin Med 1995; 71:9-12.
10. Moodley P, Hoppenbrouwers J, Bohlken L, et al. Emergence of TetM-mediated tetracycline resistance in rural South Africa. J Antimicrob Chemother 2001; 48:142-143. (Pubitemid 32684741)
11. de Jongh M, Dangor Y, Adam A, et al. Gonococcal resistance: Evolving from penicillin, tetracycline to the quinolones in South Africa-implications for treatment guidelines. Int J STD AIDS 2007; 18:697-699. (Pubitemid 351738901)
12. Mason PR, Gwanzura L, Latif AS, et al. Antimicrobial susceptibility of Neisseria gonorrhoeae in Harare, Zimbabwe. Relationship to serogroup. Sex Transm Dis 1990; 17:63-66. (Pubitemid 20224325)
13. Chalkley LJ, Janse van Rensburg MN, Matthee PC, et al. Plasmid analysis of Neisseria gonorrhoeae isolates and dissemination of tetM genes in southern Africa 1993-1995. J Antimicrob Chemother 1997; 40:817-822. (Pubitemid 28022146)
14. Dillon JR, Li H, Yeung KH, et al. A PCR assay for discriminating Neisseria gonorrhoeae-lactamase-producing plasmids. Mol Cell Probes 1999; 13:89-92.
15. Turner A, Gough KR, Leeming JP. Molecular epidemiology of tetM genes in Neisseria gonorrhoeae. Sex Transm Infect 1999; 75:60-66. (Pubitemid 29117485)
16. National Committee for Clinical Laboratory Standards. Performance Standards for Antimicrobial Susceptibility Testing. Wayne, PA: National Committee for Clinical Laboratory Standards,. 2010. Informational supplement, M100-S20.
17. Dillon JA, Yeung KH. Beta-lactamase plasmids and chromosomally mediated antibiotic resistance in pathogenic Neisseria species. Clin Microbiol Rev 1989; 2(suppl):S125-S133.
18. Gouby A, Bourg G, Ramuz M. Previously undescribed 6.6-kilobase R plasmid in penicillinase-producing Neisseria gonorrhoeae. Antimicrob Agents Chemother 1986; 29:1095-1097. (Pubitemid 16084077)
19. Brett M. A novel gonococcal beta-lactamase plasmid. J Antimicrob Chemother 1989; 23:653-654.
20. Pagotto F, Aman AT, Ng LK, et al. Sequence analysis of the family of penicillinase-producing plasmids of Neisseria gonorrhoeae. Plasmid 2000; 43:24-34. (Pubitemid 30049001)
21. CDC. Tetracycline-resistant Neisseria gonorrhoeae-Georgia, Pennsylvania, New Hampshire. Morb Mortal Wkly Rep 1985; 34:563-564, 569-570.
22. Roberts MC, Wagenvoort JH, van Klingeren B, et al. TetM-and beta-lactamase-containing Neisseria gonorrhoeae (tetracycline resistant and penicillinase producing) in The Netherlands. Antimicrob Agents Chemother 1988; 32:158. (Pubitemid 18025701)
23. Gascoyne-Binzi DM, Hawkey PM, Heritage J, et al. World-wide distribution of high level tetracycline-resistant Neisseria gonorrhoeae. Genitourin Med 1992; 68:277-278.
24. Ison CA, Tekki N, Gill MJ. Detection of the tetM determinant in Neisseria gonorrhoeae. Sex Transm Dis 1993; 20:329-333. (Pubitemid 23347228)
25. Gascoyne DM, Heritage J, Hawkey PM, et al. Molecular evolution of tetracycline-resistance plasmids carrying TetM found in Neisseria gonorrhoeae from different countries. J Antimicrob Chemother 1991; 28:173-183.
26. Gascoyne-Binzi DM, Heritage J, Hawkey PM. Nucleotide sequences of the tet(M) genes from the American and Dutch type tetracycline resistance plasmids of Neisseria gonorrhoeae. J Antimicrob Chemother 1993; 32:667-676. (Pubitemid 23343750)
27. Gascoyne-Binzi DM, Hawkey PM, Heritage J. The distribution of variants of the TetM determinant in tetracycline-resistant Neisseria gonorrhoeae. J Antimicrob Chemother 1994; 33:1011-1016. (Pubitemid 24170901)