Impact of obesity on total and cardiovascular mortality-fat or fiction?

Nature Reviews Cardiology

Volumn 8, Issue 4, 2011, Pages 233-237

  Cepeda Valery, Beatriz ^a   Pressman, Gregg S ^a   Figueredo, Vincent M ^a   Romero Corral, Abel ^a  

^a ALBERT EINSTEIN MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADIPONECTIN; APOLIPOPROTEIN B; CYTOKINE; FATTY ACID; GLUCOSE; INSULIN; TRIACYLGLYCEROL; VERY LOW DENSITY LIPOPROTEIN;

ABDOMINAL OBESITY; ADIPOSE TISSUE; ANTHROPOMETRY; BODY COMPOSITION; BODY FAT DISTRIBUTION; BODY MASS; CARDIOVASCULAR RISK; CHRONIC RESPIRATORY TRACT DISEASE; CLINICAL ASSESSMENT; CLINICAL EVALUATION; CLINICAL STUDY; COMPUTER ASSISTED TOMOGRAPHY; CORONARY ARTERY DISEASE; CORRELATION ANALYSIS; DIABETES MELLITUS; DUAL ENERGY X RAY ABSORPTIOMETRY; DYSLIPIDEMIA; HEART INFARCTION; HUMAN; HYPERTENSION; HYPERTRIGLYCERIDEMIA; INSULIN RESISTANCE; INTRAABDOMINAL FAT; LEAN BODY WEIGHT; LIPOLYSIS; METABOLIC DISORDER; MORBIDITY; MORTALITY; NUCLEAR MAGNETIC RESONANCE IMAGING; OBESITY; PREDICTIVE VALUE; PREDICTOR VARIABLE; PREVALENCE; PRIORITY JOURNAL; REVIEW; RISK ASSESSMENT; RISK MANAGEMENT; SENSITIVITY AND SPECIFICITY; SMOKING; SURVIVAL; TRIACYLGLYCEROL BLOOD LEVEL; WAIST CIRCUMFERENCE; WAIST HIP RATIO;

ADIPOSE TISSUE; BODY COMPOSITION; BODY MASS INDEX; CARDIOVASCULAR DISEASES; HUMANS; OBESITY; OBESITY, ABDOMINAL; RISK; RISK ASSESSMENT;

EID: 79953207628     PISSN: 17595002     EISSN: 17595010     Source Type: Journal    
DOI: 10.1038/nrcardio.2010.209     Document Type: Review

References (35)

1. Centers for Disease Control and Prevention. State-specific obesity prevalence among adults\United States 2009 [online] http://www.cdc.gov/mmwr/ preview/mmwrhtml/mm59e0803a1.htm?s cid=mm59e0803a1 e%0D%0A (2010).
2. WHO. World Health Report (WHO, Geneva, 2006).
3. National Institute of Diabetes and Digestive and Kidney Diseases. Understanding adult obesity [online] http://www.win.niddk.nih.gov/publications/ understanding.htm (2008).
4. WHO. Obesity and overweight [online], http://www.who.int/mediacentre/ factsheets/fs311/en/index.html (2006).
5. AACE/ACE Obesity Task Force. AACE/ACE position statement on the prevention, diagnosis and treatment of obesity (1998 revision). Endocr. Pract 4, 297-350 (1998).
6. National Heart, Lung and Blood Institute. Overweight and obesity [online], http://www.nhlbi.nih.gov/health/dci/Diseases/obe/obe whatare.html (2010).
7. Gallagher, D. et al. Healthy percentage body fat ranges: an approach for developing guidelines based on body mass index. Am. J. Clin. Nutr. 72, 694-701 (2000). (Pubitemid 30667089)
8. Romero-Corral, A. et al. Normal weight obesity: a risk factor for cardiometabolic dysregulation and cardiovascular mortality. Eur. Heart J. 31, 737-746 (2010).
9. Poirier, P et al. Obesity and cardiovascular disease: pathophysiology, evaluation, and effect of weight loss: an update of the 1997 American Heart Association Scientific Statement on Obesity and Heart Disease from the Obesity Committee of the Council on Nutrition, Physical Activity, and Metabolism. Circulation 113, 898-918 (2006).
10. Romero-Corral, A. et al. Association of bodyweight with total mortality and with cardiovascular events in coronary artery disease: a systematic review of cohort studies. Lancet 368, 666-678 (2006). (Pubitemid 44223694)
11. Allison, D. B., Zhu, S. K., Plankey, M., Faith, M. S. & Heo, M. Differential associations of body mass index and adiposity with all-cause mortality among men in the first and second National Health and Nutrition Examination Surveys (NHANES I and NHANES II) follow-up studies. Int. J. Obes. Relat Metab. Disord. 26, 410-416 (2002). (Pubitemid 34226168)
12. Flegal, K. M., Graubard, B. I., Williamson, D. F. & Gail, M. H. Cause-specific excess deaths associated with underweight, overweight, and obesity. JAMA 298, 2028-2037 (2007). (Pubitemid 350074800)
13. McGee, D. L. et al. for the Diverse Populations Collaboration. Body mass index and mortality: a meta-analysis based on person-level data from twenty-six observational studies. Ann. Epidemiol. 15, 87-97 (2005). (Pubitemid 40126638)
14. Adams, K. F. et al. Overweight, obesity, and mortality in a large prospective cohort of persons 50 to 71 years old. N. Engl. J. Med. 355, 763-778 (2006). (Pubitemid 44285582)
15. Whitlock, G. et al. Body-mass index and cause-specific mortality in 900,000 adults: collaborative analyses of 57 prospective studies. Lancet 373, 1083-1096 (2009).
16. Lewis, C. E. et al. Mortality, health outcomes, and body mass index in the overweight range: a science advisory from the American Heart Association. Circulation 119, 3263-3271 (2009).
17. Romero-Corral, A. et al. Accuracy of body mass index in diagnosing obesity in the adult general population. Int. J. Obes. (Lond.) 32, 959-966 (2008). (Pubitemid 351986216)
18. Pouliot, M. C. et al. Waist circumference and abdominal sagittal diameter: best simple anthropometric indexes of abdominal visceral adipose tissue accumulation and related cardiovascular risk in men and women. Am. J. Cardiol. 73, 460-468 (1994).
19. Després, J. P & Lemieux, I. Abdominal obesity and metabolic syndrome. Nature 444, 881-887 (2006). (Pubitemid 46024995)
20. Després, J. P et al. Abdominal obesity and the metabolic syndrome: contribution to global cardiometabolic risk. Arterioscler. Thromb. Vasc. Biol. 28, 1039-1049 (2008).
21. Lee, C. M., Huxley, R., Wildman, R. P & Woodward, M. Indices of abdominal obesity are better discriminators of cardiovascular risk factors than BMI: a meta-analysis. J. Clin. Epidemiol. 61, 646-653 (2008).
22. Balkau, B. et al. International Day for the Evaluation of Abdominal Obesity (IDEA): a study of waist circumference, cardiovascular disease, and diabetes mellitus in 168,000 primary care patients in 63 countries. Circulation 116, 1942-1951 (2007). (Pubitemid 350287090)
23. Janssen, I., Katzmarzyk, P T. & Ross, R. Waist circumference and not body mass index explains obesity-related health risk. Am. J. Clin. Nutr. 79, 379-384 (2004). (Pubitemid 41115579)
24. Arsenault, B. J. et al. The hypertriglyceridemic-waist phenotype and the risk of coronary artery disease: results from the EPIC-Norfolk prospective population study. CMAJ 182, 1427-1432 (2010).
25. Yusuf, S. et al. Obesity and the risk of myocardial infarction in 27,000 participants from 52 countries: a case-control study. Lancet 366, 1640-1649 (2005). (Pubitemid 41552419)
26. de Koning, L., Merchant, A. T., Pogue, J. & Anand, S. S. Waist circumference and waist-to-hip ratio as predictors of cardiovascular events: meta-regression analysis of prospective studies. Eur. Heart J. 28, 850-856 (2007). (Pubitemid 47343598)
27. Zeller, M. et al. Relation between body mass index, waist circumference, and death after acute myocardial infarction. Circulation 118, 482-490 (2008).
28. Hsieh, S. D., Yoshinaga, H. & Muto, T. Waist-to-height ratio, a simple and practical index for assessing central fat distribution and metabolic risk in Japanese men and women. Int. J. Obes. Relat Metab. Disord. 27, 610-616 (2003). (Pubitemid 36561019)
29. Romero-Corral, A. et al. The waist index is better associated with history of myocardial infarction than body mass index, waist circumference and waist-to-hip ratio [abstract]. Circulation 118 (Suppl.), a3222 (2008).
30. Heitmann, B. L., Erikson, H., Ellsinger, B. M., Mikkelsen, K. L. & Larsson, B. Mortality associated with body fat, fat-free mass and body mass index among 60-year-old Swedish men\a 22-year follow-up. The study of men born in 1913. Int. J. Obes. Relat Metab. Disord. 24, 33-37 (2000). (Pubitemid 30098876)
31. Bigaard, J. et al. Body fat and fat-free mass and all-cause mortality. Obes. Res. 12, 1042-1049 (2004). (Pubitemid 41132482)
32. De Lorenzo, A., Martinoli, R., Vaia, F. & Di Renzo, L. Normal weight obese (NWO) women: an evaluation of a candidate new syndrome. Nutr. Metab. Cardiovasc. Dis. 16, 513-523 (2006). (Pubitemid 44794584)
33. Flegal, K. M. & Graubard, B. I. Estimates of excess deaths associated with body mass index and other anthropometric variables. Am. J. Clin. Nutr. 89, 1213-1219 (2009).
34. Fuller, N. J., Sawyer, M. B., Laskey, M. A., Paxton, P & Elia, M. Prediction of body composition in elderly men over 75 years of age. Ann. Hum. Biol. 23, 127-147 (1996). (Pubitemid 126482139)
35. Lee, S. Y. & Gallagher, D. Assessment methods in human body composition. Curr. Opin. Clin. Nutr. Metab. Care 11, 566-572 (2008).