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Volumn 71, Issue 5, 2011, Pages 515-525

Use of inotropic agents in patients with advanced heart failure: Lessons from recent trials and hopes for new agents

Author keywords

Cardiotonics; Chronic heart failure; Digoxin; Dobutamine; Dopamine; Enoximone; Epoprostenol; Etomoxir; Istaroxime; Levosimendan; Milrinone; Omecamtiv mecarbil; Perhexiline; Ranolazine; Research and development; Trimetazidine; Urocortin

Indexed keywords

CALCIUM; CYCLIC AMP; DIGOXIN; INOTROPIC AGENT; MYOSIN;

EID: 79953206654     PISSN: 00126667     EISSN: 11791950     Source Type: Journal    
DOI: 10.2165/11585480-000000000-00000     Document Type: Review
Times cited : (16)

References (81)
  • 1
    • 0034609529 scopus 로고    scopus 로고
    • Evidence of improving prognosis in heart failure: Trends in case fatality in 66,547 patients hospitalized between 1986 and 1995
    • MacIntyre K, Capewell S, Stewart S, et al. Evidence of improving prognosis in heart failure: trends in case fatality in 66,547 patients hospitalized between 1986 and 1995. Circulation 2000; 102: 1126-31.
    • (2000) Circulation , vol.102 , pp. 1126-31
    • MacIntyre, K.1    Capewell, S.2    Stewart, S.3
  • 3
    • 77958545980 scopus 로고    scopus 로고
    • 2010 focused update of ESC guidelines on device therapy in heart failure: An update of the 2008 ESC guidelines for the diagnosis and treatment of acute and chronic heart failure and the 2007 ESC guidelines for cardiac and resynchronization therapy
    • Developed with the special contribution of the Heart Failure Association and the European Heart Rhythm Association
    • Dickstein K, Vardas PE, Auricchio A, et al. 2010 focused update of ESC guidelines on device therapy in heart failure: an update of the 2008 ESC guidelines for the diagnosis and treatment of acute and chronic heart failure and the 2007 ESC guidelines for cardiac and resynchronization therapy. Developed with the special contribution of the Heart Failure Association and the European Heart Rhythm Association. Eur J Heart Fail 2010; 12: 1143-53.
    • (2010) Eur J Heart Fail , vol.12 , pp. 1143-53
    • Dickstein, K.1    Vardas, P.E.2    Auricchio, A.3
  • 5
    • 38949162580 scopus 로고    scopus 로고
    • Fluid overload in acute heart failure - Re-distribution and other mechanisms beyond fluid accumulation
    • DOI 10.1016/j.ejheart.2008.01.007, PII S1388984208000081
    • Cotter G, Metra M, Milo-Cotter O, et al. Fluid overload in acute heart failure: re-distribution and other mechanisms beyond fluid accumulation. Eur J Heart Fail 2008; 10: 165-9. (Pubitemid 351222743)
    • (2008) European Journal of Heart Failure , vol.10 , Issue.2 , pp. 165-169
    • Cotter, G.1    Metra, M.2    Milo-Cotter, O.3    Dittrich, H.C.4    Gheorghiade, M.5
  • 6
    • 54049105749 scopus 로고    scopus 로고
    • Transition from chronic compensated to acute decompensated heart failure: Pathophysiological insights obtained from continuous monitoring of intracardiac pressures
    • Zile MR, Bennett TD, St John Sutton M, et al. Transition from chronic compensated to acute decompensated heart failure: pathophysiological insights obtained from continuous monitoring of intracardiac pressures. Circulation 2008; 118: 1433-41.
    • (2008) Circulation , vol.118 , pp. 1433-41
    • Zile, M.R.1    Bennett, T.D.2    St John Sutton, M.3
  • 7
    • 77957895867 scopus 로고    scopus 로고
    • Chronic ambu- latory intracardiac pressures and future heart failure events
    • Stevenson LW, Zile M, Bennett TD, et al. Chronic ambu- latory intracardiac pressures and future heart failure events. Circ Heart Fail 2010; 3: 580-7.
    • (2010) Circ Heart Fail , vol.3 , pp. 580-7
    • Stevenson, L.W.1    Zile, M.2    Bennett, T.D.3
  • 8
    • 33645058195 scopus 로고    scopus 로고
    • Are hemodynamic goals viable in tailoring heart failure therapy? Hemodynamic goals are relevant
    • Stevenson LW. Are hemodynamic goals viable in tailoring heart failure therapy? Hemodynamic goals are relevant. Circulation 2006; 113: 1020-7.
    • (2006) Circulation , vol.113 , pp. 1020-7
    • Stevenson, L.W.1
  • 10
    • 0042092537 scopus 로고    scopus 로고
    • Clinical use of inotropic therapy for heart failure: Looking backward or forward? Part I: Inotropic infusions during hospitalization
    • DOI 10.1161/01.CIR.0000078348.44634.BA
    • Stevenson LW. Clinical use of inotropic therapy for heart failure: looking backward or forward? Part I: inotropic infusions during hospitalization. Circulation 2003; 108: 367-72. (Pubitemid 36899031)
    • (2003) Circulation , vol.108 , Issue.3 , pp. 367-372
    • Stevenson, L.W.1
  • 13
    • 70449527550 scopus 로고    scopus 로고
    • Agents with inotropic properties for the management of acute heart failure syndromes: Traditional agents and beyond
    • Teerlink JR, Metra M, Zaca V, et al. Agents with inotropic properties for the management of acute heart failure syndromes: traditional agents and beyond. Heart Fail Rev 2009; 14: 243-53.
    • (2009) Heart Fail Rev , vol.14 , pp. 243-53
    • Teerlink, J.R.1    Metra, M.2    Zaca, V.3
  • 14
    • 65749117737 scopus 로고    scopus 로고
    • INTERMACS profiles of advanced heart failure: The current picture
    • Stevenson LW, Pagani FD, Young JB, et al. INTERMACS profiles of advanced heart failure: the current picture. J Heart Lung Transplant 2009; 28: 535-41.
    • (2009) J Heart Lung Transplant , vol.28 , pp. 535-41
    • Stevenson, L.W.1    Pagani, F.D.2    Young, J.B.3
  • 16
    • 53549085406 scopus 로고    scopus 로고
    • ESC guidelines for the diagnosis and treatment of acute and chronic heart failure 2008: The Task Force for the diagnosis and treatment of acute and chronic heart failure 2008 of the European Society of Cardiology
    • Developed in collaboration with the Heart Failure Association of the ESC and endorsed by the European Society of Intensive Care Medicine (ESICM)
    • Dickstein K, Cohen-Solal A, Filippatos G, et al. ESC guidelines for the diagnosis and treatment of acute and chronic heart failure 2008: the Task Force for the diagnosis and treatment of acute and chronic heart failure 2008 of the European Society of Cardiology. Developed in collaboration with the Heart Failure Association of the ESC and endorsed by the European Society of Intensive Care Medicine (ESICM). Eur J Heart Fail 2008; 10: 933-89.
    • (2008) Eur J Heart Fail , vol.10 , pp. 933-89
    • Dickstein, K.1    Cohen-Solal, A.2    Filippatos, G.3
  • 17
    • 65549154913 scopus 로고    scopus 로고
    • 2009 focused update: ACCF/AHA Guidelines for the Diagnosis and Management of Heart Failure in Adults A report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines: developed in collaboration with the International Society for Heart and Lung Transplantation
    • Jessup M, Abraham WT, Casey DE, et al. 2009 focused update: ACCF/AHA Guidelines for the Diagnosis and Management of Heart Failure in Adults. A report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines: developed in collaboration with the International Society for Heart and Lung Transplantation. Circulation 2009; 119: 1977-2016.
    • (2009) Circulation , vol.119 , pp. 1977-2016
    • Jessup, M.1    Abraham, W.T.2    Casey, D.E.3
  • 18
    • 77953630575 scopus 로고    scopus 로고
    • Executive summary: HFSA 2010 Comprehensive Heart Failure Practice Guideline
    • Lindenfeld J, Albert NM, Boehmer JP, et al. Executive summary: HFSA 2010 Comprehensive Heart Failure Practice Guideline. J Card Fail 2010; 16: 475-539.
    • (2010) J Card Fail , vol.16 , pp. 475-539
    • Lindenfeld, J.1    Albert, N.M.2    Boehmer, J.P.3
  • 19
    • 66249108231 scopus 로고    scopus 로고
    • Palliative care in heart failure: A position statement from the palliative care workshop of the Heart Failure Association of the European Society of Cardiology
    • Jaarsma T, Beattie JM, Ryder M, et al. Palliative care in heart failure: a position statement from the palliative care workshop of the Heart Failure Association of the European Society of Cardiology. Eur J Heart Fail 2009; 11: 433-43.
    • (2009) Eur J Heart Fail , vol.11 , pp. 433-43
    • Jaarsma, T.1    Beattie, J.M.2    Ryder, M.3
  • 21
    • 21344469500 scopus 로고    scopus 로고
    • In-hospital mortality in patients with acute decompensated heart failure requiring intravenous vasoactive medications: An analysis from the Acute Decompensated Heart Failure National Registry (ADHERE)
    • DOI 10.1016/j.jacc.2005.03.051, PII S0735109705008557
    • Abraham WT, Adams KF, Fonarow GC, et al. In-hospital mortality in patients with acute decompensated heart failure requiring intravenous vasoactive medications: an analysis from the Acute Decompensated Heart Failure National Registry (ADHERE). J Am Coll Cardiol 2005; 46: 57-64. (Pubitemid 40905130)
    • (2005) Journal of the American College of Cardiology , vol.46 , Issue.1 , pp. 57-64
    • Abraham, W.T.1    Adams, K.F.2    Fonarow, G.C.3    Costanzo, M.R.4    Berkowitz, R.L.5    Lejemtel, T.H.6    Cheng, M.L.7    Wynne, J.8
  • 22
    • 0032416913 scopus 로고    scopus 로고
    • Parenteral inotropic support for advanced congestive heart failure
    • DOI 10.1016/S0033-0620(98)80056-X
    • Leier CV, Binkley PF. Parenteral inotropic support for ad- vanced congestive heart failure. Prog Cardiovasc Dis 1998; 41: 207-24. (Pubitemid 29009200)
    • (1998) Progress in Cardiovascular Diseases , vol.41 , Issue.3 , pp. 207-224
    • Leier, C.V.1    Binkley, P.E.2
  • 24
    • 0027321634 scopus 로고
    • Development of short-term myocardial hibernation: Its limitation by the severity of ischemia and inotropic stimulation
    • Schulz R, Rose J, Martin C, et al. Development of short- term myocardial hibernation: its limitation by the severity of ischemia and inotropic stimulation. Circulation 1993; 88: 684-95. (Pubitemid 23228069)
    • (1993) Circulation , vol.88 , Issue.2 , pp. 684-695
    • Schulz, R.1    Rose, J.2    Martin, C.3    Brodde, O.-E.4    Heusch, G.5
  • 26
    • 0024294162 scopus 로고
    • Com- parative effects of therapy with captopril and digoxin in patients with mild to moderate heart failure
    • Captopril-Digoxin Multicenter Research Group
    • Captopril-Digoxin Multicenter Research Group. Com- parative effects of therapy with captopril and digoxin in patients with mild to moderate heart failure. JAMA 1988; 259: 539-44.
    • (1988) JAMA , vol.259 , pp. 539-44
  • 28
    • 0031051347 scopus 로고    scopus 로고
    • The effect of digoxin on mortality and morbidity in patients with heart failure
    • The Digitalis Investigation Group
    • The Digitalis Investigation Group. The effect of digoxin on mortality and morbidity in patients with heart failure. N Engl J Med 1997; 336: 525-33.
    • (1997) N Engl J Med , vol.336 , pp. 525-33
  • 30
    • 58149461718 scopus 로고    scopus 로고
    • Effectiveness of digoxin in reducing one year mortality in chronic heart failure in the Digoxin Investigation Group trial
    • Ahmed A, Waagstein F, Pitt B, et al. Effectiveness of digoxin in reducing one year mortality in chronic heart failure in the Digoxin Investigation Group trial. Am J Cardiol 2009; 103: 82-7.
    • (2009) Am J Cardiol , vol.103 , pp. 82-7
    • Ahmed, A.1    Waagstein, F.2    Pitt, B.3
  • 31
    • 0342655943 scopus 로고    scopus 로고
    • Rationale, design, im- plementation, and baseline characteristics of patients in the DIG trial: A large, simple, long-term trial to evaluate the effect of digitalis on mortality in heart failure
    • The Digitalis Investigation Group
    • The Digitalis Investigation Group. Rationale, design, im- plementation, and baseline characteristics of patients in the DIG trial: a large, simple, long-term trial to evaluate the effect of digitalis on mortality in heart failure. Control Clin Trials 1996; 17: 77-97.
    • (1996) Control Clin Trials , vol.17 , pp. 77-97
  • 32
    • 71749086540 scopus 로고    scopus 로고
    • Reconsidering the role for digoxin in the management of acute heart failure syndromes
    • Nov 18
    • Gheorghiade M, Braunwald E. Reconsidering the role for digoxin in the management of acute heart failure syndromes. JAMA 2009 Nov 18; 302 (19): 2146-7.
    • (2009) JAMA , vol.302 , Issue.19 , pp. 2146-7
    • Gheorghiade, M.1    Braunwald, E.2
  • 33
    • 0034878357 scopus 로고    scopus 로고
    • Inotropic therapy for heart failure: An evidence-based approach
    • DOI 10.1067/mhj.2001.117606
    • Felker GM, O'Connor CM. Inotropic therapy for heart failure: an evidence-based approach. Am Heart J 2001; 142: 393-401. (Pubitemid 32801622)
    • (2001) American Heart Journal , vol.142 , Issue.3 , pp. 393-401
    • Felker, G.M.1    O'Connor, C.M.2
  • 35
    • 0036673089 scopus 로고    scopus 로고
    • The effectiveness and relative effectiveness of intravenous inotropic drugs acting through the adrenergic pathway in patients with heart failure - A meta-regression analysis
    • DOI 10.1016/S1388-9842(02)00041-7, PII S1388984202000417
    • Thackray S, Easthaugh J, Fremantle N, et al. The effec- tiveness and relative effectiveness of intravenous inotropic drugs acting through the adrenergic pathway in patients with heart failure: meta-regression analysis. Eur J Heart Fail 2002; 4: 515-29. (Pubitemid 36564973)
    • (2002) European Journal of Heart Failure , vol.4 , Issue.4 , pp. 515-529
    • Thackray, S.1    Easthaugh, J.2    Freemantle, N.3    Cleland, J.G.F.4
  • 36
    • 15944372322 scopus 로고    scopus 로고
    • Meta-ana- lysis: Low-dose dopamine increases urine output but does not prevent renal dysfunction or death
    • Friedrich JO, Adhikari N, Herridge MS, et al. Meta-ana- lysis: low-dose dopamine increases urine output but does not prevent renal dysfunction or death. Ann Intern Med 2005; 142: 510-24.
    • (2005) Ann Intern Med , vol.142 , pp. 510-24
    • Friedrich, J.O.1    Adhikari, N.2    Herridge, M.S.3
  • 38
    • 0037010006 scopus 로고    scopus 로고
    • Beta-blocker therapy influences the hemodynamic response to inotropic agents in patients with heart failure: A randomized comparison of dobutamine and enoximone before and after chronic treatment with metoprolol or carvedilol
    • Metra M, Nodari S, D'Aloia A, et al. Beta-blocker therapy influences the hemodynamic response to inotropic agents in patients with heart failure: a randomized comparison of dobutamine and enoximone before and after chronic treatment with metoprolol or carvedilol. J Am Coll Cardiol 2002; 40: 1248-58.
    • (2002) J Am Coll Cardiol , vol.40 , pp. 1248-58
    • Metra, M.1    Nodari, S.2    D'Aloia, A.3
  • 41
    • 0026072848 scopus 로고
    • Effect of oral milrinone on mortality in severe chronic heart failure: The PROMISE Study Research Group
    • Packer M, Carver JR, Rodeheffer RJ, et al. Effect of oral milrinone on mortality in severe chronic heart failure: the PROMISE Study Research Group. N Engl J Med 1991; 325: 1468-75.
    • (1991) N Engl J Med , vol.325 , pp. 1468-75
    • Packer, M.1    Carver, J.R.2    Rodeheffer, R.J.3
  • 43
    • 0025071304 scopus 로고
    • Multicenter trial of oral enoximone in patients with moderate to moderately severe congestive heart failure. Lack of benefit compared with placebo
    • Uretsky BF, Jessup M, Konstam MA, et al. Multicenter trial of oral enoximone in patients with moderate to moderately severe congestive heart failure: lack of benefit compared with placebo. Enoximone Multicenter Trial Group. Circ 1990; 82: 774-80. (Pubitemid 20316728)
    • (1990) Circulation , vol.82 , Issue.3 , pp. 774-780
    • Uretsky, B.F.1    Jessup, M.2    Konstam, M.A.3    Dec, G.W.4    Leier, C.V.5    Benotti, J.6    Murali, S.7    Herrmann, H.C.8    Sandberg, J.A.9
  • 44
    • 70449531838 scopus 로고    scopus 로고
    • Effects of low- dose oral enoximone administration on mortality, morbidity, and exercise capacity in patients with advanced heart failure: The randomized, double-blind, placebo-controlled, parallel group ESSENTIAL trials
    • Metra M, Eichhorn E, Abraham WT, et al. Effects of low- dose oral enoximone administration on mortality, morbidity, and exercise capacity in patients with advanced heart failure: the randomized, double-blind, placebo-controlled, parallel group ESSENTIAL trials. Eur Heart J 2009; 30: 3015-26.
    • (2009) Eur Heart J , vol.30 , pp. 3015-26
    • Metra, M.1    Eichhorn, E.2    Abraham, W.T.3
  • 45
    • 0028172183 scopus 로고
    • Binding of a new Ca2+ sensitizer, levosimendan, to recombinant human cardiac troponin C: A molecular modelling, fluorescence probe and proton nuclear magnetic resonance study
    • 269
    • Pollesello P, Ovaska M, Kaivola J, et al. Binding of a new Ca2+ sensitizer, levosimendan, to recombinant human cardiac troponin C: a molecular modelling, fluorescence probe and proton nuclear magnetic resonance study. J Biol Chem 1994 18; 269 (46): 28584-90.
    • (1994) J Biol Chem , vol.18 , Issue.46 , pp. 28584-90
    • Pollesello, P.1    Ovaska, M.2    Kaivola, J.3
  • 46
    • 29444454634 scopus 로고    scopus 로고
    • Clinical trials update from the American Heart Association: REPAIR-AMI, ASTAMI, JELIS, MEGA, REVIVE-II, SURVIVE, and PROACTIVE
    • DOI 10.1016/j.ejheart.2005.12.003, PII S1388984205003466
    • Cleland JG, Freemantle N, Coletta AP, et al. Clinical trials update from the American Heart Association: REPAIR-AMI, ASTAMI, JELIS, MEGA, REVIVE-II, SURVIVE, and PROACTIVE. Eur J Heart Fail 2006; 8: 105-10. (Pubitemid 43012109)
    • (2006) European Journal of Heart Failure , vol.8 , Issue.1 , pp. 105-110
    • Cleland, J.G.F.1    Freemantle, N.2    Coletta, A.P.3    Clark, A.L.4
  • 48
    • 65549133015 scopus 로고    scopus 로고
    • Levosi- mendan vs. dobutamine: Outcomes for acute heart failure patients on b-blockers in SURVIVE
    • Mebazaa A, Nieminen MS, Filippatos GS, et al. Levosi- mendan vs. dobutamine: outcomes for acute heart failure patients on b-blockers in SURVIVE. Eur J Heart Fail 2009; 11: 304-11.
    • (2009) Eur J Heart Fail , vol.11 , pp. 304-11
    • Mebazaa, A.1    Nieminen, M.S.2    Filippatos, G.S.3
  • 49
    • 56349153125 scopus 로고    scopus 로고
    • Oral levosimendan in patients with severe chronic heart failure: The PERSIST study
    • Nieminen MS, Cleland JG, Eha J, et al. Oral levosimendan in patients with severe chronic heart failure: the PERSIST study. Eur J Heart Fail 2008; 10: 1246-54.
    • (2008) Eur J Heart Fail , vol.10 , pp. 1246-54
    • Nieminen, M.S.1    Cleland, J.G.2    Eha, J.3
  • 50
    • 70449090165 scopus 로고    scopus 로고
    • Istaroxime, a first in class new chemical entity exhibiting SERCA-2 activation and Na-K-ATPase inhibition: A new promising treatment for acute heart failure syndromes?
    • Khan H, Metra M, Blair JE, et al. Istaroxime, a first in class new chemical entity exhibiting SERCA-2 activation and Na-K-ATPase inhibition: a new promising treatment for acute heart failure syndromes? Heart Fail Rev 2009; 14: 277-87.
    • (2009) Heart Fail Rev , vol.14 , pp. 277-87
    • Khan, H.1    Metra, M.2    Blair, J.E.3
  • 51
    • 44449084777 scopus 로고    scopus 로고
    • Hemody- namic, echocardiographic, and neurohormonal effects of istaroxime, a novel intravenous inotropic and lusitropic agent: A randomized controlled trial in patients hospitalized with heart failure
    • Gheorghiade M, Blair JE, Filippatos GS, et al. Hemody- namic, echocardiographic, and neurohormonal effects of istaroxime, a novel intravenous inotropic and lusitropic agent: a randomized controlled trial in patients hospitalized with heart failure. J Am Coll Cardiol 2008; 51: 2276-85.
    • (2008) J Am Coll Cardiol , vol.51 , pp. 2276-85
    • Gheorghiade, M.1    Blair, J.E.2    Filippatos, G.S.3
  • 52
    • 67049100043 scopus 로고    scopus 로고
    • Effects of istaroxime on diastolic stiffness in acute heart failure syndromes: Results from the Hemodynamic, Echocardiographic, and Neurohormonal Effects of Istaroxime, a Novel Intravenous Inotropic and Lusitropic Agent: A Randomized Controlled Trial in Patients Hospitalized with Heart Failure (HORIZON-heart failure) trial
    • Shah SJ, Blair JE, Filippatos GS, et al. Effects of istaroxime on diastolic stiffness in acute heart failure syndromes: results from the Hemodynamic, Echocardiographic, and Neurohormonal Effects of Istaroxime, a Novel Intravenous Inotropic and Lusitropic Agent: a Randomized Controlled Trial in Patients Hospitalized with Heart Failure (HORIZON-heart failure) trial. Am Heart J 2009; 157: 1035-41.
    • (2009) Am Heart J , vol.157 , pp. 1035-41
    • Shah, S.J.1    Blair, J.E.2    Filippatos, G.S.3
  • 53
    • 44449135982 scopus 로고    scopus 로고
    • Istaroxime in heart failure: New hope or more hype
    • Dec GW. Istaroxime in heart failure: new hope or more hype. J Am Coll Cardiol 2008; 51: 2286-8.
    • (2008) J Am Coll Cardiol , vol.51 , pp. 2286-8
    • Dec, G.W.1
  • 54
    • 70449112931 scopus 로고    scopus 로고
    • A novel approach to improve cardiac perfor- mance: Cardiac myosin activators
    • Teerlink JR. A novel approach to improve cardiac perfor- mance: cardiac myosin activators. Heart Fail Rev 2009; 14: 289-98.
    • (2009) Heart Fail Rev , vol.14 , pp. 289-98
    • Teerlink, J.R.1
  • 55
    • 77955506679 scopus 로고    scopus 로고
    • Improvement of cardiac function by a cardiac myosin activator in conscious dogs with systolic heart failure
    • Shen YT, Malik FI, Zhao X, et al. Improvement of cardiac function by a cardiac myosin activator in conscious dogs with systolic heart failure. Circ Heart Fail 2010; 3: 522-7.
    • (2010) Circ Heart Fail , vol.3 , pp. 522-7
    • Shen, Y.T.1    Malik, F.I.2    Zhao, X.3
  • 56
    • 71649102466 scopus 로고    scopus 로고
    • Highlights of the 2009 scientific sessions of the European Society of Cardiology
    • Bax JJ, Casadei B, Di Mario C, et al. Highlights of the 2009 scientific sessions of the European Society of Cardiology. J Am Coll Cardiol 2009; 54: 2447-58.
    • (2009) J Am Coll Cardiol , vol.54 , pp. 2447-58
    • Bax, J.J.1    Casadei, B.2    Di Mario, C.3
  • 57
    • 0028819695 scopus 로고
    • Urocortin, a mammalian neuropeptide related to fish urotensin i and to corticotropin-releasing factor
    • Vaughan J, Donaldson C, Bittencourt J, et al. Urocortin, a mammalian neuropeptide related to fish urotensin I and to corticotropin-releasing factor. Nature 1995; 378: 287-92.
    • (1995) Nature , vol.378 , pp. 287-92
    • Vaughan, J.1    Donaldson, C.2    Bittencourt, J.3
  • 58
    • 33644877288 scopus 로고    scopus 로고
    • Integrated hemodynamic, hormonal, and renal actions of urocortin 2 in normal and paced sheep: Beneficial effects in heart failure
    • DOI 10.1161/CIRCULATIONAHA.105.561308, PII 0000301720051206000015
    • Rademaker MT, Cameron VA, Charles CJ, et al. Integrated hemodynamic, hormonal, and renal actions of urocortin 2 in normal and paced sheep: beneficial effects in heart failure. Circulation 2005; 112: 3624-32. (Pubitemid 43739541)
    • (2005) Circulation , vol.112 , Issue.23 , pp. 3624-3632
    • Rademaker, M.T.1    Cameron, V.A.2    Charles, C.J.3    Richards, A.M.4
  • 60
    • 33748777684 scopus 로고    scopus 로고
    • Urocortin 3: Haemodynamic, hormonal, and renal effects in experimental heart failure
    • DOI 10.1093/eurheartj/ehl138
    • Rademaker MT, Cameron VA, Charles CJ, et al. Urocortin 3: haemodynamic, hormonal, and renal effects in experimental heart failure. Eur Heart J 2006; 27: 2088-98. (Pubitemid 44412817)
    • (2006) European Heart Journal , vol.27 , Issue.17 , pp. 2088-2098
    • Rademaker, M.T.1    Cameron, V.A.2    Charles, C.J.3    Richards, A.M.4
  • 61
    • 77952521665 scopus 로고    scopus 로고
    • Urocortin 2 inhibits furosemide-induced activation of renin and enhances renal function and diuretic responsiveness in experimental heart failure
    • Rademaker MT, Charles CJ, Nicholls MG, et al. Urocortin 2 inhibits furosemide-induced activation of renin and enhances renal function and diuretic responsiveness in experimental heart failure. Circ Heart Fail 2009; 2: 532-40.
    • (2009) Circ Heart Fail , vol.2 , pp. 532-40
    • Rademaker, M.T.1    Charles, C.J.2    Nicholls, M.G.3
  • 62
    • 2342526006 scopus 로고    scopus 로고
    • Metabolic manipulation in ischaemic heart disease, a novel approach to treatment
    • DOI 10.1016/j.ehj.2004.02.018
    • Lee L, Horowitz J, Frenneaux M. Metabolic manipulation in ischaemic heart disease, a novel approach to treatment. Eur Heart J 2004; 25: 634-41. (Pubitemid 38579491)
    • (2004) European Heart Journal , vol.25 , Issue.8 , pp. 634-641
    • Lee, L.1    Horowitz, J.2    Frenneaux, M.3
  • 63
    • 70350020285 scopus 로고    scopus 로고
    • Micronutrient defi- ciencies an unmet need in heart failure
    • Soukoulis V, Dihu JB, Sole M, et al. Micronutrient defi- ciencies an unmet need in heart failure. J Am Coll Cardiol 2009; 54: 1660-73.
    • (2009) J Am Coll Cardiol , vol.54 , pp. 1660-73
    • Soukoulis, V.1    Dihu, J.B.2    Sole, M.3
  • 64
    • 70350072972 scopus 로고    scopus 로고
    • The adrenergic-fatty acid load in heart failure
    • Opie LH, Knuuti J. The adrenergic-fatty acid load in heart failure. J Am Coll Cardiol 2009; 54: 1637-46.
    • (2009) J Am Coll Cardiol , vol.54 , pp. 1637-46
    • Opie, L.H.1    Knuuti, J.2
  • 65
    • 77953774342 scopus 로고    scopus 로고
    • Modulation of myocardial metabolism: An emerging therapeutic principle
    • Horowitz JD, Chirkov YY, Kennedy JA, et al. Modulation of myocardial metabolism: an emerging therapeutic principle. Curr Opin Cardiol 2010; 25: 329-34.
    • (2010) Curr Opin Cardiol , vol.25 , pp. 329-34
    • Horowitz, J.D.1    Chirkov, Y.Y.2    Kennedy, J.A.3
  • 66
    • 0007619884 scopus 로고    scopus 로고
    • Systematic review of the efficacy and safety of perhexiline in the treatment of ischemic heart disease
    • Killalea SM, Krum H. Systematic review of the efficacy and safety of perhexiline in the treatment of ischemic heart disease. Am J Cardiovasc Drugs 2001; 1: 193-204.
    • (2001) Am J Cardiovasc Drugs , vol.1 , pp. 193-204
    • Killalea, S.M.1    Krum, H.2
  • 68
    • 1542496389 scopus 로고    scopus 로고
    • Short- and long- term beneficial effects of trimetazidine in patients with diabetes and ischemic cardiomyopathy
    • Fragasso G, Piatti Md PM, Monti L, et al. Short- and long- term beneficial effects of trimetazidine in patients with diabetes and ischemic cardiomyopathy. Am Heart J 2003; 146: E18.
    • (2003) Am Heart J , vol.146
    • Fragasso, G.1    Piatti Md, P.M.2    Monti, L.3
  • 70
    • 53449101397 scopus 로고    scopus 로고
    • Trimetazidine, a metabolic modulator, has cardiac and extracardiac benefits in idiopathic dilated cardiomyopathy
    • Tuunanen H, Engblom E, Naum A, et al. Trimetazidine, a metabolic modulator, has cardiac and extracardiac benefits in idiopathic dilated cardiomyopathy. Circulation 2008; 118: 1250-8.
    • (2008) Circulation , vol.118 , pp. 1250-8
    • Tuunanen, H.1    Engblom, E.2    Naum, A.3
  • 71
    • 36349008130 scopus 로고    scopus 로고
    • Trimetazidine and reduction in mortality and hospitalization in patients with ischemic dilated cardiomyopathy: A post hoc analysis of the Villa Pini d'Abruzzo trimetazidine trial
    • DOI 10.1097/FJC.0b013e31814fa9cb, PII 0000534420071100000017
    • Di Napoli P, Di Giovanni P, Gaeta MA, et al. Trimetazidine and reduction in mortality and hospitalization in patients with ischemic dilated cardiomyopathy: a post hoc analysis of the Villa Pini d'Abruzzo Trimetazidine Trial. J Cardio-vasc Pharmacol 2007; 50: 585-9. (Pubitemid 350146463)
    • (2007) Journal of Cardiovascular Pharmacology , vol.50 , Issue.5 , pp. 585-589
    • Napoli, P.D.1    Giovanni, P.D.2    Gaeta, M.A.3    Taccardi, A.A.4    Barsotti, A.5
  • 72
    • 33645466318 scopus 로고    scopus 로고
    • Effects of metabolic modulation by trimetazidine on left ventricular function and phosphocreatine/adenosine triphosphate ratio in patients with heart failure
    • Fragasso G, Perseghin G, De Cobelli F, et al. Effects of metabolic modulation by trimetazidine on left ventricular function and phosphocreatine/adenosine triphosphate ratio in patients with heart failure. Eur Heart J 2006; 27: 942-8.
    • (2006) Eur Heart J , vol.27 , pp. 942-8
    • Fragasso, G.1    Perseghin, G.2    De Cobelli, F.3
  • 73
    • 45549105581 scopus 로고    scopus 로고
    • Ranolazine im- proves diastolic dysfunction in isolated myocardium from failing human hearts: Role of late sodium current and in-tracellular ion accumulation
    • Sossalla S, Wagner S, Rasenack EC, et al. Ranolazine im- proves diastolic dysfunction in isolated myocardium from failing human hearts: role of late sodium current and in-tracellular ion accumulation. J Mol Cell Cardiol 2008; 45: 32-43.
    • (2008) J Mol Cell Cardiol , vol.45 , pp. 32-43
    • Sossalla, S.1    Wagner, S.2    Rasenack, E.C.3
  • 74
    • 67651067954 scopus 로고    scopus 로고
    • The late Na+ current (INa) inhibitor ranolazine attenuates effects of palmitoyl-L-carnitine to increase late INa and cause ventricular dia-stolic dysfunction
    • Wu Y, Song Y, Belardinelli L, et al. The late Na+ current (INa) inhibitor ranolazine attenuates effects of palmitoyl-L-carnitine to increase late INa and cause ventricular dia-stolic dysfunction. J Pharmacol Exp Ther 2009; 330: 550-7.
    • (2009) J Pharmacol Exp Ther , vol.330 , pp. 550-7
    • Wu, Y.1    Song, Y.2    Belardinelli, L.3
  • 75
    • 57049182027 scopus 로고    scopus 로고
    • Ranolazine combined with enalapril or metoprolol prevents progressive LV dysfunction and remodeling in dogs with moderate heart failure
    • Rastogi S, Sharov VG, Mishra S, et al. Ranolazine combined with enalapril or metoprolol prevents progressive LV dysfunction and remodeling in dogs with moderate heart failure. Am J Physiol Heart Circ Physiol 2008; 295: H2149-55.
    • (2008) Am J Physiol Heart Circ Physiol , vol.295
    • Rastogi, S.1    Sharov, V.G.2    Mishra, S.3
  • 76
    • 4344605042 scopus 로고    scopus 로고
    • Recombinant glucagon-like peptide-1 increases myocardial glucose uptake and improves left ventricular performance in conscious dogs with pacing-induced dilated cardiomyopathy
    • DOI 10.1161/01.CIR.0000139339.85840.DD
    • Nikolaidis LA, Elahi D, Hentosz T, et al. Recombinant glucagon-like peptide-1 increases myocardial glucose uptake and improves left ventricular performance in conscious dogs with pacing-induced dilated cardiomyopathy. Circulation 2004; 110: 955-61. (Pubitemid 39128621)
    • (2004) Circulation , vol.110 , Issue.8 , pp. 955-961
    • Nikolaidis, L.A.1    Elahi, D.2    Hentosz, T.3    Doverspike, A.4    Huerbin, R.5    Zourelias, L.6    Stolarski, C.7    Shen, Y.-T.8    Shannon, R.P.9
  • 77
    • 33845293219 scopus 로고    scopus 로고
    • Glucagon-Like Peptide-1 Infusion Improves Left Ventricular Ejection Fraction and Functional Status in Patients With Chronic Heart Failure
    • DOI 10.1016/j.cardfail.2006.08.211, PII S1071916406011092
    • Sokos GG, Nikolaidis LA, Mankad S, et al. Glucagon-like peptide-1 infusion improves left ventricular ejection fraction and functional status in patients with chronic heart failure. J Card Fail 2006; 12: 694-9. (Pubitemid 44881367)
    • (2006) Journal of Cardiac Failure , vol.12 , Issue.9 , pp. 694-699
    • Sokos, G.G.1    Nikolaidis, L.A.2    Mankad, S.3    Elahi, D.4    Shannon, R.P.5
  • 78
    • 77749273703 scopus 로고    scopus 로고
    • Cardiovascular and metabolic effects of 48-h glucagon-like peptide-1 infusion in compensated chronic patients with heart failure
    • Halbirk M, Nørrelund H, Møller N, et al. Cardiovascular and metabolic effects of 48-h glucagon-like peptide-1 infusion in compensated chronic patients with heart failure. Am J Physiol Heart Circ Physiol 2010; 298: H1096-102.
    • (2010) Am J Physiol Heart Circ Physiol , vol.298
    • Halbirk, M.1    Nørrelund, H.2    Møller, N.3
  • 79
    • 70449089788 scopus 로고    scopus 로고
    • Abnormalities of cal- cium metabolism and myocardial contractility depression in the failing heart
    • Lehnart SE, Maier LS, Hasenfuss G. Abnormalities of cal- cium metabolism and myocardial contractility depression in the failing heart. Heart Fail Rev 2009; 14 (4): 213-24.
    • (2009) Heart Fail Rev , vol.14 , Issue.4 , pp. 213-24
    • Lehnart, S.E.1    Maier, L.S.2    Hasenfuss, G.3
  • 80
    • 62649133817 scopus 로고    scopus 로고
    • Calcium upregu- lation by percutaneous administration of gene therapy in cardiac disease (CUPID trial), a first-in-human phase 1/2 clinical trial
    • Jaski BE, Jessup ML, Mancini DM, et al. Calcium upregu- lation by percutaneous administration of gene therapy in cardiac disease (CUPID trial), a first-in-human phase 1/2 clinical trial. J Card Fail 2009; 15: 171-81.
    • (2009) J Card Fail , vol.15 , pp. 171-81
    • Jaski, B.E.1    Jessup, M.L.2    Mancini, D.M.3
  • 81


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