Scientific evidence supporting the use of micafungin in the treatment of invasive candidiasis;Evidencias científicas que respaldan el uso de micafungina en el tratamiento de la candidiasis invasora

Enfermedades Infecciosas y Microbiologia Clinica

Volumn 29, Issue SUPPL. 2, 2011, Pages 15-22

  Montejo, Miguel ^a,b   Quindós, Guillermo ^b  

^a HOSPITAL DE CRUCES   (Spain)

^b UNIVERSITY OF THE BASQUE COUNTRY UPV EHU   (Spain)

Author keywords

Activity; Biofilms; Candida; Candidemia; Candidiasis; Indications; Micafungin; Neonates

Indexed keywords

AMPHOTERICIN B; ECHINOCANDIN; MICAFUNGIN;

ANTIFUNGAL SUSCEPTIBILITY; ARTICLE; BIOFILM; CANDIDA; CANDIDA GLABRATA; CANDIDA KRUSEI; CANDIDEMIA; CANDIDIASIS; CLAVISPORA LUSITANIAE; DRUG EFFICACY; ESOPHAGUS CANDIDIASIS; EVIDENCE BASED MEDICINE; GRAFT RECIPIENT; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HUMAN; IN VITRO STUDY; INVASIVE CANDIDIASIS; NEUTROPENIA;

ADOLESCENT; ADULT; AGED; ANIMALS; ANTIFUNGAL AGENTS; BIOFILMS; CANDIDA; CANDIDIASIS, INVASIVE; CELL WALL; CHILD; CHILD, PRESCHOOL; CLINICAL TRIALS AS TOPIC; DOUBLE-BLIND METHOD; DRUG EVALUATION, PRECLINICAL; ECHINOCANDINS; ESOPHAGITIS; FUNGAL PROTEINS; GLUCOSYLTRANSFERASES; HUMANS; IMMUNOCOMPROMISED HOST; INFANT; INFANT, NEWBORN; LIPOPEPTIDES; MICE; MIDDLE AGED; MULTICENTER STUDIES AS TOPIC; POSTOPERATIVE COMPLICATIONS; SPECIES SPECIFICITY; TRANSPLANTATION; YOUNG ADULT;

EID: 79953197920     PISSN: 0213005X     EISSN: 15781852     Source Type: Journal    
DOI: 10.1016/S0213-005X(11)70004-0     Document Type: Article

References (96)

1. A. Del Palacio, J. Villar, and A. Alhambra Epidemiología de las candidiasis invasoras en población pediátrica y adulta Rev Iberoam Micol 26 2009 2 7
2. J. Gómez, E. García-Vázquez, C. Espinosa, J. Ruiz, M. Canteras, and A. Hernández-Torres Nosocomial candidemia at a general hospital: the change of epidemiological and clinical characteristics. A comparative study of 2 cohorts (1993-1998 versus 2002-2005) Rev Iberoam Micol 26 2009 184 188
3. G. Quindós Candidemias nosocomiales y candidiasis invasoras Med Clin (Barc) 134 2010 17 19
4. M. Tumbarello, B. Posteraro, E.M. Trecarichi, B. Fiori, M. Rossi, and R. Porta Biofilm production by Candida species and inadequate antifungal therapy as predictors of mortality for patients with candidemia J Clin Microbiol 45 2007 1843 1850 (Pubitemid 46933916)
5. G. Quindós, M. Villar-Vidal, and E. Eraso Actividad de la micafungina contra las biopelículas de Candida Rev Iberoam Micol 26 2009 35 45
6. G. Aperis, N. Myriounis, E.K. Spanakis, and E. Mylonakis Developments in the treatment of candidiasis: more choices and new challenges Expert Opin Investig Drugs 15 2006 1319 1336 (Pubitemid 44615283)
7. P.H. Chandrasekar, and J.D. Sobel Micafungin: a new echinocandin Clin Infect Dis 42 2006 1171 1178
8. A.M. Bal The echinocandins: three useful choices or three too many? Int J Antimicrob Agents 35 2010 13 18
9. H. Mikamo, Y. Sato, and T. Tamaya In vitro antifungal activity of FK463, a new water-soluble echinocandin-like lipopeptide J Antimicrob Chemother 46 2000 485 487
10. Y. Nishiyama, K. Uchida, and H. Yamaguchi Morphological changes of Candida albicans induced by micafungin (FK463), a water-soluble echinocandin-like lipopeptide J Electron Microsc (Tokyo) 51 2002 247 255 (Pubitemid 34979146)
11. L. Angiolella, B. Maras, A.R. Stringaro, G. Arancia, F. Mondello, and A. Girolamo Glucan-associated protein modulations and ultrastructural changes of the cell wall in Candida albicans treated with micafungin, a water-soluble, lipopeptide antimycotic J Chemother 17 2005 409 416 (Pubitemid 41284780)
12. J. Pontón La pared celular de los hongos y el mecanismo de acción de la anidulafungina Rev Iberoam Micol 25 2008 78 82 (Pubitemid 351798334)
13. L. Ostrosky-Zeichner, J.H. Rex, P.G. Pappas, R.J. Hamill, R.A. Larsen, and H.W. Horowitz Antifungal susceptibility survey of 2,000 bloodstream Candida isolates in the United States Antimicrob Agents Chemother 47 2003 3149 3154 (Pubitemid 37229571)
14. S.A. Messer, D.J. Diekema, L. Boyken, S. Tendolkar, R.J. Hollis, and M.A. Pfaller Activities of micafungin against 315 invasive clinical isolates of fluconazole-resistant Candida spp J Clin Microbiol 44 2006 324 326 (Pubitemid 43222217)
15. M.A. Pfaller, D.J. Diekema, D.L. Gibbs, V.A. Newell, K.P. Ng, and A. Colombo Geographic and temporal trends in isolation and antifungal susceptibility of Candida parapsilosis: a global assessment from the ARTEMIS DISK Antifungal Surveillance Program, 2001 to 2005 J Clin Microbiol 46 2008 842 849 (Pubitemid 351379967)
16. M.A. Pfaller, D.J. Diekema, L. Ostrosky-Zeichner, J.H. Rex, B.D. Alexander, and D. Andes Correlation of MIC with outcome for Candida species tested against caspofungin, anidulafungin, and micafungin: analysis and proposal for interpretive MIC breakpoints J Clin Microbiol 46 2008 2620 2629
17. G. Quindós, E. Eraso, A.J. Carrillo-Muñoz, E. Cantón, and J. Pemán Actividad antifúngica in vitro de la micafungina Rev Iberoam Micol 26 2009 35 45
18. J. Pemán Epidemiología de las candidemias. III Congreso de Microbiología Clínica. Sociedad Española de Microbiología Ávila 2010
19. F. Ikeda, T. Saika, Y. Sato, M. Suzuki, M. Hasegawa, and T. Mikawa Antifungal activity of micafungin against Candida and Aspergillus spp. isolated from pediatric patients in Japan Med Mycol 47 2009 145 148
20. S.R. Lockhart, S.A. Messer, M.A. Pfaller, and D.J. Diekema Geographic distribution and antifungal susceptibility of the newly described species Candida orthopsilosis and Candida metapsilosis in comparison to the closely related species Candida parapsilosis J Clin Microbiol 46 2008 2659 2664
21. A. Gómez-López, A. Alastruey-Izquierdo, D. Rodríguez, B. Almirante, A. Pahissa, and J.L. Rodríguez-Tudela Prevalence and susceptibility profile of Candida metapsilosis and Candida orthopsilosis: results from population-based surveillance of candidemia in Spain Antimicrob Agents Chemother 52 2008 1506 1509 (Pubitemid 351522020)
22. I. Miranda Zapico, E. Eraso, J.L. Hernández Almaraz, A.J. Carrillo Muñoz, J.M. Hernández Molina, and G. Quindós Prevalence of Candida orthopsilosis and Candida metapsilosis among Candida parapsilosis clinical isolates from a Spanish yeast stock collection during 12 Mycoses 52 Suppl 1 2009 66
23. M.A. Ghannoum, A. Chen, M. Buhari, J. Chandra, P.K. Mukherjee, and D. Baxa Differential in vitro activity of anidulafungin, caspofungin and micafungin against Candida parapsilosis isolates recovered from a burn unit Clin Microbiol Infect 15 2009 274 279
24. C. Cheung, Y. Guo, P. Gialanella, and M. Feldmesser Development of candidemia on caspofungin therapy: a case report Infection 34 2006 345 348 (Pubitemid 44968928)
25. N. Kabbara, C. Lacroix, R. Peffalt de Latour, G. Socié, M. Ghannoum, and P. Ribaud Breakthrough C. parapsilosis and C. guilliermondii blood stream infection in allogeneic hematopoietic stem cell trasplnat recipients receiving long-term caspofungin therapy Haematologica 93 2008 639 640 (Pubitemid 351536400)
26. G.N. Forrest, E. Weekes, and J.K. Johnson Increasing incidence of Candida parapsilosis candidemia with caspofungin usage J Infect 56 2008 126 129
27. V. Moudgal, T. Little, D. Boikov, and J.A. Vázquez Multiechinocandin- and multiazole-resistant Candida parapsilosis isolates serially obtained during therapy for prosthetic valve endocarditis Antimicrob Agents Chemother 49 2005 767 769 (Pubitemid 40175691)
28. M. Hakki, J.F. Staab, and K.A. Marr Emergence of a Candida krusei isolate with reduced susceptibility to caspofungin during therapy Antimicrob Agents Chemother 50 2006 2522 2524 (Pubitemid 43993195)
29. J.N. Kahn, G. García-Effron, M.J. Hsu, S. Park, K.A. Marr, and D.S. Perlin Acquired echinocandin resistance in a Candida krusei isolate due to modification of glucan synthase Antimicrob Agents Chemother 51 2007 1876 1878 (Pubitemid 46744179)
30. R. Pelletier, I. Alarie, R. Lagace, and T.J. Walsh Emergence of disseminated candidiasis caused by Candida krusei during treatment with caspofungin: case report and review of literature Med Mycol 43 2005 559 564 (Pubitemid 41700950)
31. M. Krogh-Madsen, M.C. Arendrup, L. Heslet, and J.D. Knudsen Amphotericin B and caspofungin resistance in Candida glabrata isolates recovered from a critically ill patient Clin Infect Dis 42 2006 938 944
32. G. Chamilos, R.E. Lewis, N. Albert, and D.P. Kontoyiannis Paradoxical effect of echinocandins across Candida species in vitro: evidence for echinocandin-specific and candida species-related differences Antimicrob Agents Chemother 51 2007 2257 2259 (Pubitemid 46903132)
33. A.S. Melo, A.L. Colombo, and B.A. Arthington-Skaggs Paradoxical growth effect of caspofungin observed on biofilms and planktonic cells of five different Candida species Antimicrob Agents Chemother 51 2007 3081 3088 (Pubitemid 350067512)
34. M. Fleischhacker, C. Radecke, B. Schulz, and M. Ruhnke Paradoxical growth effects of the echinocandins caspofungin and micafungin, but not of anidulafungin, on clinical isolates of Candida albicans and C. dubliniensis Eur J Clin Microbiol Infect Dis 27 2008 127 131
35. E.R. Kuse, P. Chetchotisakd, C.A. Da Cunha, M. Ruhnke, C. Barrios, and D. Raghunadharao Micafungin versus liposomal amphotericin B for candidaemia and invasive candidosis: a phase III randomised double-blind trial Lancet 369 2007 1519 1527 (Pubitemid 46670281)
36. M. Mariné, C. Serena, J. Pastor, G. Quindós, A.J. Carrillo, and J. Guarro In vitro activity of micafungin combined with itraconazole against Candida spp Int J Antimicrob Agents 30 2007 463 465 (Pubitemid 47498962)
37. M.M. Rodríguez, M. Ruiz, F.J. Pastor, G. Quindós, A. Carrillo, and J. Guarro In vitro interaction of micafungin and fluconazole against Candida J Antimicrob Chemother 60 2007 188 190 (Pubitemid 47073308)
38. C. Serena, M. Mariné, G. Quindós, A.J. Carrillo, J.F. Cano, and F.J. Pastor In vitro interactions of micafungin with amphotericin B against clinical isolates of Candida spp Antimicrob Agents Chemother 52 2008 1529 1532 (Pubitemid 351522027)
39. M.P. Pai, M.L. Samples, R.C. Mercier, and M.N. Spilde Activities and ultrastructural effects of antifungal combinations against simulated Candida endocardial vegetations Antimicrob Agents Chemother 52 2008 2367 2376 (Pubitemid 351915664)
40. F.J. Pastor, and J. Guarro Micafungina en el tratamiento de la infección fúngica en modelos animales Rev Iberoam Micol 26 2009 42 48
41. R.S. Al-Dhaheri, and L.J. Douglas Absence of amphotericin B-tolerant persister cells in biofilms of some Candida species Antimicrob Agents Chemother 52 2008 1884 1887 (Pubitemid 351614696)
42. M.A. Al-Fattani, and L.J. Douglas Biofilm matrix of Candida albicans and Candida tropicalis: chemical composition and role in drug resistance J Med Microbiol 55 2006 999 1008 (Pubitemid 44215557)
43. F.C. Bizerra, C.V. Nakamura, P.C. De, T.I. Estivalet Svidzinski, R.M. Borsato Quesada, and S. Goldenberg Characteristics of biofilm formation by Candida tropicalis and antifungal resistance FEMS Yeast Res 8 2008 442 450 (Pubitemid 351596147)
44. S.P. Bachmann, K. Vandewalle, G. Ramage, T.F. Patterson, B.L. Wickes, and J.R. Graybill In vitro activity of caspofungin against Candida albicans biofilms Antimicrob Agents Chemother 46 2002 3591 3596 (Pubitemid 35192931)
45. J.A. Shuford, M.S. Rouse, K.E. Piper, J.M. Steckelberg, and R. Patel Evaluation of caspofungin and amphotericin B deoxycholate against Candida albicans biofilms in an experimental intravascular catheter infection model J Infect Dis 194 2006 710 713 (Pubitemid 44297859)
46. E. Cateau, M.H. Rodier, and C. Imbert In vitro efficacies of caspofungin or micafungin catheter lock solutions on Candida albicans biofilm growth J Antimicrob Chemother 62 2008 153 155 (Pubitemid 351865889)
47. M.J. Jacobson, K.E. Piper, G. Nguyen, J.M. Steckelberg, and R. Patel In vitro activity of anidulafungin against Candida albicans biofilms Antimicrob Agents Chemother 52 2008 2242 2243 (Pubitemid 351758568)
48. A. Katragkou, A. Chatzimoschou, M. Simitsopoulou, M. Dalakiouridou, E. Dizaza-Mataftsi, and C. Tsantali Differential activities of newer antifungal agents against Candida albicans and Candida parapsilosis biofilms Antimicrob Agents Chemother 52 2008 357 360
49. J. Pemán, E. Cantón, and A. Valentín Actividad de la anidulafungina sobre biopelículas de Candida Rev Iberoam Micol 25 2008 124 128 (Pubitemid 351798340)
50. A. Valentín, E. Cantón, J. Pemán, and G. Quindós Actividad in vitro de la anfotericina B y la anidulafungina sobre biopelículas de Candida albicans y Candida tropicalis Rev Iberoam Micol 24 2007 272 277
51. J. Nett, L. Lincoln, K. Marchillo, R. Massey, K. Holoyda, and B. Hoff Putative role of beta-1,3 glucans in Candida albicans biofilm resistance Antimicrob Agents Chemother 51 2007 510 520 (Pubitemid 46185268)
52. M. Seidler, S. Salvenmoser, and F.M. Muller In vitro effects of micafungin against Candida biofilms on polystyrene and central venous catheter sections Int J Antimicrob Agents 28 2006 568 573 (Pubitemid 44779180)
53. D.M. Kuhn, T. George, J. Chandra, P.K. Mukherjee, and M.A. Ghannoum Antifungal susceptibility of Candida biofilms: unique efficacy of amphotericin B lipid formulations and echinocandins Antimicrob Agents Chemother 46 2002 1773 1780 (Pubitemid 34535196)
54. H.W. Choi, J.H. Shin, S.I. Jung, K.H. Park, D. Cho, and S.J. Kee Species-specific differences in the susceptibilities of biofilms formed by Candida bloodstream isolates to echinocandin antifungals Antimicrob Agents Chemother 51 2007 1520 1523 (Pubitemid 46586842)
55. J.A. Shuford, K.E. Piper, J.M. Steckelberg, and R. Patel In vitro biofilm characterization and activity of antifungal agents alone and in combination against sessile and planktonic clinical Candida albicans isolates Diagn Microbiol Infect Dis 57 2007 277 281 (Pubitemid 46330658)
56. A.H. Groll, T. Stergiopoulou, E. Roilides, and T.J. Walsh Micafungin: pharmacology, experimental therapeutics and clinical applications Expert Opin Investig Drugs 14 2005 489 509 (Pubitemid 40711857)
57. J.A. Stone, S.D. Holland, P.J. Wickersham, A. Sterrett, M. Schwartz, and C. Bonfiglio Single- and multiple-dose pharmacokinetics of caspofungin in healthy men Antimicrob Agents Chemother 46 2002 739 745 (Pubitemid 34157659)
58. J. Hiemenz, P. Cagnoni, D. Simpson, S. Devine, N. Chao, and J. Keirns Pharmacokinetic and maximum tolerated dose study of micafungin in combination with fluconazole versus fluconazole alone for prophylaxis of fungal infections in adult patients undergoing a bone arrow or peripheral stem cell transplant Antimicrob Agents Chemother 49 2005 1331 1336 (Pubitemid 40463357)
59. M.F. Hebert, H.E. Smith, T.C. Marbury, S.K. Swan, W.B. Smith, and R.W. Townsend Pharmacokinetics of micafungin in healthy volunteers, volunteers with moderate liver disease, and volunteers with renal dysfunction J Clin Pharmacol 45 2005 1145 1152 (Pubitemid 41361914)
60. Y. Nakagawa, Y. Ichii, Y. Saeki, M. Kodaka, K. Suzuki, and S. Kishino Plasma concentration of micafungin in patients with hematologic malignancies J Infect Chemother 13 2007 39 45 (Pubitemid 46356242)
61. R. Townsend, M. Terakawa, and I. Bebersky Pharmacokinetics of FK 463, a novel echinocandin antifungal, in bone marrow or peripheral stem cell transplant patients J Clin Pharmacol 40 2000 1049
62. M. Catalán-González, and J. Carlos Montejo-González Farmacodinamia y farmacocinética de la micafungina en adultos, niños y neonatos Rev Iberoam Micol 26 2009 23 34
63. Astellas Pharma. Summary of product Characteristics of Mycamine 50 mg/100 mg. Astellas, April 2008.
64. T. Gumbo, J. Hiemenz, L. Ma, J.J. Keirns, D.N. Buell, and G.L. Drusano Population pharmacokinetics of micafungin in adult patients Diagn Microbiol Infect Dis 60 2008 329 331 (Pubitemid 351253603)
65. T. Suzuki, T. Uno, G. Chen, and Y. Ohashi Ocular distribution of intravenously administered micafungin in rabbits J Infect Chemother 14 2008 204 207 (Pubitemid 351875926)
66. S. Okugawa, Y. Ota, K. Tatsuno, K. Tsukada, S. Kishino, and K. Koike A case of invasive central nervous system aspergillosis treated with micafungin with monitoring of micafungin concentrations in the cerebrospinal fluid Scand J Infect Dis 39 2007 344 346 (Pubitemid 46567386)
67. A.C. Reboli, C. Rotstein, P.G. Pappas, S.W. Chapman, D.H. Kett, and D. Kumar Anidulafungin versus fluconazole for invasive candidiasis N Engl J Med 356 2007 2472 2482 (Pubitemid 46919773)
68. E. Pérez-Blázquez Importancia de la vigilancia oftalmológica durante el tratamiento de la enfermedad invasora por Candida Rev Iberoam Micol 26 2009 78 80
69. K. Hirata, T. Aoyama, Y. Matsumoto, F. Ogawa, H. Yamazaki, and A. Kikuti Pharmacokinetics of antifungal agent micafungin in critically ill patients receiving continuous hemodialysis filtration Yakugaku Zasshi 127 2007 897 901 (Pubitemid 46684737)
70. N.L. Seibel, C. Schwartz, A. Arrieta, P. Flynn, A. Shad, and E. Albano Safety, tolerability, and pharmacokinetics of micafungin (FK463) in febrile neutropenic pediatric patients Antimicrob Agents Chemother 49 2005 3317 3324 (Pubitemid 41060577)
71. G.P. Heresi, D.R. Gerstmann, M.D. Reed, J.N. Van den Anker, J.L. Blumer, and L. Kovanda The pharmacokinetics and safety of micafungin, a novel echinocandin, in premature infants Pediatr Infect Dis J 25 2006 1110 1115 (Pubitemid 44900673)
72. O.A. Cornely Pooled analysis of safety for micafungin. 47th Interscience Conference on Antimicrobial Agents and Chemotherapy Chicago 2007 Poster M-1175
73. M. Ninomiya, H. Mikamo, K. Tanaka, K. Watanabe, and T. Tamaya Efficacy of micafungin against deep-seated candidiasis in cyclophosphamide-induced immunosuppressed mice J Antimicrob Chemother 55 2005 587 590 (Pubitemid 40542607)
74. S. Maesaki, M.A. Hossain, Y. Miyazaki, K. Tomono, T. Tashiro, and S. Kohno Efficacy of FK463, a (1,3)-Beta-D-glucan synthase inhibitor, in disseminated azole-resistant candida albicans infection in mice Antimicrob Agents Chemother 44 2000 1728 1730 (Pubitemid 30340827)
75. R.L. Chapman, and R.G. Faix Invasive neonatal candidiasis: an overview Semin Perinatol 27 2003 352 356 (Pubitemid 37363187)
76. L. Clerihew, T.L. Lamagni, P. Brocklehurst, and W. McGuire Invasive fungal infection in very low birthweight infants: national prospective surveillance study Arch Dis Child Fetal Neonatal Ed 91 2006 F188 F192
77. L. Saiman, E. Ludington, M. Pfaller, S. Rangel-Frausto, R.T. Wiblin, and J. Dawson Risk factors for candidemia in Neonatal Intensive Care Unit patients Pediatr Infect Dis J 19 2000 319 324 (Pubitemid 30213071)
78. D.K. Benjamin Jr, H. Garges, and W.J. Steinbach Candida bloodstream infection in neonates Semin Perinatol 27 2003 375 383 (Pubitemid 37363190)
79. D. Rodríguez, B. Almirante, B.J. Park, M. Cuenca-Estrella, A.M. Planes, and F. Sánchez Candidemia in neonatal intensive care units: Barcelona, Spain Pediatr Infect Dis J 25 2006 224 229 (Pubitemid 43379062)
80. D.K. Benjamin Jr, and B.J. Stoll Infection in late preterm infants Clin Perinatol 33 2006 871 882 (Pubitemid 44828736)
81. L. Ostrosky-Zeichner, D. Kontoyiannis, J. Raffalli, K.M. Mullane, J. Vázquez, and E.J. Anaissie International, open-label, noncomparative, clinical trial of micafungin alone and in combination for treatment of newly diagnosed and refractory candidemia Eur J Clin Microbiol Infect Dis 24 2005 654 661 (Pubitemid 41667052)
82. A. Arrieta Micafungina in pediatric patients: assessment of safety in clinical trials. 47th Interscience Conference on Antimicrobial Agents and Chemotherapy Chicago 2007 Poster M.1162
83. F. Queiroz-Telles, E. Berezin, G. Leverger, A. Freire, A. Van der Vyver, and T. Chotpitayasunondh Micafungin versus liposomal amphotericin B for pediatric patients with invasive candidiasis: substudy of a randomized double-blind trial Pediatr Infect Dis J 27 2008 820 826
84. T. Nakamura, and H. Takahashi Epidemiological study of Candida infections in blood: susceptibilities of Candida spp. to antifungal agents, and clinical features associated with the candidemia J Infect Chemother 12 2006 132 138 (Pubitemid 44025015)
85. P.G. Pappas, C.M. Rotstein, R.F. Betts, M. Nucci, D. Talwar, and J.J. De Waele Micafungin versus caspofungin for treatment of candidemia and other forms of invasive candidiasis Clin Infect Dis 45 2007 883 893 (Pubitemid 47580382)
86. W.W. Hope, N.L. Seibel, C.L. Schwartz, A. Arrieta, P. Flynn, and A. Shad Population pharmacokinetics of micafungin in pediatric patients and implications for antifungal dosing Antimicrob Agents Chemother 51 2007 3714 3719 (Pubitemid 47519363)
87. K. Pettengell, J. Mynhardt, T. Kluyts, W. Lau, D. Facklam, D Buell FK463 South African Study Group Successful treatment of oesophageal candidiasis by micafungin: a novel systemic antifungal agent Aliment Pharmacol Ther 20 2004 475 481 (Pubitemid 39120260)
88. N. De Wet, A. Llanos-Cuentas, J. Suleiman, E. Baraldi, E.F. Krantz, and N.M. Della A randomized, double-blind, parallel-group, dose-response study of micafungin compared with fluconazole for the treatment of esophageal candidiasis in HIV-positive patients Clin Infect Dis 39 2004 842 849 (Pubitemid 39244300)
89. N.T. De Wet, A.J. Bester, J.J. Viljoen, F. Filho, J.M. Suleiman, and E. Ticona A randomized, double blind, comparative trial of micafungin (FK463) vs. fluconazole for the treatment of oesophageal candidiasis Aliment Pharmacol Ther 21 2005 899 907 (Pubitemid 40477250)
90. S.A. Cross, and L.J. Scott Micafungin: a review of its use in adults for the treatment of invasive and oesophageal candidiasis, and as prophylaxis against Candida infections Drugs 68 2008 2225 2255
91. E. Anaissie 13 th Focus on Fungal Infections Meeting 2003 Hawaii Mauri
92. K. Tamura, A. Urabe, M. Yoshida, A. Kanamaru, Y. Kodera, and S. Okamoto Efficacy and safety of micafungin, an echinocandin antifungal agent, on invasive fungal infections in patients with hematological disorders Leukemia & Lymphoma 50 2009 92 100
93. J.A. Van Burik, V. Ratanatharathorn, D.E. Stepan, C.B. Miller, J.H. Lipton, and D.H. Vesole Micafungin versus fluconazole for prophylaxis against invasive fungal infections during neutropenia in patients undergoing hematopoietic stem cell transplantation Clin Infect Dis 39 2004 1407 1416 (Pubitemid 39518200)
94. G.N. Forrest, F. Rasetto, G. Akpek, and B. Philosophe Safety and efficacy of micafungin in transplantation recipients Transplantation 82 2006 1549 (Pubitemid 44967644)
95. J. Mensa, R. De la Cámara, E. Carreras, M. Cuenca Estrella, J.A. García Rodríguez, and M. Gobernado Tratamiento de las infecciones fúngicas en pacientes con neoplasias hematológicas Med Clin (Barc) 132 2009 507 521
96. P.G. Pappas, C.A. Kauffman, D. Andes, D.K. Benjamin Jr, T.F. Calandra, and J.E. Edwards Jr Clinical practice guidelines for the management of candidiasis: 2009 update by the Infectious Diseases Society of America Clin Infect Dis 48 2009 503 535