Stem cell therapy of tendon injuries - Clinical outcome in 98 cases;Stammzellentherapie von Sehnenverletzungen klinische Ergebnisse von 98 Fällen

Pferdeheilkunde

Volumn 27, Issue 2, 2011, Pages 153-161

  Burk, Janina ^a   Brehm, Walter ^a  

^a UNIVERSITY OF LEIPZIG   (Germany)

Author keywords

Bone marrow; Horse; Long term results; Mesenchymal stem cells; Superficial digital flexor tendon; Suspensory ligament; Tendinitis

Indexed keywords

EQUIDAE;

EID: 79953191801     PISSN: 01777726     EISSN: None     Source Type: Journal    
DOI: 10.21836/PEM20110207     Document Type: Article

References (18)

1. Dowling B. A., Dart A. J, Hodgson D. R. und Smith R. K. (2000) Superficial digital flexor tendonitis in the horse. Equine Vet. J. 32, 369-378
2. Dyson S. (1991). Proximal suspensory desmitis: clinical, ultrasonographic and radiographic features. Equine Vet. J. 23, 25-31
3. Dyson S. J. (2004) Medical management of superficial digital flexor tendonitis: a comparative study in 219 horses (1992-2000). Equine Vet. J. 36, 415-419
4. Ely E. R., Avella C S., Price J. S., Smith R. K., Wood J. L und Verheyen K. L. (2009) Descriptive epidemiology of fracture, tendon and suspensory ligament injuries in National Hunt racehorses in training. Equine Vet. J. 41, 372-378
5. Guest D. J., Smith M. R. und Allen W. R. (2010) Equine embryonic stem-like cells and mesenchymal stromal cells have different survival rates and migration patterns following their injection into damaged superficial digital flexor tendon. Equine Vet. J. 42, 636-642
6. Kasashima Y, Takahashi T, Smith R. K., Goodship A. E., Kuwano A., Ueno T. und Hirano S. (2004) Prevalence of superficial digital flexor tendonitis and suspensory desmitis in Japanese Thoroughbred flat racehorses in 1999. Equine Vet. J. 36, 346-350
7. Kern S., Eichler H., Stoeve J., Kluter H. und Bieback K. (2006). Comparative analysis of mesenchymal stem cells from bone marrow, umbilical cord blood, or adipose tissue. Stem Cells 24, 1294-1301
8. Koch T. G., Heerkens T, Thomsen P. D. und Betts D. H. (2007) Isolation of mesenchymal stem cells from equine umbilical cord blood. BMC. Biotechnol. 7, 26
9. Mountford D. R., Smith R. K. und Patterson-Kane J. C. (2006) Mesenchymal stem cell treatment of suspensory ligament branch desmitis; post mortem findings in a 10 year old Russian Warmblood gelding- a case report. Pferdeheilkunde 22, 559-563
10. Pacini S., Spinabella S., Trombi L., Fazzi R., Galimberti S., Dini F, Carlucci F. und Petrini M. (2007) Suspension of bone marrow-derived undifferentiated mesenchymal stromal cells for repair of superficial digital flexor tendon in race horses. Tissue Eng. 13, 2949-2955
11. Passeri S., Nocchi F., Lamanna R., Lapi S., Miragliotta V, Giannessi E., Abromo F., Stornelli M. R., Matarazzo M., Plenteda D., Urciuoli R., Scatena F. und Coli A. (2009) Isolation and expansion of equine umbilical cord-derived matrix cells (EUCMCs). Cell Biol. Int. 33, 100-105
12. Richardson L. E., Dudhia J., Clegg P. D. und Smith R. (2007) Stem cells in veterinary medicine-attempts at regenerating equine tendon after injury. Trends Biotechnol. 25, 409-416
13. Schnabel L.V., Lynch M. E., van der Meulen M. C., Yeager A. E., Kornatowski M. A und Nixon A. J. (2009) Mesenchymal stem cells and insulin-like growth factor-I gene-enhanced mesenchymal stem cells improve structural aspects of healing in equine flexor digitorum superficialis tendons. J. Orthop. Res. 27, 1392-1398
14. Smith R. K. (2008a) Mesenchymal stem cell therapy for equine tendinopathy. Disabil. Rehabil. 30, 1752-1758
15. Smith R. K. (2008b) Stem cell therapy for tendon and ligament injuries in the horse- technique and outcome. Pferdeheilkunde 24, 513-518
16. Smith R. K., Korda M., Blunn G. W. und Goodship A. E. (2003) Isolation and implantation of autologous equine mesenchymal stem cells from bone marrow into the superficial digital flexor tendon as a potential novel treatment. Equine Vet. J. 35, 99-102
17. Smith R. K. and Webbon R M. (2005) Harnessing the stem cell for the treatment of tendon injuries: heralding a new dawn? Br. J. Sports Med. 39, 582-584
18. Violini S., Ramelli P., Pisani L. F., Gorni C. und Mariani P. (2009) Horse bone marrow mesenchymal stem cells express embryo stem cell markers and show the ability for tenogenic differentiation by in vitro exposure to BMP-12. BMC. Cell Biol. 10, 29