Ancestries hidden in plain sight: Methylation patterns for clonal analysis

Gastroenterology

Volumn 140, Issue 4, 2011, Pages 1139-1143

  Fearon, Eric R ^a   Bommer, Guido T ^b  

^a UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^b DE DUVE INSTITUTE   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOSINE; DINUCLEOTIDE; DNA;

ADULT; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; CANCER GENETICS; CELL CLONE; CELL MUTANT; CELL TYPE; CHROMATIN; COLON CARCINOGENESIS; COLORECTAL CANCER; CPG ISLAND; DNA METHYLATION; DNA SEQUENCE; GENE EXPRESSION; GENE MUTATION; HUMAN; HUMAN CELL; HUMAN TISSUE; INTESTINE CRYPT; KINETICS; MOUSE; NONHUMAN; PRIORITY JOURNAL; REVIEW; SOMATIC MUTATION; STEM CELL; X CHROMOSOME INACTIVATION;

EID: 79953191800     PISSN: 00165085     EISSN: None     Source Type: Journal    
DOI: 10.1053/j.gastro.2011.02.027     Document Type: Editorial

References (15)

1. D.A. Haber, and J. Settleman Cancer: drivers and passengers Nature 446 2007 145 146 (Pubitemid 46398653)
2. N. Barker, R.A. Ridgway, and J.H. van Es Crypt stem cells as the cells-of-origin of intestinal cancer Nature 457 2009 608 611
3. T.A. Graham, A. Humphries, and T. Sanders Use of methylation patterns to determine expansion of stem cell clones in human colon tissue Gastroenterology 140 2011 1241 1250
4. J. Totafurno, M. Bjerknes, and H. Cheng The crypt cycle Crypt and villus production in the adult intestinal epithelium Biophys J 52 1987 279 294
5. N. Barker, M. van de Wetering, and H. Clevers The intestinal stem cell Genes Dev 22 2008 1856 1864 (Pubitemid 352008634)
6. L.C. Greaves, S.L. Preston, and P.J. Tadrous Mitochondrial DNA mutations are established in human colonic stem cells, and mutated clones expand by crypt fission Proc Natl Acad Sci U S A 103 2006 714 719 (Pubitemid 43153091)
7. H.J. Snippert, L.G. van der Flier, and T. Sato Intestinal crypt homeostasis results from neutral competition between symmetrically dividing Lgr5 stem cells Cell 143 2010 134 144
8. M.R. Novelli, J.A. Williamson, and I.P. Tomlinson Polyclonal origin of colonic adenomas in an XO/XY patient with FAP Science 272 1996 1187 1190 (Pubitemid 26169475)
9. M. Novelli, A. Cossu, and D. Oukrif X-inactivation patch size in human female tissue confounds the assessment of tumor clonality Proc Natl Acad Sci U S A 100 2003 3311 3314 (Pubitemid 36356579)
10. N. Ahuja, and J.P. Issa Aging, methylation and cancer Histol Histopathol 15 2000 835 842 (Pubitemid 30488566)
11. S. Maegawa, G. Hinkal, and H.S. Kim Widespread and tissue specific age-related DNA methylation changes in mice Genome Res 20 2010 332 340
12. K.M. Kim, and D. Shibata Methylation reveals a niche: stem cell succession in human colon crypts Oncogene 21 2002 5441 5449 (Pubitemid 34983480)
13. P. Nicolas, K.M. Kim, and D. Shibata The stem cell population of the human colon crypt: analysis via methylation patterns PLoS Comput Biol 3 2007 e28
14. K.M. Kim, and D. Shibata Tracing ancestry with methylation patterns: most crypts appear distantly related in normal adult human colon BMC Gastroenterol 4 2004 8
15. R.W. Taylor, M.J. Barron, and G.M. Borthwick Mitochondrial DNA mutations in human colonic crypt stem cells J Clin Invest 112 2003 1351 1360 (Pubitemid 38057689)