Optimum design of experiments for enzyme inhibition kinetic models

Journal of Biopharmaceutical Statistics

Volumn 21, Issue 3, 2011, Pages 555-572

  Bogacka, Barbara ^a   Patan, Maciej ^b   Johnson, Patrick J ^c   Youdim, Kuresh ^c   Atkinson, Anthony C ^d  

^a QUEEN MARY UNIVERSITY OF LONDON   (United Kingdom)

^b UNIVERSITY OF ZIELONA GÓRA   (Poland)

^c PFIZER GLOBAL RESEARCH AND DEVELOPMENT   (United Kingdom)

^d LONDON SCHOOL OF ECONOMICS   (United Kingdom)

Author keywords

Closed form design; Comparison of designs; Compound design; Cost saving; D optimality; Efficiency; Parameter estimation

Indexed keywords

CYTOCHROME P450 1A2; CYTOCHROME P450 2C19; CYTOCHROME P450 2C9; CYTOCHROME P450 2D6; CYTOCHROME P450 3A4; DEXTROMETHORPHAN; SERTRALINE;

ARTICLE; COMPETITION; COST CONTROL; DRUG BINDING SITE; DRUG METABOLISM; DRUG SENSITIVITY; ENZYME INHIBITION; HUMAN; MICHAELIS MENTEN KINETICS; PARTIAL LEAST SQUARES REGRESSION; PRIORITY JOURNAL; PROCESS OPTIMIZATION; STATISTICAL PARAMETERS; STEADY STATE;

ANTITUSSIVE AGENTS; CLINICAL TRIALS AS TOPIC; COMPUTER SIMULATION; CYTOCHROME P-450 ENZYME SYSTEM; DEXTROMETHORPHAN; ENZYME INHIBITORS; HUMANS; MODELS, BIOLOGICAL; MODELS, STATISTICAL; NONLINEAR DYNAMICS; RESEARCH DESIGN; SEROTONIN UPTAKE INHIBITORS; SERTRALINE;

EID: 79953186495     PISSN: 10543406     EISSN: 15205711     Source Type: Journal    
DOI: 10.1080/10543406.2010.489979     Document Type: Article

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