Plasma erythromycin concentrations predict feeding outcomes in critically ill patients with feed intolerance

Critical Care Medicine

Volumn 39, Issue 4, 2011, Pages 868-871

  Nguyen, Nam Q ^a,b   Grgurinovich, Nick ^c   Bryant, Laura K ^e   Burgstad, Carly M ^a   Chapman, Marianne J ^b   Holloway, Richard H ^a,b   Mangoni, Arduino A ^c,d   Fraser, Robert J L ^b,e  

^a ROYAL ADELAIDE HOSPITAL   (Australia)

^b UNIVERSITY OF ADELAIDE   (Australia)

^c FLINDERS UNIVERSITY   (Australia)

^d UNIVERSITY OF ABERDEEN   (United Kingdom)

^e REPATRIATION GENERAL HOSPITAL   (Australia)

Author keywords

critically ill; erythromycin; feed intolerance; feeding outcome; tachyphylaxis

Indexed keywords

CREATININE; ERYTHROMYCIN; GLUCOSE; INOTROPIC AGENT; MIDAZOLAM; MORPHINE;

ADULT; ARTICLE; ARTIFICIAL VENTILATION; BODY MASS; BURN; CLINICAL ARTICLE; COMPARATIVE STUDY; CONTROLLED STUDY; CREATININE BLOOD LEVEL; CREATININE CLEARANCE; CRITICALLY ILL PATIENT; DRUG BLOOD LEVEL; DRUG TREATMENT FAILURE; FEMALE; GLUCOSE BLOOD LEVEL; HEAD INJURY; HEART FAILURE; HUMAN; LIVER FAILURE; MALE; NOSE FEEDING; NUTRITIONAL INTOLERANCE; OBSERVATIONAL STUDY; OUTCOME ASSESSMENT; PREDICTION; PRIORITY JOURNAL; RESPIRATORY FAILURE; SENSITIVITY AND SPECIFICITY; SEPSIS; TERTIARY HEALTH CARE;

EID: 79953176947     PISSN: 00903493     EISSN: 15300293     Source Type: Journal    
DOI: 10.1097/CCM.0b013e318206d57b     Document Type: Article

References (13)

1. Heyland DK, Dhaliwal R, Drover JW, et al: Canadian clinical practice guidelines for nutrition support in mechanically ventilated, critically ill adult patients. JPEN J Parenter Enteral Nutr 2003; 27:355-373. (Pubitemid 37022781)
2. Nguyen NQ, Fraser RJ, Bryant LK, et al: The impact of delaying enteral feeding on gastric emptying, plasma cholecystokinin, and peptide YY concentrations in critically ill patients. Crit Care Med 2008; 36:1469-1474. (Pubitemid 351620655)
3. Mutlu GM, Mutlu EA, Factor P: GI complications in patients receiving mechanical ventilation. Chest 2001; 119:1222-1241. (Pubitemid 32679452)
4. Nguyen NQ, Chapman MJ, Fraser RJ, et al: Erythromycin is more effective than metoclopramide in the treatment of feed intolerance in critical illness. Crit Care Med 2007; 35:483-489. (Pubitemid 46151663)
5. Lamian V, Rich A, Ma Z, et al: Characterization of agonist-induced motilin receptor traf-ficking and its implications for tachyphylaxis. Mol Pharmacol 2006; 69:109-118. (Pubitemid 43048898)
6. Thielemans L, Depoortere I, Perret J, et al: Desensitization of the human motilin recep-tor by motilides. J Pharmacol Exp Ther 2005; 313:1397-1405. (Pubitemid 40727047)
7. Tack J, Janssens J, Vantrappen G, et al: Effect of erythromycin on gastric motility in controls and in diabetic gastroparesis. Gastroenterology 1992; 103:72-79.
8. Stubbs C, Haigh JM, Kanfer I: Highperformance liquid chromatographic analysis of oleandomycin in serum and urine. J Chromatogr 1986; 353:33-38. (Pubitemid 16016334)
9. Frazee LA, Mauro LS: Erythromycin in the treatment of diabetic gastroparesis. Am J Ther 1994; 1:287-295.
10. Yamashita T, Tsubura E: [Influence of meal on the plasma concentration of patients received repeated administration of OE-7, erythromycin stearate capsules (author's transl)]. Jpn J Antibiot 1977; 30: 517-520. (Pubitemid 8151597)
11. Paulus TJ, Tuan JS, Luebke VE, et al: Mutation and cloning of eryG, the structural gene for erythromycin O-methyltransferase from Saccharopolyspora erythraea, and expression of eryG in Escherichia coli. J Bacteriol 1990; 172:2541-2546. (Pubitemid 20141408)
12. Lee CC, Anderson RC, Chen KK: Renal clearance of erythromycin. Proc Soc Exp Biol Med 1955; 88:584-586.
13. Ritz MA, Chapman MJ, Fraser RJ, et al: Erythromycin dose of 70 mg accelerates gastric emptying as effectively as 200 mg in the critically ill. Intensive Care Med 2005; 31: 949-954 (Pubitemid 40941727)