-
2
-
-
84930450274
-
ABT-869 in combination with paclitaxel (P) as first-line treatment in patients (Pts) with advanced breast cancer
-
abstr. 5076, 10 Dec, Available from URL:, USA. English
-
Rugo HS, Lopez-Hernandez J, Gomez-Villanueva A, et al. ABT-869 in Combination with Paclitaxel (P) as First-Line Treatment in Patients (Pts) with Advanced Breast Cancer. 32nd Annual San Antonio Breast Cancer Symposium: abstr. 5076, 10 Dec. 2009. Available from URL: http://www.sabcs.org/. USA. [English]
-
(2009)
32nd Annual San Antonio Breast Cancer Symposium
-
-
Rugo, H.S.1
Lopez-Hernandez, J.2
Gomez-Villanueva, A.3
-
3
-
-
79953192832
-
Linifanib phase II trial in patients with advanced hepatocellular carcinoma
-
abstr. 4038, 4 Jun, Available from URL:, Singapore. English
-
Toh H, Chen P, Carr BI, et al. Linifanib phase II trial in patients with advanced hepatocellular carcinoma. 46th Annual Meeting of the American Society of Clinical Oncology: abstr. 4038, 4 Jun. 2010. Available from URL: http://www.asco.org. Singapore. [English]
-
(2010)
46th Annual Meeting of the American Society of Clinical Oncology
-
-
Toh, H.1
Chen, P.2
Carr, B.I.3
-
4
-
-
79953194928
-
Linifanib treatment in patients with non-small cell lung cancer (NSCLC): Phase II results
-
abstr. 7590, 4 Jun, Available from URL:, Singapore. English. Clinical Trials Insight
-
Soo RA, Goss GD, Salgia R, et al. Linifanib treatment in patients with non-small cell lung cancer (NSCLC): Phase II results. 46th Annual Meeting of the American Society of Clinical Oncology: abstr. 7590, 4 Jun. 2010. Available from URL: http://www.asco.org. Singapore. [English]. Clinical Trials Insight
-
(2010)
46th Annual Meeting of the American Society of Clinical Oncology
-
-
Soo, R.A.1
Goss, G.D.2
Salgia, R.3
-
5
-
-
79953188493
-
ABT-869 in non-small cell lung cancer: Interim results
-
abstr. 8074, 30 May, Available from URL:, Singapore. English. Clinical Trials Insight
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Tan E, Salgia R, Besse B, et al. ABT-869 in non-small cell lung cancer: Interim results. 45th Annual Meeting of the American Society of Clinical Oncology: 425s abstr. 8074, 30 May 2009. Available from URL: http://www.abstract. asco.org. Singapore. [English]. Clinical Trials Insight
-
(2009)
45th Annual Meeting of the American Society of Clinical Oncology
-
-
Tan, E.1
Salgia, R.2
Besse, B.3
-
6
-
-
79958836569
-
Phase II trial of linifanib in patients with advanced renal cell cancer after sunitinib failure
-
abstr. 4527, 4 Jun, Available from URL:, USA. English
-
Tannir NM, Wong Y, Kollmannsberger CK, et al. Phase II trial of linifanib in patients with advanced renal cell cancer after sunitinib failure. 46th Annual Meeting of the American Society of Clinical Oncology: abstr. 4527, 4 Jun. 2010. Available from URL: http://www.asco.org. USA. [English]
-
(2010)
46th Annual Meeting of the American Society of Clinical Oncology
-
-
Tannir, N.M.1
Wong, Y.2
Kollmannsberger, C.K.3
-
7
-
-
79953227494
-
Multi-targeted receptor tyrosine kinase inhibitor, ABT-869, induces apoptosis and suppresses proliferation of Ba/F3 FLT-3 ITD mutant cells in vitro and in vivo through inhibition of FLT3 and AKT
-
abstr. 1938, 7 Dec, Available from URL:, USA. English
-
Hernandez JE, Zape J, Glaser K, et al. Multi-targeted receptor tyrosine kinase inhibitor, ABT-869, induces apoptosis and suppresses proliferation of Ba/F3 FLT-3 ITD mutant cells in vitro and in vivo through inhibition of FLT3 and AKT. 50th Annual Meeting and Exposition of the American Society of Hematology: abstr. 1938, 7 Dec. 2008. Available from URL: http://www.hematology.org. USA. [English]
-
(2008)
50th Annual Meeting and Exposition of the American Society of Hematology
-
-
Hernandez, J.E.1
Zape, J.2
Glaser, K.3
-
8
-
-
79953174070
-
Phase 1 comparison of pharmacokientics, safety and efficacy with low versus high doses of ABT-869 in refractory solid tumors
-
abstr. 476P, 12 Sep, Available from URL:, USA. English
-
Humerickhouse R, Gupta N, Goh B, et al. Phase 1 comparison of pharmacokientics, safety and efficacy with low versus high doses of ABT-869 in refractory solid tumors. 33rd Congress of the European Society for Medical Oncology: abstr. 476P, 12 Sep. 2008. Available from URL: http://annonc. oxfordjournals.org. USA. [English]
-
(2008)
33rd Congress of the European Society for Medical Oncology
-
-
Humerickhouse, R.1
Gupta, N.2
Goh, B.3
-
9
-
-
79953191584
-
Preliminary analysis of ABT-869 safety, pharmacokinetics and efficacy in three phase 2 solid tumor studies
-
abstr. 477P, 12 Sep, Available from URL:, USA. English
-
Steinberg J, Tan E, Wei-Peng Y, et al. Preliminary analysis of ABT-869 safety, pharmacokinetics and efficacy in three phase 2 solid tumor studies. 33rd Congress of the European Society for Medical Oncology: abstr. 477P, 12 Sep. 2008. Available from URL: http://annonc.oxfordjournals.org. USA. [English]
-
(2008)
33rd Congress of the European Society for Medical Oncology
-
-
Steinberg, J.1
Tan, E.2
Wei-Peng, Y.3
-
10
-
-
79953195271
-
A Phase 1 open-label study evaluating pharmacokinetics, safety, and tolerability of linifanib in Japanese patients with solid tumors
-
abstr. C37, 15 Nov, Available from URL:, Japan. English
-
Tamura T, Yamamoto N, Nokihara H, et al. A Phase 1 open-label study evaluating pharmacokinetics, safety, and tolerability of linifanib in Japanese patients with solid tumors. 21st AACR-NCI-EORTC International Conference on Molecular Targets and Cancer Therapeutics: abstr. C37, 15 Nov. 2009. Available from URL: http://www.aacr.org/home/scientists/meetings-workshops/molecular- targets-andcancer-therapeutics.aspx. Japan. [English]
-
(2009)
21st AACR-NCI-EORTC International Conference on Molecular Targets and Cancer Therapeutics
-
-
Tamura, T.1
Yamamoto, N.2
Nokihara, H.3
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11
-
-
79953206043
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Assessment of the effect of food on the oral bioavailability and assessment of diurnal variation in the pharmacokinetics of linifanib
-
abstr. B53, 15 Nov, Available from URL:, USA.English. Clinical Trials Insight
-
Gupta N, Yan Z, Lo Russo P, et al. Assessment of the effect of food on the oral bioavailability and assessment of diurnal variation in the pharmacokinetics of linifanib. 21st AACR-NCI-EORTC International Conference on Molecular Targets and Cancer Therapeutics: abstr. B53, 15 Nov. 2009. Available from URL: http://www.aacr.org/home/scientists/meetings-workshops/molecular- targets-and-cancertherapeutics.aspx. USA. [English]. Clinical Trials Insight
-
(2009)
21st AACR-NCI-EORTC International Conference on Molecular Targets and Cancer Therapeutics
-
-
Gupta, N.1
Yan, Z.2
Lo Russo, P.3
-
12
-
-
37149022507
-
Phase I and biomarker study of ABT869, a multiple receptor tyrosine kinase inhibitor, in patients with refractory solid malignancies
-
No. 18, Part 1, 20 Jun, Singapore. English
-
Wong CI, Thng CH, Soo R, et al. Phase I and biomarker study of ABT869, a multiple receptor tyrosine kinase inhibitor, in patients with refractory solid malignancies. Journal of Clinical Oncology. 25 (Suppl.): 142, No. 18, Part 1, 20 Jun. 2007. Singapore. [English]
-
(2007)
Journal of Clinical Oncology
, vol.25
, Issue.SUPPL.
, pp. 142
-
-
Wong, C.I.1
Thng, C.H.2
Soo, R.3
-
13
-
-
34548407914
-
Phase I study of ABT869, a multiple receptor tyrosine kinase inhibitor, in patients with refractory solid malignancies
-
Nov, Singapore. English
-
Goh BC, Thng CH, Sukri N, et al. Phase I study of ABT869, a multiple receptor tyrosine kinase inhibitor, in patients with refractory solid malignancies. EJC Supplements. 4:36, No. 12, Nov. 2006. Singapore. [English]
-
(2006)
EJC Supplements
, vol.4
, Issue.12
, pp. 36
-
-
Goh, B.C.1
Thng, C.H.2
Sukri, N.3
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14
-
-
79953173724
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Extended linifanib therapy in patients with advanced solid tumors in a phase I trial
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abstr. 3053, 4 Jun, Available from URL:, Singapore. English
-
Goh BC, Wong C, Qian J, et al. Extended linifanib therapy in patients with advanced solid tumors in a phase I trial. 46th Annual Meeting of the American Society of Clinical Oncology: abstr. 3053, 4 Jun. 2010. Available from URL: http://www.asco.org. Singapore. [English]
-
(2010)
46th Annual Meeting of the American Society of Clinical Oncology
-
-
Goh, B.C.1
Wong, C.2
Qian, J.3
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15
-
-
79953179484
-
The broad spectrum antitumor efficacy and tolerability of the RTK inhibitor, linifanib (ABT-869) alone and in combination with various cytotoxic therapies
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plus poster, abstr. B14, 15 Nov, Available from URL:, USA. English
-
Donawho CK, Bukofzer G, Ellis PA, et al. The broad spectrum antitumor efficacy and tolerability of the RTK inhibitor, linifanib (ABT-869) alone and in combination with various cytotoxic therapies. 21st AACR-NCI-EORTC International Conference on Molecular Targets and Cancer Therapeutics: (plus poster) abstr. B14, 15 Nov. 2009. Available from URL: http://www.aacr.org/home/scientists/ meetings-workshops/molecular-targets-and-cancer-therapeutics.aspx. USA. [English]
-
(2009)
21st AACR-NCI-EORTC International Conference on Molecular Targets and Cancer Therapeutics
-
-
Donawho, C.K.1
Bukofzer, G.2
Ellis, P.A.3
-
16
-
-
33750348247
-
The multi-targeted receptor tyrosine kinase inhibitor, ABT-869, induces apoptosis of AML cells both in vitro and in vivo
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Part 1, 16 Nov, USA. English
-
Shankar DB, Chang JC, Parcells B, et al. The multi-targeted receptor tyrosine kinase inhibitor, ABT-869, induces apoptosis of AML cells both in vitro and in vivo. Blood. 106:183, No. 11, Part 1, 16 Nov. 2005. USA. [English]
-
(2005)
Blood
, vol.106
, Issue.11
, pp. 183
-
-
Shankar, D.B.1
Chang, J.C.2
Parcells, B.3
-
17
-
-
79953196257
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Identification of core gene signature associated with synergism between ABT-869, a FLT3 inhibitor and SAHA, a HDAC inhibitor in AML with FLT3-ITD mutation
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abstr. 1618, 6 Dec, Available from URL:, Singapore English
-
Zhou J, Bi C, Liu S-C, et al. Identification of core gene signature associated with synergism between ABT-869, a FLT3 inhibitor and SAHA, a HDAC inhibitor in AML with FLT3-ITD mutation. 50th Annual Meeting and Exposition of the American Society of Hematology: abstr. 1618, 6 Dec. 2008. Available from URL: http://www.hematology.org. Singapore. [English]
-
(2008)
50th Annual Meeting and Exposition of the American Society of Hematology
-
-
Zhou, J.1
Bi, C.2
Liu, S.-C.3
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18
-
-
29244468633
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ABT-869, a novel multitargeted receptor tyrosine kinase inhibitor: Characterization of FLT3 phosphorylation in a model of acute myelogenous leukemia
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plus poster abstr, 5981. Apr, USA. English
-
Li J, Pease LJ, Tapang P, et al. ABT-869, a novel multitargeted receptor tyrosine kinase inhibitor: characterization of FLT3 phosphorylation in a model of acute myelogenous leukemia. 96th Annual Meeting ofthe American Association for Cancer Research. 46:1407 (plus poster) abstr. 5981, Apr. 2005. USA. [English]
-
(2005)
96th Annual Meeting Ofthe American Association for Cancer Research
, vol.46
, pp. 1407
-
-
Li, J.1
Pease, L.J.2
Tapang, P.3
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19
-
-
29244469740
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Preclinical activity of ABT-869, a multi-targeted receptor tyrosine kinase inhibitor
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Apr, USA. English
-
Albert DH, Tapang P, Magoc TJ, et al. Preclinical activity of ABT-869, a multi-targeted receptor tyrosine kinase inhibitor. 96th Annual Meeting of the American Association for Cancer Research. 46:159-160, Apr. 2005. USA. [English]
-
(2005)
96th Annual Meeting of the American Association for Cancer Research
, vol.46
, pp. 159-160
-
-
Albert, D.H.1
Tapang, P.2
Magoc, T.J.3
-
20
-
-
79953219909
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Cellular activity of ABT-869 against colony-stimulating-factor-1 receptor in macrophage-like cell lines
-
abstr. 1789, 19 Apr, Available from URL:, USA. English
-
Guo J, Dai Y, Bui MH, et al. Cellular activity of ABT-869 against colony-stimulating-factor-1 receptor in macrophage-like cell lines. 100th Annual Meeting of the American Association for Cancer Research: abstr. 1789, 19 Apr. 2009. Available from URL: http://www.aacr.org. USA. [English]
-
(2009)
100th Annual Meeting of the American Association for Cancer Research
-
-
Guo, J.1
Dai, Y.2
Bui, M.H.3
-
21
-
-
79953224945
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Phase 2 trials of linifanib (ABT-869) in advanced hepatocellular, renal cell and non-small cell lung cancer: Associations of response by CT or DCE-MRI with patient outcome
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plus poster, abstr. A105, 15 Nov, Available from URL:, Singapore. English
-
Toh HC, Yong WP, Wong Y-N, et al. Phase 2 trials of linifanib (ABT-869) in advanced hepatocellular, renal cell and non-small cell lung cancer: Associations of response by CT or DCE-MRI with patient outcome. 21st AACR-NCI-EORTC International Conference on Molecular Targets and Cancer Therapeutics: (plus poster) abstr. A105, 15 Nov. 2009. Available from URL: http://www.aacr.org/home/scientists/meetings-workshops/molecular-targets-and- cancertherapeutics.aspx. Singapore. [English]
-
(2009)
21st AACR-NCI-EORTC International Conference on Molecular Targets and Cancer Therapeutics
-
-
Toh, H.C.1
Yong, W.P.2
Wong, Y.-N.3
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