Low-dose rabbit antithymocyte globulin induction therapy results in prolonged selective lymphocyte depletion irrespective of maintenance immunosuppression

Transplantation Proceedings

Volumn 43, Issue 2, 2011, Pages 462-465

  Pankewycz, O ^a,d   Leca, N ^b   Kohli, R ^a   Wallace, P K ^c   Said, M ^a   Feng, L ^a   Alnimri, M ^a   Patel, S ^a   Laftavi, M R ^a  

^a UNIVERSITY AT BUFFALO   (United States)

^b UNIVERSITY OF WASHINGTON   (United States)

^c ROSWELL PARK CANCER INSTITUTE   (United States)

^d BUFFALO GENERAL HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD19 ANTIGEN; METHYLPREDNISOLONE SODIUM SUCCINATE; MYCOPHENOLIC ACID; PREDNISONE; RAPAMYCIN; TACROLIMUS; THYMOCYTE ANTIBODY; TRANSCRIPTION FACTOR FOXP3;

ADULT; B LYMPHOCYTE; CARCINOGENESIS; CD3+ T LYMPHOCYTE; CD4+ CD25+ T LYMPHOCYTE; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CONFERENCE PAPER; CONTROLLED STUDY; DRUG EFFICACY; FEMALE; FLOW CYTOMETRY; HUMAN; IMMUNOSUPPRESSIVE TREATMENT; INFECTION; KIDNEY GRAFT REJECTION; KIDNEY TRANSPLANTATION; LOW DRUG DOSE; LYMPHOCYTE DEPLETION; LYMPHOCYTE SUBPOPULATION; LYMPHOCYTOPENIA; MAINTENANCE THERAPY; MAJOR CLINICAL STUDY; MALE; PERIPHERAL LYMPHOCYTE; PRIORITY JOURNAL; PROSPECTIVE STUDY; RANDOMIZED CONTROLLED TRIAL; REGULATORY T LYMPHOCYTE;

ADULT; AGED; ANIMALS; ANTIGENS, CD19; ANTIGENS, CD3; ANTILYMPHOCYTE SERUM; B-LYMPHOCYTES; CD4-POSITIVE T-LYMPHOCYTES; FEMALE; FLOW CYTOMETRY; FORKHEAD TRANSCRIPTION FACTORS; HUMANS; IMMUNOSUPPRESSIVE AGENTS; INTERLEUKIN-2 RECEPTOR ALPHA SUBUNIT; LYMPHOCYTE SUBSETS; LYMPHOCYTES; MALE; MIDDLE AGED; PROSPECTIVE STUDIES; RABBITS; RISK; T-LYMPHOCYTES;

EID: 79953176313     PISSN: 00411345     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.transproceed.2011.01.034     Document Type: Conference Paper

References (19)

1. US Renal Data System, USRDS 2010 Annual Data Report: Atlas of Chronic Kidney Disease and End-Stage Renal Disease in the United States 2010 National Institutes of Health, National Institute of Diabetes and Digestive and Kidney Diseases Bethesda, MD
2. 2009 Annual Report of the U.S. Organ Procurement and Transplantation Network and the Scientific Registry of Transplant Recipients: Transplant Data 19992008., Rockville, MD: U.S. Department of Health and Human Services, Health Resources and Services Administration, Healthcare Systems Bureau, Division of Transplantation
3. A.O. Gaber, R.J. Knight, and S. Patel A review of the evidence for use of thymoglobulin induction in renal transplantation Transplant Proc 42 2010 1395
4. R.M. Merion 2008 SRTR report on the state of transplantation Am J Transplant 9 2008 867
5. T.F. Mueller Mechanisms of action of thymoglobulin Transplantation 84 11S 2007 S5
6. T.F. Muller, S.O. Grebe, and M. Neumann Persistent long-term changes in lymphocyte subsets induced by polyclonal antibodies Transplantation 64 1997 1432
7. W. Wong, N. Agrawal, and M. Pascual Comparison of two doses of thymoglobulin used as a short course for induction in kidney transplantation Transpl Int 19 2006 629
8. S. Gurkan, Y. Luan, and N. Dhillon Immune reconstitution following rabbit antithymocyte globulin Am J Transplant 10 2010 2132
9. E. Morelon, N. Lefrancois, and C. Besson Preferential increase in memory and regulatory subsets during T-lymphocyte immune reconstitution after Thymoglobulin induction therapy with maintenance sirolimus vs cyclosporine Transpl Immunol 23 2010 53
10. J. Grant, K. Bourcier, and S. Wallace Validated protocol for Foxp3 reveals increased expression in type 1 diabetes patients Cytometry B Clin Cytom 76B 2009 67
11. C.C. Stewart Multiparameter analysis of leukocytes by flow cytometry Methods Cell Biol 33 1990 427
12. D.C. Brennan, K. Flavin, and J.A. Lowell A randomized, double-blinded, comparison of Thymoglobulin versus Atgam for induction immunosuppressive therapy in adult renal transplant recipients Transplantation 67 1999 1011
13. K.L. Hardinger, S. Rhee, and P. Buchanan A randomized, double-blinded, comparison of Thymoglobulin versus Atgam for induction immunosuppressive therapy: 10-year results Transplantation 86 2008 947
14. I.A. Agha, J. Rueda, and A. Alvarez Short course induction immunosuppression with thymoglobulin for renal transplant recipients Transplantation 73 2002 473
15. M. Zand Therapeutic antibody agents for B-cell immunomodulation in renal transplantation Transplantation 84 2007 S11
16. G. LaCorcia, M. Swistak, and C. Lawendowski Polyclonal rabbit antithymocyte globulin exhibits consistent immunosuppressive capabilities beyond cell depletion Transplantation 87 2009 966
17. + regulatory T cells from cells of patients with end-stage renal disease Transplantation 89 2010 655
18. + regulatory T cells J Am Soc Nephrol 17 2006 2844
19. J. Bas, M. Mestre, and J.M. Grinyo Peripheral blood lymphoid subsets and long-term clinical course of kidney recipients: a longitudinal study Cytometry 34 1998 103