Spindle-assembly checkpoint and gastrointestinal cancer

New England Journal of Medicine

Volumn 364, Issue 13, 2011, Pages 1279-1280

  De Voer, Richarda M ^a   Hoogerbrugge, Nicoline ^a   Kuiper, Roland P ^a  

^a RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

ANEUPLOIDY; BUB1B GENE; CHROMOSOME SEGREGATION; DIGESTIVE SYSTEM CANCER; GENE; GENE DELETION; GENE DOSAGE; GENE EXPRESSION; GENE FREQUENCY; GENE FUNCTION; GENE LOCUS; GENE MUTATION; HOMOZYGOSITY; HUMAN; LETTER; LYMPHOCYTE; METAPHASE; PRIORITY JOURNAL; PUBLICATION;

EID: 79953174923     PISSN: 00284793     EISSN: 15334406     Source Type: Journal    
DOI: 10.1056/NEJMc1101053     Document Type: Letter

References (4)

1. Rio Frio T, Lavoie J, Hamel N, et al. Homozygous BUB1B mutation and susceptibility to gastrointestinal neoplasia. N Engl J Med 2010;363:2628-37.
2. Scully R. The spindle-assembly checkpoint, aneuploidy, and gastrointestinal cancer. N Engl J Med 2010;363:2665-6.
3. Rao CV, Yang YM, Swamy MV, et al. Colonic tumorigenesis in BubR1+/-ApcMin/+ compound mutant mice is linked to premature separation of sister chromatids and enhanced genomic instability. Proc Natl Acad Sci U S A 2005;102:4365-70. (Pubitemid 40397117)
4. Baker DJ, Jin F, Jeganathan KB, van Deursen JM. Whole chromosome instability caused by Bub1 insufficiency drives tumorigenesis through tumor suppressor gene loss of heterozygosity. Cancer Cell 2009;16:475-86.