Do chromosomally abnormal pregnancies really preclude autoimmune etiologies of spontaneous miscarriages?

Autoimmunity Reviews

Volumn 10, Issue 6, 2011, Pages 361-363

  Gleicher, Norbert ^a,b   Weghofer, Andrea ^a,c   Barad, David H ^a,d  

^a Center for Human Reproduction (CHR) and Foundation for Reproductive Medicine   (United States)

^b YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF VIENNA   (Austria)

^d ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

Author keywords

Aneuploidy; Autoimmunity; Chromosomal abnormality; Habitual aborter; Karyotype; Miscarriage; Pregnancy loss

Indexed keywords

ANEUPLOIDY; AUTOIMMUNE DISEASE; AUTOIMMUNITY; CHROMOSOME ABERRATION; HUMAN; IMMUNOPATHOGENESIS; PREGNANCY; PREVALENCE; REVIEW; SPONTANEOUS ABORTION; SYSTEMATIC REVIEW;

ABORTION, SPONTANEOUS; AUTOIMMUNE DISEASES; AUTOIMMUNITY; FEMALE; HUMANS; NONDISJUNCTION, GENETIC; OVARY; PREGNANCY; SEX CHROMOSOME ABERRATIONS;

EID: 79953163567     PISSN: 15689972     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.autrev.2010.12.004     Document Type: Review

References (28)

1. Gleicher N., Vidali A., Karande V. The immunological "Wars of Roses:" disagreements amongst reproductive immunologists. Hum Reprod 2002, 17:539-542.
2. Pandey M.K., Rani R., Agrawal S. An update in recurrent spontaneous abortion. Arch Gynecol Obstet 2005, 272:95-108.
3. Lambopoulou M., Tamiolakis D., Venizelos J., Liberis V., Galazios G., Tsikouras P., Karamanidis D., et al. Imbalance of mononuclear cell infiltrates in the placental tissue from fetuses after spontaneous abortion versus therapeutic termination from 8th to 12th week of gestational age. Clin Exp Med 2006, 6:171-176.
4. Pollard J.E. Uterine DCs are essential for pregnancy. J Clin Invest 2008, 118:3832-3835.
5. Brown S. Miscarriage and its associations. Semin Reprod Med 2008, 26:391-400.
6. Bettio D., Venci A., Levi Setti P.E. Chromosomal abnormalities in miscarriages after different assisted reproduction procedures. Placenta 2008, 29(Suppl B):126-128.
7. Morales C., Sánchez A., Bruguera J., Margarit E., Borrell A., Borobia V., Soler A. Cytogenetic study of spontaneous abortions using semi-direct analysis of chorionic villi samples detects the broadest spectrum of chromosome abnormalities. Am J Med Genet A 2008, 146A:66-70.
8. Canfield V.C., Daiger S.P., Gambello M., Hashmi S.S., King T., Noblin S.J., Walker D.K., et al. Survival of Texas infants born with trisomies 21, 18, and 13. Am J Med Genet A 2010, 152A:360-366.
9. Pessach I.M., Notarangelo L.D. X-linked primary immunodeficiencies as a bridge to better understanding X-chromosome related autoimmunity. J Autoimmun 2009, 33:17-24.
10. Gleicher N., Barad D.H. Gender as a risk factor for autoimmune diseases. J Autoimmun 2007, 28:1-6.
11. Larizza D., Calcaterra V., Martinetti M. Autoimmune stigmata in Turner syndrome: when lacks an X chromosome. J Autoimmun 2009, 33:25-30.
12. Persani L., Rossetti R., Cacciatore C., Bonomi M. Primary ovarian insufficiency: X chromosome defects and autoimmunity. J Autoimmun 2009, 33:35-41.
13. Hoek A., Schoemaker J., Drexhage H.A. Premature ovarian failure and ovarian autoimmunity. Endocrinol Rev 1997, 18:108-134.
14. Fialkow P.J. Autoimmunity and chromosomal aberrations. Am J Hum Genet 1966, 18:93-108.
15. Vallotton M.B., Forbes A.P. Autoimmunity in gonadal dysgenesis and Klinefelter's syndrome. Lancet 1967, (i):648-651.
16. Cassidy S.B., Niblack G.D., Lorber C.A., Mann J.M., Engel E. HLA frequencies, diabetes mellitus and autoimmunity in Turner's patients and their relatives. Ann Génét 1978, 21:203-208.
17. Larizza D., Martinetti Bianchi M., Lorini R., Maghnie M., Dugoujon J.M., Cuccia Belvedere M., Severi F. Autoimmunity, HLA, Gm and Km polymorphisms in Turner's syndrome. Autoimmunity 1989, 4:69-78.
18. Barad D.H., Brill H., Gleicher N. Update on the use of dehydroepiandrosterone supplementation among women with diminished ovarian function. J Assist Reprod Genet 2007, 24:629-634.
19. Casson P.R., Andersen R.N., Herrod H.G., Stentz F.B., Straughn A.B., Abraham G.E., Buster J.E. Oral dehydroepiandrosterone in physiologic doses modulates immune function in postmenopausal women. Am J Obstet Gynecol 1993, 169:1536-1539.
20. Hazeldine J., Arlt W., Lord J.M. Dehydroepiandrosterone as a regulator of immune cell function. J Steroid Biochem Mol Biol 2010, 120:127-136.
21. Crosbie D., Black C., McIntyre L., Royle P.L., Thomas S. Dehydroepiandrosterone for systemic lupus erythematosus. Cochrane database Syst rev Oct 17 2007, (4):CD005114.
22. Sawalha A.H., Kovats S. Dehydroepiandrosterone in systemic lupus erythematosus. Curr Rheumatol Rep 2008, 10:286-291.
23. Gleicher N., Weghofer A., Barad D.H. Increased euploid embryos after supplementation with dehydroepiandrosterone (DHEA) in women with premature ovarian aging. Fertil Steril 2007, 88((Suppl1):S):232.
24. Gleicher N., Weghofer A., Barad D.H. Dehydroepiandrosterone (DHEA) reduces embryo aneuploidy: Direct evidence from preimplantation genetic screening (PGS). Reprod Biol Endocrinol 2010, 8:140.
25. Gleicher N., Ryan E., Weghofer A., Blanco-Mjia S., Barad D.H. Miscarriage rates after dehydroepiandrosterone (DHEA) supplementation in women with diminished ovarian reserve: a case control study. Reprod Biol Endocrinol 2009, 7:108.
26. Barad D.H., Weghofer A., Goyal A., Gleicher N. Further refinement in defining the effect of heterozygous abnormal CGG counts on the FMR1 (fragile X) gene: definition of distinct subgroup of PCOS patients, based on normal/low genotype. Fertil Steril 2009, 92(Suppl 1):S105.
27. Gleicher N, Weghofer A, Lee IH, Barad DH. FMR1 genotype with autoimmune-associated polycystic ovary-like phenotype and decreased pregnancy chance. PLoS One in press.
28. Stern J.J., Dorfmann A.D., Gutiérrez-Najar A.J., Cerrillo M., Coulam C.B. Frequency of abnormal karotypes among abortuses from women with and without a history of recurrent spontaneous abortion. Fertil Steril 1996, 65:250-253.