Overexpression of the c-Myb but not its leukemogenic mutant DNA-binding domain increased adipogenic differentiation in mesenchymal stem cells

Biochemical and Biophysical Research Communications

Volumn 407, Issue 1, 2011, Pages 202-206

  Chen, Yilan ^a   Liu, Jin ^b   Xu, Hong ^b   Luo, Zhijuan ^a   Zhang, Chongjie ^a  

^a SICHUAN UNIVERSITY   (China)

^b SICHUAN UNIVERSITY   (China)

Author keywords

Adipogenic differentiation; C Myb; Human mesenchymal stem cells

Indexed keywords

ADENOVIRUS VECTOR; DNA; GREEN FLUORESCENT PROTEIN; PROTEIN C MYB;

ADIPOGENESIS; ARTICLE; BONE MARROW CELL; CELL DIFFERENTIATION; CONTROLLED STUDY; DNA BINDING; GENE OVEREXPRESSION; GENE TRANSFER; HUMAN; HUMAN CELL; MESENCHYMAL STEM CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION;

ADIPOGENESIS; ADOLESCENT; CELLS, CULTURED; EPIGENESIS, GENETIC; FEMALE; HUMANS; MESENCHYMAL STEM CELLS; MUTATION; PROTEIN STRUCTURE, TERTIARY; PROTO-ONCOGENE PROTEINS C-MYB;

ADENOVIRIDAE;

EID: 79953161893     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2011.02.140     Document Type: Article

References (15)

1. Ness S.A. The Myb oncoprotein: regulating a regulator. Biochim. Biophys. Acta 1996, 1288:F123-F139.
2. Ogata K., Morikawa S., Nakamura H., Hojo H., Yoshimura S., Zhang R., Aimoto S., Ametani Y., Hirata Z., Sarai A., et al. Comparison of the free and DNA-complexed forms of the DNA-binding domain from c-Myb. Nat. Struct. Biol. 1995, 2:309-320.
3. Howe K.M., Reakes C.F., Watson R.J. Characterization of the sequence-specific interaction of mouse c-myb protein with DNA. EMBO J. 1990, 9:161-169.
4. Sakura H., Kanei-Ishii C., Nagase T., Nakagoshi H., Gonda T.J., Ishii S. Delineation of three functional domains of the transcriptional activator encoded by the c-myb protooncogene. Proc. Natl. Acad. Sci. USA 1989, 86:5758-5762.
5. Klempnauer K.H., Gonda T.J., Bishop J.M. Nucleotide sequence of the retroviral leukemia gene v-myb and its cellular progenitor c-myb: the architecture of a transduced oncogene. Cell 1982, 31:453-463.
6. Introna M., Golay J., Frampton J., Nakano T., Ness S.A., Graf T. Mutations in v-myb alter the differentiation of myelomonocytic cells transformed by the oncogene. Cell 1990, 63:1289-1297.
7. Mo X., Kowenz-Leutz E., Laumonnier Y., Xu H., Leutz A. Histone H3 tail positioning and acetylation by the c-Myb but not the v-Myb DNA-binding SANT domain. Genes Dev. 2005, 19:2447-2457.
8. Tahirov T.H., Sato K., Ichikawa-Iwata E., Sasaki M., Inoue-Bungo T., Shiina M., Kimura K., Takata S., Fujikawa A., Morii H., Kumasaka T., Yamamoto M., Ishii S., Ogata K. Mechanism of c-Myb-C/EBP beta cooperation from separated sites on a promoter. Cell 2002, 108:57-70.
9. Emambokus N., Vegiopoulos A., Harman B., Jenkinson E., Anderson G., Frampton J. Progression through key stages of haemopoiesis is dependent on distinct threshold levels of c-Myb. EMBO J. 2003, 22:4478-4488.
10. Fahl S.P., Crittenden R.B., Allman D., Bender T.P. C-Myb is required for pro-B cell differentiation. J. Immunol. 2009, 183:5582-5592.
11. Kolodziejska K.M., Noyan-Ashraf M.H., Nagy A., Bacon A., Frampton J., Xin H.B., Kotlikoff M.I., Husain M. C-Myb-dependent smooth muscle cell differentiation. Circ. Res. 2008, 102:554-561.
12. Pittenger M.F., Mackay A.M., Beck S.C., Jaiswal R.K., Douglas R., Mosca J.D., Moorman M.A., Simonetti D.W., Craig S., Marshak D.R. Multilineage potential of adult human mesenchymal stem cells. Science 1999, 284:143-147.
13. Zuk P.A., Zhu M., Ashjian P., De Ugarte D.A., Huang J.I., Mizuno H., Alfonso Z.C., Fraser J.K., Benhaim P., Hedrick M.H. Human adipose tissue is a source of multipotent stem cells. Mol. Biol. Cell 2002, 13:4279-4295.
14. Rosen E.D., Spiegelman B.M. PPARgamma: a nuclear regulator of metabolism, differentiation, and cell growth. J. Biol. Chem. 2001, 276:37731-37734.
15. Treisman J., Gonczy P., Vashishtha M., Harris E., Desplan C. A single amino acid can determine the DNA binding specificity of homeodomain proteins. Cell 1989, 59:553-562.