Metabolism of levulinate in perfused rat livers and live rats: Conversion to the drug of abuse 4-hydroxypentanoate

Journal of Biological Chemistry

Volumn 286, Issue 7, 2011, Pages 5895-5904

  Harris, Stephanie R ^a   Zhang, Guo Fang ^a   Sadhukhan, Sushabhan ^a   Murphy, Anne M ^a   Tomcik, Kristyen A ^a   Vazquez, Edwin J ^a   Anderson, Vernon E ^a   Tochtropand, Gregory P ^a   Brunengraber, Henri ^a  

^a CASE WESTERN RESERVE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYL-COA; CYTOSOLIC; DRUG OF ABUSE; ETHANOL OXIDATION; METABOLOMICS; PARALLEL PATHWAYS; PUBLIC HEALTH; RACEMASE; RAT LIVERS; SUB-CELLULAR;

LIVER; MITOCHONDRIA; RATS;

ETHANOL;

3 HYDROXYACYL COENZYME A DEHYDROGENASE; ACETYL COENZYME A; ACETYL COENZYME A ACYLTRANSFERASE; ACYL COENZYME A DEHYDROGENASE; ALCOHOL; COENZYME A; ENOYL COENZYME A HYDRATASE; LACTIC ACID; LEVULINIC ACID; LONG CHAIN FATTY ACID COENZYME A LIGASE; MALONYL COENZYME A; PROPIONYL COENZYME A; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CATABOLISM; CONTROLLED STUDY; CYTOSOL; DISTRIBUTION VOLUME; DRUG METABOLISM; ENZYME ACTIVITY; ENZYME SYNTHESIS; IN VIVO STUDY; ISOMERIZATION; LIVER METABOLISM; LIVER PERFUSION; MALE; METABOLOMICS; NONHUMAN; PRIORITY JOURNAL; RAT;

ANIMALS; CALCIUM; CENTRAL NERVOUS SYSTEM DEPRESSANTS; CYTOPLASM; ENZYME INHIBITORS; ETHANOL; LEVULINIC ACIDS; LIVER; MALE; MITOCHONDRIA, LIVER; OXIDATION-REDUCTION; PENTANOIC ACIDS; PERFUSION; RATS; RATS, SPRAGUE-DAWLEY; SUBSTANCE-RELATED DISORDERS;

RATTUS;

EID: 79953160086     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M110.196808     Document Type: Article

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