Molecular imaging with contrast enhanced ultrasound

Journal of Nuclear Cardiology

Volumn 17, Issue 4, 2010, Pages 667-677

  Chadderdon, Scott M ^a   Kaul, Sanjiv ^a  

^a OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA INTEGRIN; APOLIPOPROTEIN E; ENDOGLIN; ENDOTHELIAL LEUKOCYTE ADHESION MOLECULE 1; FIBRINOGEN RECEPTOR; FIBROBLAST GROWTH FACTOR 2; INTERCELLULAR ADHESION MOLECULE 1; L SELECTIN; MONOCYTE CHEMOTACTIC PROTEIN 1; PADGEM PROTEIN; VASCULAR CELL ADHESION MOLECULE 1; VASCULOTROPIN RECEPTOR; VASCULOTROPIN RECEPTOR 2;

ACUTE HEART INFARCTION; ANGIOGENESIS; ATHEROSCLEROSIS; CARDIAC GRAFT REJECTION; CARDIOVASCULAR DISEASE; CONTRAST ENHANCEMENT; DIAGNOSTIC VALUE; ECHOGRAPHY; GENETIC TRANSFECTION; HEART MUSCLE ISCHEMIA; HUMAN; INFLAMMATION; LEG ISCHEMIA; MICROBUBBLE; MOLECULAR IMAGING; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; REPERFUSION INJURY; REVIEW; THROMBOSIS;

ANIMALS; BIOLOGICAL MARKERS; CARDIOVASCULAR DISEASES; CONTRAST MEDIA; ECHOCARDIOGRAPHY; HUMANS; IMAGE ENHANCEMENT; MOLECULAR PROBE TECHNIQUES; MYOCARDIUM;

EID: 79953155328     PISSN: 10713581     EISSN: None     Source Type: Journal    
DOI: 10.1007/s12350-010-9240-4     Document Type: Review

References (49)

1. Kaufmann B, Wei K, Lindner JR. Contrast echocardiography. Curr Probl Cardiol 2007;32:45-96.
2. Lindner JR. Molecular imaging of cardiovascular disease with contrast-enhanced ultrasonography. Nat Rev 2009;6:475-80.
3. Lindner JR, Coggins MP, Kaul S, Klibanov AL, Brandenburger GH, Ley K. Microbubble persistence in the microcirculation during ischemia-reperfusion and inflammation: Integrin and complement mediated adherence to activated leukocytes. Circulation 2000;101:668-75.
4. Lindner JR, Song J, Fang X, Klibanov AL, Singbartl K, Ley K, et al. Noninvasive ultrasound imaging of inflammation using microbubbles targeted to activated leukocytes. Circulation 2000;102:2745-50.
5. Jayaweera AR, Edwards N, Glasheen WP, Villanueva FS, Abbott RD, Kaul S. In vivo myocardial kinetics of air-filled albumin microbubbles during myocardial contrast echocardiography: Comparison with radiolabeled red blood cells. Circ Res 1994;74:1157-65.
6. Lindner JR, Song J, Jayaweera AR, Skelnar J, Kaul S. Microvascular rheology of definity microbubbles after intra-arterial and intravenous administration. J Am Soc Echocardiogr 2002;15:396-403.
7. Keller MW, Spotnitz WD, Matthew TL, Glasheen WP, Watson DD, Kaul S. Intraoperative assessment of regional myocardial perfusion using quantitative myocardial contrast echocardiography: An experimental evaluation. J Amer Coll Cardiol 1990;16:1267-79.
8. Villanueva FS, Spotnitz WD, Jayaweera AR, Gimple LW, Dent J, Kaul S. On-line intraoperative quantitation of regional myocardial perfusion during coronary artery bypass graft operations with myocardial contrast two-dimensional echocardiography. J Thorac Cardiovasc Surg 1992;104:1524-31.
9. Bayfield M, Lindner JR, Kaul S, Ismail S, Goodman NC, Spotnitz WD. Deoxygenated blood minimizes adherence of sonicated albumin microbubbles during cardioplegic arrest after blood reperfusion: Experimental and clinical observations with myocardial contrast echocardiography. J Thorac Cardiovasc Surg 1997;113:1100-8.
10. Lindner JR, Ismail S, Spotnitz WD, Skyba DM, Jayaweera AR, Kaul S. Albumin microbubble persistence during myocardial ischemia is associated with microvascular endothelial glycocalyx damage. Circulation 1998;98:2187-94.
11. Christiansen JP, Leong-Poi HL, Klibanov AL, Kaul S, Lindner JR. Noninvasive imaging of myocardial reperfusion injury using leukocyte-targeted contrast echocardiography. Circulation 2002;105:1764-7.
12. Bevilacqua MP, Nelson RM. Selectins. J Clin Invest 1993;91:379-87.
13. Chukwuemeka AO, Brown A, Venn GE, Chambers DJ. Changes in P-selectin expression on cardiac microvessels in blood-perfused rat hearts subjected to ischemia reperfusion. Ann Thorac Surg 2005;79:204-11.
14. Lindner JR, Song J, Christiansen MB, Klibanov AL, Fang X, Ley K. Ultrasound assessment of inflammation and renal tissue injury with microbubbles targeted to p-selectin. Circulation 2001;104:2107-12.
15. Villaneuva FS, Lu E, Bowry S, Kilic S, Tom E, Wang J, et al. Myocardial ischemic memory imaging with molecular echocardiography. Circulation 2007;115:345-52.
16. Kaufmann BA, Lewis C, Xie A, Mirza-Mohd A, Lindner JR. Detection of recent myocardial ischemia by molecular imaging of p-selectin with targeted contrast echocardiography. Eur Heart J 2007;28:2011-7.
17. Ramos CL, Hou Y, Jung U, Ghosh S, Manka DR, Sarembock IJ, et al. Direct demonstration of p-selectin and VCAM-1 dependent mononuclear cell rolling in early atherosclerotic lesions of apolipoprotein E deficient mice. Circ Res 1999;84:1237-44.
18. Iiyama K, Hajra L, Iiyama M, Li H, DiChiara M, Medoff BD, et al. Patterns of vascular cell adhesion molecule-1 and intercellular adhesion molecule-1 expression in rabbit and mouse atherosclerotic lesions and at sites predisposed to lesion formation. Circ Res 1999;85:199-207.
19. Demos SM, Alkan-Onyuksel H, Kane BJ, Ramania K, Nagaraj A, Greene R, et al. In vivo targeting of acoustically reflective liposomes for intravascular and transvascular ultrasonic enhancement. J Am Coll Cardiol 1999;33:867-75.
20. Kaufmann BA, Sanders JM, Davis C, Xie A, Aldred P, Sarembock IJ, et al. Molecular imaging of inflammation in atherosclerosis with targeted ultrasound detection of vascular cell adhesion molecule-1. Circulation 2007;116:276-84.
21. Powell-Braxton L, Veniant M, Latvala RD, Hirano KI, Won WB, Ross J, et al. A mouse model of human familial hypercholesterolemia: Markedly elevated low density lipoprotein levels and severe atherosclerosis on a low-fat chow diet. Nat Med 1998;4(8):934-8.
22. Kaufmann BA, Carr CL, Belcik JT, Xie A, Yue Q, Chadderdon S, et al. Molecular imaging of the initial inflammatory response in atherosclerosis: Implications for early detection of disease. Arterioscler Thromb Vasc Biol 2010;30:54-9.
23. 18F-FDG PET: carotid, iliac, and femoral uptake reproducibility, quantification methods, and recommendations. J Nucl Med 2008;49:871-8.
24. Ohtani H, Strauss W, Southern JF, Tamatani T, Miyasaka M, Sekiguchi M, et al. Intracellular adhesion molecule-1 induction: A sensitive and quantitative marker for cardiac allograft rejection. J Amer Coll Cardiol 1995;26:793-9.
25. Weller GE, Lu E, Csikari MM, Klibanov A, Fischer D, Wagner WR, et al. Ultrasound imaging of acute cardiac transplant rejection with microbubbles targeted to intracellular adhesion molecule-1. Circulation 2003;108:218-24.
26. Kondo I, Ohmori K, Oshita A, Takeuchi H, Yoshida J, Shinomiya K, et al. Leukocyte-targeted myocardial contrast echocardiography can assess the degree of acute allograft rejection in a rat cardiac transplantation model. Circulation 2004;109:1056-61.
27. 3 for angiogensis. Science 1994;264:569-71.
28. v integrins. Circulation 2003;107:455-60. (Pubitemid 36158049)
29. 3. Circulation 2003;108:336-41. (Pubitemid 36899026)
30. Leong-Poi H, Christiansen J, Heppner P, Lewis CW, Klibanov AL, Kaul S, et al. Assessment of endogenous and therapeutic arteriogenesis by contrast ultrasound molecular imaging of integrin expression. Circulation 2005;111:3248-54.
31. Behm CZ, Kaufmann BA, Carr C, Lankford M, Sanders JM, Rose E, et al. Molecular imaging of endothelial vascular cell adhesion molecule-1 expression and inflammatory cell recruitment during vasculogenesis and ischemia-mediated arteriogenesis. Circulation 2008;117:2902-11.
32. Duff SE, Li C, Garland JM, Kumar S. CD 105 is important for angiogenesis: Evidence and potential applications. FASEB J 2003;17:984-92.
33. Korpanty G, Crabon JG, Grayburn PA, Fleming JB, Brekken RA. Monitoring response to anticancer therapy by targeting microbubbles to tumor vasculature. Clin Cancer Res 2007;13:323-30.
34. Rychak JJ, Graba J, Cheung A, Mystry BS, Lindner JR, Kerbel RS, et al. Microultrasound molecular imaging of vascular endothelial growth factor receptor 2 in a mouse model of tumor angiogenesis. Mol Imag 2007;6:289-96.
35. Xuan JW, Bygrave M, Valiyeva F, Moussa M, Izawa JI, Bauman GS, et al. Molecular targeted enhanced ultrasound imaging of FLK1 reveals diagnosis and prognosis potential in a genetically engineered mouse prostate cancer model. Mol Imag 2009;8:209-20.
36. Lloyd-Jones D, Adams RJ, Brown TM, Carnethon M, Dai S, De Simone G, et al. Heart disease and stroke statistics-2010 update. Circulation 2010;121: e1-170.
37. Unger EC, McCreery TP, Sweitzer RH, Shen D, Wu G. In vitro studies of a new thrombus-specific ultrasound contrast agent. Am J Cardiol 1998;81:58G-61G.
38. Takeuchi M, Ogunyankin K, Pandian NG, McCreery TP, Sweitzer RH, Caldwell VE, et al. Enhanced visualization of intravascular and left atrial appendage thrombus with the use of a thrombustargeting ultrasounographic contrast agent (MRX-408A1): In vivo experimental ehcocardiographic studies. J Am Soc Echocardiogr 1999;12:1015-21.
39. Schumann PA, Christiansen JP, Quigkeley RM, McCreery TP, Sweitzer RH, Unger EC, et al. Targeted-microbubble binding selectivity to GPIIb/IIIa receptors of platelet thrombi. Invest Radiol 2002;37:587-93.
40. Alonso A, Martina AD, Stroik M, Fatar M, Griebe M, Poshon S, et al. Molecular imaging of human thrombus with novel abciximab immunobubbles and ultrasound. Stroke 2007;38:1508-14.
41. Porter TR. The utilization of ultrasound and microbubbles for therapy in acute coronary syndromes. Cardiovasc Res 2009;83:636-42.
42. Wang B, Wang L, Zhou XB, Lou YM, Wang M, Qin H, et al. Thrombolysis effect of a novel targeted microbubble with low frequency ultrasound in vivo. Thromb Haemost 2008;100:356-61.
43. Alonso A, Dempfle CE, Martina AD, Stroick M, Fatar M, Zohsel K, et al. In vivo lysis of human thrombus with intravenous abciximab immunobubbles and ultrasound. Thromb Res 2009;124:70-4.
44. Xie F, Lof J, Matsunaga T, Zutshi R, Porter TR. Diagnositic ultrasound combined with glycoprotein IIb/IIIa-targeted microbubbles improves microvascular recovery after acute coronary thrombotic occlusions. Circulation 2009;119:1378-85.
45. Kulisaewski MA, Fuji H, Liao C, Smith AH, Xie A, Lindner JR, et al. Molecular imaging of endothelial progenitor cell engraftment using contrast-enhanced ultrasound and targeted microbubbles. Cardiovasc Res 2009;83:653-62.
46. Sinusas AJ, Bengel F, Nahrendorf M, Epstein FH, Wu JC, Villanueva FS, et al. Multimodality cardiovascular molecular imaging, Part 1. Circ Cardiovasc Imag 2008;1:244-56.
47. Lanza GM, Winter PM, Shelton CD, Morawski AM, Schmieder AH, Crowder KC, et al. Magnetic resonance molecular imaging with nanoparticles. J Nucl Cardiol 2004;11:733-43.
48. Sosnovik DE, Nahrendorf M, Weissleder R. Molecular magnetic resonance imaging in cardiovascular medicine. Circulation 2007;115:2076-86. (Pubitemid 46625959)
49. Abdelmoneim SS, Bernier M, Dhoble A, Ness SA, Hagen ME, Moir S, et al. Safety of contrast agent use during stress echocardiography: A 4-year experience from a single-center cohort study of 26, 774 patients. JACC Cardiovasc Imag 2009;9:1048-56.