Insulin administration for treatment of pediatric diabetic ketoacidosis: Are lower rates of infusion beneficial?

Pediatric Critical Care Medicine

Volumn 12, Issue 2, 2011, Pages 217-219

  Marcin, James P ^a   Kuppermann, Nathan ^a   Tancredi, Daniel J ^a   Glaser, Nicole S ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

cerebral edema; diabetes; diabetic ketoacidosis; DKS

Indexed keywords

GLUCOSE; INSULIN;

BRAIN EDEMA; BRAIN HYPOPERFUSION; BRAIN PERFUSION; CLINICAL PROTOCOL; DEHYDRATION; DIABETIC KETOACIDOSIS; DISEASE SEVERITY; DRUG INFUSION; EDEMA; EDITORIAL; FLUID THERAPY; GLUCOSE BLOOD LEVEL; HUMAN; HYPERGLYCEMIA; HYPERVENTILATION; HYPOGLYCEMIA; INSULIN TREATMENT; KIDNEY FUNCTION; LABORATORY TEST; NEWBORN INTENSIVE CARE; OSMOLALITY; PATHOPHYSIOLOGY; PEDIATRICS; PRIORITY JOURNAL; REHYDRATION; REPERFUSION; RISK FACTOR; RISK REDUCTION; THERAPEUTIC HYPERVENTILATION; TREATMENT INDICATION; TREATMENT OUTCOME; UNSPECIFIED SIDE EFFECT; VASOGENIC EDEMA;

EID: 79953117022     PISSN: 15297535     EISSN: None     Source Type: Journal    
DOI: 10.1097/PCC.0b013e3181e8b1c0     Document Type: Editorial

References (25)

1. Al Hanshi S, Shann F: Insulin infused at 0.05 versus 0.1 units/kg/hr in children admitted to intensive care with diabetic ketoacidosis. Pediatr Crit Care Med 2011; 12:137-140
2. Yuen N, Anderson SE, Glaser N, et al: Cere-bral blood flow and cerebral edema in rats with diabetic ketoacidosis. Diabetes 2008; 57: 2588-2594
3. Glaser N: Cerebral injury and cerebral edema in children with diabetic ketoacidosis: Could cerebral ischemia and reperfusion injury be involved? Pediatr Diabetes 2009; 10:534-541
4. Glaser N, Yuen N, Anderson SE, et al: Cere-bral metabolic alterations in rats with dia-betic ketoacidosis: Effects of treatment with insulin and intravenous fluids and effects of bumetanide. Diabetes 2010; 59:702-709
5. Schade DS, Eaton RP: Dose response to in-sulin in man: differential effects on glucose and ketone body regulation. J Clin Endocri-nolMetab 1977; 44:1038-1053 (Pubitemid 8104292)
6. Lord FM: A paradox in the interpretation of group comparisons. Psychol Bull 1967; 68: 304-305
7. Elashoff JD: Analysis of covariance\Delicate instrument. Am Educ Res J 1969; 6:383-401
8. Miller GA, Chapman JP: Misunderstanding analysis of covariance. J Abnorm Psychol 2001; 110:40-48 (Pubitemid 32205156)
9. Greenland S, Pearl J, Robins JM: Causal dia-grams for epidemiologic research. Epidemiology 1999; 10:37-48
10. Isales C, Min L, Hoffman W: Acetoacetate and B-hydroxybutyrate differentially regulate en-dothelin-1 and vascular endothelial growth factor in mouse brain microvascular endo-thelial cells. J Diab Comp 1999; 13:91-97 (Pubitemid 29320015)
11. Kuppermann N, Park J, Glatter K, et al: Pro-longed QT interval corrected for heart rate during diabetic ketoacidosis in children. Arch Pediatr Adolesc Med 2008; 162:544-549 (Pubitemid 351786955)
12. Edge JA, Roy Y, Bergomi A, et al: Conscious level in children with diabetic ketoacidosis is related to severity of acidosis and not to blood glucose concentration. Pediatr Diabetes 2006; 7:11-15 (Pubitemid 43732636)
13. Glaser N, Barnett P, McCaslin I, et al: Risk factors for cerebral edema in children with diabetic ketoacidosis. The Pediatric Emer-gency Medicine Collaborative Research Com-mittee of the American Academy of Pediat-rics. N Engl J Med 2001; 344:264-269 (Pubitemid 32108531)
14. Marcin JP, Glaser N, Barnett P, et al: Factors associated with adverse outcomes in children with diabetic ketoacidosis-related cerebral edema. J Pediatr 2002; 141:793-797 (Pubitemid 35471640)
15. Grimberg A, Cerri R, Satin-Smith M, et al: The "two bag system" for variable intrave-nous dextrose and fluid administration: Ben-efits in diabetic ketoacidosis management. J Pediatr 1999; 134:376-378 (Pubitemid 30417654)
16. Duck S, Wyatt D: Factors associated with brain herniation in the treatment of diabetic ketoacidosis. J Pediatr 1988; 113:10-14
17. Harris G, Fiordalisi I, Finberg L: Safe man-agement of diabetic ketoacidemia. J Pediatr 1988; 113:65-67
18. Harris GD, Fiordalisi I: Physiologic manage-ment of diabetic ketoacidemia. A 5-year pro-spective pediatric experience in 231 episodes. Arch Pediatr Adolesc Med 1994; 148: 1046-1052 (Pubitemid 24314573)
19. Edge JA, Jakes RW, Roy Y, et al: The UK case-control study of cerebral oedema com-plicating diabetic ketoacidosis in children. Diabetologia 2006; 49:2002-2009 (Pubitemid 44168465)
20. Lam T, Anderson S, Glaser N, et al: Bumet-anide reduces cerebral edema formation in rats with diabetic ketoacidosis. FASEB J 2003; 17-76
21. Hulley S, Grady D, Bush T, et al: Randomized trial of estrogen plus progestin for secondary prevention of coronary heart disease in post-menopausal women. Heart and Estrogen/progestin Replacement Study (HERS) Re-search Group. JAMA 1998; 280:605-613 (Pubitemid 28502636)
22. Moseley JB, O'Malley K, Petersen NJ, et al: A controlled trial of arthroscopic surgery for osteoarthritis of the knee. N Engl J Med 2002; 347:81-88 (Pubitemid 34753477)
23. Fairman KA, Curtiss FR: Still looking for health outcomes in all the wrong places? Misinterpreted observational evidence, med-ication adherence promotion, and value-based insurance design. J Manag Care Pharm 2009; 15:501-507
24. Clarke R, Armitage J: Antioxidant vitamins and risk of cardiovascular disease. Review of large-scale randomised trials. Cardiovasc Drugs Ther 2002; 16:411-415 (Pubitemid 36255741)
25. Omenn GS, Goodman GE, ThornquistMD, et al: Effects of a combination of beta carotene and vitamin A on lung cancer and cardiovas-cular disease. N Engl J Med 1996; 334: 1150-1155 (Pubitemid 26137973)