Generation of novel cationic antimicrobial peptides from natural non-antimicrobial sequences by acid-amide substitution

Annals of Clinical Microbiology and Antimicrobials

Volumn 10, Issue , 2011, Pages

  Ueno, Satoshi ^a   Minaba, Masaomi ^a   Nishiuchi, Yuji ^b   Taichi, Misako ^b   Tamada, Yasushi ^a   Yamazaki, Toshimasa ^a   Kato, Yusuke ^a  

^a NATIONAL INSTITUTE OF AGROBIOLOGICAL SCIENCES   (Japan)

^b Peptide Institute Inc   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

AMPHOTERICIN B; ANTIINFECTIVE AGENT; ASPARTIC ACID; CATIONIC ANTIMICROBIAL PEPTIDE; CECROPIN; GLUTAMINE; GLYCINE; LIPOSOME; MUTANT PROTEIN; NP1P PROTEIN; NP2P PROTEIN; NP3P PROTEIN; NP4P PROTEIN; UNCLASSIFIED DRUG; ANTIMICROBIAL CATIONIC PEPTIDE; CECROPIN P1 LI; CECROPIN P1-LI; PEPTIDE;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ARTICLE; BACILLUS SUBTILIS; BACTERICIDAL ACTIVITY; CIRCULAR DICHROISM; CONCENTRATION RESPONSE; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; CYTOPLASM; DRUG STRUCTURE; ESCHERICHIA COLI; HEMOLYSIS; HUMAN; HUMAN CELL; MEMBRANE DAMAGE; MEMBRANE PERMEABILITY; MICROCOCCUS LUTEUS; NONHUMAN; PROTEIN STRUCTURE; PROTEIN SYNTHESIS; PSEUDOMONAS AERUGINOSA; SACCHAROMYCES CEREVISIAE; SALMONELLA TYPHIMURIUM; SEQUENCE ALIGNMENT; SERRATIA MARCESCENS; STAPHYLOCOCCUS AUREUS; STRUCTURE ACTIVITY RELATION; ULTRAVIOLET RADIATION; BACTERIUM; CHEMISTRY; DRUG EFFECT; GENETICS; MICROBIOLOGICAL EXAMINATION; MOLECULAR GENETICS; SYNTHESIS;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ANTI-BACTERIAL AGENTS; ANTIMICROBIAL CATIONIC PEPTIDES; BACTERIA; MICROBIAL SENSITIVITY TESTS; MOLECULAR SEQUENCE DATA; PEPTIDES; SEQUENCE ALIGNMENT; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 79953089761     PISSN: None     EISSN: 14760711     Source Type: Journal    
DOI: 10.1186/1476-0711-10-11     Document Type: Article

References (21)

1. Brogden KA. Antimicrobial peptides: pore formers or metabolic inhibitors in bacteria?. Nat Rev Microbiol 2005, 3:238-350. 10.1038/nrmicro1098, 15703760.
2. Zelezetsky I, Tossi A. Alpha-helical antimicrobial peptides--Using a sequence template to guide structure-activity relationship studies. Biochim Biophys Acta 2006, 1758:1436-1449. 10.1016/j.bbamem.2006.03.021, 16678118.
3. Blondelle SE, Takahashi E, Dinh KT, Houghten RA. The antimicrobial activity of hexapeptides derived from synthetic combinatorial libraries. J Appl Bacteriol 1995, 78:39-46.
4. Hilpert K, Volkmer-Engert R, Walter T, Hancock RE. High-throughput generation of small antibacterial peptides with improved activity. Nat Biotechnol 2005, 23:1008-1012. 10.1038/nbt1113, 16041366.
5. Rausch JM, Marks JR, Rathinakumar R, Wimley WC. Rational combinatorial design of pore-forming beta-sheet peptides. Proc Natl Acad Sci USA 2005, 102:10511-10515. 10.1073/pnas.0502013102, 1180767, 16020534.
6. Xie Q, Matsunaga S, Wen Z, Kumano M, Sakakibara Y, Machida S. In vitro system for high-throughput screening of random peptide libraries for antimicrobial peptides that recognize bacterial membranes. J Pept Sci 2006, 12:643-652. 10.1002/psc.774, 16878349.
7. Loit E, Wu K, Cheng X, Hincke MT, Altosaar I. Functional whole-colony screening method to identify antimicrobial peptides. J Microbial Methods 2008, 75:425-431.
8. Fjell CD, Jenssen H, Hilpert K, Cheung WA, Panté N, Hancock RE, Cherkasov A. Identification of novel antibacterial peptides by chemoinformatics and machine learning. J Med Chem 2009, 52:2006-2015. 10.1021/jm8015365, 19296598.
9. Jian H, Yarbrough DK, Kreth J, Anderson MH, Shi W, Eckert R. Systematic approach to optimizing specificifically targeted antimicrobial peptides against Streptococcus mutans. Antimicrob Agents Chemother 2010, 54:2143-2151. 10.1128/AAC.01391-09, 2863653, 20211885.
10. Blondelle SE, Takahashi E, Weber PA, Houghten RA. Identification of antimicrobial peptides by using combinatorial libraries made up of unnatural amino acids. Antimicrob Agents Chemother 1994, 38:2280-2286. 284731, 7840558.
11. Radzishevsky I, Krugliak M, Ginsburg H, Mor A. Antiplasmodial activity of lauryl-lysine oligomers. Antimicrob Agents Chemother 2007, 51:1753-1759. 10.1128/AAC.01288-06, 1855553, 17307975.
12. Chongsiriwatana NP, Patch JA, Czyzewski AM, Dohm MT, Ivankin A, Gidalevitz D, Zuckermann RN, Barron AE. Peptoids that mimic the structure, function, and mechanism of helical antimicrobial peptides. Proc Natl Acad Sci USA 2008, 105:2794-2799. 10.1073/pnas.0708254105, 2268539, 18287037.
13. Lee JY, Boman A, Sun CX, Andersson M, Jornvall H, Mutt V, Boman HG. Antibacterial peptides from pig intestine: isolation of a mammalian cecropin. Proc Natl Acad Sci USA 1989, 86:9159-9162. 10.1073/pnas.86.23.9159, 298453, 2512577.
14. Andersson MA, Boman A, Boman HG. Ascaris nematodes from pig and human make three antibacterial peptides: isolation of cecropin P1 and two ASABF peptides. Cell Mol Life Sci 2003, 60:599-606. 10.1007/s000180300051, 12737319.
15. Pillai A, Ueno S, Zhang H, Lee JM, Kato Y. Cecropin P1 and novel nematode cecropins: a bacteria-inducible antimicrobial peptide family in the nematode Ascaris suum. Biochem J 2005, 390:207-214. 10.1042/BJ20050218, 1184576, 15850460.
16. Ueno S, Kusaka K, Tamada Y, Minaba M, Zhang H, Wang PC, Kato Y. Anionic C-terminal proregion of nematode antimicrobial peptide cecropin P4 precursor inhibits antimicrobial activity of the mature peptide. Biosci Biotechnol Biochem 2008, 72:3281-3284. 10.1271/bbb.80397, 19060389.
17. Zhang H, Morikawa K, Ohta T, Kato Y. In vitro resistance to the CSαβ-type antimicrobial peptide ASABF-α is conferred by overexpression of sigma factor sigB in Staphylococcus aureus. J Antimicrob Chemother 2005, 55:686-691. 10.1093/jac/dki070, 15761069.
18. Zhang H, Yoshida S, Aizawa T, Murakami R, Suzuki M, Koganezawa N, Matsuura A, Miyazawa M, Kawano K, Nitta K, Kato Y. In vitro antimicrobial properties of recombinant ASABF, an antimicrobial peptide isolated from the nematode Ascaris suum. Antimicrob Agents Chemother 2000, 44:2701-2705. 10.1128/AAC.44.10.2701-2705.2000, 90138, 10991847.
19. Ueno S, Kusaka K, Tamada Y, Zhang H, Minaba M, Kato Y. An enhancer peptide for membrane-disrupting antimicrobial peptides. BMC Microbiol 2010, 10:46. 10.1186/1471-2180-10-46, 2834666, 20152058.
20. Chou HT, Wen HW, Kuo TY, Lin CC, Chen WJ. Interaction of cationic antimicrobial peptides with phospholipid vesicles and their antibacterial activity. Peptides 2010, 31:1811-1820. 10.1016/j.peptides.2010.06.021, 20600422.
21. Jones DT, Taylor WR, Thornton JM. The rapid generation of mutation data matrices from protein sequences. Comput Appl Biosci 1992, 8:275-282.