Vitamin D status and supplementation in pediatric gastrointestinal disease

Journal for Specialists in Pediatric Nursing

Volumn 16, Issue 2, 2011, Pages 140-150

  O'malley, Tarah ^a   Heuberger, Roschelle ^b  

^a CHILDREN S HOSPITAL   (United States)

^b CENTRAL MICHIGAN UNIVERSITY   (United States)

Author keywords

Celiac disease; Cholecalciferol; Ergocalciferol; Inflammatory bowel disease; Liver disease; Pediatric; Review; Status; Supplementation; Vitamin d

Indexed keywords

VITAMIN D;

ADOLESCENT; CELIAC DISEASE; CHILD; COMORBIDITY; DIET SUPPLEMENTATION; ENTERITIS; GASTROINTESTINAL DISEASE; HEALTH CARE POLICY; HUMAN; INFANT; LIVER DISEASE; PRESCHOOL CHILD; PREVALENCE; REVIEW; UNITED STATES; VITAMIN D DEFICIENCY;

ADOLESCENT; CELIAC DISEASE; CHILD; CHILD, PRESCHOOL; COMORBIDITY; DIETARY SUPPLEMENTS; GASTROINTESTINAL DISEASES; HUMANS; INFANT; INFLAMMATORY BOWEL DISEASES; LIVER DISEASES; NUTRITION POLICY; PREVALENCE; UNITED STATES; VITAMIN D; VITAMIN D DEFICIENCY;

EID: 79953060769     PISSN: 15390136     EISSN: 17446155     Source Type: Journal    
DOI: 10.1111/j.1744-6155.2011.00280.x     Document Type: Review

References (40)

1. Abreu, M. T., Kantorovich, V., Vasilauskas, E.A., Gruntmanis, U., Matuk, R., Daigle, K., ...Adams, J. S. (2004). Measurement of vitamin D levels in inflammatory bowel disease patients reveals a subset of Crohn's disease patients with elevated 1, 25-dihydroxyvitamin D and low bone mineral density. Gut, 53, 1129-1136. doi:10.1136/gut.2003.036657
2. de Albuquerque Taveira, A. T., Fernandes, M. I. M., Galvae, L. C., Sawamura, R., de Mello Vieira, E., & Albuquerque de Paula, F. J. (2007). Impairment of bone mass development in children with chronic cholestatic liver disease. Clinical Endocrinology, 66, 518-523. doi:10.1016/j.bone.2010.06.008
3. Aloia, J., Patel, M., DiMaano, R., Li-Ng, M., Talwar, S., Mikhail, M., ...Yeh, J.K. (2008). Vitamin D intake to attain a desired serum 25-hydroxyvitamin D concentration. American Journal of Clinical Nutrition, 87, 1952-1958.
4. Argao, E., Balistreri, W., Hollis, B., Ryckman, F., & Heubi, J. (1994). Effect of orthotopic liver transplantation on bone mineral content and serum vitamin D metabolites in infants and children with chronic cholestasis. Hepatology, 20(3), 598-603.
5. Arteh, J., Narra, S., & Nair, S. (2009). Prevalence of vitamin D deficiency in chronic liver disease. Digestive Diseases and Sciences, 55(9), 2624-2628. doi:10.1007/s10620-009-1069-9
6. Benchimol, E., Ward, L., Gallagher, J. C., Rauch, F., Barrowman, N., Warren, J., ...Mack, D.R. (2007). Effect of calcium and vitamin D supplementation on bone mineral density in children with inflammatory bowel disease. Journal of Pediatric Gastroenterology and Nutrition, 45(5), 538-545. doi:10.1097/MPG.0b013e3180dca0cc
7. Bikle, D. (2007). Vitamin D insufficiency/deficiency in gastrointestinal disorders. Journal of Bone and Mineral Research, 22(2), V50-V54. doi:10.1359/jbmr.07s208
8. Bischoff-Ferrari, H. A., Shao, A., Dawson-Hughes, B., Hathcock, J., Giovannucci, E., & Willett, W. C. (2010). Benefit-risk assessment of vitamin D supplementation. Osteoporosis International, 21(7), 1121-1132. doi:10.1007/s00198-009-1119-3
9. Blazina, S., Bratanic, N., Campa, A. S., Balus, R., & Orel, R. (2010). Bone mineral density and importance of strict gluten-free diet in children and adolescents with celiac disease. Bone, 47(3), 598-603. doi:10.1016/j.bone.2010.06.008
10. El-Matary, W., Sikora, S., & Spady, D. (2010). Bone mineral density, vitamin D, and disease activity in children newly diagnosed with inflammatory bowel disease. Digestive Diseases and Sciences. Epub ahead of print. Retrieved from
11. Fisher, L., Byrnes, E., & Fisher, A. A. (2009). Prevalence of vitamin K and vitamin D deficiency in patients with hepatobiliary and pancreatic disorders. Nutrition Research, 29(9), 676-683. doi:10.1016/j.nutres.2009.09.001
12. Fuleihan, G. E., Nabulsi, M., Tamim, H., Maalouf, J., Salamoun, M., Khalife, H., ...Vieth, R. (2006). Effect of vitamin D replacement on musculoskeletal parameters in school children: A randomized controlled trial. Journal of Clinical Endocrinology and Metabolism, 91(2), 405-412. doi:10.1210/jc.2005-1436
13. Greer, F. (2004). Issues in establishing vitamin D recommendations for infants and children. American Journal of Clinical Nutrition, 80(Suppl.), 1759S-1762S.
14. Hochberg, Z., Bereket, A., Davenport, M., Delemarre-Van de Waal, H., De Schepper, J., Levine, M., ...Zadik, Y. (2003). Consensus development for the supplementation of vitamin D in childhood and adolescence. Endocrine Involvement in Developmental Syndromes, 6, 259-281.
15. Holick, M. (2006). High prevalence of vitamin D inadequacy and implications for health. Mayo Clinic Proceedings, 81(3), 353-373.
16. Holick, M. (2007). Vitamin D deficiency. New England Journal of Medicine, 357(3), 266-281. doi:10.1056/NEJMra070553
17. Holick, M., Biancuzzo, R., Chen, T., Klein, E., Young, A., Bibuld, D., ...Tannenbaum, A. (2008). Vitamin D2 is as effective as vitamin D3 in maintaining circulating concentrations of 25-hydroxyvitamin D. Journal of Clinical Endocrinology and Metabolism, 93(3), 677-681.
18. Jahnsen, J., Falch, J. A., Mowinckel, P., & Aadland, E. (2002). Vitamin D status, parathyroid hormone and bone mineral density in patients with inflammatory bowel disease. Scandinavian Journal of Gastroenterology, 37(2), 192-199.
19. Javorsky, B. R., Maybee, N., Padia, S., & Dalkin, A. (2006). Vitamin D deficiency in gastrointestinal disease. Practical Gastroenterology, 36, 52-72.
20. Kumar, J., Muntner, P., Kaskel, F., Hailpern, S., & Melamed, M. (2009). Prevalence and associations of 25-hydroxyvitamin D deficiency in U.S. children: NHANES 2001 2004. Pediatrics, 124(3), e362-e370. doi:10.1542/peds.2009-0051
21. Kuwabara, A., Tanaka, K., Tsugawa, N., Nakase, H., Tsuji, H., Shide, K., ...Kido, S. (2009). High prevalence of vitamin K and D deficiency and decreased BMD in inflammatory bowel disease. Osteoporosis International, 20(6), 935-942. doi:10.1007/s00198-008-0764-2
22. Lehtonen-Veromaa, M., Mottonen, T., Nuotio, I., Irjala, K., & Viikari, J. (2002). The effect of conventional vitamin D supplementation on serum 25(OH)D concentration is weak among peripubertal Finnish girls: A 3-y prospective study. European Journal of Clinical Nutrition, 56, 431-437. doi:10.1038/sj.ejcn.1601330
23. Leslie, W., Miller, N., Rogala, L., & Bernstein, C. (2008). Vitamin D status and bone density in recently diagnosed inflammatory bowel disease: The Manitoba IBD cohort study. American Journal of Gastroenterology, 103, 1451-1459. doi:10.1111/j.1572-0241.2007.01753.x
24. Maalouf, J., Nabulsi, M., Vieth, R., Kimball, S., El-Rassi, R., Mahfoud, Z., & Fuleihan, G. (2008). Short- and long-term safety of weekly high-dose vitamin D3 supplementation in school children. Journal of Clinical Endocrinology and Metabolism, 93(7), 2693-2701. doi:10.1210/jc.2007-2530
25. Madar, A. A., Klepp, K., & Meyer, H. (2009). Effect of free vitamin D2 drops on serum 25-hydroxyvitamin D in infants with immigrant origin: A cluster randomized controlled trial. European Journal of Clinical Nutrition, 63, 478-484. doi:10.1038/sj.ejcn.1602982
26. Mascarenhas, M., & Thayu, M. (2010). Pediatric inflammatory bowel disease and bone health. Nutrition in Clinical Practice, 25(4), 347-352. doi:10.1177/0884533610374962
27. Misra, M., Pacaud, D., Petryk, A., Collett-Solberg, P. F., & Kappy, M. (2008). Vitamin D deficiency in children and its management: Review of current knowledge and recommendations. Pediatrics, 122(2), 398-417. doi:10.1542/peds.2007-1894
28. Munns, C., Zacharin, M., Rodda, C., Batch, J., Morley, R., Cranswich, N., ...Cowell, C. (2006). Prevention and treatment of infant and childhood vitamin D deficiency in Australia and New Zealand: A consensus statement. Medical Journal of Australia, 185(5), 268-272.
29. Onal, H., Adal, E., Alpaslan, S., Ersen, A., & Aydin, A. (2010). Is daily 400IU of vitamin D supplementation appropriate for every country: A cross-sectional study. European Journal of Nutrition, 45(7), 395-400.
30. Pappa, H., Bern, E., Kamin, D., & Grand, R. (2008). Vitamin D status in gastrointestinal and liver disease. Current Opinion in Gastroenterology, 24(2), 176-183. doi:10.1097/MOG.0b013e3282f4d2f3
31. Pappa, H., Gordon, C., Saslowsky, T., Zholudev, A., Horr, B., Shih, M. C., & Grand, R. J. (2006). Vitamin D status in children and young adults with inflammatory bowel disease. Pediatrics, 118(5), 1950-1961. doi:10.1542/peds.2006-0841
32. Saron, M., Godoy, H., & Hessel, G. (2009). Nutritional status of patients with biliary atresia and autoimmune hepatitis related to serum levels of vitamin A, D and E. Arquivos de Gastroenterologia, 46(1), 62-68.
33. Sathe, M., & Patel, A. (2010). Update in pediatrics: Focus on fat-soluble vitamins. Nutrition in Clinical Practice, 25(4), 340-346. doi:10.1177/0884533610374198
34. Sentongo, T., Semaeo, E., Stettler, N., Piccoli, D., Stallings, V., & Zemel, B. (2002). Vitamin D status in children, adolescents, and young adults with Crohn disease. American Journal of Clinical Nutrition, 76, 1077-1081.
35. Sokol, R., & Durie, P. (1999). Recommendations for management of liver and biliary tract disease in cystic fibrosis. Journal of Pediatric Gastroenterology and Nutrition, 28, S1-S13.
36. Soliman, A., El-Dabbagh, M., Adel, A., Ali, M., Aziz Bedair, E., & ElAlaily, R. (2010). Clinical responses to a mega-dose of vitamin D3 in infants and toddlers with vitamin D deficiency rickets. Journal of Tropical Pediatrics, 56(1), 19-26. doi:10.1093/tropej/fmp040
37. Tau, C., Ciriani, V., Scaiola, E., & Acuna, M. (2007). Twice single doses of 100, 000IU of vitamin D in winter is adequate and safe for prevention of vitamin D deficiency in healthy children from Ushuaia, Tierra Del Fuego, Argentina. Journal of Steroid Biochemistry and Molecular Biology, 103, 651-654. doi:10.1016/j.jsbmb.2006.12.027
38. Turner, J., Pellerin, G., & Mager, D. (2009). Prevalence of metabolic bone disease in children with celiac disease is independent of symptoms at diagnosis. Journal of Pediatric Gastroenterology and Nutrition, 49(5), 589-593. doi:10.1097/MPG.0b013e31819ca18e
39. Viljakainen, H., Natri, A. M., Karkkainen, M., Huttunen, M., Palssa, A., Jakobsen, J., ...Lamberg-Allardt, C. (2006). A positive dose-response effect of vitamin D supplementation on site-specific bone mineral augmentation in adolescent girls: A double-blinded randomized placebo-controlled 1-year intervention. Journal of Bone and Mineral Research, 21(6), 836-844. doi:10.1359/jbmr.060302
40. Wagner, C., Greer, F., & The Section on Breastfeeding and Committee on Nutrition. (2008). Prevention of rickets and vitamin D deficiency in infants, children, and adolescents. Pediatrics, 122(5), 1142-1152. doi:10.1542/peds.2008-1862