Uremic Toxin Indoxyl Sulfate Inhibits Human Vascular Smooth Muscle Cell Proliferation

Therapeutic Apheresis and Dialysis

Volumn 15, Issue 2, 2011, Pages 135-139

  Mozar, Anaïs ^a,b   Louvet, Loïc ^a,b   Morlière, Patrice ^a,c   Godin, Corinne ^a,b   Boudot, Cédric ^a,b   Kamel, Saïd ^a,b,c   Drüeke, Tilman B ^a,b   Massy, Ziad A ^a,b,d  

^a NATIONAL INSTITUTES OF HEALTH   (United States)

^b UNIVERSITÉ DE PICARDIE JULES VERNE   (France)

^c Biochemistry Laboratory   (France)

^d AMIENS UNIVERSITY HOSPITAL   (France)

Author keywords

Atherosclerosis; Chronic kidney disease; Human vascular aortic smooth muscle cells; Indoxyl sulfate; Oxidative stress; Proliferation

Indexed keywords

INDICAN; PROTEIN P21; PROTEIN P27; REACTIVE OXYGEN METABOLITE;

ARTICLE; CELL PROLIFERATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOTOXICITY; GROWTH INHIBITION; HUMAN; HUMAN CELL; LONG TERM EXPOSURE; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN EXPRESSION; SMOOTH MUSCLE FIBER; UPREGULATION; VASCULAR SMOOTH MUSCLE;

AORTA; CELL PROLIFERATION; CELLS, CULTURED; CYCLIN-DEPENDENT KINASE INHIBITOR P21; CYCLIN-DEPENDENT KINASE INHIBITOR P27; DOSE-RESPONSE RELATIONSHIP, DRUG; EPIDERMAL GROWTH FACTOR; HUMANS; INDICAN; MUSCLE, SMOOTH, VASCULAR; REACTIVE OXYGEN SPECIES; TIME FACTORS; UP-REGULATION;

EID: 79953053814     PISSN: 17449979     EISSN: 17449987     Source Type: Journal    
DOI: 10.1111/j.1744-9987.2010.00885.x     Document Type: Article

References (19)

1. Niwa T, Takeda N, Tatematsu A etal. Accumulation of indoxyl sulfate, an inhibitor of drug-binding, in uremic serum as demonstrated by internal-surface reversed-phase liquid chromatography. Clin Chem 1988;34:2264-7.
2. Motojima M, Hosokawa A, Yamato H etal. Uremic toxins of organic anions up-regulate PAI-1 expression by induction of NF-κB and free radical in proximal tubular cells. Kidney Int 2003;63:1671-80.
3. Enomoto A, Takeda M, Tojo A etal. Role of Organic Anion Transporters in the Tubular Transport of Indoxyl Sulfate and the Induction of its Nephrotoxicity. J Am Soc Nephrol 2002;13:1711-20.
4. Gelasco AK, Raymond JR. Indoxyl sulfate induces complex redox alterations in mesangial cells. Am J Physiol Renal Physiol 2006;290:F1551-8.
5. Adijiang A, Goto S, Uramoto S, Nishijima F, Niwa T. Indoxyl sulphate promotes aortic calcification with expression of osteoblast-specific proteins in hypertensive rats. Nephrol Dial Transplant 2008;6:1892-901.
6. Shimoishi K, Anraku M, Kitamura K etal. An oral adsorbent, AST-120 protects against the progression of oxidative stress by reducing the accumulation of indoxyl sulfate in the systemic circulation in renal failure. Pharm Res 2007;24:1283-9.
7. Dou L, Jourde-Chiche N, Faure V etal. The uremic solute indoxyl sulfate induces oxidative stress in endothelial cells. J Thromb Haemost 2007;5:1302-8.
8. Dou L, Bertrand E, Cerini C etal. The uremic solutes p-cresol and indoxyl sulfate inhibit endothelial proliferation and wound repair. Kidney Int 2004;65:442-51.
9. Yamamoto H, Tsuruoka S, Ioka T etal. Indoxyl sulfate stimulates proliferation of rat vascular smooth muscle cells. Kidney Int 2006;69:1780-5.
10. Muteliefu G, Enomoto A, Niwa T. Indoxyl sulfate promotes proliferation of human aortic smooth muscle cells by inducing oxidative stress. J Ren Nutr 2009;19:29-32.
11. Vanholder R, De Smet R, Glorieux G etal. Review on uremic toxins: classification, concentration, and interindividual variability. Kidney Int 2003;63:1934-43.
12. Ross R. The smooth muscle cell. II. Growth of smooth muscle in culture and formation of elastic fibers. J Cell Biol 1971;50:172-86.
13. Skalli O, Pelte MF, Peclet MC etal. Alpha-smooth muscle actin, a differentiation marker of smooth muscle cells, is present in microfilamentous bundles of pericytes. J Histochem Cytochem 1989;37:315-21.
14. Gorenne I, Kavurma M, Scott S, Bennett M. Vascular smooth muscle cell senescence in atherosclerosis. Cardiovasc Res 2006;72:9-17.
15. Price KL, Sautin YY, Long DA etal. Human Vascular Smooth Muscle Cells Express a Urate Transporter. J Am Soc Nephrol 2006;17:1791-5.
16. Nii-Kono T, Iwasaki Y, Uchida M etal. Indoxyl sulfate induces skeletal resistance to parathyroid hormone in cultured osteoblastic cells. Kidney Int 2007;71:738-43.
17. Griendling KK, Ushio-Fukai M. Redox control of vascular smooth muscle proliferation. J Lab Clin Med 1998;132:9-15.
18. Miyamoto Y, Iwao Y, Tasaki Y etal. The uremic solute indoxyl sulfate acts as an antioxidant against superoxide anion radicals under normal-physiological conditions. FEBS Lett 2010;584:2816-20.
19. Shao JS, Cheng SL, Sadhu J, Towler DA. Inflammation and the osteogenic regulation of vascular calcification: a review and perspective. Hypertension 2010;55:579-92.