Epidemiology of Clostridium difficile and vancomycin-resistant Enterococcus colonization in patients on a spinal cord injury unit

Journal of Spinal Cord Medicine

Volumn 34, Issue 1, 2011, Pages 22-27

  Dumford III, Donald M ^a,b   Nerandzic, Michelle ^a   Chang, Shelley ^a   Richmond, Mary Ann ^b   Donskey, Curtis ^a  

^a LOUIS STOKES CLEVELAND VA MEDICAL CENTER   (United States)

^b VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

Clostridium difficile; Colonization; Enterococcus; Environment; Spinal cord injuries; Urinary tract infection; Vancomycin resistant

Indexed keywords

ADULT; AGED; ARTICLE; BACTERIAL COLONIZATION; BACTERIUM CARRIER; BACTERIUM CULTURE; CLINICAL ARTICLE; CLOSTRIDIUM DIFFICILE; CLOSTRIDIUM DIFFICILE INFECTION; CROSS-SECTIONAL STUDY; ENTEROCOCCAL INFECTION; FECES ANALYSIS; FISHER EXACT TEST; HOSPITAL SUBDIVISIONS AND COMPONENTS; HUMAN; HUMAN TISSUE; LENGTH OF STAY; MALE; POLLUTION; POLYMERASE CHAIN REACTION; RIBOTYPING; SPINAL CORD INJURY; UNIVARIATE ANALYSIS; VANCOMYCIN RESISTANT ENTEROCOCCUS; ANTIBIOTIC RESISTANCE; DRUG EFFECTS; ENTEROCOCCUS; ENTEROCOLITIS, PSEUDOMEMBRANOUS; HETEROZYGOTE; MIDDLE AGED; PEPTOCLOSTRIDIUM DIFFICILE; RISK FACTOR; SPINAL CORD INJURIES; URINARY TRACT INFECTIONS;

ADULT; AGED; ANTI-BACTERIAL AGENTS; CARRIER STATE; CLOSTRIDIUM DIFFICILE; ENTEROCOCCUS; ENTEROCOLITIS, PSEUDOMEMBRANOUS; HUMANS; MIDDLE AGED; RISK FACTORS; SPINAL CORD INJURIES; URINARY TRACT INFECTIONS; VANCOMYCIN; VANCOMYCIN RESISTANCE;

ANTIINFECTIVE AGENT; VANCOMYCIN;

EID: 79953048893     PISSN: 10790268     EISSN: None     Source Type: Journal    
DOI: 10.1179/107902610x12883422813822     Document Type: Article

References (21)

1. Poutanen SM, Simor AE. Clostridium difficile-associated diarrhea in adults. CMAJ 2004;171(1):51-8.
2. McDonald LC, Killgore GE, Thompson A, Owens RC, Kazakova SV, Sambol SP, et al. An epidemic, toxin gene-variant strain of Clostridium difficile. N Engl J Med 2005;353(23):2433-41. (Pubitemid 41770164)
3. Loo VG, Poirier L, Miller MA, Oughton M, Libman MD, Michaud S, et al. A predominantly clonal multi-institutional outbreak of Clostridium difficile-associated diarrhea with high morbidity and mortality. N Engl J Med 2005;353(23):2442-9. (Pubitemid 41770165)
4. Muto CA, Blank MK, Marsh JW, Vergis EN, O'Leary MM, Shutt KA, et al. Control of an outbreak of infections with the hypervirulent Clostridium difficile BI strain in a University Hospital using a comprehensive bundle approach. Clin Infect Dis 2007;45(10):1266-73. (Pubitemid 351411898)
5. Valiquette L, Cossette B, Garant MP, Diab H, Pepin J. Impact of a reduction in high-risk antibiotics on the course of an epidemic of Clostridium difficile-associated disease caused by the hypervirulent NAP1/027 strain. Clin Infect Dis 2007;45(Suppl 2):S112-21.
6. Gerding DN, Johnson S, Peterson LR, Mulligan ME, Silva J. Clostridium difficile-associated diarrhea and colitis. Infect Control Hosp Epidemiol 1995;16(8):459-77.
7. Dubberke ER, Gerding DN, Classen D, Arias KM, Podgorny K, Anderson DJ, et al. Strategies to prevent Clostridium difficile infections in acute care hospitals. Infect Control Hosp Epidemiol 2008;29(Suppl 1):S81-92.
8. Al-Nassir WN, Sethi AK, Nerandzic MM, Bobulsky G, Jump RL, Donskey CJ. Comparison of clinical and microbiological response to treatment of Clostridium difficile-associated disease with metronidazole and vancomycin. Clin Infect Dis 2008;47(1):56-62.
9. Riggs MM, Sethi AK, Zabarsky TF, Eckstein EC, Jump RL, Donskey CJ. Asymptomatic carriers are a potential source for transmission of epidemic and nonepidemic Clostridium difficile strains among long-term care facility residents. Clin Infect Dis 2007;45(8):992-8.
10. Donskey CJ. The role of the intestinal tract as a reservoir and source for transmission of nosocomial pathogens. Clin Infect Dis 2004;39(2):219-26. (Pubitemid 38971493)
11. McFarland LV, Coyle MB, Kremer WH, Stamm WE. Rectal swab cultures for Clostridium difficile surveillance studies. J Clin Microbiol 1987;25(11):2241-2.
12. Bidet P, Lalande V, Salauze B. Comparison of PCR-ribotyping, arbitrarily primed PCR, and pulsed-field gel electrophoresis for typing Clostridium difficile. J Clin Microbiol 2000;38(7):2484-7. (Pubitemid 30487377)
13. Terhes G, Urban E, Soki J, Hamid KA, Nagy E. Community-acquired Clostridium difficile diarrhea caused by binary toxin, toxin A, and toxin B gene-positive isolates in Hungary. J Clin Microbiol 2004;42(9):4316-8.
14. Spigaglia P, Mastrantonio P. Molecular analysis of the pathogenicity locus and polymorphism in the putative negative regulator of toxin production (TcdC) among Clostridium difficile isolates. J Clin Microbiol 2002;40(9):3470-5. (Pubitemid 34977470)
15. National Committee for Clinical Laboratory Standards. Methods for dilution antimicrobial susceptibility tests for bacteria that grow aerobically. Approved standard M7. Wayne, PA: National Committee for Clinical Laboratory Standards; 2005.
16. Johnson DK, Balmaseda MT. Pseudomembranous colitis in spinal cord injury. Arch Phys Med Rehabil 1985;66(6):394-6. (Pubitemid 15227267)
17. Bahadursingh AN, Vagefi PA, Longo WE. Fulminant Clostridium difficile colitis in a patient with spinal cord injury: a case report. J Spinal Cord Med 2004;27(3):266-8.
18. Marciniak C, Chen D, Stein AC, Semik PE. Prevalence of Clostridium difficile colonization at admission to rehabilitation. Arch Phys Med Rehabil 2006;87(12):1086-90.
19. Eckstein BD, Adams DA, Eckstein EC, Rao A, Sethi AK, Yadavalli GK, et al. Reduction of Clostridium difficile and vancomycin-resistant Enterococcus contamination of environmental surfaces after an intervention to improve cleaning methods. BMC Infect Dis 2007;7:61.
20. Mody L, Maheshwari S, Galecki A, Kauffaman CA, Bradley SF. Indwelling device use and antibiotic resistance in nursing homes: identifying a high-risk group. J Am Geriatr Soc 2007;55(12):1921-6. (Pubitemid 350230967)
21. Mody L, Kauffman CA, Donabedian S, Zervos M, Bradley SF. Epidemiology of Staphylococcus aureus colonization in nursing home residents. Clin Infect Dis 2008;46(9):1368-73.