Brain-derived neurotrophic factor expression is increased in the hippocampus of 5-HT2C receptor knockout mice

Hippocampus

Volumn 21, Issue 4, 2011, Pages 434-445

  Hill, Rachel A ^a   Murray, Simon S ^b   Halley, Paul G ^a   Binder, Michele D ^b   Martin, Sally J ^a   van den Buuse, Maarten ^a  

^a FLOREY INSTITUTE OF NEUROSCIENCE AND MENTAL HEALTH   (Australia)

^b UNIVERSITY OF MELBOURNE   (Australia)

Author keywords

Cognition; Depression; Memory; Neurotrophin; Serotonin

Indexed keywords

BRAIN DERIVED NEUROTROPHIC FACTOR; BRAIN DERIVED NEUROTROPHIC FACTOR RECEPTOR; MESSENGER RNA; SEROTONIN 2C RECEPTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ANXIETY; ARTICLE; AVOIDANCE BEHAVIOR; CLIMBING; CONTROLLED STUDY; CORPUS STRIATUM; FRONTAL CORTEX; GENOTYPE; HIPPOCAMPUS; LOCOMOTION; MALE; MAZE TEST; MOUSE; NEUROPSYCHOLOGICAL TEST; NONHUMAN; PRIORITY JOURNAL; PROTEIN CLEAVAGE; PROTEIN EXPRESSION; PROTEIN INTERACTION; REFERENCE MEMORY; SENSORIMOTOR FUNCTION; TASK PERFORMANCE; WESTERN BLOTTING; WILD TYPE; WORKING MEMORY;

ANIMALS; BEHAVIOR, ANIMAL; BRAIN-DERIVED NEUROTROPHIC FACTOR; CORPUS STRIATUM; DEPRESSION; FRONTAL LOBE; HIPPOCAMPUS; MEMORY; MICE; MICE, KNOCKOUT; PROTEIN PRECURSORS; RECEPTOR, SEROTONIN, 5-HT2C; RECEPTOR, TRKB; SEROTONIN;

EID: 79953041134     PISSN: 10509631     EISSN: 10981063     Source Type: Journal    
DOI: 10.1002/hipo.20759     Document Type: Article

References (51)

1. Adachi M, Barrot M, Autry AE, Theobald D, Monteggia LM. 2008. Selective loss of brain-derived neurotrophic factor in the dentate gyrus attenuates antidepressant efficacy. Biol Psychiatry 63: 642-649.
2. Altar CA. 1999. Neurotrophins and depression. Trends Pharmacol Sci 20: 59-61.
3. Ambrogi Lorenzini CG, Baldi E, Bucherelli C, Sacchetti B, Tassoni G. 1997. Role of ventral hippocampus in acquisition, consolidation and retrieval of rat's passive avoidance response memory trace. Brain Res 768: 242-248.
4. Bannerman DM, Rawlins JN, McHugh SB, Deacon RM, Yee BK, Bast T, Zhang WN, Pothuizen HH, Feldon J. 2004. Regional dissociations within the hippocampus-Memory and anxiety. Neurosci Biobehav Rev 28: 273-283.
5. 2c receptor function in the brain: Molecular and functional implications. Neuropharmacology 55: 969-976.
6. Chioca LR, Raupp IM, Da Cunha C, Losso EM, Andreatini R. 2008. Subchronic fluoride intake induces impairment in habituation and active avoidance tasks in rats. Eur J Pharmacol 579: 196-201.
7. Croll SD, Suri C, Compton DL, Simmons MV, Yancopoulos GD, Lindsay RM, Wiegand SJ, Rudge JS, Scharfman HE. 1999. Brain-derived neurotrophic factor transgenic mice exhibit passive avoidance deficits, increased seizure severity and in vitro hyperexcitability in the hippocampus and entorhinal cortex. Neuroscience 93: 1491-1506.
8. Cryan JF, Page ME, Lucki I. 2002. Noradrenergic lesions differentially alter the antidepressant-like effects of reboxetine in a modified forced swim test. Eur J Pharmacol 436: 197-205.
9. 2C receptor antagonist displaying broad-based antidepressant and anxiolytic properties in rodent models. Psychopharmacology (Berl) 199: 549-568.
10. Deltheil T, Guiard BP, Cerdan J, David DJ, Tanaka KF, Reperant C, Guilloux JP, Coudore F, Hen R, Gardier AM. 2008a. Behavioral and serotonergic consequences of decreasing or increasing hippocampus brain-derived neurotrophic factor protein levels in mice. Neuropharmacology 55: 1006-1014.
11. Deltheil T, Guiard BP, Guilloux JP, Nicolas L, Delomenie C, Reperant C, Le Maitre E, Leroux-Nicollet I, Benmansour S, Coudore F, David DJ, Gardier AM. 2008b. Consequences of changes in BDNF levels on serotonin neurotransmission, 5-HT transporter expression and function: Studies in adult mice hippocampus. Pharmacol Biochem Behav 90: 174-183.
12. Gobert A, Rivet JM, Lejeune F, Newman-Tancredi A, Adhumeau-Auclair A, Nicolas JP, Cistarelli L, Melon C, Millan MJ. 2000. Serotonin(2C) receptors tonically suppress the activity of mesocortical dopaminergic and adrenergic, but not serotonergic, pathways: A combined dialysis and electrophysiological analysis in the rat. Synapse 36: 205-221.
13. Griesbach GS, Hovda DA, Gomez-Pinilla F. 2009. Exercise-induced improvement in cognitive performance after traumatic brain injury in rats is dependent on BDNF activation. Brain Res 1288: 105-115.
14. Gulyas AI, Acsady L, Freund TF. 1999. Structural basis of the cholinergic and serotonergic modulation of GABAergic neurons in the hippocampus. Neurochem Int 34: 359-372.
15. He J, Yamada K, Nakajima A, Kamei H, Nabeshima T. 2002. Learning and memory in two different reward tasks in a radial arm maze in rats. Behav Brain Res 134: 139-148.
16. Hollup SA, Molden S, Donnett JG, Moser MB, Moser EI. 2001. Accumulation of hippocampal place fields at the goal location in an annular watermaze task. J Neurosci 21: 1635-1644.
17. Kemp A, Gordon E, Rush AJ, Williams LM. 2009. Improving the prediction of treatment response in depression: Integration of clinical, cognitive, psychophysiological, neuroimaging, and genetic measures. CNS Spectrums 13: 1066-1086.
18. Kernie SG, Liebl DJ, Parada LF. 2000. BDNF regulates eating behavior and locomotor activity in mice. EMBO J 19: 1290-1300.
19. Kozisek ME, Middlemas D, Bylund DB. 2008. The differential regulation of BDNF and TrkB levels in juvenile rats after four days of escitalopram and desipramine treatment. Neuropharmacology 54: 251-257.
20. Lacaille JC, Schwartzkroin PA. 1988. Stratum lacunosum-moleculare interneurons of hippocampal CA1 region. I. Intracellular response characteristics, synaptic responses, and morphology. J Neurosci 8: 1400-1410.
21. Li B, Suemaru K, Cui R, Araki H. 2007. Repeated electroconvulsive stimuli have long-lasting effects on hippocampal BDNF and decrease immobility time in the rat forced swim test. Life Sci 80: 1539-1543.
22. -ΔΔCT method. Methods 25: 402-408.
23. Lu B. 2003. BDNF and activity-dependent synaptic modulation. Learn Mem 10: 86-98.
24. Ma YL, Wang HL, Wu HC, Wei CL, Lee EH. 1998. Brain-derived neurotrophic factor antisense oligonucleotide impairs memory retention and inhibits long-term potentiation in rats. Neuroscience 82: 957-967.
25. Mamounas LA, Molliver ME. 1988. Evidence for dual serotonergic projections to neocortex: Axons from the dorsal and median raphe nuclei are differentially vulnerable to the neurotoxin p-chloroamphetamine (PCA). Exp Neurol 102: 23-36.
26. Martinowich K, Lu B. 2008. Interaction between BDNF and serotonin: role in mood disorders. Neuropsychopharmacology 33: 73-83.
27. Matsumoto T, Rauskolb S, Polack M, Klose J, Kolbeck R, Korte M, Barde YA. 2008. Biosynthesis and processing of endogenous BDNF: CNS neurons store and secrete BDNF, not pro-BDNF. Nat Neurosci 11: 131-133.
28. Millan MJ, Dekeyne A, Gobert A. 1998. Serotonin (5-HT)2C receptors tonically inhibit dopamine (DA) and noradrenaline (NA), but not 5-HT, release in the frontal cortex in vivo. Neuropharmacology 37: 953-955.
29. Minor TR, Dess NK, Ben-David E, Chang WC. 1994. Individual differences in vulnerability to inescapable shock in rats. J Exp Psychol Anim Behav Process 20: 402-412.
30. Monteggia LM, Barrot M, Powell CM, Berton O, Galanis V, Gemelli T, Meuth S, Nagy A, Greene RW, Nestler EJ. 2004. Essential role of brain-derived neurotrophic factor in adult hippocampal function. Proc Natl Acad Sci USA 101: 10827-10832.
31. Moser MB, Moser EI. 1998. Functional differentiation in the hippocampus. Hippocampus 8: 608-619.
32. Mowla SJ, Farhadi HF, Pareek S, Atwal JK, Morris SJ, Seidah NG, Murphy RA. 2001. Biosynthesis and post-translational processing of the precursor to brain-derived neurotrophic factor. J Biol Chem 276: 12660-12666.
33. Nagappan G, Lu B. 2005. Activity-dependent modulation of the BDNF receptor TrkB: Mechanisms and implications. Trends Neurosci 28: 464-471.
34. Nibuya M, Morinobu S, Duman RS. 1995. Regulation of BDNF and trkB mRNA in rat brain by chronic electroconvulsive seizure and antidepressant drug treatments. J Neurosci 15: 7539-7547.
35. O'Keefe J, Dostrovsky J. 1971. The hippocampus as a spatial map. Preliminary evidence from unit activity in the freely-moving rat. Brain Res 34: 171-175.
36. Ribak CE, Vaughn JE, Saito K. 1978. Immunocytochemical localization of glutamic acid decarboxylase in neuronal somata following colchicine inhibition of axonal transport. Brain Res 140: 315-332.
37. Rios M, Fan G, Fekete C, Kelly J, Bates B, Kuehn R, Lechan RM, Jaenisch R. 2001. Conditional deletion of brain-derived neurotrophic factor in the postnatal brain leads to obesity and hyperactivity. Mol Endocrinol 15: 1748-1757.
38. Sauer H, Fischer W, Nikkhah G, Wiegand SJ, Brundin P, Lindsay RM, Bjorklund A. 1993. Brain-derived neurotrophic factor enhances function rather than survival of intrastriatal dopamine cell-rich grafts. Brain Res 626: 37-44.
39. Schechter LE, Ring RH, Beyer CE, Hughes ZA, Khawaja X, Malberg JE, Rosenzweig-Lipson S. 2005. Innovative approaches for the development of antidepressant drugs: Current and future strategies. NeuroRx 2: 590-611.
40. Shirayama Y, Chen AC, Nakagawa S, Russell DS, Duman RS. 2002. Brain-derived neurotrophic factor produces antidepressant effects in behavioral models of depression. J Neurosci 22: 3251-3261.
41. Siuciak JA, Lewis DR, Wiegand SJ, Lindsay RM. 1997. Antidepressant-like effect of brain-derived neurotrophic factor (BDNF). Pharmacol Biochem Behav 56: 131-137.
42. Takahashi M, Kakita A, Futamura T, Watanabe Y, Mizuno M, Sakimura K, Castren E, Nabeshima T, Someya T, Nawa H. 2006. Sustained brain-derived neurotrophic factor up-regulation and sensorimotor gating abnormality induced by postnatal exposure to phencyclidine: Comparison with adult treatment. J Neurochem 99: 770-780.
43. Tecott LH, Logue SF, Wehner JM, Kauer JA. 1998. Perturbed dentate gyrus function in serotonin 5-HT2C receptor mutant mice. Proc Natl Acad Sci USA 95: 15026-15031.
44. Tecott LH, Sun LM, Akana SF, Strack AM, Lowenstein DH, Dallman MF, Julius D. 1995. Eating disorder and epilepsy in mice lacking 5-HT2c serotonin receptors. Nature 374: 542-546.
45. Teng HK, Teng KK, Lee R, Wright S, Tevar S, Almeida RD, Kermani P, Torkin R, Chen ZY, Lee FS, Kraemer RT, Nykjaer A, Hempstead BL. 2005. ProBDNF induces neuronal apoptosis via activation of a receptor complex of p75NTR and sortilin. J Neurosci 25: 5455-5463.
46. 1A receptor stimulation, which are strongly dependent on the genetic background. Psychopharmacology (Berl) 195: 273-283.
47. van den Buuse M, Wischhof L, Xi Lee R, Martin S, Karl T. 2009. Neuregulin 1 hypomorphic mutant mice: Enhanced baseline locomotor activity but normal psychotropic drug-induced hyperlocomotion and prepulse inhibition regulation. Int J Neuropsychopharmacol 12: 1383-1393.
48. Wang JH, van den Buuse M, Tian SW, Ma YY. 2003. Effect of paradoxical sleep deprivation and stress on passive avoidance behavior. Physiol Behav 79: 591-596.
49. Wilson MA, McNaughton BL. 1993. Dynamics of the hippocampal ensemble code for space. Science 261: 1055-1058.
50. Woo NH, Teng HK, Siao CJ, Chiaruttini C, Pang PT, Milner TA, Hempstead BL, Lu B. 2005. Activation of p75NTR by proBDNF facilitates hippocampal long-term depression. Nat Neurosci 8: 1069-1077.
51. Zhou J, Li L, Tang S, Cao X, Li Z, Li W, Li C, Zhang X. 2008. Effects of serotonin depletion on the hippocampal GR/MR and BDNF expression during the stress adaptation. Behav Brain Res 195: 129-138.