Pharmacokinetics, efficacy and safety of alitretinoin in moderate or severe chronic hand eczema

Clinical and Experimental Dermatology

Volumn 36, Issue SUPPL. 2, 2011, Pages 29-34

  Schmitt Hoffmann, A H ^a   Roos, B ^a   Sauer, J ^a   Spickermann, J ^a   Stoeckel, K ^b   Edwards, D ^c   van de Wetering, J ^d   Coenraads, P J ^e   Maares, J ^a  

^a BASILEA PHARMACEUTICA INTERNATIONAL LTD   (Switzerland)

^b CLINPHARM SUPPORT GmbH   (Switzerland)

^c WAYNE STATE UNIVERSITY   (United States)

^d PRA International USA   (Netherlands)

^e UNIVERSITY MEDICAL CENTER GRONINGEN   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

ALITRETINOIN; CORTICOSTEROID; DRUG METABOLITE; HIGH DENSITY LIPOPROTEIN; TRIACYLGLYCEROL;

ABDOMINAL PAIN; ADULT; AGED; AREA UNDER THE CURVE; ARTHRALGIA; ARTICLE; BACKACHE; CATARACT; CHRONIC DISEASE; CHRONIC DRUG ADMINISTRATION; CLINICAL ARTICLE; CORTICOSTEROID THERAPY; DIARRHEA; DIPLOPIA; DISEASE SEVERITY; DISTRIBUTION VOLUME; DIZZINESS; DOUBLE BLIND PROCEDURE; DRUG ACCUMULATION; DRUG BLOOD LEVEL; DRUG CLEARANCE; DRUG DISPOSITION; DRUG EFFICACY; DRUG ELIMINATION; DRUG EXPOSURE; DRUG HALF LIFE; DRUG POTENCY; DRUG SAFETY; DRUG TOLERABILITY; DRUG WITHDRAWAL; ECZEMA; ELECTROCARDIOGRAM; ELECTRORETINOGRAM; EYE REFRACTION; FATIGUE; FEMALE; FLU LIKE SYNDROME; HAND ECZEMA; HEADACHE; HOT FLUSH; HUMAN; LIP DISEASE; MALE; MYALGIA; PERIPHERAL EDEMA; PHARYNGITIS; PHYSICIAN GLOBAL ASSESSMENT SCALE; PRIORITY JOURNAL; PRURITUS; RANDOMIZED CONTROLLED TRIAL; RASH; RHINOPHARYNGITIS; SIDE EFFECT; SKIN TOXICITY; TREATMENT DURATION; TRIACYLGLYCEROL BLOOD LEVEL; VISUAL ACUITY; VITAL SIGN; XEROSTOMIA;

ADOLESCENT; ADULT; AGED; CHRONIC DISEASE; DERMATOLOGIC AGENTS; DOSE-RESPONSE RELATIONSHIP, DRUG; DOUBLE-BLIND METHOD; DRUG ADMINISTRATION SCHEDULE; FEMALE; HAND DERMATOSES; HUMANS; MALE; MIDDLE AGED; TREATMENT OUTCOME; TRETINOIN; YOUNG ADULT;

EID: 79953034275     PISSN: 03076938     EISSN: 13652230     Source Type: Journal    
DOI: 10.1111/j.1365-2230.2011.04035.x     Document Type: Article

References (4)

1. Diepgen TL, Agner T, Aberer W et al. Management of chronic hand eczema. Contact Dermatitis 2007; 57: 203-10.
2. Ruzicka T, Lynde CW, Jemec GB et al. Efficacy and safety of oral alitretinoin (9-cis retinoic acid) in patients with severe chronic hand eczema refractory to topical corticosteroids: results of a randomized, double-blind, placebo-controlled, multicentre trial. Br J Dermatol 2008; 158: 808-17.
3. Coenraads PJ, Van Der Walle H, Thestrup-Pedersen K et al. Construction and validation of a photographic guide for assessing severity of chronic hand dermatitis. Br J Dermatol 2005; 152: 296-301.
4. Ruzicka T, Larsen FG, Galewicz D et al. Oral alitretinoin (9-cis-retinoic acid) therapy for chronic hand dermatitis in patients refractory to standard therapy: results of a randomized, double-blind, placebo-controlled, multicenter trial. Arch Dermatol 2004; 140: 1453-9.