Reassessment of the threshold of urinary cadmium by using hybrid approach in a cadmium non-polluted area in Japan

International Journal of Hygiene and Environmental Health

Volumn 214, Issue 2, 2011, Pages 175-178

  Suwazono, Yasushi ^a   Nogawa, Kazuhiro ^a   Uetani, Mirei ^a   Kido, Teruhiko ^b   Nakagawa, Hideaki ^c  

^a CHIBA UNIVERSITY   (Japan)

^b KANAZAWA UNIVERSITY   (Japan)

^c KANAZAWA MEDICAL UNIVERSITY   (Japan)

Author keywords

Benchmark dose; Continuous data; Environmental exposure; Human; Renal effect; Risk assessment; Urinary cadmium

Indexed keywords

ACETYLGLUCOSAMINIDASE; BETA 2 MICROGLOBULIN; BIOLOGICAL MARKER; CADMIUM; CREATININE;

AGED; ARTICLE; CADMIUM POISONING; DRUG EFFECT; ENVIRONMENTAL EXPOSURE; ENVIRONMENTAL MONITORING; FEMALE; HUMAN; JAPAN; KIDNEY; MALE; METABOLISM; METHODOLOGY; MIDDLE AGED; POLLUTANT; REFERENCE VALUE; RISK; SEX DIFFERENCE; STATISTICAL MODEL; URINE;

ACETYLGLUCOSAMINIDASE; AGED; BETA 2-MICROGLOBULIN; BIOLOGICAL MARKERS; CADMIUM; CADMIUM POISONING; CREATININE; ENVIRONMENTAL EXPOSURE; ENVIRONMENTAL MONITORING; ENVIRONMENTAL POLLUTANTS; FEMALE; HUMANS; JAPAN; KIDNEY; LINEAR MODELS; MALE; MIDDLE AGED; REFERENCE VALUES; RISK; SEX FACTORS;

EID: 79953031437     PISSN: 14384639     EISSN: 1618131X     Source Type: Journal    
DOI: 10.1016/j.ijheh.2010.09.002     Document Type: Article

References (19)

1. Amzal B., Julin B., Vahter M., Wolk A., Johanson G., Åkesson A. Population toxicokinetic modeling of cadmium for health risk assessment. Environ. Health Perspect. 2009, 117:1293-1301.
2. Bonness R.W., Taussky M.H. On the calorimetric determination of creatinine by the Jaffe reaction. J. Biol. Chem. 1945, 158:581-591.
3. Crump K. Calculation of benchmark doses from continuous data. Risk Anal. 1995, 15:79-89.
4. Crump K. Critical issues in benchmark calculations from continuous data. Crit. Rev. Toxicol. 2002, 32:133-153.
5. Crump K.S. A new method for determining allowable daily intakes. Fundam. Appl. Toxicol. 1984, 4:854-871.
6. EFSA, 2009. Scientific Opinion of the Panel on Contaminants in the Food Chain on a request from the European Commission on cadmium in food. EFSA J. 980, 1-139. Available from: (accessed 04.06.10.). http://www.efsa.europa.eu/en/scdocs/doc/contam_op_ej980_cadmium_en_rev.1,2.pdf.
7. FAO/WHO (Food and Agriculture Organization/World Health Organization), 1988. Evaluation of certain food additives and contaminants (Thirty-third report of the Joint FAO/WHO Expert Committee on Food Additives). WHO Technical Report Series, No. 776. World Health Organization: Geneva.
8. Järup L., Åkesson A. Current status of cadmium as an environmental health problem. Toxicol. Appl. Pharmacol. 2009, 238:201-208.
9. Kido T., Tsuritani I., Honda R., Ishizaki M., Yamada Y., Nogawa K. A direct determination of urinary cadmium by graphite-furnace atomic absorption spectrometry using the Zeeman effect. J. Kanazawa Med. Univ. 1984, 9:70-75.
10. Kobayashi E., Suwazono Y., Uetani M., Inaba T., Oishi M., Kido T., Nishijo M., Nakagawa H., Nogawa K. Estimation of benchmark dose for renal dysfunction in a cadmium non-polluted area in Japan. J. Appl. Toxicol. 2006, 26:351-355.
11. Kobayashi E., Suwazono Y., Dochi M., Honda R., Nishijo M., Kido T., Nakagawa H. Estimation of benchmark doses as threshold levels of urinary cadmium, based on excretion of beta2-microglobulin in cadmium-polluted and non-polluted regions in Japan. Toxicol. Lett. 2008, 179:108-112.
12. Royston P., Sauerbrei W., Altman D.G. Modeling the effects of continuous risk factors. J. Clin. Epidemiol. 2000, 53:219-221.
13. Sand S., Victorin K., Filipsson A.F. The current state of knowledge on the use of the benchmark dose concept in risk assessment. J. Appl. Toxicol. 2008, 28:405-421.
14. Shimizu A., Kobayashi E., Suwazono Y., Uetani M., Oishi M., Inaba T., Kido T., Nogawa K. Estimation of benchmark doses for urinary cadmium based on beta2-microglobulin excretion in cadmium-polluted regions of the Kakehashi River basin, Japan. Int. J. Environ. Health Res. 2006, 16:329-337.
15. Suwazono Y., Sand S., Vahter M., Filipsson A.F., Skerfving S., Lidfeldt J., Akesson A. Benchmark dose for cadmium-induced renal effects in humans. Environ. Health Perspect. 2006, 114:1072-1076.
16. Suwazono Y., Kobayashi E., Okubo Y., Nogawa K., Kido T., Nakagawa H. Renal effects of cadmium exposure in cadmium nonpolluted areas in Japan. Environ. Res. 2000, 84:44-55.
17. Suwazono Y., Kido T., Nakagawa H., Nishijo M., Honda R., Kobayashi E., Dochi M., Nogawa K. Biological half-life of cadmium in the urine of inhabitants after cessation of cadmium exposure. Biomarkers 2009, 14:77-81.
18. U.S. EPA, 1995. The Use of the Benchmark Dose (BMD) Approach in Health Risk Assessment. Final report. Washington, DC: Risk Assessment Forum, U.S. Environmental Protection Agency. Report nr EPA/630/R-94/007.
19. Uno T., Kobayashi E., Suwazono Y., Okubo Y., Miura K., Sakata K., Okayama A., Ueshima H., Nakagawa H., Nogawa K. Health effects of cadmium exposure in the general environment in Japan with special reference to the lower limit of the benchmark dose as the threshold level of urinary cadmium. Scand. J. Work Environ. Health 2005, 31:307-315.