In vitro indentation to determine the mechanical properties of epidermis

Journal of Biomechanics

Volumn 44, Issue 6, 2011, Pages 1176-1181

  Geerligs, Marion ^a   van Breemen, Lambert ^b   Peters, Gerrit ^b   Ackermans, Paul ^c   Baaijens, Frank ^b   Oomens, Cees ^b  

^a Innovation Laboratory   (Netherlands)

^b EINDHOVEN UNIVERSITY OF TECHNOLOGY   (Netherlands)

^c PHILIPS RESEARCH LABORATORIES   (Netherlands)

Author keywords

Epidermis; In vitro; Mechanical properties; Micro indentation; Stratum corneum

Indexed keywords

ANALYTICAL METHOD; EPIDERMIS; HUMAN SKIN; IN VITRO; LARGE DIAMETER; MECHANICAL BEHAVIOR; MICRO JET; MICRO-INDENTATION; MICRONEEDLES; NUMERICAL MODELS; SAMPLE THICKNESS; STRATUM CORNEUM; YOUNG'S MODULUS;

BEHAVIORAL RESEARCH; DRUG DELIVERY; ELASTIC MODULI; ELASTICITY; NUMERICAL METHODS; STIFFNESS;

MECHANICAL PROPERTIES;

SILICONE;

ACCURACY; ADULT; ARTICLE; BIOMECHANICS; CONTROLLED STUDY; EX VIVO STUDY; FEMALE; FINITE ELEMENT ANALYSIS; HUMAN; HUMAN TISSUE; IN VITRO STUDY; LOADING TEST; MATHEMATICAL MODEL; NANOANALYSIS; POROSITY; PRIORITY JOURNAL; RELIABILITY; REPRODUCIBILITY; RIGIDITY; SKIN SURFACE; SKINFOLD THICKNESS; STRATUM CORNEUM; SURFACE PROPERTY; VISCOELASTICITY; YOUNG MODULUS;

ADULT; DRUG DELIVERY SYSTEMS; EPIDERMIS; FEMALE; HUMANS; MIDDLE AGED; MODELS, BIOLOGICAL; PRESSURE;

EID: 79953017355     PISSN: 00219290     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jbiomech.2011.01.015     Document Type: Article

References (14)

1. Boyer G., LaquiFze L., Le Bot A., LaquiFze S., Zahouani H. Dynamic indentation on human skin in vivo: ageing effects. Skin Research and Technology: Official Journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI) 2009, 15(1):55-67.
2. Ebenstein D.M., Pruitt L.A. Nanoindentation of biological materials. Nano Today 2006, 1(3):26-33.
3. Elias P.M., Feingold K.R. Skin Barrier 2005, Taylor and Frances Group, New York.
4. Graves C.J., Edwards C. Hardware and measuring principles: the microindentometer. Bioengineering of the Skin: Skin Biomechanics 2002, CRC Press LLC, Boca Raton. P. Elsner, E. Berardesca, K.P. Wilhelm, H.I. Maibach (Eds.).
5. Hendley A., Marks R., Payne P.A. Measurement of forces for point indentation of the stratum corneum in vivo: the influences of age, sex, site delipidisation and hydration. Bioengineering and the skin 1982, 234-240:3234-3240.
6. Holbrook K.A., Odland G.F. Regional differences in the thickness (cell layers) of the human stratum corneum: an ultrastructural analysis. Journal of Investigative Dermatology 1974, 62(4):415-422.
7. Jachowicz J., McMullen R., Prettypaul D. Indentometric analysis of in vivo skin and comparison with artificial skin models. Skin Research and Technology 2007, 13(3):299-309.
8. Kendall M.A., Chong Y.F., Cock A. The mechanical properties of the skin epidermis in relation to targeted gene and drug delivery. Biomaterials 2007, 28(33):4968-4977.
9. Oliver W.C., Pharr G.M. An improved technique for determining hardness and elastic-modulus using load and displacement sensing indentation experiments. Journal of Materials Research 1992, 7(6):1564-1583.
10. Pailler-Mattei C., Pavan S., Vargiolu R., Pirot F., Falson F., Zahouani H. Contribution of stratum corneum in determining bio-tribological properties of the human skin. Wear 2007, 263(7-12):1038-1043.
11. Pailler-Mattei C., Zahouani H. Study of adhesion forces and mechanical properties of human skin in vivo. Journal of Adhesion Science and Technology 2004, 18(15-16):1739-1758.
12. Plewig G., Marples R.R. Regional differences of cell sizes in the human stratum corneum. I. Journal of Investigative Dermatology 1970, 54(1):13-18.
13. Wu K.S., van Osdol W.W., Dauskardt R.H. Mechanical properties of human stratum corneum: effects of temperature, hydration, and chemical treatment. Biomaterials 2005, 27(5):785-795.
14. Yuan Y., Verma R. Measuring microelastic properties of stratum corneum. Colloids and Surfaces B: Biointerfaces 2006, 48(1):6-12.