Treating acid reflux disease in patients with Down syndrome: Pharmacological and physiological approaches

Clinical and Experimental Gastroenterology

Volumn 4, Issue 1, 2011, Pages 19-22

  Macchini, Francesco ^a   Leva, Ernesto ^a   Torricelli, Maurizio ^a   Valadè, Alberto ^a  

^a FONDAZIONE IRCCS CA GRANDA OSPEDALE MAGGIORE POLICLINICO   (Italy)

Author keywords

Chromosome 21; Down syndrome; Gastro esophageal reflux disease

Indexed keywords

ANTACID AGENT; HISTAMINE H2 RECEPTOR ANTAGONIST; PROKINETIC AGENT; PROTON PUMP INHIBITOR;

DIET THERAPY; DISEASE ASSOCIATION; DOWN SYNDROME; DRUG MECHANISM; GASTROESOPHAGEAL REFLUX; GASTROINTESTINAL DISEASE; GASTROSCOPY; GASTROSTOMY; HUMAN; PATHOPHYSIOLOGY; REVIEW; RISK FACTOR; STOMACH FUNDOPLICATION;

EID: 79953016134     PISSN: None     EISSN: 11787023     Source Type: Journal    
DOI: 10.2147/CEG.S15872     Document Type: Review

References (32)

1. Van Trotsenburg AS, Heymans HS, Tijssen JG, de Vijlder JJ, Vulsma T. Comorbidity, hospitalization, and medication use and their influence on mental and motor development of young infants with Down syndrome. Pediatrics. 2006;118(4):1633-1639.
2. Wallace RA. Clinical audit of gastrointestinal conditions occurring among adults with Down syndrome attending a specialist clinic. J Intellect Dev Disabil. 2007;32(1):45-50.
3. Spahis JK, Wilson GN. Down syndrome: perinatal complications and counseling experiences in 216 patients. Am J Med Genet. 1999;25; 89(2):96-99.
4. Källén B, Mastroiacovo P, Robert E. Major congenital malformations in Down syndrome. Am J Med Genet. 1996;16;65(2):160-166.
5. Buchin PJ, Levy JS, Schullinger JN. Down's syndrome and the gastrointestinal tract. J Clin Gastroenterol. 1986;8(2):111-114.
6. Levy J. The gastrointestinal tract in down syndrome. Prog Clin Biol Res. 1991;373:245-256.
7. Zárate N, Mearin F, Gil-Vernet JM, Camarasa F, Malagelada JR. Achalasia and down's syndrome: coincidental association or something else? Am J Gastroenterol. 1999;94(6):1674-1677.
8. Nakazato Y, Landing BH. Reduced number of neurons in esophageal plexus ganglia in down syndrome: additional evidence for reduced cell number as a basic feature of the disorder. Pediatr Pathol. 1986;5(1): 55-63.
9. Mrak RE, Griffin WS. Trisomy 21 and the brain. J Neuropathol Exp Neurol. 2004;63(7):679-685.
10. Moore SW. Down syndrome and the enteric nervous system. Pediatr Surg Int. 2008;24(8):873-883.
11. Hillemeier C, Buchin PJ, Gryboski J. Esophageal dysfunction in Down's syndrome. J Pediatr Gastroenterol Nutr. 1982;1(1):101-104.
12. Vakil N, van Zanten SV, Kahrilas P, Dent J, Jones R. Global Consensus Group. The Montreal definition and classification of gastroesophageal reflux disease: a global evidence-based consensus. Am J Gastroenterol. 2006;101(8):1900-1920.
13. Sherman PM, Hassall E, Fagundes-Neto U, et al. A global, evidence-based consensus on the definition of gastroesophageal reflux disease in the pediatric population. Am J Gastroenterol. 2009;104(5): 1278-1295.
14. Sullivan PB. Gastrointestinal disorders in children with neurodevelopmental disabilities. Dev Disabil Res Rev. 2008;14(2):128-136.
15. de Veer AJ, Bos JT, Niezen-de Boer RC, Böhmer CJ, Francke AL. Symptoms of gastroesophageal reflux disease in severely mentally retarded people: a systematic review. BMC Gastroenterol. 2008;11; 8:23.
16. Luzzani S, Macchini F, Valadè A, Milani D, Selicorni A. Gastroesophageal reflux and Cornelia de Lange syndrome: typical and atypical symptoms. Am J Med Genet A. 2003;15;119 A(3):283-287.
17. Macchini F, Fava G, Selicorni A, Torricelli M, Leva E, Valadè A. Barrett's esophagus and Cornelia de Lange Syndrome. Acta Paediatr. 2010;99(9):1407-1410.
18. Rudolph CD, Mazur LJ, Liptak GS, et al. North American Society for Pediatric Gastroenterology and Nutrition. Guidelines for evaluation and treatment of gastroesophageal reflux in infants and children: recommendations of the North American Society for Pediatric Gastroenterology and Nutrition. J Pediatr Gastroenterol Nutr. 2001; 32(Suppl 2):S1-S31.
19. DeVault KR. Overview of medical therapy for gastroesophageal reflux disease. Gastroenterol Clin North Am. 1999;28(4):831-845.
20. Fonkalsrud EW, Ament ME. Gastroesophageal reflux in childhood. Curr Probl Surg. 1996;33(1):1-70.
21. Tighe MP, Afzal NA, Bevan A, Beattie RM. Current pharmacological management of gastro-esophageal reflux in children: an evidence-based systematic review. Paediatr Drugs. 2009;11(3):185-202.
22. Pritchard DS, Baber N, Stephenson T. Should domperidone be used for the treatment of gastro-oesophageal reflux in children? Systematic review of randomized controlled trials in children aged 1 month to 11 years old. Br J Clin Pharmacol. 2005;59(6):725-729.
23. Saedon M, Gourgiotis S, Germanos S. Is there a changing trend in surgical management of gastroesophageal reflux disease in children? World J Gastroenterol. 2007;7;13(33):4417-4422.
24. Cheung KM, Tse PW, Ko CH, Chan YC, Leung CY, Chan KH. Clinical efficacy of proton pump inhibitor therapy in neurologically impaired children with gastroesophageal reflux: prospective study. Hong Kong Med J. 2001;7(4):356-359.
25. Fonkalsrud EW, Ashcraft KW, Coran AG, et al. Surgical treatment of gastroesophageal reflux in children: a combined hospital study of 7467 patients. Pediatrics. 1998;101(3 pt 1):419-422.
26. Hinder RA, Perdikis G, Klinger PJ, deVault KR. The surgical option for gastroesophageal reflux disease. Am J Med. 1997;24;103(5A): 144S-148S.
27. Esposito C, Van Der Zee DC, Settimi A, Doldo P, Staiano A, Bax NM. Risks and benefits of surgical management of gastroesophageal reflux in neurologically impaired children. Surg Endosc. 2003;17(5): 708-710.
28. Van Trotsenburg AS, Heymans HS, Tijssen JG, de Vijlder JJ, Vulsma T. Comorbidity, hospitalization, and medication use and their influence on mental and motor development of young infants with Down syndrome. Pediatrics. 2006;118(4):1633-1639.
29. Bozinovski J, Poenaru D, Paterson W, Kamal I. Esophageal aperistalsis following fundoplication in a patient with trisomy 21. Pediatr Surg Int. 1999;15(7):510-511.
30. Esposito C, Settimi A, Centonze A, Capano G, Ascione G. Laparoscopic-assisted jejunostomy: an effective procedure for the treatment of neurologically impaired children with feeding problems and gastroesophageal reflux. Surg Endosc. 2005;19(4):501-504.
31. Bianchi A. Total esophagogastric dissociation: an alternative approach. J Pediatr Surg. 1997;32(9):1291-1294.
32. Danielson PD, Emmens RW. Esophagogastric disconnection for gastroesophageal reflux in children with severe neurological impairment. J Pediatr Surg. 1999;34(1):84-86.