Ultrastructural, immunofluorescence, and RNA evidence support the hypothesis of a "new" virus associated with Kawasaki disease

Journal of Infectious Diseases

Volumn 203, Issue 7, 2011, Pages 1021-1030

  Rowley, Anne H ^a   Baker, Susan C ^b   Shulman, Stanford T ^a   Rand, Kenneth H ^c   Tretiakova, Maria S ^d   Perlman, Elizabeth J ^a   Garcia, Francesca L ^a   Tajuddin, Nuzhath F ^b   Fox, Linda M ^b   Huang, Julia H ^a   Ralphe, J Carter ^e   Takahashi, Kei ^f   Flatow, Jared ^g   Lin, Simon ^g   Kalelkar, Mitra B ^h   Soriano, Benjamin ^e   Orenstein, Jan M ⁱ  

^a NORTHWESTERN UNIVERSITY   (United States)

^b LOYOLA UNIVERSITY CHICAGO   (United States)

^c UNIVERSITY OF FLORIDA COLLEGE OF MEDICINE   (United States)

^d UNIVERSITY OF CHICAGO   (United States)

^e UNIVERSITY OF WISCONSIN SCHOOL OF MEDICINE AND PUBLIC HEALTH   (United States)

^f TOHO UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^g NORTHWESTERN UNIVERSITY   (United States)

^h Office of Cook County Med Examiner   (United States)

ⁱ GEORGE WASHINGTON UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKERATIN;

ARTICLE; BIOTINYLATION; BRONCHUS MUCOSA; CELL INCLUSION; CHILD; CILIATED EPITHELIUM; CONTROLLED STUDY; DOWN REGULATION; FEMALE; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; HIGH THROUGHPUT SCREENING; HUMAN; HUMAN TISSUE; IMMUNOFLUORESCENCE; IMMUNOHISTOCHEMISTRY; INFANT; MALE; MUCOCUTANEOUS LYMPH NODE SYNDROME; PATHOGENESIS; PRESCHOOL CHILD; PRIORITY JOURNAL; PROTEIN AGGREGATION; REAL TIME POLYMERASE CHAIN REACTION; RNA VIRUS; TRANSMISSION ELECTRON MICROSCOPY; ULTRASTRUCTURE; UPREGULATION; VIRUS IDENTIFICATION;

CHILD, PRESCHOOL; EPITHELIAL CELLS; FEMALE; FLUORESCENT ANTIBODY TECHNIQUE; HUMANS; INCLUSION BODIES, VIRAL; INFANT; INFANT, NEWBORN; MALE; MICROSCOPY, ELECTRON, TRANSMISSION; MUCOCUTANEOUS LYMPH NODE SYNDROME; RESPIRATORY MUCOSA; RNA, VIRAL; VIROSOMES; VIRUSES;

EID: 79953013235     PISSN: 00221899     EISSN: None     Source Type: Journal    
DOI: 10.1093/infdis/jiq136     Document Type: Article

References (23)

1. Rowley AH, Baker SC, Orenstein JM, Shulman ST. Searching for the cause of Kawasaki disease-cytoplasmic inclusion bodies provide new insight. Nat Rev Microbiol 2008; 6:394-401.
2. Rowley AH, Shulman ST, Spike BT, Mask CA, Baker SC. Oligoclonal IgA response in the vascular wall in acute Kawasaki disease. J Immunol 2001; 166:1334-43. (Pubitemid 32060296)
3. Rowley AH, Baker SC, Shulman ST, et al. Detection of antigen in bronchial epithelium and macrophages in acute Kawasaki disease by use of synthetic antibody. J Infect Dis 2004; 190:856-65. (Pubitemid 39050018)
4. Rowley AH, Baker SC, Shulman ST, et al. Cytoplasmic inclusion bodies are detected by synthetic antibody in ciliated bronchial epithelium during acute Kawasaki disease. J Infect Dis 2005; 192:1757-66. (Pubitemid 41587826)
5. Rowley AH, Baker SC, Shulman ST, et al. RNA-containing cytoplasmic inclusion bodies in ciliated bronchial epithelium months to years after acute Kawasaki disease. PLoS One 2008; 3:e1582.
6. Garcia-Mata R, Gao YS, Sztul E. Hassles with taking out the garbage: Aggravating aggresomes. Traffic 2002; 3:388-96. (Pubitemid 34746406)
7. Johnston JA, Ward CL, Kopito RR. Aggresomes: A cellular response to misfolded proteins. J Cell Biol 1998; 143:1883-98. (Pubitemid 29022611)
8. Yang ZP, Cummings PK, Patton DL, Kuo CC. Ultrastructural lung pathology of experimental Chlamydia pneumoniae pneumonitis in mice. J Infect Dis 1994; 170:464-7. (Pubitemid 24226384)
9. Toivola DM, Strnad P, Habtezion A, Omary MB. Intermediate filaments take the heat as stress proteins. Trends Cell Biol 2010; 20:79-91.
10. Rowley AH, Shulman ST, Garcia FL, et al. Cloning the arterial IgA antibody response during acute Kawasaki disease. J Immunol 2005; 175:8386-91. (Pubitemid 41798405)
11. Chari R, Lonergan KM, Ng RT, MacAulay C, Lam WL, Lam S. Effect of active smoking on the human bronchial epithelium transcriptome. BMC Genomics 2007; 8:297.
12. Komuro A, Bamming D, Horvath CM. Negative regulation of cytoplasmic RNA-mediated antiviral signaling. Cytokine 2008; 43:350-8.
13. Koenig S, Gendelman HE, Orenstein JM, et al. Detection of AIDS virus in macrophages in brain tissue from AIDS patients with encephalopathy. Science 1986; 233:1089-93. (Pubitemid 16032241)
14. Orenstein JM, Jannotta F. Human immunodeficiency virus and papovavirus infections in acquired immunodeficiency syndrome: An ultrastructural study of three cases. Hum Pathol 1988; 19:350-61.
15. Eilbott DJ, Peress N, Burger H, et al. Human immunodeficiency virus type 1 in spinal cords of acquired immunodeficiency syndrome patients with myelopathy: Expression and replication in macrophages. Proc Natl Acad Sci USA 1989; 86:3337-41. (Pubitemid 19129606)
16. Orenstein JM. Ultrastructural pathology of human immunodeficiency virus infection. Ultrastruct Pathol 1992; 16:179-210.
17. Orenstein JM, Alkan S, Blauvelt A, et al. Visualization of human herpesvirus type 8 in Kaposi's sarcoma by light and transmission electron microscopy. AIDS 1997; 11:F35-45.
18. Orenstein JM. Isn't a picture still worth a thousand words? Ultrastruct Pathol 2000; 24:67-74.
19. Orenstein JM. Human endogenous retroviral expression by leukocytes. Ultrastruct Pathol 2000; 24:123-4. (Pubitemid 30241165)
20. Orenstein JM. Replication of HIV-1 in vivo and in vitro. Ultrastruct Pathol 2007; 31:151-67. (Pubitemid 47037182)
21. Graham L, Orenstein JM. Processing tissue and cells for transmission electron microscopy in diagnostic pathology and research. Nat Protoc 2007; 2:2439-50.
22. Wu Q, Luo Y, Lu R, et al. Virus discovery by deep sequencing and assembly of virus-derived small silencing RNAs. Proc Natl Acad Sci USA 2010; 107:1606-11.
23. Rowley AH. Finding the cause of Kawasaki disease: a pediatric infectious diseases research priority. J Infect Dis 2006; 194:1635-7. (Pubitemid 44901993)