Determination of myrtucommulone from myrtus communis in human and rat plasma by liquid chromatography/tandem mass spectrometry

Planta Medica

Volumn 77, Issue 5, 2011, Pages 450-454

  Gerbeth, Kathleen ^a   Meins, Jürgen ^a   Werz, Oliver ^b   Schubert Zsilavecz, Manfred ^a,c   Abdel Tawab, Mona ^a  

^a ABDA Bundesvereinigung Deutscher Apothekerverbande   (Germany)

^b UNIVERSITY OF TÜBINGEN   (Germany)

^c GOETHE UNIVERSITY   (Germany)

Author keywords

human rat plasma; LC MS; myrtle; myrtucommulone; Myrtus communis Myrtaceae

Indexed keywords

ACETONITRILE; AMMONIUM FORMATE; HYPERFORIN; MYRTUCOMMULONE; PLANT MEDICINAL PRODUCT; UNCLASSIFIED DRUG; WATER;

ARTICLE; CONTROLLED STUDY; DRUG DETERMINATION; DRUG SOLUBILITY; DRUG STABILITY; ELECTROSPRAY; HUMAN; LIQUID CHROMATOGRAPHY TANDEM MASS SPECTROMETRY; LIQUID LIQUID EXTRACTION; MASS SPECTROMETRY; MYRTLE; NONHUMAN; PLASMA; RAT; TEMPERATURE;

ANIMALS; CHROMATOGRAPHY, LIQUID; DRUG STABILITY; HUMANS; MYRTUS; PHLOROGLUCINOL; RATS; REPRODUCIBILITY OF RESULTS; SENSITIVITY AND SPECIFICITY; TANDEM MASS SPECTROMETRY;

ANIMALIA; MYRTACEAE; MYRTUS COMMUNIS; RATTUS;

EID: 79953001134     PISSN: 00320943     EISSN: 14390221     Source Type: Journal    
DOI: 10.1055/s-0030-1250459     Document Type: Article

References (23)

1. Feißt C, Franke L, Appendino G, Werz O. Identification of molecular targets of the oligomeric nonprenylated acylphloroglucinols from Myrtus communis and their implication as anti-inflammatory compounds. J Pharm Exp Ther 2005 315 389-396 (Pubitemid 41380535)
2. Bonjar G H. Antibacterial screening of plants used in Iranian folkloric medicine. Fitoterapia 2004 75 231-235 (Pubitemid 38353092)
3. Elfellah M S., Akhter M H., Khan M T. Anti-hyperglycaemic effect of an extract of Myrtus communis in streptozotocin-induced diabetes in mice. J Ethnopharmacol 1984 11 275-281 (Pubitemid 14045965)
4. Sepici A, Gürbüz I, Cevik C, Yesilada E. Hypoglycaemic effects of myrtle oil in normal and alloxan-diabetic rabbits. J Ethnopharmacol 2004 93 311-318 (Pubitemid 38962422)
5. Levesque H, Lafont O. Aspirin throughout the ages: a historical review. Rev Med Interne 2000 21 (Suppl. 1) 8s-17s
6. Rosa A, Deiana M, Casu V, Corona G, Appendino G, Bianchi F, Ballero M, Dessi M A. Antioxidant activity of oligomeric acylphloroglucinols from Myrtus communis L. Free Radic Res 2003 37 1013-1019 (Pubitemid 37229049)
7. Hayder N, Abdelwahed A, Kilani S, Ammar R B., Mahmoud A, Ghedira K, Chekir-Ghedira L. Anti-genotoxic and free-radical scavenging activities of extracts from (Tunisian) Myrtus communis. Mutat Res 2004 564 89-95 (Pubitemid 39345830)
8. Romani A, Coinu R, Carta S, Pinelli P, Galvardi C, Vincieri F F., Franconi F. Evaluation of antioxidant effect of different extracts of Myrtus communis L. Free Radic Res 2004 38 97-103 (Pubitemid 38128520)
9. Appendino G, Bianchi F, Minassi A, Sterner O, Ballero M, Gibbons S. Oligomeric acylphloroglucinols from myrtle (Myrtus communis). J Nat Prod 2002 65 334-338 (Pubitemid 34260803)
10. Koeberle A, Pollastro F, Northoff H, Werz O. Myrtucommulone, a natural acylphloroglucinol, inhibits microsomal prostaglandin E(2) synthase-1. Br J Pharmacol 2009 156 952-961
11. Rossi A, Paola R D., Mazzon E, Genovese T, Caminiti R, Bramanti P, Pergola C, Koeberle A, Werz O, Sautebin L, Cuzzocrea S. Myrtucommulone from Myrtus communis exhibits potent anti-inflammatory effectiveness in vivo. J Pharm Exp Ther 2009 329 76-86
12. Gioti E M., Skalkos D C., Fiamegos Y C., Stalikas C D. Single-drop liquid phase microextraction for the determination of hypericin, pseudohypericin and hyperforin in biological fluids by high performance liquid chromatography. J Chromatogr A 2005 1093 1-10 (Pubitemid 41446941)
13. Rozio M, Fracasso C, Riva A, Morazzoni P, Caccia S. High-performance liquid chromatography measurement of hyperforin and its reduced derivatives in rodent plasma. J Chromatogr B Anal Technol Biomed Life Sci 2005 816 21-27 (Pubitemid 40143485)
14. Cui Y, Gurley B, Ang C Y., Leakey J. Determination of hyperforin in human plasma using solid-phase extraction and high-performance liquid chromatography with ultraviolet detection. J Chromatogr B Anal Technol Biomed Life Sci 2002 780 129-135 (Pubitemid 35279751)
15. Bauer S, Störmer E, Graubaum H J., Roots I. Determination of hyperforin, hypericin and pseudohypericin in human plasma using high-performance liquid chromatography analysis with fluorescence and ultraviolet detection. J Chromatogr B Biomed Sci Appl 2001 765 29-35 (Pubitemid 33055805)
16. Chi J D., Franklin M. Measurement of hyperforin a constituent of St.John's wort in plasma by high-performance liquid chromatography. J Chromatogr B Biomed Sci Appl 1999 735 285-288
17. Paulke A, Schubert-Zsilavecz M, Wurglics M. Determination of St. John's wort flavonoid-metabolites in rat brain through high performance liquid chromatography coupled with fluorescence detection. J Chromatogr B Anal Technol Biomed Life Sci 2006 832 109-113 (Pubitemid 43213017)
18. Hollman P C. H., van Trijp J M. P., Buysman M N. C. P. Fluorescence detection of flavonols in HPLC by postcolumn chelation with aluminum. Anal Chem 1996 68 3511-3515
19. Rückert U, Eggenreich K, Wintersteiger R, Wurglics M, Likussar W, Michelitsch A. Development of a high-performance liquid chromatographic method with electrochemical detection for the determination of hyperforin. J Chromatogr A 2004 1041 181-185 (Pubitemid 38760223)
20. Keller J-H, Karas M, Müller W E., Volmer D A., Eckert G P., Tawab M A., Blume H H., Dingermann T, Schubert-Zsilavecz M. Determination of hyperforin in mouse brain by high-performance liquid chromatography/tandem mass spectrometry. Anal Chem 2003 75 6084-6088 (Pubitemid 37420598)
21. Kim H, Roh H, Lee H J., Chung S Y., Choi S O., Lee K R., Han S B. Determination of phloroglucinol in human plasma by high-performance liquid chromatography-mass spectrometry. J Chromatogr B Anal Technol Biomed Life Sci 2003 792 307-312 (Pubitemid 36830880)
22. Riedel K D., Rieger K, Martin-Facklam M, Mikus G, Haefeli W E., Burhenne J. Simultaneous determination of hypericin and hyperforin in human plasma with liquid chromatography-tandem mass spectrometry. J Chromatogr B Anal Technol Biomed Life Sci 2004 813 27-33 (Pubitemid 39535425)
23. Müller H, Paul M, Hartmann D, Huch V, Blaesius D, Koeberle A, Werz O, Jauch J. Total synthesis of myrtucommulone A. Angew Chem Int Ed 2010 49 2045-2049