Lys3-bombesin conjugated to 99mTc-labelled gold nanoparticles for in vivo gastrin releasing peptide-receptor imaging

Journal of Biomedical Nanotechnology

Volumn 6, Issue 4, 2010, Pages 375-384

  Mendoza Sánchez, Andrei N ^a,b   Ferro Flores, Guillermina ^a   Ocampo García, Blanca E ^a,b   Morales Avila, Enrique ^a,b   Ramírez, Flor De M ^a   De León Rodríguez, Luis M ^c   Santos Cuevas, Clara L ^a,b   Medina, Luis A ^d,e   Rojas Calderón, Eva L ^a   Camacho López, Marco A ^b  

^a INSTITUTO NACIONAL DE INVESTIGACIONES NUCLEARES   (Mexico)

^b UNIVERSIDAD AUTÓNOMA DEL ESTADO DE MÉXICO   (Mexico)

^c UNIVERSITY OF GUANAJUATO   (Mexico)

^d UNIVERSIDAD NACIONAL AUTÓNOMA DE MÉXICO   (Mexico)

^e INSTITUTO NACIONAL DE CANCEROLOGÍA   (Mexico)

Author keywords

99mTc gold nanoparticles; GRP receptor imaging; Lys3 bombesin; Radiolabelled gold nanoparticles

Indexed keywords

ATHYMIC MICE; BIODISTRIBUTIONS; CO-LIGANDS; FUNCTIONALIZED; GOLD NANOPARTICLES; GRP-RECEPTOR IMAGING; HIGH AFFINITY; HUMAN PROSTATE CANCER; IN-VITRO; IN-VIVO; LYMPH NODE METASTASIS; LYS3-BOMBESIN; MOLECULAR IMAGING; MULTIFUNCTIONAL SYSTEMS; N-TERMINALS; NANOCONJUGATES; PROSTATE CANCERS; RADIOCHEMICAL PURITY; RADIOLABELLED GOLD NANOPARTICLES; SIZE EXCLUSION; SPECIFIC RECOGNITION; SPECT/CT; SPONTANEOUS REACTIONS; TECHNETIUM-99M; TEM; THIOL GROUPS; TUMOURS;

AMINO ACIDS; CHROMATOGRAPHIC ANALYSIS; DISEASES; GOLD; NANOPARTICLES; ORGANIC POLYMERS; SIZE EXCLUSION CHROMATOGRAPHY; TECHNETIUM; TRANSMISSION ELECTRON MICROSCOPY; TUMORS; X RAY PHOTOELECTRON SPECTROSCOPY;

PEPTIDES;

AMINE; BOMBESIN DERIVATIVE; CYSTEINE; GASTRIN RELEASING PEPTIDE RECEPTOR; GLYCYLGLYCYLCYSTEINAMIDE; GOLD NANOPARTICLE; GOLD NANOPARTICLE TC 99M LYSINE3 BOMBESIN; HYDRAZINONICOTINAMIDE; LIGAND; LYSINE3 BOMBESIN; PEPTIDE; RADIOPHARMACEUTICAL AGENT; TECHNETIUM 99M; THIOL; THIOL DERIVATIVE; TIN CHLORIDE; TRICINE; UNCLASSIFIED DRUG; BOMBESIN RECEPTOR; DIAGNOSTIC AGENT; GOLD; METAL NANOPARTICLE; NANOCONJUGATE; TECHNETIUM; TECHNETIUM COMPLEX;

AMINO TERMINAL SEQUENCE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BINDING AFFINITY; CANCER CELL; CONJUGATION; CONTROLLED STUDY; DRUG TARGETING; DRUG UPTAKE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; INFRARED SPECTROSCOPY; ISOTOPE LABELING; MALE; MOLECULAR INTERACTION; MOUSE; NONHUMAN; RADIOCHROMATOGRAPHY; RAMAN SPECTROMETRY; SINGLE PHOTON EMISSION COMPUTER TOMOGRAPHY; TRANSMISSION ELECTRON MICROSCOPY; ULTRAVIOLET SPECTROSCOPY; X RAY PHOTOELECTRON SPECTROSCOPY; ANIMAL; CHEMICAL STRUCTURE; CHEMISTRY; INFRARED SPECTROPHOTOMETRY; NUDE MOUSE; PROSTATE TUMOR; SCINTISCANNING;

ANIMALS; GOLD; MALE; METAL NANOPARTICLES; MICE; MICE, NUDE; MICROSCOPY, ELECTRON, TRANSMISSION; MOLECULAR STRUCTURE; NANOCONJUGATES; ORGANOTECHNETIUM COMPOUNDS; PROSTATIC NEOPLASMS; RADIONUCLIDE IMAGING; RADIOPHARMACEUTICALS; RECEPTORS, BOMBESIN; SPECTROPHOTOMETRY, INFRARED; TECHNETIUM;

EID: 79952997110     PISSN: 15507033     EISSN: 15507041     Source Type: Journal    
DOI: 10.1166/jbn.2010.1132     Document Type: Article

References (32)

1. J. C. Reubi, Peptide receptors as molecular targets for cancer diagnosis and therapy. Endocrine Rev. 24, 389 (2003).
2. K. E. Baidoo, K. S. Lin, Y. Zhan, P. Finley, U. Scheffel, and H. N. Wagner, Design, synthesis, and initial evaluation of high-affinity technetium bombesin analogues. Bioconjug. Chem. 9, 218 (1998).
3. 3]-Bombesin for imaging of GRP receptor-positive tumours. Nucl. Med. Comm. 27, 371 (2006).
4. C. L. Santos-Cuevas, G. Ferro-Flores, C. A. Arteaga de Murphy, F. de M. Ramírez, M. A. Luna-Gutierrez, M. Pedraza-López, R. García-Becerra, and D. Ordaz-Rosado, Design, preparation, in vitro and in vivo evaluation of 99mTc-N2S2-Tat(49-57)-bombesin: A target-specific hybrid radiopharmaceutical. Int. J. Pharm. 375, 75 (2009).
5. 3]-bombesin: Biokinetics and dosimetry in women. Nucl. Med. Commun. 29, 741 (2008).
6. R. Bhattacharya and P. Mukherjee, Biological properties of "naked" metal nanoparticles. Adv. Drug Deliv. Rev. 60, 1289 (2008).
7. M. J. Kogan, I. Olmedo, L. Hosta, A. R. Guerrero, L. J. Cruz, and F. Albericio, Peptides and metallic nanoparticles for biomedical applications. Nanomedicine 2, 287 (2007).
8. E. E. Connor, J. Mwamuka, A. Gole, C. J. Murphy, and M. D. Wyatt, Gold nanoparticles are taken up by human cells but do not cause acute cytotoxicity. Small 1, 325 (2005).
9. C. M. Goodman, C. D. McCusker, T. Yilmaz, and V. M. Rotello, Toxicity of gold nanoparticles functionalized with cationic and anionic side chains. Bioconjugate Chem. 15, 897 (2004).
10. J. M. De la Fuente and C. C. Berry, Tat peptide as an efficient molecule to translocate gold nanoparticles into the cell nucleus. Bioconjugate Chem. 16, 1176 (2005).
11. Z. Wang, R. Levy, D. G. Femig, and M. Brust, The peptide route to multifunctional gold nanoparticles. Bioconjugate Chem. 16, 497 (2005).
12. 2 can modify the conjugation and stability of gold nanoparticles and their affinity for beta-amyloid fibrils. Bioconjugate Chem. 19, 1154 (2008).
13. Y. Liu, M. K. Shipton, J. Ryan, E. D. Kaufman, S. Franzen, and D. L. Feldheim, Synthesis, stability, and cellular internalization of gold nanoparticles containing mixed peptide-poly(ethylene glycol) monolayers. Anal. Chem. 79, 2221 (2007).
14. 3] octreotide peptide. Biophys. Chem. 138, 83 (2008).
15. F. Porta, G. Speranza, Z. Krpetic, V. D. Santo, P. Francescato, and G. Scari, Gold nanoparticles capped by peptides. Mater. Sci. Eng. B 140, 187 (2007).
16. R. Levy, N. T. K. Thanh, R. C. Doty, I. Hussain, R. J. Nichols, and D. J. Schiffrin, Rational and combinatorial design of peptide capping ligands for gold nanoparticles. J. Am. Chem. Soc. 126, 10076 (2004).
17. P. D. Jadzinsky, G. Calero, C. J. Ackerson, D. A. Bushnell, and R. D. Komberg, Structure of a thiol monolayer-protected gold nanoparticle at 1.1 A resolution. Science 318, 430 (2007).
18. 111In-octreotide. J. Nucl. Med. 41, 1114 (2000).
19. 99mTc-labelling and in vitro and in vivo evaluation of HYNIC- and (N alpha-His)acetic acid-modified [D-Glu1]-minigastrin. Bioconjugate Chem. 15, 864 (2004).
20. 3 expression. Nucl. Med. Biol. 33, 945 (2006).
21. A. D. Miranda-Olvera, G. Ferro-Flores, M. Pedraza-Lopez, C. Arteaga de Murphy, and L. M. Leon-Rodriguez, Synthesis of oxytocin HYNIC derivatives as potential diagnostic agents for breast cancer. Bioconjugate Chem. 18, 1560 (2007).
22. 99mTc-labelled gold nanoparticles capped with HYNIC-peptide/mannose for sentinel lymph node detection. Nucl. Med. Biol. doi:10.1016/j.nucmedbio.2010.07.007 (2010).
23. G. Socrates, Infrared and Raman Characteristic Group Frequencies, Tables and Charts, John Wiley and Sons, England (2005).
24. I. Razmute-Razme, Z. Kuodis, O. Eicher-Iorka, and G. Niaura, In-situ surface-enhanced Raman spectroscopic investigation of NH site of índole ring-terminated self-assembled monolayer on gold electrode. Chemija 18, 16 (2007).
25. E. Podstawka and Y. Ozaki, Surface-enhanced Raman difference between bombesin and its modified analogues on the colloidal and electrochemically roughen silver surface. Biopolymers 89, 807 (2008).
26. B. D. Chithrani, A. A. Ghazani, and W. C. W. Chan, Determining the size and shape dependence of gold nanoparticle uptake into mammalian cells. Nano Lett. 6, 662 (2006).
27. X. Montet, H. Yuan, R. Weissleder, and L. Josephson, Enzyme-based visualization of receptor-ligand binding in tissues. Lab. Invest. 86, 517 (2006).
28. N. Chanda, V. Kattumuri, R. Shukla, A. Zambre, K. Katti, and A. Upendran, Bombesin functionalized gold nanoparticles show in vitro and in vivo cancer receptor specificity. Proc. Natl. Acad. Sci. USA 107, 8760 (2010).
29. M. Gugger and C. Reubi, Gastrin-releasing peptide receptors in non-neoplastic and neoplastic human breast. Am. J. Pathol. 155, 2067 (1999).
30. E. Sadauskas, H. Wallin, M. Stoltenberg, U. Vogel, P. Doering, A. Larsen, and G. Danscher, Kupffer cells are central in the removal of nanoparticles from the organism. Part. Fibre Toxicol. 4, 1 (2007).
31. S. Kim, Y. T. Lim, E. G. Soltesz, A. M. De Grand, J. Lee, and A. Nakayama, Near-infrared fluorescent type II quantum dots for sentinel lymph node mapping. Nat. Biotechnol. 22, 93 (2004).
32. K. H. Song, C. Kim, C. M. Cobley, Y. Xia, and L. V. Wang, Near-infrared gold nanocages as a new class of tracers for photoacustic sentinel lymph node mapping on a rat model. Nano Lett. 9, 183 (2009).