Contraceptive efficacy of a combined oral contraceptive containing ethinyloestradiol 20 μg/drospirenone 3 mg administered in a 24/4 regimen: A pooled analysis of four open-label studies

European Journal of Obstetrics and Gynecology and Reproductive Biology

Volumn 155, Issue 2, 2011, Pages 180-182

  Anttila, Leena ^a   Bachmann, Gloria ^b   Hernádi, László ^c   Kunz, Michael ^d   Marr, Joachim ^d   Klipping, Christine ^e  

^a Family Federation of Finland   (Finland)

^b ROBERT WOOD JOHNSON MEDICAL SCHOOL   (United States)

^c Department of Obstetrics and Gynaecology   (Hungary)

^d BAYER PHARMA AG   (Germany)

^e Dinox BV   (Netherlands)

Author keywords

Combined oral contraceptive; Drospirenone; Ethinyloestradiol; Pearl Index

Indexed keywords

DROSPIRENONE PLUS ETHINYLESTRADIOL;

ADOLESCENT; ADULT; ARTICLE; DRUG EFFICACY; FEMALE; HUMAN; HUMAN EXPERIMENT; LOW DRUG DOSE; MAJOR CLINICAL STUDY; MULTIPLE CYCLE TREATMENT; NORMAL HUMAN; OPEN STUDY; ORAL CONTRACEPTION; PATIENT COMPLIANCE; PREGNANCY; PREGNANCY OUTCOME; PREGNANCY RATE; PRIORITY JOURNAL; TREATMENT DURATION; TREATMENT RESPONSE;

EID: 79952990243     PISSN: 03012115     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejogrb.2010.12.037     Document Type: Article

References (20)

1. G. Bachmann, P.J. Sulak, C. Sampson-Landers, N. Benda, and J. Marr Efficacy and safety of a low-dose 24-day combined oral contraceptive containing 20 micrograms ethinylestradiol and 3 mg drospirenone Contraception 70 3 2004 191 198 (Pubitemid 39119980)
2. L. Hernádi, J. Marr, V. De Leo, and F. Petraglia Efficacy and safety of a low-dose combined oral contraceptive containing drospirenone 3 mg and ethinylestradiol 20 mcg in a 24/4-day regimen Contraception 80 1 2009 18 24
3. L. Anttila, M. Kunz, and J. Marr Bleeding pattern with drospirenone 3 mg + ethinyl estradiol 20 mcg 24/4 combined oral contraceptive compared with desogestrel 150 mcg + ethinyl estradiol 20 mcg 21/7 combined oral contraceptive Contraception 80 5 2009 445 451
4. D.M. Gruber, J.C. Huber, G.B. Melis, C. Stagg, S. Parke, and J. Marr A comparison of the cycle control, safety, and efficacy profile of a 21-day regimen of ethinylestradiol 20 mug and drospirenone 3 mg with a 21-day regimen of ethinylestradiol 20 mug and desogestrel 150 mug Treat Endocrinol 5 2 2006 115 121
5. C. Klipping, and J. Marr Effects of two combined oral contraceptives containing ethinyl estradiol 20 microg combined with either drospirenone or desogestrel on lipids, hemostatic parameters and carbohydrate metabolism Contraception 71 6 2005 409 416 (Pubitemid 40725775)
6. K.A. Yonkers, C. Brown, T.B. Pearlstein, M. Foegh, C. Sampson-Landers, and A. Rapkin Efficacy of a new low-dose oral contraceptive with drospirenone in premenstrual dysphoric disorder Obstet Gynecol 106 3 2005 492 501 (Pubitemid 41208780)
7. T.B. Pearlstein, G.A. Bachmann, H.A. Zacur, and K.A. Yonkers Treatment of premenstrual dysphoric disorder with a new drospirenone-containing oral contraceptive formulation Contraception 72 6 2005 414 421 (Pubitemid 41676830)
8. J.M. Maloney, S. Lee-Rugh, M. Kunz, C. Sampson-Landers, and P. Korner Drospirenone 3 mg/ethinylestradiol 20 mcg in the treatment of Acne vulgaris: patient self-assessment Obstet Gynecol 109 4 Suppl. 2007 102S
9. J.M. Maloney, M. Kunz, S. Lee-Rugh, C. Sampson-Landers, and P. Korner Drospirenone 3 mg/ethinylestradiol 20 mcg combined oral contraceptive in the treatment of acne vulgaris: lesion count, ISGA Obstet Gynecol 109 4 Suppl. 2007 11S
10. C. Gerlinger, J. Endrikat, E.A. van der Meulen, T.O. Dieben, and B. Dusterberg Recommendation for confidence interval and sample size calculation for the Pearl Index Eur J Contracept Reprod Health Care 8 2 2003 87 92 (Pubitemid 36791750)
11. P.J. Boerrigter, H. Ellman, and M. Dolker International clinical experience with a new low-dose, monophasic oral contraceptive containing levonorgestrel 100 microg and ethinyl estradiol 20 microg Clin Ther 21 1 1999 118 127 (Pubitemid 29106694)
12. R.C. Hite, R. Bannemerschult, P. Fox-Kuchenbecker, R. Turck, and K. Brill Large observational trial of a new low-dose oral contraceptive containing 20 micrograms ethinylestradiol and 100 micrograms levonorgestrel (Miranova) in Germany Eur J Contracept Reprod Health Care 4 1 1999 7 13 (Pubitemid 29268480)
13. B. Dusterberg, H. Ellman, U. Muller, E. Rowe, and B. Muhe A three-year clinical investigation into efficacy, cycle control and tolerability of a new low-dose monophasic oral contraceptive containing gestodene Gynecol Endocrinol 10 1 1996 33 39
14. D.F. Archer, R. Maheux, A. DelConte, and F.B. O'Brien Efficacy and safety of a low-dose monophasic combination oral contraceptive containing 100 microg levonorgestrel and 20 microg ethinyl estradiol (Alesse). North American Levonorgestrel Study Group (NALSG) Am J Obstet Gynecol 181 5 Pt 2 1999 39 44
15. An open-label, multicenter, noncomparative safety and efficacy study of Mircette, a low-dose estrogen-progestin oral contraceptive. The Mircette Study Group Am J Obstet Gynecol 179 1 1998 S2 8
16. J. Spona, M. Elstein, and W. Feichtinger Shorter pill-free interval in combined oral contraceptives decreases follicular development Contraception 54 2 1996 71 77 (Pubitemid 26256707)
17. S.A. Willis, T.J. Kuehl, A.M. Spiekerman, and P.J. Sulak Greater inhibition of the pituitary-ovarian axis in oral contraceptive regimens with a shortened hormone-free interval Contraception 74 2 2006 100 103 (Pubitemid 44062466)
18. H. Sullivan, H. Furniss, J. Spona, and M. Elstein Effect of 21-day and 24-day oral contraceptive regimens containing gestodene (60 microg) and ethinyl estradiol (15 microg) on ovarian activity Fertil Steril 72 1 1999 115 120 (Pubitemid 29300271)
19. C. Klipping, I. Duijkers, D. Trummer, and J. Marr Suppression of ovarian activity with a drospirenone-containing oral contraceptive in a 24/4 regimen Contraception 78 1 2008 16 25
20. J.C. Dinger, A. Assmann, and C. Westhoff Contraceptive effectiveness of oral contraceptives: the impact of a 24-day regimen Abstract Plus Oral Presentation at the 57th Annual Clinical Meeting of the American College of Obstetricians & Gynecologists May 2-6, Chicago, IL, USA 2009