Significance of dysadherin and E-cadherin expression in differentiated-type gastric carcinoma with submucosal invasion

Human Pathology

Volumn 42, Issue 4, 2011, Pages 558-567

  Maehata, Yoshitomo ^a   Hirahashi, Minako ^a   Aishima, Shinichi ^a   Kishimoto, Junji ^a   Hirohashi, Setsuo ^b   Yao, Takashi ^c   Takashima, Hiroshi ^d   Tsuneyoshi, Masazumi ^a   Oda, Yoshinao ^a  

^a KYUSHU UNIVERSITY   (Japan)

^b NATIONAL CANCER CENTER RESEARCH INSTITUTE   (Japan)

^c JUNTENDO UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^d KAGOSHIMA UNIVERSITY   (Japan)

Author keywords

Differentiated type; Dysadherin; E cadherin; Gastric carcinoma; Submucosal invasion

Indexed keywords

DYSADHERIN; UVOMORULIN;

ADULT; AGED; ARTICLE; CANCER INVASION; CELL DIFFERENTIATION; FEMALE; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; INFORMATION; LYMPH NODE METASTASIS; MAJOR CLINICAL STUDY; MALE; METASTASIS; PROTEIN EXPRESSION; STOMACH CARCINOMA; SUBMUCOSA;

AGED; CADHERINS; CARCINOMA; CELL DIFFERENTIATION; FEMALE; GASTRIC MUCOSA; HUMANS; IMMUNOHISTOCHEMISTRY; MALE; MEMBRANE GLYCOPROTEINS; NEOPLASM METASTASIS; NEOPLASM PROTEINS; STOMACH NEOPLASMS; TUMOR MARKERS, BIOLOGICAL;

EID: 79952987885     PISSN: 00468177     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.humpath.2010.08.016     Document Type: Article

References (35)

1. Lauren P. The two histological main types of gastric carcinoma: diffuse and so-called intestinal-type carcinoma. An attempt at a histo-clinical classification Acta Pathol Microbiol Scand 64 1965 31 49
2. Nakamura K., Sugano H., and Takagi K. Carcinoma of the stomach in incipient phase: its histogenesis and histological appearances Gann 59 1968 251 258
3. Ikeda Y., Mori M., and Kamakura T. Increased incidence of undifferentiated type of gastric cancer with tumor progression in 912 patients with early gastric cancer and 1245 with advanced gastric cancer Cancer 73 1994 2459 2463 (Pubitemid 24155519)
4. Ohkura Y. Histological diversity of early gastric carcinoma M. Kaminishi, The diversity of gastric carcinoma: pathogenesis, diagnosis, and therapy 2005 Springer-Verlag Press Tokyo, Japan 117 125
5. Oya M., Yao T., and Nagai E. Metastasizing intramucosal gastric carcinomas. Well differentiated type and proliferative activity using proliferative cell nuclear antigen and Ki-67 Cancer 75 1995 926 935
6. Mita T., and Shimoda T. Risk factors for lymph node metastasis of submucosal invasive differentiated type gastric carcinoma: clinical significance of histological heterogeneity J Gastroenterol 36 2001 661 668 (Pubitemid 33040938)
7. Nishida T., Tanaka S., and Haruma K. Histologic grade and cellular proliferation at the deepest invasive portion correlate with the high malignancy of submucosal invasive gastric carcinoma Oncology 52 1995 340 346
8. Zheng H.C., Li X.H., and Hara T. Mixed-type gastric carcinomas exhibit more aggressive features and indicate the histogenesis of carcinomas Virchows Arch 452 2008 525 534
9. Takeichi M. Cadherin cell adhesion receptors as a morphogenetic regulator Science 251 1991 1451 1455 (Pubitemid 121000430)
10. Takeichi M. Cadherins in cancer: implications for invasion and metastasis Curr Opin Cell Biol 5 1993 806 811
11. Shiozaki H., Oka H., and Inoue M. E-cadherin mediated adhesion system in cancer cells Cancer 77 1996 1605 1613 (Pubitemid 26111841)
12. Hirohashi S., and Kanai Y. Cell adhesion system and human cancer morphogenesis Cancer Sci 94 2003 575 581 (Pubitemid 36975010)
13. Ghadimi B.M., Behrens J., and Hoffmann I. Immunohistological analysis of E-cadherin, alpha-, beta- and gamma-catenin expression in colorectal cancer: implications for cell adhesion and signaling Eur J Cancer 35 1999 60 65 (Pubitemid 29079492)
14. Pignatelli M., Ansari T.W., and Gunter P. Loss of membranous E-cadherin expression in pancreatic cancer: correlation with lymph node metastasis, high grade, and advanced stage J Pathol 174 1994 243 248
15. Oka H., Shiozaki H., and Kobayashi K. Expression of E-cadherin cell adhesion molecules in human breast cancer tissues and its relationship to metastasis Cancer Res 53 1993 1696 1701 (Pubitemid 23113254)
16. Umbas R., Isaacs W.B., and Bringuier P.P. Relation between aberrant alpha-catenin expression and loss of E-cadherin function in prostate cancer Int J Cancer 74 1997 374 377 (Pubitemid 27400154)
17. Hirohashi S. Inactivation of the E-cadherin-mediated cell adhesion system in human cancers Am J Pathol 153 1998 333 339 (Pubitemid 28373643)
18. Ino Y., Gotoh M., and Sakamoto M. Dysadherin, a cancer-associated cell membrane glycoprotein, down-regulates E-cadherin and promotes metastasis Proc Natl Acad Sci U S A 99 2002 365 370 (Pubitemid 34060368)
19. Aoki S., Shimamura T., and Shibata T. Prognostic significance of dysadherin expression in advanced colorectal carcinoma Br J Cancer 88 2003 726 732 (Pubitemid 36411452)
20. Shimada Y., Yamasaki S., and Hashimoto Y. Clinical significance of dysadherin expression in gastric cancer patients Clin Cancer Res 10 2004 2818 2823 (Pubitemid 38509161)
21. Shimamura T., Sakamoto M., and Ino Y. Dysadherin overexpression in pancreatic ductal adenocarcinoma reflects tumor aggressiveness: relationship to E-cadherin expression J Clin Oncol 21 2003 659 667 (Pubitemid 46621900)
22. Kyzas P.A., Stefanou D., and Batistatou A. Dysadherin expression in head and neck squamous cell carcinoma: association with lymphangiogenesis and prognostic significance Am J Surg Pathol 30 2006 185 193 (Pubitemid 43740187)
23. Sato H., Ino Y., and Miura A. Dysadherin: expression and clinical significance in thyroid carcinoma J Clin Endocrinol Metab 88 2003 4407 4412 (Pubitemid 37153750)
24. Nakanishi Y., Akimoto S., and Sato Y. Prognostic significance of dysadherin expression in tongue cancer: immunohistochemical analysis of 91 cases Appl Immunohistochem Mol Morphol 12 2004 323 328 (Pubitemid 39602071)
25. Shimamura T., Yasuda J., and Ino Y. Dysadherin expression facilitates cell motility and metastatic potential of human pancreatic cancer cells Cancer Res 64 2004 6989 6995 (Pubitemid 39331008)
26. Batistatou A., Charalabopoulos A.K., and Scopa C.D. Expression patterns of dysadherin and E-cadherin in lymph node metastases of colorectal carcinoma Virchows Arch 448 2006 763 767 (Pubitemid 43824433)
27. Japanese Gastric Cancer Association Japanese classification of gastric carcinoma, 2nd English edition Gastric Cancer 1 1998 10 24
28. Japanese Gastric Cancer Association Japanese classification of gastric carcinoma, 13th edition (in Japanese) 1999 Kanehara Press Tokyo, Japan
29. Shino Y., Watanabe A., and Yamada Y. Clinicopathologic evaluation of immunohistochemical E-cadherin expression in human gastric carcinomas Cancer 76 1995 2193 2201
30. Mayer B., Johnson J.P., and Leitl F. E-cadherin expression in primary and metastatic gastric cancer: down-regulation correlates with cellular dedifferentiation and glandular disintegration Cancer Res 53 1993 1690 1695 (Pubitemid 23113253)
31. Blok P., Craanen M.E., and Dekker W. Loss of E-cadherin expression in early gastric cancer Histopathology 34 1999 410 415 (Pubitemid 29244165)
32. Yonemura Y., Ninomiya I., and Kaji M. Decreased E-cadherin expression correlates with poor survival in patients with gastric cancer Anal Cell Pathol 8 1995 177 190
33. Isozaki H., Okajima K., and Ichinona T. Significance of proliferating cell nuclear antigen (PCNA) expression in gastric cancer in relation to lymph node metastasis J Surg Oncol 61 1996 106 110 (Pubitemid 26066070)
34. Ikeguchi M., Makino M., and Kaibara N. Clinical significance of E-cadherin-catenin complex expression in metastatic foci of colorectal carcinoma J Surg Oncol 77 2001 201 207 (Pubitemid 32645776)
35. Oka H., Shiozaki H., and Kobayashi K. Immunohistochemical evaluation of E-cadherin adhesion molecule expression in human gastric cancer Virchows Arch A Pathol Anat Histopathol 421 1992 149 156