Decreased galanin serum levels are associated with alcohol-craving during withdrawal

Progress in Neuro-Psychopharmacology and Biological Psychiatry

Volumn 35, Issue 2, 2011, Pages 568-572

  Heberlein, Annemarie ^a,b   Muschler, Marc ^a   Frieling, Helge ^a,b   Lenz, Bernd ^b   Wilhelm, Julia ^a,b   Gröschl, Michael ^b   Kornhuber, Johannes ^b   Bleich, Stefan ^a,b   Hillemacher, Thomas ^a,b  

^a HANNOVER MEDICAL SCHOOL   (Germany)

^b UNIVERSITY HOSPITAL ERLANGEN   (Germany)

Author keywords

Alcohol craving; Alcohol dependence; Alcohol withdrawal; Galanin; Neurotrophic growth factors

Indexed keywords

CLOMETHIAZOLE; GALANIN; GLUCOSE; INSULIN; OXCARBAZEPINE; TRIACYLGLYCEROL;

ADULT; ALCOHOL CONSUMPTION; ALCOHOL WITHDRAWAL; ALCOHOLISM; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; DISEASE ASSOCIATION; FOOD INTAKE; GLUCOSE BLOOD LEVEL; HOMEOSTASIS; HUMAN; INSULIN BLOOD LEVEL; MALE; PILOT STUDY; PROTEIN BLOOD LEVEL; PSYCHOMETRY; QUESTIONNAIRE; TRIACYLGLYCEROL BLOOD LEVEL; WITHDRAWAL SYNDROME;

ALCOHOLISM; BEHAVIOR, ADDICTIVE; BLOOD GLUCOSE; BLOOD PRESSURE; BODY TEMPERATURE; CHOLESTEROL; ETHANOL; GALANIN; HEART RATE; HUMANS; HYPOTHALAMUS; INSULIN; MALE; PILOT PROJECTS; PSYCHOMETRICS; SUBSTANCE WITHDRAWAL SYNDROME; TRIGLYCERIDES;

EID: 79952984553     PISSN: 02785846     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.pnpbp.2010.12.021     Document Type: Article

References (33)

1. Anton R.F., Moak D.H., Latham P. The Obsessive Compulsive Drinking Scale: a self-rated instrument for the quantification of thoughts about alcohol and drinking behavior. Alcohol Clin Exp Res 1995, 19:92-99.
2. Balint A., Feher E., Kisfalvi I., Mate M., Zelles T., Vizi E.S., et al. Functional and immunocytochemical evidence that galanin is a physiological regulator of human jejunal motility. J Physiol Paris 2001, 95:129-135.
3. Baranowska B., Wasilewska-Dziubinska E., Radzikowska M., Plonowski A., Roguski K. Neuropeptide Y, galanin, and leptin release in obese women and in women with anorexia nervosa. Metabolism 1997, 46:1384-1389.
4. Beck A.T., W.C.H., Mendelson M., Mock J., Erbaugh J. An inventory for measuring depression. Arch Gen Psychiatry 1961, 4:561-571.
5. Belfer I., Hipp H., McKnight C., Evans C., Buzas B., Bollettino A., et al. Association of galanin haplotypes with alcoholism and anxiety in two ethnically distinct populations. Mol Psychiatry 2006, 11:301-311.
6. Belfer I., Hipp H., Bollettino A., McKnight C., Evans C., Virkkunen M., et al. Alcoholism is associated with GALR3 but not two other galanin receptor genes. Genes Brain Behav 2007, 6:473-481.
7. Brodish R.J., Kuvshinoff B.W., Fink A.S., McFadden D.W. Inhibition of pancreatic exocrine secretion by galanin. Pancreas 1994, 9:297-303.
8. Heberlein A., Muschler M.A., Lenz B., Frieling H., Büchl C., Gröschl M., et al. Serum levels of vascular endothelial growth factor A increase during alcohol withdrawal. Addict Biol 2010, 15:362-364.
9. Hökfelt T., Tatemoto K. Galanin in ascending systems: focus on co-existence with 5-hydroxytryptamine and noradrenaline. Cell Mol Life Sci 2008, 65:1793-1795.
10. John U., Hapke U., Rumpf H.J. A new measure of the alcohol dependence syndrome: the severity scale of alcohol dependence. Eur Addict Res 2003, 9:87-93.
11. Kisfalvi I., Burghardt B., Balint A., Zelles T., Vizi E.S., Varga G. Antisecretory effects of galanin and its putative antagonists M15, M35 and C7 in the rat stomach. J Physiol Paris 2000, 94:37-42.
12. Kyrkouli S.E., Stanley B.G., Seirafi R.D., Leibowitz S.F. Stimulation of feeding by galanin: anatomical localization and behavioral specificity of this peptide's effects in the brain. Peptides 1990, 11:995-1001.
13. Leibowitz S.F. Differential functions of hypothalamic galanin cell grows in the regulation of eating and body weight. Ann NY Acad Sci 1998, 863:206-220.
14. Leibowitz S.F. Overconsumption of dietary fat and alcohol: mechanisms involving lipids and hypothalamic peptides. Physiol Behav 2007, 91:513-521.
15. Leibowitz S.F., Avena N.M., Chang G.Q., Karatayev O., Chau D.T., Hoebel B.G. Ethanol intake increases galanin mRNA in the hypothalamus and withdrawal decreases it. Physiol Behav 2003, 79:103-111.
16. Leibowitz S.F., Akabayashi A., Wang J., Alexander J.T., Dourmashkin J.T., Chang G.Q. Increased caloric intake on a fat-rich diet: role of ovarian steroids and galanin in the medial preoptic and paraventricular nuclei and anterior pituitary of female rats. J Neuroendocrinol 2007, 19:753-766.
17. Lewis M.J., Johnson D.F., Waldman D., Leibowitz S.F., Hoebel B.G. Galanin microinjection in the third ventricle increases voluntary ethanol intake. Alcohol Clin Exp Res 2004, 28:1822-1828.
18. Martinotti G., Romanelli R., Di Nicola M., Reina D., Mazza M., Janiri L. Oxcarbazepine at high dosages for the treatment of alcohol dependence. Am J Addict 2007, 16:247-248.
19. Mayfield D., McLeod G., Hall P. The CAGE questionnaire: validation of a new alcoholism screening instrument. Am J Psychiatry 1974, 131:1121-1123.
20. Ögren S.O., Kuteeva E., Elvander-Tottie E., Hokfelt T. Neuropeptides in learning and memory processes with focus on galanin. Eur J Pharmacol 2010, 626:9-17.
21. Pierce R.C., Kumaresan V. The mesolimbic dopamine system: the final common pathway for the reinforcing effect of drugs of abuse?. Neurosci Biobehav Rev 2006, 30:215-238.
22. Plaisier C.L., Kyttala M., Weissglas-Volkov D., Sinsheimer J.S., Huertas-Vazquez A., Riba L., et al. Galanin preproprotein is associated with elevated plasma triglycerides. Arterioscler Thromb Vasc Biol 2009, 29:147-152.
23. Poritsanos N.J., Mizuno T.M., Lautatzis M.E., Vrontakis M. Chronic increase of circulating galanin levels induces obesity and marked alterations in lipid metabolism similar to metabolic syndrome. Int J Obes (Lond) 2009, 33:1381-1389.
24. Rada P., Avena N.M., Leibowitz S.F., Hoebel B.G. Ethanol intake is increased by injection of galanin in the paraventricular nucleus and reduced by a galanin antagonist. Alcohol 2004, 33:91-97.
25. Robinson J.K., Brewer A. Galanin: a potential role in mesolimbic dopamine-mediated instrumental behavior. Neurosci Biobehav Rev 2008, 32:1485-1493.
26. Saunders J.B., Aasland O.G., Babor T.F., de la Fuente J.R., Grant M. Development of the Alcohol Use Disorders Identification Test (AUDIT): WHO collaborative project on early detection of persons with harmful alcohol consumption-II. Addiction 1993, 88:791-804.
27. Sevcik J., Finta E.P., Illes P. Galanin receptors inhibit the spontaneous firing of locus coeruleus neurones and interact with mu-opioid receptors. Eur J Pharmacol 1993, 230:223-230.
28. Spielberger C.D., Gorusch R.L., Lushene R.E. STAI manual 1970, Consulting Psychologists Press, Inc.
29. Sullivan J.T., Sykora K., Schneiderman J., Naranjo C.A., Sellers E.M. Assessment of alcohol withdrawal: the revised clinical institute withdrawal assessment for alcohol scale (CIWA-Ar). Br J Addict 1989, 84:1353-1357.
30. Tang C., Akabayashi A., Manitiu A., Leibowitz S.F. Hypothalamic galanin gene expression and peptide levels in relation to circulating insulin: possible role in energy balance. Neuroendocrinology 1997, 65:265-275.
31. Tsuda K., Tsuda S., Nishio I., Masuyama Y., Goldstein M. Effects of galanin on dopamine release in the central nervous system of normotensive and spontaneously hypertensive rats. Am J Hypertens 1998, 11:1475-1479.
32. Verheul R., van den Brink W., Geerlings P. A three-pathway psychobiological model of craving for alcohol. Alcohol Alcohol 1999, 34:197-222.
33. Wang J., Leibowitz K.L. Central insulin inhibits hypothalamic galanin and neuropeptide Y gene expression and peptide release in intact rats. Brain Res 1997, 777:231-236.