Implication of Snail in metabolic stress-induced necrosis

PLoS ONE

Volumn 6, Issue 3, 2011, Pages

  Kim, Cho Hee ^a,d   Jeon, Hyun Min ^a   Lee, Su Yeon ^a   Ju, Min Kyung ^a   Moon, Ji Young ^a   Park, Hye Gyeong ^a   Yoo, Mi Ae ^a   Choi, Byung Tae ^a   Yook, Jong In ^b   Lim, Sung Chul ^c   Han, Song Iy ^c   Kang, Ho Sung ^a  

^a Pusan National University   (South Korea)

^b Yonsei University College of Dentistry   (South Korea)

^c Chosun University   (South Korea)

^d National Forensic Service   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

COPPER ZINC SUPEROXIDE DISMUTASE; MANGANESE SUPEROXIDE DISMUTASE; REACTIVE OXYGEN METABOLITE; SHORT HAIRPIN RNA; TRANSCRIPTION FACTOR SNAIL; CARRIER PROTEIN; GLUCOSE; MITOCHONDRIAL PERMEABILITY TRANSITION PORE; SMALL INTERFERING RNA; SNAIL FAMILY TRANSCRIPTION FACTORS; TRANSCRIPTION FACTOR;

ARTICLE; CELL CULTURE; CELL DEATH; CONTROLLED STUDY; DOWN REGULATION; EPITHELIAL MESENCHYMAL TRANSITION; EXPRESSION VECTOR; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; IN VITRO STUDY; METABOLIC STRESS; MITOCHONDRIAL MEMBRANE POTENTIAL; MITOCHONDRIAL PERMEABILITY; NUCLEOTIDE SEQUENCE; TRANSCRIPTION REGULATION; TUMOR GROWTH; TUMOR SPHEROID; UPREGULATION; CELL HYPOXIA; IMMUNOHISTOCHEMISTRY; METABOLISM; MITOCHONDRION; MULTICELLULAR SPHEROID; NECROSIS; PATHOLOGY; PHYSIOLOGICAL STRESS; TUMOR CELL CULTURE; ULTRASTRUCTURE;

GASTROPODA;

CELL HYPOXIA; GLUCOSE; HUMANS; IMMUNOHISTOCHEMISTRY; MEMBRANE POTENTIAL, MITOCHONDRIAL; MITOCHONDRIA; MITOCHONDRIAL MEMBRANE TRANSPORT PROTEINS; NECROSIS; REACTIVE OXYGEN SPECIES; RNA, SMALL INTERFERING; SPHEROIDS, CELLULAR; STRESS, PHYSIOLOGICAL; TRANSCRIPTION FACTORS; TUMOR CELLS, CULTURED;

EID: 79952976450     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0018000     Document Type: Article

References (64)

1. Vakkila J, Lotze MT, (2004) Inflammation and necrosis promote tumour growth. Nat Rev Immunol 4: 641-648.
2. Jin S, White E, (2007) Role of autophagy in cancer: management of metabolic stress. Autophagy 3: 28-31.
3. Degenhardt K, Mathew R, Beaudoin B, Bray K, Anderson D, et al. (2006) Autophagy promotes tumor cell survival and restricts necrosis, inflammation, and tumorigenesis. Cancer Cell 10: 51-64.
4. Lotze MT, Tracey KJ, (2005) High-mobility group box 1 protein (HMGB1): nuclear weapon in the immune arsenal. Nat Rev Immunol 5: 331-342.
5. Schlueter C, Weber H, Meyer B, Rogalla P, Roser K, et al. (2005) Angiogenetic signaling through hypoxia: HMGB1: an angiogenetic switch molecule. Am J Pathol 166: 1259-1263.
6. Taguchi A, Blood DC, del Toro G, Canet A, Lee DC, et al. (2000) Blockade of RAGE-amphoterin signalling suppresses tumour growth and metastases. Nature 405: 354-360.
7. Gatenby RA, Gillies RJ, (2004) Why do cancers have high aerobic glycolysis? Nat Rev Cancer 4: 891-899.
8. Jin S, DiPaola RS, Mathew R, White E, (2007) Metabolic catastrophe as a means to cancer cell death. J Cell Sci 120: 379-383.
9. Tomes L, Emberley E, Niu Y, Troup S, Pastorek J, et al. (2003) Necrosis and hypoxia in invasive breast carcinoma. Breast Cancer Res Treat 81: 61-69.
10. Hippert MM, O'Toole PS, Thorburn A, (2006) Autophagy in cancer: good, bad, or both? Cancer Res 66: 9349-9351.
11. Shintani T, Klionsky DJ, (2004) Autophagy in health and disease: a double-edged sword. Science 306: 990-995.
12. Zong WX, Thompson CB, (2006) Necrotic death as a cell fate. Genes Dev 20: 1-15.
13. Cheville JC, Lohse CM, Zincke H, Weaver AL, Blute ML, (2003) Comparisons of outcome and prognostic features among histologic subtypes of renal cell carcinoma. Am J Surg Pathol 27: 612-624.
14. Choi YR, Kim H, Kang HJ, Kim NG, Kim JJ, et al. (2003) Overexpression of high mobility group box 1 in gastrointestinal stromal tumors with KIT mutation. Cancer Res 63: 2188-2193.
15. Ishiguro H, Nakaigawa N, Miyoshi Y, Fujinami K, Kubota Y, et al. (2005) Receptor for advanced glycation end products (RAGE) and its ligand, amphoterin are overexpressed and associated with prostate cancer development. Prostate 64: 92-100.
16. Golstein P, Kroemer G, (2007) Cell death by necrosis: towards a molecular definition. Trends Biochem Sci 32: 37-43.
17. Nieto MA, (2002) The snail superfamily of zinc-finger transcription factors. Nat Rev Mol Cell Biol 3: 155-166.
18. Peinado H, Olmeda D, Cano A, (2007) Snail, Zeb and bHLH factors in tumour progression: an alliance against the epithelial phenotype? Nat Rev Cancer 7: 415-428.
19. Zavadil J, Bottinger EP, (2005) TGF-beta and epithelial-to-mesenchymal transitions. Oncogene 24: 5764-5774.
20. Cano A, Perez-Moreno MA, Rodrigo I, Locascio A, Blanco MJ, et al. (2000) The transcription factor snail controls epithelial-mesenchymal transitions by repressing E-cadherin expression. Nat Cell Biol 2: 76-83.
21. Carver EA, Jiang R, Lan Y, Oram KF, Gridley T, (2001) The mouse snail gene encodes a key regulator of the epithelial-mesenchymal transition. Mol Cell Biol 21: 8184-8188.
22. Dominguez D, Montserrat-Sentis B, Virgos-Soler A, Guaita S, Grueso J, et al. (2003) Phosphorylation regulates the subcellular location and activity of the snail transcriptional repressor. Mol Cell Biol 23: 5078-5089.
23. Zhou BP, Deng J, Xia W, Xu J, Li YM, et al. (2004) Dual regulation of Snail by GSK-3beta-mediated phosphorylation in control of epithelial-mesenchymal transition. Nat Cell Biol 6: 931-940.
24. Yook JI, Li XY, Ota I, Fearon ER, Weiss SJ, (2005) Wnt-dependent regulation of the E-cadherin repressor snail. J Biol Chem 280: 11740-11748.
25. Yook JI, Li XY, Ota I, Hu C, Kim HS, et al. (2006) A Wnt-Axin2-GSK3beta cascade regulates Snail1 activity in breast cancer cells. Nat Cell Biol 8: 1398-1406.
26. Blanco MJ, Moreno-Bueno G, Sarrio D, Locascio A, Cano A, et al. (2002) Correlation of Snail expression with histological grade and lymph node status in breast carcinomas. Oncogene 21: 3241-3246.
27. Sugimachi K, Tanaka S, Kameyama T, Taguchi K, Aishima S, et al. (2003) Transcriptional repressor snail and progression of human hepatocellular carcinoma. Clin Cancer Res 9: 2657-2664.
28. Kajita M, McClinic KN, Wade PA, (2004) Aberrant expression of the transcription factors snail and slug alters the response to genotoxic stress. Mol Cell Biol 24: 7559-7566.
29. Vega S, Morales AV, Ocana OH, Valdes F, Fabregat I, et al. (2004) Snail blocks the cell cycle and confers resistance to cell death. Genes Dev 18: 1131-1143.
30. Perez-Mancera PA, Perez-Caro M, Gonzalez-Herrero I, Flores T, Orfao A, et al. (2005) Cancer development induced by graded expression of Snail in mice. Hum Mol Genet 14: 3449-3461.
31. Escriva M, Peiro S, Herranz N, Villagrasa P, Dave N, et al. (2008) Repression of PTEN phosphatase by Snail1 transcriptional factor during gamma radiation-induced apoptosis. Mol Cell Biol 28: 1528-1540.
32. Kurrey NK, Jalgaonkar SP, Joglekar AV, Ghanate AD, Chaskar PD, et al. (2009) Snail and slug mediate radioresistance and chemoresistance by antagonizing p53-mediated apoptosis and acquiring a stem-like phenotype in ovarian cancer cells. Stem Cells 27: 2059-2068.
33. Olmeda D, Jorda M, Peinado H, Fabra A, Cano A, (2007) Snail silencing effectively suppresses tumour growth and invasiveness. Oncogene 26: 1862-1874.
34. Moody SE, Perez D, Pan TC, Sarkisian CJ, Portocarrero CP, et al. (2005) The transcriptional repressor Snail promotes mammary tumor recurrence. Cancer Cell 8: 197-209.
35. Kim CH, Han SI, Lee SY, Youk HS, Moon JY, et al. (2007) Protein kinase C-ERK1/2 signal pathway switches glucose depletion-induced necrosis to apoptosis by regulating superoxide dismutases and suppressing reactive oxygen species production in A549 lung cancer cells. J Cell Physiol 211: 371-385.
36. Petronilli V, Miotto G, Canton M, Brini M, Colonna R, et al. (1999) Transient and long-lasting openings of the mitochondrial permeability transition pore can be monitored directly in intact cells by changes in mitochondrial calcein fluorescence. Biophys J 76: 725-734.
37. LaRue KE, Khalil M, Freyer JP, (2004) Microenvironmental regulation of proliferation in multicellular spheroids is mediated through differential expression of cyclin-dependent kinase inhibitors. Cancer Res 64: 1621-1631.
38. Horning JL, Sahoo SK, Vijayaraghavalu S, Dimitrijevic S, Vasir JK, et al. (2008) 3-D tumor model for in vitro evaluation of anticancer drugs. Mol Pharm 5: 849-862.
39. Ivascu A, Kubbies M, (2007) Diversity of cell-mediated adhesions in breast cancer spheroids. Int J Oncol 31: 1403-1413.
40. Jeong EK, Lee SY, Jeon HM, Ju MK, Kang HS, (2010) Role of extracellular signal-regulated kinase (ERK)1/2 in multicelluar resistance to docetaxel in MCF-7 cells. Int J Oncol 37: 655-661.
41. Ahmad IM, Aykin-Burns N, Sim JE, Walsh SA, Higashikubo R, et al. (2005) Mitochondrial O2*- and H2O2 mediate glucose deprivation-induced stress in human cancer cells. J Biol Chem 280: 4254-4263.
42. Spitz DR, Sim JE, Ridnour LA, Galoforo SS, Lee YJ, (2000) Glucose deprivation-induced oxidative stress in human tumor cells. A fundamental defect in metabolism? Ann N Y Acad Sci 899: 349-362.
43. Adam-Vizi V, Chinopoulos C, (2006) Bioenergetics and the formation of mitochondrial reactive oxygen species. Trends Pharmacol Sci 27: 639-645.
44. Muller FL, Liu Y, Van Remmen H, (2004) Complex III releases superoxide to both sides of the inner mitochondrial membrane. J Biol Chem 279: 49064-49073.
45. Lim SO, Gu JM, Kim MS, Kim HS, Park YN, et al. (2008) Epigenetic changes induced by reactive oxygen species in hepatocellular carcinoma: methylation of the E-cadherin promoter. Gastroenterology 135: 2128-2140, 2140 e2121-2128.
46. Radisky DC, Levy DD, Littlepage LE, Liu H, Nelson CM, et al. (2005) Rac1b and reactive oxygen species mediate MMP-3-induced EMT and genomic instability. Nature 436: 123-127.
47. Imai T, Horiuchi A, Wang C, Oka K, Ohira S, et al. (2003) Hypoxia attenuates the expression of E-cadherin via up-regulation of SNAIL in ovarian carcinoma cells. Am J Pathol 163: 1437-1447.
48. Evans AJ, Russell RC, Roche O, Burry TN, Fish JE, et al. (2007) VHL promotes E2 box-dependent E-cadherin transcription by HIF-mediated regulation of SIP1 and snail. Mol Cell Biol 27: 157-169.
49. Viñas-Castells R, Beltran M, Valls G, Gómez I, García JM, et al. (2010) The hypoxia-controlled FBXL14 ubiquitin ligase targets SNAIL1 for proteasome degradation. J Biol Chem 285: 3794-3805.
50. Lester RD, Jo M, Montel V, Takimoto S, Gonias SL, (2007) uPAR induces epithelial mesenchymal transition in hypoxic breast cancer cells. J Cell Biol 178: 425-436.
51. Cannito S, Novo E, Compagnone A, Valfrè di Bonzo L, Busletta C, et al. (2008) Redox mechanisms switch on hypoxia-dependent epithelial-mesenchymal transition in cancer cells. Carcinogenesis 29: 2267-2278.
52. Kunz-Schughart LA, Freyer JP, Hofstaedter F, Ebner R, (2004) The use of 3-D cultures for high-throughput screening: the multicellular spheroid model. J Biomol Screen 9: 273-285.
53. Aykin-Burns N, Ahmad IM, Zhu Y, Oberley LW, Spitz DR, (2009) Increased levels of superoxide and H2O2 mediate the differential susceptibility of cancer cells versus normal cells to glucose deprivation. Biochem J 418: 29-37.
54. Kim JS, He L, Lemasters JJ, (2003) Mitochondrial permeability transition: a common pathway to necrosis and apoptosis. Biochem Biophys Res Commun 304: 463-470.
55. Kim CH, Jeon HM, Lee SY, Jeong EK, Ju MK, et al. (2010) Role of reactive oxygen species-dependent protein aggregation in metabolic stress-induced necrosis. Int J Oncol 37: 97-102.
56. Ge P, Luo Y, Liu CL, Hu B, (2007) Protein aggregation and proteasome dysfunction after brain ischemia. Stroke 38: 3230-3236.
57. Hu BR, Janelidze S, Ginsberg MD, Busto R, Perez-Pinzon M, et al. (2001) Protein aggregation after focal brain ischemia and reperfusion. J Cereb Blood Flow Metab 21: 865-875.
58. Hu BR, Martone ME, Jones YZ, Liu CL, (2000) Protein aggregation after transient cerebral ischemia. J Neurosci 20: 3191-3199.
59. Ross CA, Poirier MA, (2005) What is the role of protein aggregation in neurodegeneration? Nat Rev Mol Cell Biol 6: 891-898.
60. Alirol E, Martinou JC, (2006) Mitochondria and cancer: is there a morphological connection? Oncogene 25: 4706-4716.
61. Brandon M, Baldi P, Wallace DC, (2006) Mitochondrial mutations in cancer. Oncogene 25: 4647-4662.
62. Zong WX, Ditsworth D, Bauer DE, Wang ZQ, Thompson CB, (2004) Alkylating DNA damage stimulates a regulated form of necrotic cell death. Genes Dev 18: 1272-1282.
63. Zorov DB, Filburn CR, Klotz LO, Zweier JL, Sollott SJ, (2000) Reactive oxygen species (ROS)-induced ROS release: a new phenomenon accompanying induction of the mitochondrial permeability transition in cardiac myocytes. J Exp Med 192: 1001-1014.
64. Zorov DB, Juhaszova M, Sollott SJ, (2006) Mitochondrial ROS-induced ROS release: an update and review. Biochim Biophys Acta 1757: 509-517.