Ayurveda-modern medicine interface: A critical appraisal of studies of Ayurvedic medicines to treat osteoarthritis and rheumatoid arthritis

Journal of Ayurveda and Integrative Medicine

Volumn 1, Issue 3, 2010, Pages 190-198

  Chopra, Arvind ^a   Saluja, Manjit ^a   Tillu, Girish ^a  

^a Center for Rheumatic Diseases   (India)

Author keywords

Ayurveda; clinical trials; osteoarthritis; Rasayana; rheumatoid arthritis

Indexed keywords

BLACK PEPPER EXTRACT; BOSWELLIA SERRATA EXTRACT; CELECOXIB; CHLOROQUINE; CURCUMA LONGA EXTRACT; DICLOFENAC; DISEASE MODIFYING ANTIRHEUMATIC DRUG; GINGER EXTRACT; GLUCOSAMINE; GREEN TEA EXTRACT; HERBACEOUS AGENT; HYDROXYCHLOROQUINE; IBUPROFEN; IRA 01; LEFLUNOMIDE; LINUM USITATISSIMUM EXTRACT; METHOTREXATE; NONSTEROID ANTIINFLAMMATORY AGENT; PARACETAMOL; PLACEBO; PREDNISOLONE; RA 1; SALAZOSULFAPYRIDINE; SEMECARPUS ANACARDIUM EXTRACT; STEROID; TRAMADOL; TRIBULUS TERRESTRIS EXTRACT; TRIGONELLA FOENUM GRAECUM EXTRACT; UNCLASSIFIED DRUG; UNINDEXED DRUG; WITHANIA SOMNIFERA EXTRACT;

ALBUMIN BLOOD LEVEL; ANTIINFLAMMATORY ACTIVITY; AYURVEDA; BIOCHEMISTRY; BIOMEDICINE; BOSWELLIA; CARDIOVASCULAR DISEASE; DAILY LIFE ACTIVITY; DIET RESTRICTION; DRUG EFFICACY; DRUG SAFETY; DRUG TOXICITY; DRUG WITHDRAWAL; EVIDENCE BASED PRACTICE; GASTROINTESTINAL DISEASE; GINSENG; HEALING; HEMATOLOGY; HUMAN; IMMUNOMODULATION; INFECTION; JOINT SWELLING; KIDNEY DISEASE; KNEE OSTEOARTHRITIS; LINSEED; LOW DRUG DOSE; MASSAGE; MEDICAL PRACTICE; MEDICINAL PLANT; METABOLIC PARAMETERS; POULTICE; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; QUALITY OF LIFE; RASAYANA; REJUVENATION; REVIEW; RHEUMATOID ARTHRITIS; RICINUS COMMUNIS; SIDE EFFECT; ULCER; VALIDATION STUDY; WITHANIA SOMNIFERA; YOGA;

EID: 79952954899     PISSN: 09759476     EISSN: 09762809     Source Type: Journal    
DOI: 10.4103/0975-9476.72620     Document Type: Review

References (43)

1. Sharma PV. Caraka Samhita (English translation). Delhi, India: Chaukhambia Orientalia; 1994.
2. Valiathan MS. The Legacy of Caraka. Chennai: Orient Longman; 2003.
3. Srikanta Murthy KR. Madhava Nidanam (roga viniscaya) of Madhavakara (English translation). Delhi, India: Chaukhambia Orientalia; 1993.
4. Mishra B. In, Bhavmishra, Bhavprakasha Nighantu. 9 th ed, Vol. 1. Nighantu, Varanasi: Chaukhambha Sanskrit Sansthan; 1999. p. 11.
5. Frawley D, Lad V. The Yoga of Herbs. Delhi, India: Motilal Banarsidass Publishers Pvt. Ltd.; 1994.
6. Chopra A. Ayurvedic medicine and arthritis. Rheum Dis Clin North Am 2000;26:133-44.
7. Chopra A, Patil J, Doiphode V, Patwardhan B. Exploring ancient Ayurveda for rheumatology: Traditional therapy, Modern relevance and challenges. APLAR Bull 2001;4:190-9.
8. Sharma PV. Caraka Samhita (English translation). Chikitsa Sthana, Chapter 28. Delhi, India: Chaukhambia Orientalia; 1994.
9. Srikanta Murthy KR. Madhava Nidanam (roga viniscaya) of Madhavakara (English translation), Chapter 22. Delhi, India: Chaukhambia Orientalia; 1993.
10. Srikanta Murthy KR. Madhava Nidanam (roga viniscaya) of Madhavakara (English translation), Chapter 28. Delhi, India: Chaukhambia Orientalia; 1993.
11. Thatte U, Chhabria S, Karandikar SM, Dahanukar S. Immuno-therapeutic modifications by Indian medicinal plants. Indian Drugs 1987; 25:85-7.
12. Thatte UM, Dahanukar SA. Immunotherapeutic modification of diverse infectious states by Indian medicinal plants. Phytother Res 1989;3:43-8.
13. Patwardhan B, Kalbag D, Patki PS, Nagsampagi BA. Search of immunomodulatory agents: A review. Indian Drugs 1991;28:249-54.
14. Upadhyay SN. Therapeutic potential of immunomodulatory agents from plant products. Immunomodulation. In: Upadhyay SN, editor. New Delhi: Narosa Publishing House; 1997. p. 149-54.
15. Katiyar CK, Brindavanam, Tiwari P, Narayana DB. Immunomodular products from Ayurveda: current status and future perspectives. Immunomodulation. In: Upadhyay SN, editor. New Delhi: Narosa Publishing House; 1997. p. 163-87.
16. Rege NN, Thatte UM, Dahanukar SA. Adaptogenic properties of six rasayana herbs used in Ayurvedic medicine. Phytother Res 1999;13:275-91. (Pubitemid 29308442)
17. Budhiraja RD, Sudhir S: Review of biological activity of withanolides. J Sci Ind Res 1987;46:400-8.
18. Begum VH, Sadique J. Long term effect of herbal drug Withania Somnifera on adjuvant induced arthritis in rats. Indian J Exp Biol 1988;26:877-82. (Pubitemid 19013326)
19. Ghosal S, Lal J, Shrivastava R, Bhattacharya SK, Upadhyay SN, Jaiswal AK, et al. Immunomodulatory and CNS effects of sitoinosides IX and X, two new glycowithanolides from W somnifera. Phytother Res 1989;3:201.
20. Ziauddin M, Phansalkar N, Patki P, Diwanay S, Patwardhan B. Studies on the immunomodulatory effects of Ashwagandha. J Ethnopharmacol 1996;50:69-76. (Pubitemid 26066791)
21. Sharma PV. Caraka Samhita (English translation). Chikitsa Sthana, Chapter 28. Delhi, India: Chaukhambia Orientalia; 1994. p. 142-56.
22. Sharma PV. Caraka Samhita (English translation). Chikitsa Sthana, Chapter 25. Delhi, India: Chaukhambia Orientalia; 1994. p. 35-40.
23. Srikanta Murthy KR. Madhava Nidanam (roga viniscaya) of Madhavakara (English translation), Chapter 23. Delhi, India: Chaukhambia Orientalia; 1993. p. 14-8
24. Chopra A, Lavin P, Patwardhan B, Chitre D. Randomized double blind trial of an Ayurvedic plant derived formulation for treatment of rheumatoid arthritis. J Rheumatol 2000;27:1365-72. (Pubitemid 30354029)
25. Chopra A, Saluja M, Patil J, V Anuradha, L Bichile. IRA-01, An ayurvedic (Asian Indian) drug for rheumatoid arthritis (RA): Evaluation for efficacy and safety, and a probable lipid modifying effect. Ann Rheum Dis 2004;63:275.
26. Chopra A, Narsimulu G, Bichile L, Handa R, Raut A, Saluja M, et al. Comparing ayurvedic (Indian) herbal drugs and HCQS (hydroxychloroquin sulfate) in the treatment of rheumatoid arthritis (RA): A randomized, double blind, multi-centric exploratory drug trial of 24 weeks duration. Arthritis Rheum 2007;56:394-5.
27. Chopra A, Lavin P, Patwardhan B, Chitre D. A 32-Week randomized, placebo-controlled clinical evaluation of RA-11, an Ayurvedic drug on osteoarthritis of the knees. J Clin Rheumatol 2004;10:236-45. (Pubitemid 39332161)
28. Chopra A, Raut A, Bichile L, G Narsimulu, Handa R, Saluja M, et al. A controlled drug trial to evaluate Ayurvedic derived Shunthi-Guduchi based standard formulations in the treatment of Osteoarthritis (OA) Knees: A Government of India NMITLI Arthritis Project. Ann Rheum Dis 2006;65:226.
29. Arvind Chopra, M. Saluja, A. Venugopalan, P. Naik, G. Tillu, S. Sarmukkaddam et al. A 24 week RDB multicentric trial to demonstrate equivalence between individual drugs for symptomatic treatment of OA Knees: Ayurvedic (Indian Asian), Glucosamine and Celecoxib. Ind Jour Rheum 2008; 3: S26.
30. Bellamy Nicholas. Musculoskeletal Clinical Metrology. Boston: Kluwer academic publishers; 1993.
31. Alyce M. Oliver E, Clair WS. Rheumatoid Arthritis-Treatment and Assessment. In: Klippel JH, editor. Primer on the Rheumatic Diseases. 13th ed. Atlanta: Arthritis Foundation; 2008. p. 133-41.
32. Chopra A, Abdel-Nasser A. Epidemiology of rheumatic musculoskeletal disorders in the developing world. Best Pract Res Clin Rheumatol 2008;22:583-604.
33. Joshi VL, Chopra A. Is there an urban-rural divide? Population surveys of rheumatic musculoskeletal disorders in the Pune region of India using the COPCORD Bhigwan model. J Rheumatol 2009;36:614-22.
34. Felson DT, Anderson JJ, Boers M, Bombardier C, Chernoff M, Fried B, et al. The American College of Rheumatology preliminary core set of disease activity measures for rheumatoid arthritis clinical trials: The committee on outcome measures in rheumatoid arthritis clinical trials. Arthritis Rheum 1993;36:729-40. (Pubitemid 23175613)
35. Chopra A, Gore A, Paranjape S, Edmonds J. Modified Health Assessment Questionnaire: An Indian study for validity and relevance. Program of the 8th APLAR Congress, Melbourne, Australia, April 21-25, 1996. Victoria, Australia:ICMS Pty Ltd; 1996. p. 87(323).
36. Sharma L. Osteoarthritis-Treatment. In: Klippel JH, editor. Primer on the Rheumatic Diseases. 13 th ed. Atlanta: Arthritis Foundation; 2008. p. 235-40.
37. Reginster JY, Deroisy R, Rovati LC, Lee RL, Lejeune E, Bruyere O, et al. Long-term effects of glucosamine sulphate on osteoarthritis progression: A randomized placebo controlled Clinical trial. Lancet 2001;357:251-6. (Pubitemid 32120855)
38. Clegg DO, Reda DJ, Harris CL, Klein MA, O'Dell JR, Hooper MM, et al. Glucosamine, chondroitin sulfate, and the two in combination for painful knee osteoarthritis. N Engl J Med 2006;354:795-808. (Pubitemid 43290918)
39. Chopra A. Rheumatology: Made in India (Camps, COPCORD, HLA, Ayurveda, HAQ, WOMAC and Drug Trials). J Indian Rheum Assoc 2004;12:43-53.
40. Patwardhan B, Vaidya A, Chorghade M. Ayurveda and natural products drug discovery. Curr Sci 2004;86:789-99. (Pubitemid 39169379)
41. Sumantran VN, Kulkarni A, Chandwaskar R, Harsulkar A, Patwardhan B, Chopra A, et al. Chondroprotective potential of fruit extracts of Phyllanthus Emblica in Osteoarthritis. Evid Based Complement Alternat Med 2008;5:329-35.
42. Engel LW, Straus SE. Development of therapeutics: Opportunities within complementary and alternative medicine. Nat Rev Drug Discov 2002;1:229-37.
43. Mashelkar RA. Second World Ayurveda Congress (Theme: Ayurveda for the Future)-Inaugural Address: Part III. Evid Based Complement Alternat Med 2008;5:367-9.