Chemokines in cerebrospinal fluid correlate with cerebral metabolite patterns in HIV-infected individuals

Journal of NeuroVirology

Volumn 17, Issue 1, 2011, Pages 63-69

  Letendre, Scott L ^a   Zheng, Jialin C ^b   Kaul, Marcus ^c   Yiannoutsos, Constantin T ^d   Ellis, Ronald J ^a   Taylor, Michael J ^a   Marquie Beck, Jennifer ^a   Navia, Bradford ^e  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF NEBRASKA MEDICAL CENTER   (United States)

^c BURNHAM INSTITUTE   (United States)

^d INDIANA UNIVERSITY   (United States)

^e TUFTS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Brain; Chemokines; CSF; HIV; Magnetic resonance spectroscopy

Indexed keywords

CHEMOKINE; CREATINE; FRACTALKINE; GAMMA INTERFERON INDUCIBLE PROTEIN 10; INTERLEUKIN 8; MACROPHAGE INFLAMMATORY PROTEIN 1BETA; MEMANTINE; MONOCYTE CHEMOTACTIC PROTEIN 1; N ACETYLASPARTIC ACID; PLACEBO; STROMAL CELL DERIVED FACTOR 1; VIRUS RNA;

ADULT; ARTICLE; BASAL GANGLION; BRAIN REGION; CD4+ T LYMPHOCYTE; CEREBROSPINAL FLUID; CLINICAL ASSESSMENT TOOL; COHORT ANALYSIS; CONTROLLED STUDY; DISEASE ASSOCIATION; DRUG EFFECT; FEMALE; FRONTAL CORTEX; HIGHLY ACTIVE ANTIRETROVIRAL THERAPY; HIV ASSOCIATED DEMENTIA; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; IMMUNE RESPONSE; MAJOR CLINICAL STUDY; MALE; MENTAL PERFORMANCE; METABOLITE; NERVE CELL; NEUROPSYCHOLOGY; PARIETAL CORTEX; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTON NUCLEAR MAGNETIC RESONANCE; WHITE MATTER;

ADULT; ASPARTIC ACID; CD4 LYMPHOCYTE COUNT; CEREBRUM; CHEMOKINES; COHORT STUDIES; CREATINE; FEMALE; HIV; HIV INFECTIONS; HUMANS; MAGNETIC RESONANCE SPECTROSCOPY; MALE; MIDDLE AGED;

EID: 79952917546     PISSN: 13550284     EISSN: 15382443     Source Type: Journal    
DOI: 10.1007/s13365-010-0013-2     Document Type: Article

References (36)

1. Alkhatib G, Combadiere C, Broder CC, Feng Y, Kennedy PE, Murphy PM et al (1996) CC CKR5: a RANTES, MIP-1alpha, MIP-1beta receptor as a fusion cofactor for macrophage-tropic HIV-1. Science 272(5270):1955-1958 (Pubitemid 26234510)
2. Andersson J, Fehniger TE, Patterson BK, Pottage J, Agnoli M, Jones P et al (1998) Early reduction of immune activation in lymphoid tissue following highly active HIV therapy. AIDS 12(11):F123-F129 (Pubitemid 28330715)
3. Asensio VC, Maier J, Milner R, Boztug K, Kincaid C, Moulard M et al (2001) Interferon-independent, human immunodeficiency virus type 1 gp120-mediated induction of CXCL10/IP-10 gene expression by astrocytes in vivo and in vitro. J Virol 75 (15):7067-7077 (Pubitemid 32641594)
4. Bajetto A, Bonavia R, Barbero S, Florio T, Schettini G (2001) Chemokines and their receptors in the central nervous system. Front Neuroendocrinol 22(3):147-184 (Pubitemid 32706335)
5. Bland JM, Altman DG (1995) Calculating correlation coefficients with repeated observations: part 1 - correlation within subjects. BMJ 310(6977):446
6. Campbell IL, Krucker T, Steffensen S, Akwa Y, Powell HC, Lane T et al (1999) Structural and functional neuropathology in transgenic mice with CNS expression ofIFN-alpha. Brain Res 835(1):46-61 (Pubitemid 29336549)
7. Chang L, Ernst T, St Hillaire C, Conant K (2004) Antiretroviral treatment alters relationship between MCP-1 and neurometabolites in HIV patients. Antivir Ther 9(3):431-440 (Pubitemid 38878759)
8. Deng H, Liu R, Ellmeier W, Choe S, Unutmaz D, Burkhart M et al (1996) Identification of a major co-receptor for primary isolates of HIV-1. Nature 381(6584):661-666 (Pubitemid 26197679)
9. Dragic T, Litwin V, Allaway GP, Martin SR, Huang Y, Nagashima KA et al (1996) HIV-1 entry into CD4+ cells is mediated by the chemokine receptor CC-CKR-5. Nature 381(6584):667-673 (Pubitemid 26197680)
10. Erichsen D, Lopez AL, Peng H, Niemann D, Williams C, Bauer M, Morgello S, Cotter RL, Ryan LA, Ghorpade A, Gendelman HE, Zheng J (2003) Neuronal injury induced fractalkine production: relevance to HIV-1 associated dementia. J Neuroimmunol 138:144-155 (Pubitemid 36566428)
11. Eugenin EA, D'Aversa TG, Lopez L, Calderon TM, Berman JW (2003) MCP-1 (CCL2) protects human neurons and astrocytes from NMDA or HIV-tat-induced apoptosis. J Neurochem 85 (5):1299-1311 (Pubitemid 36613277)
12. Feng Y, Broder CC, Kennedy PE, Berger EA (1996) HIV-1 entry cofactor: functional cDNA cloning of a seven-transmembrane, G protein-coupled receptor. Science 272(5263):872-877 (Pubitemid 26154590)
13. Gabuzda D, He J, Ohagen A, Vallat AV (1998) Chemokine receptors in HIV-1 infection of the central nervous system. Semin Immunol 10(3):203-213 (Pubitemid 28347037)
14. Gisolf EH, van Praag RM, Jurriaans S, Portegies P, Goudsmit J, Danner SA et al (2000) Increasing cerebrospinal fluid chemokine concentrations despite undetectable cerebrospinal fluid HIV RNA in HIV-1-infected patients receiving antiretroviral therapy. J Acquir Immune Defic Syndr 25(5):426-433 (Pubitemid 32055572)
15. Gonzalez E, Rovin BH, Sen L, Cooke G, Dhanda R, Mummidi S et al (2002) HIV-1 infection and AIDS dementia are influenced by a mutant MCP-1 allele linked to increased monocyte infiltration of tissues and MCP-1 levels. Proc Natl Acad Sci USA 99 (21):13795-13800 (Pubitemid 35215460)
16. Gonzalez E, Kulkarni H, Bolivar H, Mangano A, Sanchez R, Catano G et al (2005) The influence of CCL3L1 gene-containing segmental duplications on HIV-1/AIDS susceptibility. Science 307(5714):1434-1440 (Pubitemid 40321934)
17. Gonzalez-Scarano F, Martin-Garcia J (2005) The neuropathogenesis of AIDS. Nat Rev Immunol 5(1):69-81 (Pubitemid 40070332)
18. Kaul M, Zheng J, Okamoto S, Gendelman HE, Lipton SA (2005) HIV-1 infection and AIDS: consequences for the central nervous system. Cell Death Differ 12(Suppl 1):878-892 (Pubitemid 41038393)
19. Kelder W, McArthur JC, Nance-Sproson T, McClernon D, Griffin DE (1998) Beta-chemokines MCP-1 and RANTES are selectively increased in cerebrospinal fluid of patients with human immunodeficiency virus-associated dementia. Ann Neurol 44(5):831-835 (Pubitemid 28516058)
20. Kolb SA, Sporer B, Lahrtz F, Koedel U, Pfister HW, Fontana A (1999) Identification of a T cell chemotactic factor in the cerebrospinal fluid of HIV-1-infected individuals as interferongamma inducible protein 10. J Neuroimmunol 93(1-2):172-181 (Pubitemid 29051563)
21. Kutsch O, Oh J, Nath A, Benveniste EN (2000) Induction of the chemokines interleukin-8 and IP-10 by human immunodeficiency virus type 1 tat in astrocytes. J Virol 74(19):9214-9221
22. Lane BR, King SR, Bock PJ, Strieter RM, Coffey MJ, Markovitz DM (2003) The C-X-C chemokine IP-10 stimulates HIV-1 replication. Virology 307(1):122-134 (Pubitemid 36349442)
23. Lee PL, Yiannoutsos CT, Ernst T, Chang L, Marra CM, Jarvik JG et al (2003) A multi-center 1H MRS study of the AIDS dementia complex: validation and preliminary analysis. J Magn Reson Imaging 17(6):625-633 (Pubitemid 36665865)
24. Letendre SL (2005) The effects of antiretroviral therapy on viral and nonviral markers in cerebrospinal fluid. In: Gendelman HE, Grant I, Everall IP, Lipton SA, Swindells S (eds) The neurology of AIDS, 2nd edn. Oxford University Press, New York, pp 617-627
25. Letendre S, Marquie-Beck J, Singh KK, de Almeida S, Zimmerman J, Spector SA et al (2004) The monocyte chemotactic protein-1-2578G allele is associated with elevated MCP-1 concentrations in cerebrospinal fluid. J Neuroimmunol 157(1-2):193-196 (Pubitemid 39576654)
26. Narumi S, Kaburaki T, Yoneyama H, Iwamura H, Kobayashi Y, Matsushima K (2002) Neutralization of IFN-inducible protein 10/ CXCL10 exacerbates experimental autoimmune encephalomyelitis. Eur J Immunol 32(6):1784-1791
27. Neville LF, Mathiak G, Bagasra O (1997) The immunobiology of interferon-gamma inducible protein 10 kD (IP-10): a novel, pleiotropic member of the C-X-C chemokine superfamily. Cytokine Growth Factor Rev 8(3):207-219 (Pubitemid 28077928)
28. Price RW, Sidtis JJ, Brew BJ (1991) AIDS dementia complex and HIV-1 infection: a view from the clinic. Brain Pathol 1(3):155-162
29. Sanders VJ, Pittman CA, White MG, Wang G, Wiley CA, Achim CL (1998) Chemokines and receptors in HIV encephalitis. AIDS 12 (9):1021-1026 (Pubitemid 28276969)
30. Sevigny JJ, Albert SM, McDermott MP, McArthur JC, Sacktor N, Conant K et al (2004) Evaluation of HIV RNA and markers of immune activation as predictors of HIV-associated dementia. Neurology 63(11):2084-2090 (Pubitemid 39636256)
31. Sui Y, Potula R, Pinson D, Adany I, Li Z, Day J et al (2003) Microarray analysis of cytokine and chemokine genes in the brains of macaques with SHIV-encephalitis. J Med Primatol 32 (4-5):229-239 (Pubitemid 37021248)
32. Taub DD, Lloyd AR, Conlon K, Wang JM, Ortaldo JR, Harada A et al (1993) Recombinant human interferon-inducible protein 10 is a chemoattractant for human monocytes and T lymphocytes and promotes T cell adhesion to endothelial cells. J Exp Med 177 (6):1809-1814 (Pubitemid 23146150)
33. Weiss JM, Nath A, Major EO, Berman JW (1999) HIV-1 Tat induces monocyte chemoattractant protein-1-mediated monocyte transmigration across a model of the human blood-brain barrier and upregulates CCR5 expression on human monocytes. J Immunol 163 (5):2953-2959 (Pubitemid 29399228)
34. Yiannoutsos CT, Ernst T, Chang L, Lee PL, Richards T, Marra CM et al (2004) Regional patterns of brain metabolites in AIDS dementia complex. Neuroimage 23(3):928-935 (Pubitemid 39451800)
35. Zheng L, Calenoff MA, Dal Canto MC (2001) Astrocytes, not microglia, are the main cells responsible for viral persistence in Theiler's murine encephalomyelitis virus infection leading to demyelination. J Neuroimmunol 118(2):256-267 (Pubitemid 32728359)
36. Zink MC, Coleman GD, Mankowski JL, Adams RJ, Tarwater PM, Fox K et al (2001) Increased macrophage chemoattractant protein-1 in cerebrospinal fluid precedes and predicts simian immunodeficiency virus encephalitis. J Infect Dis 184(8):1015-1021 (Pubitemid 32955118)