A literature review on the safety assessment of genetically modified plants

Environment International

Volumn 37, Issue 4, 2011, Pages 734-742

  Domingo, José L ^a   Giné Bordonaba, Jordi ^a  

^a UNIVERSITAT ROVIRA I VIRGILI   (Spain)

Author keywords

Adverse effects; Genetically modified (GM) plants; Health risks; Safety assessment; Toxicity

Indexed keywords

ANIMALS; HEALTH RISKS; RISK ASSESSMENT; SAFETY ENGINEERING; TOXICITY;

ADVERSE EFFECT; BIOTECHNOLOGY COMPANIES; ENVIRONMENTAL NON-GOVERNMENTAL ORGANIZATIONS; GENETICALLY MODIFIED FOOD; HUMAN CONSUMPTION; LITERATURE REVIEWS; SAFETY ASSESSMENTS; SCIENTIFIC JOURNALS;

GENETICALLY MODIFIED PLANTS;

BIOTECHNOLOGY; FOOD SAFETY; GENETICALLY MODIFIED ORGANISM; HEALTH RISK; LITERATURE REVIEW; NONGOVERNMENTAL ORGANIZATION; TOXICITY;

CORN; CUCUMBER; FOOD INTAKE; FOOD SAFETY; GENETICALLY MODIFIED FOOD; HEALTH HAZARD; HUMAN; MAIZE; NONHUMAN; NUTRITIONAL VALUE; PEA; POTATO; PRIORITY JOURNAL; REVIEW; RICE; RISK ASSESSMENT; SCIENTIFIC LITERATURE; SOYBEAN; TOMATO; TOXICITY TESTING; TRANSGENIC PLANT;

ANIMALIA; CUCUMIS SATIVUS; GLYCINE MAX; LYCOPERSICON ESCULENTUM; PISUM SATIVUM; SCOPUS; SOLANUM TUBEROSUM; ZEA MAYS;

EID: 79952901043     PISSN: 01604120     EISSN: 18736750     Source Type: Journal    
DOI: 10.1016/j.envint.2011.01.003     Document Type: Review

References (58)

1. Appenzeller L.M., Munley S.M., Hoban D., Sykes G.P., Malley L.A., Delaney B. Subchronic feeding study of herbicide-tolerant soybean DP-356Ø43-5 in Sprague-Dawley rats. Food Chem Toxicol 2008, 46:2201-2213.
2. Appenzeller L.M., Malley L., MacKenzie S.A., Hoban D., Delaney B. Subchronic feeding study with genetically modified stacked trait lepidopteran and coleopteran resistant (DAS-Ø15Ø7-1×DAS-59122-7) maize grain in Sprague-Dawley rats. Food Chem Toxicol 2009, 47:1512-1520.
3. Appenzeller L.M., Munley S.M., Hoban D., Sykes G.P., Malley L.A., Delaney B. Subchronic feeding study of grain from herbicide-tolerant maize DP-Ø9814Ø-6 in Sprague-Dawley rats. Food Chem Toxicol 2009, 47:2269-2280.
4. Arvanitoyannis I.S., Vaitsi O., Mavromatis A. Potato: a comparative study of the effect of cultivars and cultivation conditions and genetic modification on the physico-chemical properties of potato tubers in conjunction with multivariate analysis towards authenticity. Crit Rev Food Sci Nutr 2008, 48:799-823.
5. Bakshi A. Potential adverse health effects of genetically modified crops. J Toxicol Environ Health 2003, 6:211-225.
6. Brake D.G., Evenson D.P. A generational study of glyphosate-tolerant soybeans on mouse fetal, postnatal, pubertal and adult testicular development. Food Chem Toxicol 2004, 42:29-36.
7. Brake D.G., Thaler R., Evenson D.P. Evaluation of Bt (Bacillus thuringiensis) corn on mouse testicular development by dual parameter flow cytometry. J Agric Food Chem 2004, 52:2097-2102.
8. Cisterna B., Flach F., Vecchio L., Barabino S.M.L., Battistelli S., Martin T.E., et al. Can a genetically-modified organism-containing diet influence embryo development? A preliminary study on pre-implantation mouse embryos. Eur J Histochem 2008, 52:263-267.
9. de Vendômois J.S., Roullier F., Cellier D., Séralini G. A comparison of the effects of three GM corn varieties on mammalian health. Int J Biol Sci 2009, 5:706-726.
10. Delaney B., Appenzeller L.M., Munley S.M., Hoban D., Sykes G.P., Malley L.A., et al. Subchronic feeding study of high oleic acid soybeans (event DP-3Ø5423-1) in Sprague-Dawley rats. Food Chem Toxicol 2008, 46:3808-3817.
11. Domingo J.L. Health risks of GM foods: many opinions but few data. Science 2000, 288:1748-1749.
12. Domingo J.L. Toxicity studies of genetically modified plants: a review of the published literature. Crit Rev Food Sci Nutr 2007, 47:721-733.
13. Domingo-Roig J.L., Gómez-Arnáiz M. Riesgos sobre la salud de los alimentos modificados geneticamente: una revision bibliográfica. Rev Esp Salud Pública 2000, 74:255-261. (in Spanish).
14. Domon E., Takagi H., Hirose S., Sugita K., Kasahara S., Ebinuma H., et al. 26-Week oral safety study in macaques for transgenic rice containing major human T-cell epitope peptides from Japanese cedar pollen allergens. J Agric Food Chem 2009, 57:5633-5638.
15. Dona A., Arvanitoyannis I.S. Health risks of genetically modified foods. Crit Rev Food Sci Nutr 2009, 49:164-175.
16. Doull J., Gaylor D., Greim H.A., Lovell D.P., Lynch B., Munro I.C. Report of an expert panel on the reanalysis by Séralini et al. (2007) of a 90-day study conducted by Monsanto in support of the safety of a genetically modified corn variety (MON 863). Food Chem Toxicol 2007, 45:2073-2085.
17. EFSA (European Food Safety Agency) Safety and nutritional assessment of GM plants and derived food and feed: the role of animal feeding trials-report of the EFSA GMO Panel Working Group on Animal Feeding Trials. Food Chem Toxicol 2008, 46:S2-S70.
18. EFSA (European Food Safety Agency) Outcome of the public consultation on the draft opinion of the Scientific Panel on Genetically Modified Organisms (GMO) on the assessment of allergenicity of GM plants and microorganisms and derived food and feed. EFSA J 2010, 8:1699.
19. He X.Y., Huang K.L., Li X., Qin W., Delaney B., Luo Y.B. Comparison of grain from corn rootworm resistant transgenic DAS-59122-7 maize with non-transgenic maize grain in a 90-day feeding study in Sprague-Dawley rats. Food Chem Toxicol 2008, 46:1994-2002.
20. He X.Y., Tang M.Z., Luo Y.B., Li X., Cao S.S., Yu J.J., et al. A 90-day toxicology study of transgenic lysine-rich maize grain (Y642) in Sprague-Dawley rats. Food Chem Toxicol 2009, 47:425-432.
21. Healy C., Hammond B., Kirkpatrick J. Results of a 13-week safety assurance study with rats fed grain from corn rootworm-protected, glyphosate-tolerant MON 88017 corn. Food Chem Toxicol 2008, 46:2517-2524.
22. Herouet-Guicheney C., Rouquié D., Freyssinet M., Currier T., Martone A., Zhou J., et al. Safety evaluation of the double mutant 5-enol pyruvylshikimate-3-phosphate synthase (2mEPSPS) from maize that confers tolerance to glyphosate herbicide in transgenic plants. Regul Toxicol Pharmacol 2009, 54:143-153.
23. Juberg D.R., Herman R.A., Thomas J., Brooks K.J., Delaney B. Acute and repeated dose (28day) mouse oral toxicology studies with Cry34Ab1 and Cry35Ab1 Bt proteins used in coleopteran resistant DAS-59122-7 corn. Regul Toxicol Pharmacol 2009, 54:154-163.
24. Key S., Ma J.K., Drake P.M.W. Genetically modified plants and human health. J R Soc Med 2008, 101:290-298.
25. Knudsen I., Poulsen M. Comparative safety testing of genetically modified foods in a 90-day rat feeding study design allowing the distinction between primary and secondary effects of the new genetic event. Regul Toxicol Pharmacol 2007, 49:53-62.
26. Kroghsbo S., Madsen C., Poulsen M., Schrøder M., Kvist P.H., Taylor M., et al. Immunotoxicological studies of genetically modified rice expressing PHA-E lectin or Bt toxin in Wistar rats. Toxicology 2008, 245:24-34.
27. Kuiper H.A., Kleter G.A., Noteborn H.P.J.M., Kok E.J. Substantial equivalence-an appropriate paradigm for the safety assessment of genetically modified foods?. Toxicology 2002, 181-182:427-431.
28. MacKenzie S.A., Lamb I., Schmidt J., Deege L., Morrisey M.J., Harper M., et al. Thirteen week feeding study with transgenic maize grain containing event DAS-Ø15Ø7-1 in Sprague-Dawley rats. Food Chem Toxicol 2007, 45:551-562.
29. Magaña-Gómez J.A., López Cervantes G., Yepiz-Plascencia G., Calderón De La Barca A.M. Pancreatic response of rats fed genetically modified soybean. J Appl Toxicol 2008, 28:217-226.
30. Magaña-Gómez J.A., de la Barca A.M. Risk assessment of genetically modified crops for nutrition and health. Nutr Rev 2009, 67:1-16.
31. Malatesta M., Caporaloni C., Rossi L., Battistelli S., Rocchi M.B.L., Tonucci F., et al. Ultrastructural analysis of pancreatic acinar cells from mice fed on genetically modified soybean. J Anat 2002, 201:409-415.
32. Malatesta M., Caporaloni C., Gavaudan S., Rocchi M.B.L., Serafini S., Tiberi C., et al. Ultrastructural morphometrical and immunocytochemical analyses of hepatocyte nuclei from mice fed on genetically modified soybean. Cell Struct Funct 2002, 27:173-180.
33. Malatesta M., Biggiogera M., Manuali E., Rocchi M.B.L., Baldelli B., Gazzanelli G. Fine structural analyses of pancreatic acinar cell nuclei from mice fed on genetically modified soybean. Eur J Histochem 2003, 47:385-388.
34. Malatesta M., Tiberi C., Baldelli B., Battistelli S., Manuali E., Biggiogera M. Reversibility of hepatocyte nuclear modifications in mice fed on genetically modified soybean. Eur J Histochem 2005, 49:237-242.
35. Malatesta M., Boraldi F., Annovi G., Baldelli B., Battistelli S., Biggiogera M., et al. A long-term study on female mice fed on a genetically modified soybean: effects on liver ageing. Histochem Cell Biol 2008, 130:967-977.
36. Malatesta M., Perdoni F., Santin G., Battistelli S., Muller S., Biggiogera M. Hepatoma tissue culture (HTC) cells as a model for investigating the effects of low concentrations of herbicide on cell structure and function. Toxicol In Vitro 2008, 22:1853-1860.
37. Malley L.A., Everds N.E., Reynolds J., Mann P.C., Lamb I., Rood T., et al. Subchronic feeding study of DAS-59122-7 maize grain in Sprague-Dawley rats. Food Chem Toxicol 2007, 45:1277-1292.
38. Mathesius C.A., Barnett J.F., Cressman R.F., Ding J., Carpenter C., Ladics G.S., et al. Safety assessment of a modified acetolactate synthase protein (GM-HRA) used as a selectable marker in genetically modified soybeans. Regul Toxicol Pharmacol 2009, 55:309-320.
39. McNaughton J., Roberts M., Smith B., Rice D., Hinds M., Schmidt J., et al. Comparison of broiler performance when fed diets containing event DP-356Ø43-5 (optimum GAT), nontransgenic near-isoline control, or commercial reference soybean meal, hulls, and oil. Poult Sci 2007, 86:2569-2581.
40. McNaughton J., Roberts M., Smith B., Rice D., Hinds M., Sanders C., et al. Comparison of broiler performance when fed diets containing event DP-3Ø5423-1, nontransgenic near-isoline control, or commercial reference soybean meal, hulls, and oil. Poult Sci 2008, 87:2549-2561.
41. Poulsen M., Schrøder M., Wilcks A., Kroghsbo S., Lindecrona R.H., Miller A., et al. Safety testing of GM-rice expressing PHA-E lectin using a new animal test design. Food Chem Toxicol 2007, 45:364-377.
42. Poulsen M., Kroghsbo S., Schrøder M., Wilcks A., Jacobsen H., Miller A., et al. A 90-day safety study in Wistar rats fed genetically modified rice expressing snowdrop lectin Galanthus nivalis (GNA). Food Chem Toxicol 2007, 45:350-363.
43. Pryme I.F., Lembcke R. In vivo studies on possible health consequences of genetically modified food and feed-with particular regard to ingredients consisting of genetically modified plant materials. Nutr Health 2003, 17:1-8.
44. Reuter H., Middelhoff U., Graef F., Verhoeven R., Batz T., Weis M., et al. Information system for monitoring environmental impacts of genetically modified organisms. Environ Sci Pollut Res 2010, 17:1479-1490.
45. Rickard C. Response to "Health risks of genetically modified foods". Crit Rev Food Sci Nutr 2010, 50:85-91.
46. Sakamoto Y., Tada Y., Fukumori N., Tayama K., Ando H., Takahashi H., et al. A 52-week feeding study of genetically modified soybeans in F344 rats. J Food Hyg Soc Jpn 2007, 48:41-50. (in Japanese).
47. Sakamoto Y., Tada Y., Fukumori N., Tayama K., Ando H., Takahashi H., et al. A 104-week feeding study of genetically modified soybeans in F344 rats. J Food Hyg Soc Jpn 2008, 49:272-282. (in Japanese).
48. Schrøder M., Poulsen M., Wilcks A., Kroghsbo S., Miller A., Frenzel T., et al. A 90-day safety study of genetically modified rice expressing Cry1Ab protein (Bacillus thuringiensis toxin) in Wistar rats. Food Chem Toxicol 2007, 45:339-349.
49. Séralini G., Cellier D., De Vendomois J.S. New analysis of a rat feeding study with a genetically modified maize reveals signs of hepatorenal toxicity. Arch Environ Contam Toxicol 2007, 52:596-602.
50. Séralini G., de Vendômois J.S., Cellier D., Sultan C., Buiatti M., Gallagher L., et al. How subchronic and chronic health effects can be neglected for GMOS, pesticides or chemicals. Int J Biol Sci 2009, 5:438-443.
51. SOT (Society of Toxicology) The safety of genetically modified foods produced through biotechnology. Toxicol Sci 2003, 71:2-8.
52. Tutel'ian V.A., Gapparov M.M.G., Avrenieva L.I., Aksyuk I.N., Guseva G.B., Kravchenko L.V., et al. Medical and biological safety assessment of genetically modified maize event MON 88017. Report 1. Toxicologo-hygienic examinations. Vopr Pitan 2008, 77:4-12. (in Russian).
53. Tutel'ian V.A., Gapparov M.M.G., Avrenyeva L.I., Aksyuk I.N., Guseva G.V., Kravchenko L.V., et al. Medical and biological safety assessment of genetically modified maize event MIR604: Report 1. Toxicologo-hygienic examinations. Vopr Pitan 2009, 78:24-32. (in Russian).
54. Tyshko N.V., Aksyuk I.N., Tutel'ian V.A. Safety assessment of genetically modified organisms of plant origin in the Russian Federation. Biotechnol J 2007, 2:826-832.
55. Tyshko N.V., Britsina M.V., Gmoshinsky I.V., Zhanataev A.K., Zakharova N.S., Zorin S.N., et al. Medical and biological safety assessment of genetically modified maize event MON 88017. Report 2. Genotoxicologic, immunologic and allergologic examinations. Vopr Pitan 2008, 77:13-17. (in Russian).
56. Vecchio L., Cisterna B., Malatesta M., Martin T.E., Biggiogera M. Ultrastructural analysis of testes from mice fed on genetically modified soybean. Eur J Histochem 2004, 48:448-454.
57. WHO (World Health Organisation) Foods derived from modern technology: 20 questions on genetically modified foods Available on-line at. http://htpp://www.who.int/fsf/GMfood/.
58. Zduńczyk Z. In vivo experiments on the safety evaluation of GM components of feeds and foods. J Anim Fed Sci 2001, 10:195-210.