Attenuation of endoplasmic reticulum stress-related myocardial apoptosis by SERCA2a gene delivery in ischemic heart disease

Molecular Medicine

Volumn 17, Issue 3-4, 2011, Pages 201-210

  Xin, Wei ^a,b   Lu, Xiaochun ^a   Li, Xiaoying ^a   Niu, Kun ^a   Cail, Jimei ^a  

^a CHINESE PLA GENERAL HOSPITAL   (China)

^b NANKAI UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

BRAIN NATRIURETIC PEPTIDE; ENHANCED GREEN FLUORESCENT PROTEIN; METHOXY ISOBUTYL ISONITRILE TECHNETIUM TC 99M; PARVOVIRUS VECTOR; SARCOPLASMIC RETICULUM CALCIUM TRANSPORTING ADENOSINE TRIPHOSPHATASE; SARCOPLASMIC RETICULUM CALCIUM TRANSPORTING ADENOSINE TRIPHOSPHATASE 2A; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; ATTENUATION; CONTROLLED STUDY; DRUG EFFICACY; DRUG MECHANISM; ECHOCARDIOGRAPHY; ENDOPLASMIC RETICULUM STRESS; ENZYME ACTIVITY; GENE THERAPY; HEART FUNCTION; HEART MUSCLE PERFUSION; ISCHEMIC HEART DISEASE; MALE; NONHUMAN; POLYADENYLATION; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; SINGLE PHOTON EMISSION COMPUTER TOMOGRAPHY; UNFOLDED PROTEIN RESPONSE; VIRAL GENE DELIVERY SYSTEM;

ANIMALS; APOPTOSIS; BCL-2-ASSOCIATED X PROTEIN; BLOTTING, WESTERN; CASPASES; DISEASE MODELS, ANIMAL; ECHOCARDIOGRAPHY; ENDOPLASMIC RETICULUM; FEMALE; GENE THERAPY; GENE TRANSFER TECHNIQUES; HEAT-SHOCK PROTEINS; HUMANS; IN SITU NICK-END LABELING; MALE; MYOCARDIAL ISCHEMIA; MYOCARDIUM; PROTO-ONCOGENE PROTEINS C-BCL-2; SARCOPLASMIC RETICULUM CALCIUM-TRANSPORTING ATPASES; SIGNAL TRANSDUCTION; SWINE;

EID: 79952852144     PISSN: 10761551     EISSN: None     Source Type: Journal    
DOI: 10.2119/molmed.2010.00197     Document Type: Article

References (45)

1. Jiang H, Ge J. (2009) Epidemiology and clinical management of cardiomyopathies and heart failure in China. Heart 95:1727-31.
2. Rahimtoola SH, Dilsizian V, Kramer CM, Marwick TH, Vanoverschelde JL. (2008) Chronic ischemic left ventricular dysfunction: from pathophysiology to imaging and its integration into clinical practice. JACC Cardiovasc. Imaging 1:536-55.
3. Talukder MA, Zweier JL, Periasamy M. (2009) Targeting calcium transport in ischaemic heart disease. Cardiovasc. Res. 84:345-52.
4. Krause S, Hess ML. (1984) Characterization of cardiac sarcoplasmic reticulum dysfunction during short-term, normothermic, global ischemia. Circ. Res. 55:176-84.
5. Kaplan P, Hendrikx M, Mattheussen M, Mubagwa K, Flameng W. (1992) Effect of ischemia and reperfusion on sarcoplasmic reticulum calcium uptake. Circ. Res. 71:1123-30.
6. Mubagwa K. (1995) Sarcoplasmic reticulum function during myocardial ischaemia and reperfusion. Cardiovasc. Res. 30:166-75.
7. Zucchi R, et al. (1996) Sarcoplasmic reticulum calcium uptake in human myocardium subjected to ischemia and reperfusion during cardiac surgery. J. Mol. Cell. Cardiol. 28:1693-701.
8. Miyamoto MI, et al. (2000) Adenoviral gene transfer of SERCA2a improves left-ventricular function in aortic-banded rats in transition to heart failure. Proc. Natl. Acad. Sci. U. S. A. 97:793-8.
9. del MF, et al. (2004) Abrogation of ventricular arrhythmias in a model of ischemia and reperfusion by targeting myocardial calcium cycling. Proc. Natl. Acad. Sci. U. S. A. 101:5622-7.
10. Byrne MJ, et al. (2008) Recirculating cardiac delivery of AAV2/1SERCA2a improves myocardial function in an experimental model of heart failure in large animals. Gene Ther. 15:1550-7.
11. Niwano K, et al. (2008) Lentiviral vector- mediated SERCA2 gene transfer protects against heart failure and left ventricular remodeling after myocardial infarction in rats. Mol. Ther. 16:1026-32.
12. Li XY, Hui HP, Lu XC, Guo YT. (2006) Treatment of chronic heart failure by overexpressing sarcoplasmic reticulum calcium ATPase through gene therapy: an experiment with rats. Zhonghua Yi Xue Za Zhi 86:1174-8.
13. Gupta D, et al. (2008) Improved exercise capacity and reduced systemic inflammation after adenoviral-mediated SERCA-2a gene transfer. J. Surg. Res. 145:257-65.
14. Kaufman RJ. (1999) Stress signaling from the lumen of the endoplasmic reticulum: coordination of gene transcriptional and translational controls. Genes Dev. 13:1211-33.
15. Ferri KF, Kroemer G. (2001) Organelle-specific initiation of cell death pathways. Nat. Cell Biol. 3:E255-63.
16. Kaufman RJ. (2002) Orchestrating the unfolded protein response in health and disease. J. Clin. Invest. 110:1389-98.
17. Ron D. (2002) Translational control in the endoplasmic reticulum stress response. J. Clin. Invest. 110:1383-88.
18. Xu C, Bailly-Maitre B, Reed JC. (2005) Endoplasmic reticulum stress: cell life and death decisions. J. Clin. Invest. 115:2656-64.
19. Bernales S, Papa FR, Walter P. (2006) Intracellular signaling by the unfolded proteinresponse. Annu. Rev. Cell Dev. Biol. 22:487-508.
20. Wang XZ, et al. (1996) Signals from the stressed endoplasmic reticulum induce C/EBP-homologous protein (CHOP/GADD153). Mol. Cell. Biol. 16:4273-80.
21. Hetz C, Russelakis-Carneiro M, Maundrell K, Castilla J, Soto C. (2003) Caspase-12 and endoplasmic reticulum stress mediate neurotoxicity of pathological prion protein. EMBO J. 22:5435-45.
22. Hotamisligil GS. (2005) Role of endoplasmic reticulum stress and c-Jun NH2-terminal kinase pathways in inflammation and origin of obesity and diabetes. Diabetes 54 Suppl 2:S73-8.
23. Azfer A, Niu J, Rogers LM, Adamski FM, Kolattukudy PE. (2006) Activation of endoplasmic reticulum stress response during the development of ischemic heart disease. Am. J. Physiol. Heart Circ. Physiol. 291:H1411-20.
24. Szegezdi E, et al. (2006) ER stress contributes to ischemia-induced cardiomyocyte apoptosis. Biochem. Biophys. Res. Commun. 349:1406-11.
25. Thuerauf DJ, et al. (2006) Activation of the unfolded protein response in infarcted mouse heart and hypoxic cultured cardiac myocytes. Circ. Res. 99:275-82.
26. Caspersen C, Pedersen PS, Treiman M. (2000) The sarco/endoplasmic reticulum calcium-ATPase 2bis an endoplasmic reticulum stress- inducible protein. J. Biol. Chem. 275:22363-72.
27. Hojmann LA, Frandsen A, Treiman M. (2001) Upregulation of the SERCA-type Ca2+ pump activity in response to endoplasmic reticulum stress in PC12 cells. BMC Biochem. 2:4.
28. Thuerauf DJ, et al. (2001) Sarco/endoplasmic reticulum calcium ATPase-2 expression is regulated by ATF6 during the endoplasmic reticulum stress response: intracellular signaling of calcium stress in a cardiac myocyte model system. J. Biol. Chem. 276:48309-17.
29. Lipskaia L, Chemaly ER, Hadri L, Lompre AM, Hajjar RJ. (2010) Sarcoplasmic reticulum Ca(2+) ATPase as a therapeutic target for heart failure. Expert Opin. Biol. Ther. 10:29-41.
30. Tuzun E, et al. (2009) Correlation of ischemic area and coronary flow with ameroid size in a porcine model. J. Surg. Res. (Epub ahead of print)
31. Mi YF, et al. (2009) Improvement in cardiac function after sarcoplasmic reticulum Ca2+-ATPase gene transfer in a beagle heart failure model. Chin. Med. J. (Engl.) 122:1423-8.
32. Kawase Y, Hajjar RJ. (2008) The cardiac sarcoplasmic/ endoplasmic reticulum calcium ATPase: a potent target for cardiovascular diseases. Nat. Clin. Pract. Cardiovasc. Med. 5:554-65.
33. Hajjar R, Fuster V. (2008) Cardiac cell and gene therapies: two trajectories, one goal. Nat. Clin. Pract. Cardiovasc. Med. 5:749.
34. Hadri L, et al. (2010) SERCA2a gene transfer enhances eNOS expression and activity in endothelial cells. Mol. Ther. 18:1284-92.
35. Dorn GW 2nd. (2009) Apoptotic and non- apoptotic programmed cardiomyocyte death in ventricular remodelling. Cardiovasc. Res. 81:465-73.
36. Lee Y, Gustafsson AB. (2009) Role of apoptosis in cardiovascular disease. Apoptosis 14:536-48.
37. Schroder M, Kaufman RJ. (2005) The mammalian unfolded protein response. Annu. Rev. Biochem. 74:739-89.
38. Wang XZ, et al. (1998) Cloning of mammalian Ire1 reveals diversity in the ER stress responses. EMBO J. 17:5708-17.
39. Yoshida H, et al. (2000) ATF6 activated by proteolysis binds in the presence of NF-Y (CBF) directly to the cis-acting element responsible for the mammalian unfolded protein response. Mol. Cell. Biol. 20:6755-67.
40. Zinszner H, et al. (1998) CHOP is implicated in programmed cell death in response to impaired function of the endoplasmic reticulum. Genes Dev. 12:982-95.
41. Oyadomari S, et al. (2002) Targeted disruption of the Chop gene delays endoplasmic reticulum stress-mediated diabetes. J. Clin. Invest. 109:525-32.
42. Nakagawa T, et al. (2000) Caspase-12 mediates endoplasmic-reticulum-specific apoptosis and cytotoxicity by amyloid-beta. Nature 403:98-103.
43. Rao RV, et al. (2002) Coupling endoplasmic reticulum stress to the cell death program: an Apaf-1-independent intrinsic pathway. J. Biol. Chem. 277:21836-42.
44. Urano F, et al. (2000) Coupling of stress in the ER to activation of JNK protein kinases by transmembrane protein kinase IRE1. Science 287:664-6.
45. Davis RJ. (2000) Signal transduction by the JNK group of MAP kinases. Cell 103:239-52.