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Volumn 6, Issue 3, 2011, Pages

Enhancing chemotherapy response with Bmi-1 silencing in ovarian cancer

Author keywords

[No Author keywords available]

Indexed keywords

BMI1 PROTEIN; CASPASE; CISPLATIN; DIOLEOYLPHOSPHATIDYLCHOLINE; GLUTATHIONE; MESSENGER RNA; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; SMALL INTERFERING RNA; ANTINEOPLASTIC AGENT; BMI1 PROTEIN, HUMAN; NUCLEAR PROTEIN; ONCOPROTEIN; REACTIVE OXYGEN METABOLITE; REPRESSOR PROTEIN;

EID: 79952824058     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0017918     Document Type: Article
Times cited : (77)

References (51)
  • 2
    • 0036388148 scopus 로고    scopus 로고
    • Relapsed ovarian cancer: challenges and management strategies for a chronic disease
    • Armstrong DK, (2002) Relapsed ovarian cancer: challenges and management strategies for a chronic disease. Oncologist 7 (Suppl 5): 20-28.
    • (2002) Oncologist , vol.7 , Issue.SUPPL. 5 , pp. 20-28
    • Armstrong, D.K.1
  • 3
    • 27744551640 scopus 로고    scopus 로고
    • 2004 consensus statements on the management of ovarian cancer: final document of the 3rd International Gynecologic Cancer Intergroup Ovarian Cancer Consensus Conference (GCIG OCCC 2004)
    • du Bois A, Quinn M, Thigpen T, Vermorken J, Avall-Lundqvist E, et al. (2005) 2004 consensus statements on the management of ovarian cancer: final document of the 3rd International Gynecologic Cancer Intergroup Ovarian Cancer Consensus Conference (GCIG OCCC 2004). Ann Oncol 16 (Suppl 8): viii7-viii12.
    • (2005) Ann Oncol , vol.16 , Issue.SUPPL. 8
    • du Bois, A.1    Quinn, M.2    Thigpen, T.3    Vermorken, J.4    Avall-Lundqvist, E.5
  • 5
    • 18544370041 scopus 로고    scopus 로고
    • Cisplatin is a DNA-damaging antitumour compound triggering multifactorial biochemical responses in cancer cells: importance of apoptotic pathways
    • Sedletska Y, Giraud-Panis MJ, Malinge JM, (2005) Cisplatin is a DNA-damaging antitumour compound triggering multifactorial biochemical responses in cancer cells: importance of apoptotic pathways. Curr Med Chem Anticancer Agents 5: 251-265.
    • (2005) Curr Med Chem Anticancer Agents , vol.5 , pp. 251-265
    • Sedletska, Y.1    Giraud-Panis, M.J.2    Malinge, J.M.3
  • 6
    • 0037673984 scopus 로고    scopus 로고
    • Bmi-1 determines the proliferative capacity of normal and leukaemic stem cells
    • Lessard J, Sauvageau G, (2003) Bmi-1 determines the proliferative capacity of normal and leukaemic stem cells. Nature 423: 255-260.
    • (2003) Nature , vol.423 , pp. 255-260
    • Lessard, J.1    Sauvageau, G.2
  • 7
    • 22344449361 scopus 로고    scopus 로고
    • Bmi-1 promotes neural stem cell self-renewal and neural development but not mouse growth and survival by repressing the p16Ink4a and p19Arf senescence pathways
    • Molofsky AV, He S, Bydon M, Morrison SJ, Pardal R, (2005) Bmi-1 promotes neural stem cell self-renewal and neural development but not mouse growth and survival by repressing the p16Ink4a and p19Arf senescence pathways. Genes Dev 19: 1432-1437.
    • (2005) Genes Dev , vol.19 , pp. 1432-1437
    • Molofsky, A.V.1    He, S.2    Bydon, M.3    Morrison, S.J.4    Pardal, R.5
  • 8
    • 0242667922 scopus 로고    scopus 로고
    • Bmi-1 dependence distinguishes neural stem cell self-renewal from progenitor proliferation
    • Molofsky AV, Pardal R, Iwashita T, Park IK, Clarke MF, et al. (2003) Bmi-1 dependence distinguishes neural stem cell self-renewal from progenitor proliferation. Nature 425: 962-967.
    • (2003) Nature , vol.425 , pp. 962-967
    • Molofsky, A.V.1    Pardal, R.2    Iwashita, T.3    Park, I.K.4    Clarke, M.F.5
  • 9
    • 0141670822 scopus 로고    scopus 로고
    • Self-renewal of hematopoietic and leukemic stem cells: a central role for the Polycomb-group gene Bmi-1
    • Raaphorst FM, (2003) Self-renewal of hematopoietic and leukemic stem cells: a central role for the Polycomb-group gene Bmi-1. Trends Immunol 24: 522-524.
    • (2003) Trends Immunol , vol.24 , pp. 522-524
    • Raaphorst, F.M.1
  • 10
    • 34247891673 scopus 로고    scopus 로고
    • Bmi-1 is essential for the tumorigenicity of neuroblastoma cells
    • Cui H, Hu B, Li T, Ma J, Alam G, et al. (2007) Bmi-1 is essential for the tumorigenicity of neuroblastoma cells. Am J Pathol 170: 1370-1378.
    • (2007) Am J Pathol , vol.170 , pp. 1370-1378
    • Cui, H.1    Hu, B.2    Li, T.3    Ma, J.4    Alam, G.5
  • 11
    • 47749128298 scopus 로고    scopus 로고
    • Stem cell protein BMI-1 is an independent marker for poor prognosis in oligodendroglial tumours
    • Hayry V, Tynninen O, Haapasalo HK, Wolfer J, Paulus W, et al. (2008) Stem cell protein BMI-1 is an independent marker for poor prognosis in oligodendroglial tumours. Neuropathol Appl Neurobiol 34: 555-563.
    • (2008) Neuropathol Appl Neurobiol , vol.34 , pp. 555-563
    • Hayry, V.1    Tynninen, O.2    Haapasalo, H.K.3    Wolfer, J.4    Paulus, W.5
  • 12
    • 39749120638 scopus 로고    scopus 로고
    • Bmi-1 expression predicts prognosis for patients with gastric carcinoma
    • Liu JH, Song LB, Zhang X, Guo BH, Feng Y, et al. (2008) Bmi-1 expression predicts prognosis for patients with gastric carcinoma. J Surg Oncol 97: 267-272.
    • (2008) J Surg Oncol , vol.97 , pp. 267-272
    • Liu, J.H.1    Song, L.B.2    Zhang, X.3    Guo, B.H.4    Feng, Y.5
  • 13
    • 27244450787 scopus 로고    scopus 로고
    • BMI-1 is highly expressed in M0-subtype acute myeloid leukemia
    • Sawa M, Yamamoto K, Yokozawa T, Kiyoi H, Hishida A, et al. (2005) BMI-1 is highly expressed in M0-subtype acute myeloid leukemia. Int J Hematol 82: 42-47.
    • (2005) Int J Hematol , vol.82 , pp. 42-47
    • Sawa, M.1    Yamamoto, K.2    Yokozawa, T.3    Kiyoi, H.4    Hishida, A.5
  • 14
    • 36549060556 scopus 로고    scopus 로고
    • Circulating Bmi-1 mRNA as a possible prognostic factor for advanced breast cancer patients
    • Silva J, Garcia V, Garcia JM, Pena C, Dominguez G, et al. (2007) Circulating Bmi-1 mRNA as a possible prognostic factor for advanced breast cancer patients. Breast Cancer Res 9: R55.
    • (2007) Breast Cancer Res , vol.9
    • Silva, J.1    Garcia, V.2    Garcia, J.M.3    Pena, C.4    Dominguez, G.5
  • 15
    • 33745685884 scopus 로고    scopus 로고
    • Bmi-1 is a novel molecular marker of nasopharyngeal carcinoma progression and immortalizes primary human nasopharyngeal epithelial cells
    • Song LB, Zeng MS, Liao WT, Zhang L, Mo HY, et al. (2006) Bmi-1 is a novel molecular marker of nasopharyngeal carcinoma progression and immortalizes primary human nasopharyngeal epithelial cells. Cancer Res 66: 6225-6232.
    • (2006) Cancer Res , vol.66 , pp. 6225-6232
    • Song, L.B.1    Zeng, M.S.2    Liao, W.T.3    Zhang, L.4    Mo, H.Y.5
  • 16
    • 49649083394 scopus 로고    scopus 로고
    • Prognostic value of Bmi-1 oncoprotein expression in NSCLC patients: a tissue microarray study
    • Vrzalikova K, Skarda J, Ehrmann J, Murray PG, Fridman E, et al. (2008) Prognostic value of Bmi-1 oncoprotein expression in NSCLC patients: a tissue microarray study. J Cancer Res Clin Oncol 134: 1037-1042.
    • (2008) J Cancer Res Clin Oncol , vol.134 , pp. 1037-1042
    • Vrzalikova, K.1    Skarda, J.2    Ehrmann, J.3    Murray, P.G.4    Fridman, E.5
  • 17
    • 41049109184 scopus 로고    scopus 로고
    • Increased polycomb-group oncogene Bmi-1 expression correlates with poor prognosis in hepatocellular carcinoma
    • Wang H, Pan K, Zhang HK, Weng DS, Zhou J, et al. (2008) Increased polycomb-group oncogene Bmi-1 expression correlates with poor prognosis in hepatocellular carcinoma. J Cancer Res Clin Oncol 134: 535-541.
    • (2008) J Cancer Res Clin Oncol , vol.134 , pp. 535-541
    • Wang, H.1    Pan, K.2    Zhang, H.K.3    Weng, D.S.4    Zhou, J.5
  • 18
    • 77950657234 scopus 로고    scopus 로고
    • Intensive expression of Bmi-1 is a new independent predictor of poor outcome in patients with ovarian carcinoma
    • Yang GF, He WP, Cai MY, He LR, Luo JH, et al. (2010) Intensive expression of Bmi-1 is a new independent predictor of poor outcome in patients with ovarian carcinoma. BMC Cancer 10: 133.
    • (2010) BMC Cancer , vol.10 , pp. 133
    • Yang, G.F.1    He, W.P.2    Cai, M.Y.3    He, L.R.4    Luo, J.H.5
  • 19
    • 42049105538 scopus 로고    scopus 로고
    • Correlations of BMI-1 expression and telomerase activity in ovarian cancer tissues
    • Zhang F, Sui L, Xin T, (2008) Correlations of BMI-1 expression and telomerase activity in ovarian cancer tissues. Exp Oncol 30: 70-74.
    • (2008) Exp Oncol , vol.30 , pp. 70-74
    • Zhang, F.1    Sui, L.2    Xin, T.3
  • 20
    • 0030611381 scopus 로고    scopus 로고
    • Pertubation of B and T cell development and predisposition to lymphomagenesis in Emu Bmi1 transgenic mice require the Bmi1 RING finger
    • Alkema MJ, Jacobs H, van Lohuizen M, Berns A, (1997) Pertubation of B and T cell development and predisposition to lymphomagenesis in Emu Bmi1 transgenic mice require the Bmi1 RING finger. Oncogene 15: 899-910.
    • (1997) Oncogene , vol.15 , pp. 899-910
    • Alkema, M.J.1    Jacobs, H.2    van Lohuizen, M.3    Berns, A.4
  • 21
    • 0027487387 scopus 로고
    • bmi-1 transgene induces lymphomas and collaborates with myc in tumorigenesis
    • Haupt Y, Bath ML, Harris AW, Adams JM, (1993) bmi-1 transgene induces lymphomas and collaborates with myc in tumorigenesis. Oncogene 8: 3161-3164.
    • (1993) Oncogene , vol.8 , pp. 3161-3164
    • Haupt, Y.1    Bath, M.L.2    Harris, A.W.3    Adams, J.M.4
  • 22
    • 69449096782 scopus 로고    scopus 로고
    • BMI1 cooperates with H-RAS to induce an aggressive breast cancer phenotype with brain metastases
    • Hoenerhoff MJ, Chu I, Barkan D, Liu ZY, Datta S, et al. (2009) BMI1 cooperates with H-RAS to induce an aggressive breast cancer phenotype with brain metastases. Oncogene 28: 3022-3032.
    • (2009) Oncogene , vol.28 , pp. 3022-3032
    • Hoenerhoff, M.J.1    Chu, I.2    Barkan, D.3    Liu, Z.Y.4    Datta, S.5
  • 23
    • 49249091523 scopus 로고    scopus 로고
    • Identification and characterization of ovarian cancer-initiating cells from primary human tumors
    • Zhang S, Balch C, Chan MW, Lai HC, Matei D, et al. (2008) Identification and characterization of ovarian cancer-initiating cells from primary human tumors. Cancer Res 68: 4311-4320.
    • (2008) Cancer Res , vol.68 , pp. 4311-4320
    • Zhang, S.1    Balch, C.2    Chan, M.W.3    Lai, H.C.4    Matei, D.5
  • 24
    • 20444457518 scopus 로고    scopus 로고
    • Microarray analysis identifies a death-from-cancer signature predicting therapy failure in patients with multiple types of cancer
    • Glinsky GV, Berezovska O, Glinskii AB, (2005) Microarray analysis identifies a death-from-cancer signature predicting therapy failure in patients with multiple types of cancer. J Clin Invest 115: 1503-1521.
    • (2005) J Clin Invest , vol.115 , pp. 1503-1521
    • Glinsky, G.V.1    Berezovska, O.2    Glinskii, A.B.3
  • 25
    • 0014691619 scopus 로고
    • Platinum compounds: a new class of potent antitumour agents
    • Rosenberg B, VanCamp L, Trosko JE, Mansour VH, (1969) Platinum compounds: a new class of potent antitumour agents. Nature 222: 385-386.
    • (1969) Nature , vol.222 , pp. 385-386
    • Rosenberg, B.1    VanCamp, L.2    Trosko, J.E.3    Mansour, V.H.4
  • 26
    • 77953456193 scopus 로고    scopus 로고
    • Enhancing the efficacy of cisplatin in ovarian cancer treatment - could arsenic have a role
    • Helm CW, States JC, (2009) Enhancing the efficacy of cisplatin in ovarian cancer treatment- could arsenic have a role. J Ovarian Res 2: 2.
    • (2009) J Ovarian Res , vol.2 , pp. 2
    • Helm, C.W.1    States, J.C.2
  • 28
    • 58849166901 scopus 로고    scopus 로고
    • The polycomb group gene Bmi1 regulates antioxidant defenses in neurons by repressing p53 pro-oxidant activity
    • Chatoo W, Abdouh M, David J, Champagne MP, Ferreira J, et al. (2009) The polycomb group gene Bmi1 regulates antioxidant defenses in neurons by repressing p53 pro-oxidant activity. J Neurosci 29: 529-542.
    • (2009) J Neurosci , vol.29 , pp. 529-542
    • Chatoo, W.1    Abdouh, M.2    David, J.3    Champagne, M.P.4    Ferreira, J.5
  • 29
    • 67349156082 scopus 로고    scopus 로고
    • Bmi1 regulates mitochondrial function and the DNA damage response pathway
    • Liu J, Cao L, Chen J, Song S, Lee IH, et al. (2009) Bmi1 regulates mitochondrial function and the DNA damage response pathway. Nature 459: 387-392.
    • (2009) Nature , vol.459 , pp. 387-392
    • Liu, J.1    Cao, L.2    Chen, J.3    Song, S.4    Lee, I.H.5
  • 30
    • 34547098814 scopus 로고    scopus 로고
    • Apoptosis by cisplatin requires p53 mediated p38alpha MAPK activation through ROS generation
    • Bragado P, Armesilla A, Silva A, Porras A, (2007) Apoptosis by cisplatin requires p53 mediated p38alpha MAPK activation through ROS generation. Apoptosis 12: 1733-1742.
    • (2007) Apoptosis , vol.12 , pp. 1733-1742
    • Bragado, P.1    Armesilla, A.2    Silva, A.3    Porras, A.4
  • 31
    • 0344825072 scopus 로고    scopus 로고
    • DNA-damaging reagents induce apoptosis through reactive oxygen species-dependent Fas aggregation
    • Huang HL, Fang LW, Lu SP, Chou CK, Luh TY, et al. (2003) DNA-damaging reagents induce apoptosis through reactive oxygen species-dependent Fas aggregation. Oncogene 22: 8168-8177.
    • (2003) Oncogene , vol.22 , pp. 8168-8177
    • Huang, H.L.1    Fang, L.W.2    Lu, S.P.3    Chou, C.K.4    Luh, T.Y.5
  • 32
    • 33745360760 scopus 로고    scopus 로고
    • GSH transport in mitochondria: defense against TNF-induced oxidative stress and alcohol-induced defect
    • Fernandez-Checa JC, Kaplowitz N, Garcia-Ruiz C, Colell A, Miranda M, et al. (1997) GSH transport in mitochondria: defense against TNF-induced oxidative stress and alcohol-induced defect. Am J Physiol 273: G7-17.
    • (1997) Am J Physiol , vol.273
    • Fernandez-Checa, J.C.1    Kaplowitz, N.2    Garcia-Ruiz, C.3    Colell, A.4    Miranda, M.5
  • 33
    • 0028176651 scopus 로고
    • Oxidative stress as a mediator of apoptosis
    • Buttke TM, Sandstrom PA, (1994) Oxidative stress as a mediator of apoptosis. Immunol Today 15: 7-10.
    • (1994) Immunol Today , vol.15 , pp. 7-10
    • Buttke, T.M.1    Sandstrom, P.A.2
  • 34
    • 0033231351 scopus 로고    scopus 로고
    • Gene expression and the thiol redox state
    • Arrigo AP, (1999) Gene expression and the thiol redox state. Free Radic Biol Med 27: 936-944.
    • (1999) Free Radic Biol Med , vol.27 , pp. 936-944
    • Arrigo, A.P.1
  • 35
    • 3042802690 scopus 로고    scopus 로고
    • Glutathione: an overview of biosynthesis and modulation
    • Anderson ME, (1998) Glutathione: an overview of biosynthesis and modulation. Chem Biol Interact 111-112: 1-14.
    • (1998) Chem Biol Interact , vol.111-112 , pp. 1-14
    • Anderson, M.E.1
  • 37
    • 17244366865 scopus 로고    scopus 로고
    • Activation of the DNA damage checkpoint and genomic instability in human precancerous lesions
    • Gorgoulis VG, Vassiliou LV, Karakaidos P, Zacharatos P, Kotsinas A, et al. (2005) Activation of the DNA damage checkpoint and genomic instability in human precancerous lesions. Nature 434: 907-913.
    • (2005) Nature , vol.434 , pp. 907-913
    • Gorgoulis, V.G.1    Vassiliou, L.V.2    Karakaidos, P.3    Zacharatos, P.4    Kotsinas, A.5
  • 38
    • 77949712722 scopus 로고    scopus 로고
    • Platinum-DNA interactions and subsequent cellular processes controlling sensitivity to anticancer platinum complexes
    • Ahmad S, (2010) Platinum-DNA interactions and subsequent cellular processes controlling sensitivity to anticancer platinum complexes. Chem Biodivers 7: 543-566.
    • (2010) Chem Biodivers , vol.7 , pp. 543-566
    • Ahmad, S.1
  • 39
    • 38049136456 scopus 로고    scopus 로고
    • DNA damage-induced cell death: lessons from the central nervous system
    • Borges HL, Linden R, Wang JY, (2008) DNA damage-induced cell death: lessons from the central nervous system. Cell Res 18: 17-26.
    • (2008) Cell Res , vol.18 , pp. 17-26
    • Borges, H.L.1    Linden, R.2    Wang, J.Y.3
  • 40
    • 0032078217 scopus 로고    scopus 로고
    • Caspases: key mediators of apoptosis
    • Thornberry NA, (1998) Caspases: key mediators of apoptosis. Chem Biol 5: R97-103.
    • (1998) Chem Biol , vol.5
    • Thornberry, N.A.1
  • 41
    • 23044506285 scopus 로고    scopus 로고
    • Therapeutic EphA2 gene targeting in vivo using neutral liposomal small interfering RNA delivery
    • Landen CN Jr, Chavez-Reyes A, Bucana C, Schmandt R, Deavers MT, et al. (2005) Therapeutic EphA2 gene targeting in vivo using neutral liposomal small interfering RNA delivery. Cancer Res 65: 6910-6918.
    • (2005) Cancer Res , vol.65 , pp. 6910-6918
    • Landen Jr., C.N.1    Chavez-Reyes, A.2    Bucana, C.3    Schmandt, R.4    Deavers, M.T.5
  • 42
    • 40949126550 scopus 로고    scopus 로고
    • Effect of interleukin-8 gene silencing with liposome-encapsulated small interfering RNA on ovarian cancer cell growth
    • Merritt WM, Lin YG, Spannuth WA, Fletcher MS, Kamat AA, et al. (2008) Effect of interleukin-8 gene silencing with liposome-encapsulated small interfering RNA on ovarian cancer cell growth. J Natl Cancer Inst 100: 359-372.
    • (2008) J Natl Cancer Inst , vol.100 , pp. 359-372
    • Merritt, W.M.1    Lin, Y.G.2    Spannuth, W.A.3    Fletcher, M.S.4    Kamat, A.A.5
  • 43
    • 26944473246 scopus 로고    scopus 로고
    • Annual report to the nation on the status of cancer, 1975-2002, featuring population-based trends in cancer treatment
    • Edwards BK, Brown ML, Wingo PA, Howe HL, Ward E, et al. (2005) Annual report to the nation on the status of cancer, 1975-2002, featuring population-based trends in cancer treatment. J Natl Cancer Inst 97: 1407-1427.
    • (2005) J Natl Cancer Inst , vol.97 , pp. 1407-1427
    • Edwards, B.K.1    Brown, M.L.2    Wingo, P.A.3    Howe, H.L.4    Ward, E.5
  • 44
    • 77957748289 scopus 로고    scopus 로고
    • BMI1-mediated histone ubiquitylation promotes DNA double-strand break repair
    • Ismail IH, Andrin C, McDonald D, Hendzel MJ, (2010) BMI1-mediated histone ubiquitylation promotes DNA double-strand break repair. J Cell Biol 191: 45-60.
    • (2010) J Cell Biol , vol.191 , pp. 45-60
    • Ismail, I.H.1    Andrin, C.2    McDonald, D.3    Hendzel, M.J.4
  • 45
    • 76149111625 scopus 로고    scopus 로고
    • Oncoprotein Bmi-1 renders apoptotic resistance to glioma cells through activation of the IKK-nuclear factor-kappaB Pathway
    • Li J, Gong LY, Song LB, Jiang LL, Liu LP, et al. (2010) Oncoprotein Bmi-1 renders apoptotic resistance to glioma cells through activation of the IKK-nuclear factor-kappaB Pathway. Am J Pathol 176: 699-709.
    • (2010) Am J Pathol , vol.176 , pp. 699-709
    • Li, J.1    Gong, L.Y.2    Song, L.B.3    Jiang, L.L.4    Liu, L.P.5
  • 46
    • 0037102196 scopus 로고    scopus 로고
    • The Bmi-1 oncogene induces telomerase activity and immortalizes human mammary epithelial cells
    • Dimri GP, Martinez JL, Jacobs JJ, Keblusek P, Itahana K, et al. (2002) The Bmi-1 oncogene induces telomerase activity and immortalizes human mammary epithelial cells. Cancer Res 62: 4736-4745.
    • (2002) Cancer Res , vol.62 , pp. 4736-4745
    • Dimri, G.P.1    Martinez, J.L.2    Jacobs, J.J.3    Keblusek, P.4    Itahana, K.5
  • 47
    • 0038349957 scopus 로고    scopus 로고
    • Bmi-1 is required for maintenance of adult self-renewing haematopoietic stem cells
    • Park IK, Qian D, Kiel M, Becker MW, Pihalja M, et al. (2003) Bmi-1 is required for maintenance of adult self-renewing haematopoietic stem cells. Nature 423: 302-305.
    • (2003) Nature , vol.423 , pp. 302-305
    • Park, I.K.1    Qian, D.2    Kiel, M.3    Becker, M.W.4    Pihalja, M.5
  • 50
    • 38349158077 scopus 로고    scopus 로고
    • Simultaneous detection of apoptosis and mitochondrial superoxide production in live cells by flow cytometry and confocal microscopy
    • Mukhopadhyay P, Rajesh M, Hasko G, Hawkins BJ, Madesh M, et al. (2007) Simultaneous detection of apoptosis and mitochondrial superoxide production in live cells by flow cytometry and confocal microscopy. Nat Protoc 2: 2295-2301.
    • (2007) Nat Protoc , vol.2 , pp. 2295-2301
    • Mukhopadhyay, P.1    Rajesh, M.2    Hasko, G.3    Hawkins, B.J.4    Madesh, M.5
  • 51
    • 44949231424 scopus 로고    scopus 로고
    • Analyzing real-time PCR data by the comparative C(T) method
    • Schmittgen TD, Livak KJ, (2008) Analyzing real-time PCR data by the comparative C(T) method. Nat Protoc 3: 1101-1108.
    • (2008) Nat Protoc , vol.3 , pp. 1101-1108
    • Schmittgen, T.D.1    Livak, K.J.2


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