Stereoselective synthesis of monoamine reuptake inhibitor NS9544 acetate

Organic Process Research and Development

Volumn 15, Issue 2, 2011, Pages 408-412

  Malmgren, Håkan ^a   Cotton, Hanna ^a   Frøstrup, Brian ^b   Jones, David Spencer ^b   Loke, Marie Louise ^b   Peters, Dan ^b   Schultz, Sara ^a   Sölver, Ellen ^a   Thomsen, Tove ^b   Wennerberg, Johan ^a  

^a DUPONT COMPANY   (United States)

^b NEUROSEARCH A S   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

ACETATE SALTS; BORONIC ACID; CANDIDATE DRUGS; CRYSTALLISATION; DEMETHYLATION; ENANTIOMERIC PURITY; ENANTIOSELECTIVE; ENOLATES; L-(+)- TARTARIC ACIDS; LITHIUM AMIDE; STEREOSELECTIVE SYNTHESIS; SUZUKI CONDITIONS; SYNTHETIC ROUTES; TRIFLATES;

ACETIC ACID; AMIDES; ENANTIOMERS; LITHIUM; STEREOSELECTIVITY; THIOPHENE;

VOLATILE FATTY ACIDS;

EID: 79952821052     PISSN: 10836160     EISSN: 1520586X     Source Type: Journal    
DOI: 10.1021/op1003117     Document Type: Article

References (13)

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13. In a glass-lined reactor tropinone (19.3 kg) was dissolved in diethyl ether (43 kg). Magnesium sulfate (1.2 kg) was added, and the mixture was stirred for 3 h. The mixture was filtered through a bag filter followed by filtering through a cartridge filter. The reactor and filter were washed with diethyl ether (11 kg). The combined organic solutions were evaporated to dryness in a Buchi Rotavapor R-250. Yield 18.4 kg (95.3%).