Mitotic activity within dermal melanocytes of benign melanocytic nevi: A study of 100 cases with clinical follow-up

American Journal of Dermatopathology

Volumn 33, Issue 2, 2011, Pages 167-172

  Ruhoy, Steven M ^a   Kolker, Steven E ^b   Murry, Todd C ^c  

^a VIRGINIA MASON MEDICAL CENTER   (United States)

^b PROVIDENCE PORTLAND MEDICAL CENTER   (United States)

^c Laboratory Med Consultants Ltd   (United States)

Author keywords

melanocytic nevi; mitosis; Mitotic

Indexed keywords

ADOLESCENT; ADULT; AGED; ANGIOMA; ARTICLE; CHILD; CLINICAL ASSESSMENT; CONGENITAL NEVUS; CONTROLLED STUDY; FEMALE; FOLLOW UP; HALO NEVUS; HISTOPATHOLOGY; HUMAN; HUMAN CELL; HUMAN TISSUE; INCIDENCE; JUVENILE MELANOMA; MAJOR CLINICAL STUDY; MALE; MELANOCYTE; MELANOCYTIC NEVUS; MELANOMA; MITOSIS RATE; PIGMENTED NEVUS; PRESCHOOL CHILD; PRIORITY JOURNAL; SCHOOL CHILD; SEASONAL VARIATION; SKIN BIOPSY;

ADOLESCENT; ADULT; AGED; CHILD; CHILD, PRESCHOOL; FEMALE; HUMANS; MALE; MELANOCYTES; MIDDLE AGED; MITOSIS; NEVUS, PIGMENTED; SKIN NEOPLASMS; YOUNG ADULT;

EID: 79952819052     PISSN: 01931091     EISSN: None     Source Type: Journal    
DOI: 10.1097/DAD.0b013e3181f3dba3     Document Type: Article

References (28)

1. Urso C, Saieva C, Borgognoni L, et al. Sensitivity and specificity of histologic criteria in the diagnosis of conventional cutaneous melanoma. Melanoma Res. 2008;18:253-258.
2. Massi G, Leboit PE. Criteria for the diagnosis of a benign melanocytic nevus. In: Massi G, Leboit PE, eds. Histological Diagnosis ofNevi and Melanoma. Germany: Steinkopff Verlag Darmstadt-Springer; 2004:13-14.
3. Ruhoy SM, Prieto VG, Eliason SL, et al. Malignant melanoma with paradoxical maturation. Am J Surg Path. 2000;24:1600-1614.
4. McKee PH, Calonje E, Granter S. Melanocytic nevi. In: McKee PH, Calonje E, Granter S, et al, eds. Pathology of the Skin With Clinical Correlations. Vol2. 3rded. Philadelphia, PA: Elsevier Mosby; 2005:1257.
5. Kesmodel SB, Karakousis GC, Botbyl JD, et al. Mitotic rate as a predictor of sentinel lymph node positivity in patients with thin melanomas. Ann Surg Oncol. 2005;12:449-458. (Pubitemid 40884259)
6. Wang Q, Prieto VG, Esmaeli B, et al. Cellular blue nevi of the eyelid: a possible diagnostic pitfall. JAm Acad Dermatol. 2008;58:257-260.
7. Crotty KA, Scolyer RA, Li LX, et al. Spitz naevus versus spitzoid melanoma: when and how can they be distinguished? Pathology. 2002;34:6-12. (Pubitemid 34155224)
8. Jensen SL, Radfar A, Bhawan J. Mitoses in conventional melanocytic nevi. J Cutan Pathol. 2007;34:713-715. (Pubitemid 47256252)
9. Zembowicz A, McCusker M, Chiarelli C, et al. Morphologic analysis of nevoid melanoma: astudyof20 cases with areviewoftheliterature. Am J Dermatopathol. 2001;23:167-175. (Pubitemid 32525403)
10. Mark GJ, Mihm MC, Liteplo MG, et al. Congenital melanocytic nevi of the small and garment type. Clinical, histologic, and ultrastructural studies. Hum Pathol. 1973;4:395-418.
11. Rhodes AR. Congenital nevomelanocytic nevi. Histologic patterns in the first year of life and evolution during childhood. Arch Dermatol. 1986; 122:1257-1262. (Pubitemid 17176829)
12. Shea CR, Vollmer RT, Prieto VG Correlating architectural disorder and cytologic atypia in Clark (dysplastic) melanocytic nevi. Hum Pathol. 1999;30:500-505. (Pubitemid 29218040)
13. McKee PH, Calonje E, Granter S. Melanocytic nevi. In: McKee PH, Calonje E, Granter S, et al, eds. Pathology of the Skin With Clinical Correlations. Vol 2. 3rd ed. Philadelphia, PA: Elsevier Mosby; 2005: 1254.
14. Gerami P, Wass A, Mafee M, et al. Fluorescence in situ hybridization for distinguishing nevoid melanomas from mitotically active nevi. Am J Surg Pathol. 2009;33:1783-1788.
15. Tronnier M, Wolff HH. UV-irradiated melanocytic nevi simulating melanoma in situ. Am J Dermatopathol. 1995;17:1-6.
16. Rosdahl LK, Szabo G Mitotic activity ofepidermal melanocytes in UV-irradiated mouse skin. J Invest Dermatol. 1978;70:143-145.
17. Holman CDJ, Heenan PJ, Caruso V, et al. Seasonal variation in the junctional component of pigmented naevi. Int J Cancer. 1983;31: 213-215. (Pubitemid 13189352)
18. Larsen TE, Mogensen SB, Holme I. Seasonal variations of pigmented naevi. Acta Derm Venereol. 1990;70:115-120.
19. Fleming MG, Swan LS, Heenan PJ. Seasonal variation in the proliferation fraction of Australian common nevi. Am J Dermatopathol. 1991;13: 463-466.
20. Boniol M, Armstrong BK, Dore JF Variation in incidence and fatality of melanoma by season of diagnosis in new South Wales, Australia. Cancer Epidemiol Biomarkers Prev. 2006;15:524-528.
21. Chan MP, Chan MM, Tahan SR. Melanocytic nevi in pregnancy: histologic features and Ki-67 proliferation index. J Cutan Pathol. 2010; 37:843-851.
22. Selim MA, Vollmer RH, Herman CM, et al. Melanocytic nevi with nonsurgical trauma: a histopathologic study. Am J Dermatopathol. 2007; 29:134-136. (Pubitemid 46573080)
23. Rhodes AR, Sober AJ, Day CL, et al. The malignant potential of small congenital nevocellular nevi. An estimate of association based on histologic study of 234 primary cutaneous melanomas. J Am Acad Dermatol. 1982;6:230-241. (Pubitemid 12165016)
24. Berg P, Lindelof B. Congenital melanocytic naevi and cutaneous melanoma. Melanoma Res. 2003;13:441-445. (Pubitemid 37266946)
25. Holly EA, Kelly JW, Shpall SN, et al. Number of melanocytic nevi as a major risk factor for malignant melanoma. JAm Acad Dermatol. 1987; 17:459-468. (Pubitemid 17118526)
26. Stefanaki C, Stefanaki K, Antoniou C, et al. G1 cell cycle regulators in congenital melanocytic nevi. Comparison with acquired nevi and melanomas. J Cutan Pathol. 2008;35:799-808.
27. Nasr MR, El-Zammar O. Comparison of pHH3, Ki-67, and surviving immunoreactivity in benign and malignant melanocytic lesion. Am J Dermatopathol. 2008;30:117-122. (Pubitemid 351441982)
28. Tapia C, Kutzneer H, Mentzel T, et al. Two mitosis-specific antibodies, mpm-2 and phospho-histone H3 (ser28), allow rapid and precise determination of mitotic activity. Am J Surg Pathol. 2006;30:83-89. (Pubitemid 43740213)