Mutations in ribosomal proteins and ribosomal RNA confer macrolide resistance in human Ureaplasma spp.

International Journal of Antimicrobial Agents

Volumn 37, Issue 4, 2011, Pages 377-379

  Xiao, Li ^a   Crabb, Donna M ^a   Duffy, Lynn B ^a   Paralanov, Vanya ^b   Glass, John I ^b   Hamilos, Daniel L ^c   Waites, Ken B ^a  

^a University of Alabama at Birmingham   (United States)

^b J CRAIG VENTER INSTITUTE   (United States)

^c MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

Antibiotic; Macrolide; Resistance; Ribosomal proteins; Ribosomal RNA; Ureaplasma

Indexed keywords

BACTERIAL RNA; ERYTHROMYCIN; RIBOSOME PROTEIN; RIBOSOME RNA; RNA 23S; TETRACYCLINE; VALINE;

ANTIBIOTIC RESISTANCE; ARTICLE; BACTERIAL GENE; BACTERIUM CULTURE; BACTERIUM ISOLATE; CONTROLLED STUDY; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; POINT MUTATION; PRIORITY JOURNAL; PROTEIN DOMAIN; RIBOSOMAL PROTEIN L4 GENE; UREAPLASMA;

ANTI-BACTERIAL AGENTS; DRUG RESISTANCE, MICROBIAL; HUMANS; MACROLIDES; POINT MUTATION; RIBOSOMAL PROTEINS; RNA, RIBOSOMAL; UREAPLASMA;

EID: 79952815778     PISSN: 09248579     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijantimicag.2010.12.012     Document Type: Article

References (17)

1. Waites KB, Duffy LB, Schwartz S, Talkington DF. Mycoplasma and Ureaplasma. In: Isenberg H, editor. Clinical microbiology procedures handbook. Washington, DC: ASM Press; 2004. p. 3.15.1-17.
2. Lapusan DL, Duffy LB, Hamilos DL. Disseminated septic arthritis in a patient with common variable hypogammaglobulinemia. Ann Allergy Asthma Immunol 2001;86:368-72. (Pubitemid 32332313)
3. Xiao L, Glass JI, Paralanov V, Yooseph S, Cassell GH, Duffy LB, et al. Detection and characterization of human Ureaplasma species and serovars by real-time PCR. J Clin Microbiol 2010;48:2715-23.
4. Pereyre S, Metifiot M, Cazanave C, Renaudin H, Charron A, Bebear C, et al. Characterisation of in vitro-selected mutants of Ureaplasma parvum resistant to macrolides and related antibiotics. Int J Antimicrob Agents 2007;29:207-11. (Pubitemid 46073671)
5. Lina G, Quaglia A, Reverdy ME, Leclercq R, Vandenesch F, Etienne J. Distribution of genes encoding resistance to macrolides, lincosamides, and streptogramins among staphylococci. Antimicrob Agents Chemother 1999;43:1062-6. (Pubitemid 29214725)
6. Patterson AJ, Colangeli R, Spigaglia P, Scott KP. Distribution of specific tetracycline and erythromycin resistance genes in environmental samples assessed by macroarray detection. Environ Microbiol 2007;9:703-15.
7. Phuc Nguyen MC, Woerther PL, Bouvet M, Andremont A, Leclercq R, Canu A. Escherichia coli as reservoir for macrolide resistance genes. Emerg Infect Dis 2009;15:1648-50.
8. Daly MM, Doktor MS, Flamm R, Shortridge V. Characterization and prevalence of MefA, MefE, and the associated msr(D) gene in Streptococcus pneumoniae clinical isolates. J Clin Microbiol 2004;42:3570-4.
9. Reynolds E, Cove JH. Enhanced resistance to erythromycin is conferred by the enterococcal msrC determinant in Staphylococcus aureus. J Antimicrob Chemother 2005;55:260-4. (Pubitemid 40331156)
10. Doherty N, Trzcinski K, Pickerill P, Zawadzki P, Dowson CG. Genetic diversity of the tet(M) gene in tetracycline-resistant clonal lineages of Streptococcus pneumoniae. Antimicrob Agents Chemother 2000;44:2979-84.
11. Vester B, Douthwaite S. Macrolide resistance conferred by base substitutions in 23S rRNA. Antimicrob Agents Chemother 2001;5:1-12. (Pubitemid 32039086)
12. Tait-Kamradt A, Davies T, Appelbaum PC, Depardieu F, Courvalin P, Petitpas J, et al. Two new mechanisms ofmacrolide resistance in clinical strains of Streptococcus pneumoniae from Eastern Europe and North America. Antimicrob Agents Chemother 2000;44:3395-401. (Pubitemid 33009501)
13. Kenny GE, Cartwright FD. Effect of pH, inoculum size, and incubation time on the susceptibility of Ureaplasma urealyticum to erythromycin in vitro. Clin Infect Dis 1993;17(Suppl. 1):S215-8.
14. Palu G, Valisena S, Barile MF, Meloni G. Mechanisms of macrolide resistance in Ureaplasma urealyticum: a study on collection and clinical strains. Eur J Epidemiol 1989;5:146-53. (Pubitemid 19162198)
15. Beeton ML, Chalker VJ, Maxwell NC, Kotecha S, Spiller B. Concurrent titration and determination of antibiotic resistance in Ureaplasma species with identification of novel point mutations in genes associated with resistance. Antimicrob Agents Chemother 2009;53:2020-7.
16. Dongya M, Wencheng X, Xiaobo M, Lu W. Transition mutations in 23S rRNA account for acquired resistance to macrolides in Ureaplasma urealyticum. Microb Drug Resist 2008;14:183-6.
17. Lu C, Ye TL, Zhu GX, Feng PY, Ma H, Lu RB, et al. Phenotypic and genetic characteristics of macrolide and lincosamide-resistant Ureaplasma urealyticum isolated in Guangzhou, China. Curr Microbiol 2010;61:44-9.