Tarka® (trandolapril/verapamil hydrochloride extended-release) overdose

Journal of Emergency Medicine

Volumn 40, Issue 3, 2011, Pages 291-295

  Cohen, Victor ^a   Jellinek, Samantha P ^a   Fancher, Lydia ^a   Sangwan, Geetanjli ^a   Wakslak, Menachem ^a   Marquart, Elizabeth ^a   Farahani, Cyrus ^a  

^a MAIMONIDES MEDICAL CENTER   (United States)

Author keywords

angiotensin converting enzyme inhibitor; calcium channel blocker; fixed dose combinations; overdose; Tarka

Indexed keywords

ACTIVATED CARBON; CALCIUM CHLORIDE; DOPAMINE; GLUCAGON; GLUCONATE CALCIUM; PIG INSULIN; TRANDOLAPRIL PLUS VERAPAMIL;

ADULT; ARTICLE; BRADYCARDIA; CASE REPORT; CONTINUOUS INFUSION; DIZZINESS; DRUG DOSE TITRATION; DRUG INTOXICATION; DRUG OVERDOSE; HUMAN; HYPERGLYCEMIA; HYPOTENSION; INSULIN TREATMENT; MALE; PRIORITY JOURNAL; VOMITING;

DELAYED-ACTION PREPARATIONS; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG ADMINISTRATION SCHEDULE; DRUG COMBINATIONS; EMERGENCY TREATMENT; FOLLOW-UP STUDIES; HUMANS; HYPERTENSION; INDOLES; MALE; MIDDLE AGED; OVERDOSE; RISK ASSESSMENT; SEVERITY OF ILLNESS INDEX; TREATMENT OUTCOME; VERAPAMIL;

EID: 79952815044     PISSN: 07364679     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jemermed.2008.10.015     Document Type: Article

References (22)

1. Prisant LM, Doll NC. Hypertension: the rediscovery of combination therapy. Geriatrics 1997;52:28-30,33-8.
2. Hilleman DE, Ryschon KL, Mohiuddin SM, Wurdeman RL. Fixed-dose combination vs monotherapy in hypertension: a meta-analysis evaluation. J Hum Hypertens 1999;12:477-83. (Pubitemid 29355891)
3. Bangalore S, Kamalakkannan G, Parkar S, Messerli FH. Fixed-dose combinations improve medication compliance: a meta-analysis. Am J Med 2007;120:713-9. (Pubitemid 47176510)
4. Sica DA. Rationale for fixed-dose combinations in the treatment of hypertension: the cycle repeats. Drugs 2002;62:443-62. (Pubitemid 34208333)
5. Naranjo CA, Busto U, Sellers EM, et al. A method for estimating the probability of adverse drug reactions. Clin Pharmacol Ther 1981;30:239-45. (Pubitemid 12149145)
6. Biron P. A hopefully biased pilot survey of physicians' knowledge of the content of drug combinations. Can Med Assoc J 1973;109:35,37,39.
7. Hemminki E, Enlund H, Hellevuo K, Laurila R, Turakka H. Trade names and generic names. Problems for prescribing physicians. Scand J Prim Health Care 1984;2:84-7. (Pubitemid 14071288)
8. Gokel Y, Paydas S, Duru M. High-dose verapamil-trandolapril induced rhabdomyolysis and acute renal failure. Am J Emerg Med 2000;18:738-9.
9. Gokel Y, Paydas S, Acikalin A, Bozkurt A. High-dose verapamil + trandolapril-induced thrombotic microangiopathy. Haematologia 2002;32:281-5. (Pubitemid 36124116)
10. Batalis NI, Harley RA, Schandl CA. Verapamil toxicity: an unusual case report and review of the literature. Am J Forensic Med Pathol 2007;28:137-40. (Pubitemid 47164692)
11. Varon J, Duncan SR. Naloxone reversal of hypotension due to captopril overdose. Ann Emerg Med 1991;20:1125-7.
12. Jackson T, Corke C, Agar J. Enalapril overdose treated with angiotensin infusion. Lancet 1993;341:703. (Pubitemid 23083296)
13. Tovar JL, Bujons I, Ruiz JC, Ibanez L, Salgado A. Treatment of severe combined overdose of calcium antagonists and converting enzyme inhibitors with angiotensin II. Nephron 1997;77:239. (Pubitemid 27440418)
14. Trilli LE, Johnson KA. Lisinopril overdose and management with intravenous angiotensin II. Ann Pharmacother 1994;28:1165-8. (Pubitemid 24312255)
15. Lip GY, Ferner RE. Poisoning with anti-hypertensive drugs: angiotensin converting enzyme inhibitors. J Hum Hypertens 1995;9:711-5.
16. Green SL, Gawarammana I, Wood DM, Jones AL, Dargan PI. Relative safety of hyperinsulinaemia/euglycaemia therapy in the management of calcium channel blocker overdose: a prospective observational study. Intensive Care Med 2007;33:2019-24. (Pubitemid 47632262)
17. Boyer EW, Shannon M. Treatment of calcium-channel-blocker intoxication with insulin infusion. N Engl J Med 2001;344:1721-2. (Pubitemid 32479976)
18. Yuan TH, Kerns WP II, Tomaszewski CA, Ford MD, Kline JA. Insulin-glucose as adjunctive therapy for severe calcium channel antagonist poisoning. J Toxicol Clin Toxicol 1999;4:463-74. (Pubitemid 29387890)
19. Shepherd G. Treatment of poisoning caused by β-adrenergic and calcium-channel blockers. Am J Health Syst Pharm 2006;63:1828-35. (Pubitemid 44477454)
20. Boyer EW, Duic PA, Evans A. Hyperinsulinemia/euglycemia therapy for calcium channel blocker poisoning. Pediatr Emerg Care 2002;18:36-7. (Pubitemid 34174344)
21. Hasin T, Leibowitz D, Antopolosky M, Chajek-Shaul T. The use of low-dose insulin in cardiogenic shock due to combined overdose of verapamil, enalapril and metoprolol. Cardiology 2006;106:233-6. (Pubitemid 44763176)
22. Verbrugge LB, van Wezel HB. Pathophysiology of verapamil overdose: new insights in the role of insulin. J Cardiothorac Vasc Anesth 2007;21:406-9. (Pubitemid 46830971)