Change in knee osteoarthritis cartilage detected by delayed gadolinium enhanced magnetic resonance imaging following treatment with collagen hydrolysate: A pilot randomized controlled trial

Osteoarthritis and Cartilage

Volumn 19, Issue 4, 2011, Pages 399-405

  McAlindon, T E ^a   Nuite, M ^a   Krishnan, N ^b   Ruthazer, R ^a   Price, L L ^a   Burstein, D ^b   Griffith, J ^a   Flechsenhar, K ^c  

^a TUFTS MEDICAL CENTER   (United States)

^b BETH ISRAEL DEACONESS MEDICAL CENTER   (United States)

^c GELITA AG   (Germany)

Author keywords

Cartilage; Collagen hydrolysate; Delayed gadolinium enhanced; Magnetic resonance imaging; MRI; Osteoarthritis

Indexed keywords

ANALGESIC AGENT; COLLAGEN; GADOLINIUM PENTETATE; PLACEBO; TESTOSTERONE;

ADULT; ARTICLE; DOUBLE BLIND PROCEDURE; FEMALE; FUNCTIONAL ASSESSMENT; HUMAN; HYALINE CARTILAGE; KNEE OSTEOARTHRITIS; MAJOR CLINICAL STUDY; MALE; NUCLEAR MAGNETIC RESONANCE IMAGING; OUTCOME ASSESSMENT; PILOT STUDY; PRIORITY JOURNAL; PROSPECTIVE STUDY; RANDOMIZED CONTROLLED TRIAL; RELAXATION TIME; SCORING SYSTEM; SECONDARY ANALYSIS; TREATMENT DURATION; TREATMENT OUTCOME; UNSPECIFIED SIDE EFFECT;

AGED; CARTILAGE, ARTICULAR; COLLAGEN; DOUBLE-BLIND METHOD; FEMALE; GADOLINIUM DTPA; HUMANS; MAGNETIC RESONANCE IMAGING; MALE; MIDDLE AGED; OSTEOARTHRITIS, KNEE; PILOT PROJECTS; PROSPECTIVE STUDIES; PROTEIN HYDROLYSATES;

EID: 79952814521     PISSN: 10634584     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.joca.2011.01.001     Document Type: Article

References (17)

1. Gray M.L., Burstein D., Kim Y.J., Maroudas A., 2007 Elizabeth Winston Lanier Award Winner Magnetic resonance imaging of cartilage glycosaminoglycan: basic principles, imaging technique, and clinical applications. J Orthop Res 2008, 26:281-291.
2. David-Vaudey E., Ghosh S., Ries M., Majumdar S. T2 relaxation time measurements in osteoarthritis. Magn Reson Imaging 2004, 22:673-682.
3. Bashir A., Gray M.L., Hartke J., Burstein D. Nondestructive imaging of human cartilage glycosaminoglycan concentration by MRI. Magn Reson Med 1999, 41:857-865.
4. Tiderius C.J., Olsson L.E., Leander P., Ekberg O., Dahlberg L. Delayed gadolinium-enhanced MRI of cartilage (dGEMRIC) in early knee osteoarthritis. Magn Reson Med 2003, 49:488-492.
5. Cunningham T., Jessel R., Zurakowski D., Millis M.B., Kim Y.J. Delayed gadolinium-enhanced magnetic resonance imaging of cartilage to predict early failure of Bernese periacetabular osteotomy for hip dysplasia. J Bone Joint Surg Am 2006, 88:1540-1548.
6. Tiderius C.J., Svensson J., Leander P., Ola T., Dahlberg L. dGEMRIC (delayed gadolinium-enhanced MRI of cartilage) indicates adaptive capacity of human knee cartilage. Magn Reson Med 2004, 51:286-290.
7. Roos E.M., Dahlberg L. Positive effects of moderate exercise on glycosaminoglycan content in knee cartilage: a four-month, randomized, controlled trial in patients at risk of osteoarthritis. Arthritis Rheum 2005, 52:3507-3514.
8. Mosher T.J., Dardzinski B.J. Cartilage MRI T2 relaxation time mapping: overview and applications. Semin Musculoskelet Radiol 2004, 8:355-368.
9. Liess C., Lusse S., Karger N., Heller M., Gluer C.C. Detection of changes in cartilage water content using MRI T2-mapping in vivo. Osteoarthritis Cartilage 2002, 10:907-913.
10. Oesser S., Seifert J. Stimulation of type II collagen biosynthesis and secretion in bovine chondrocytes cultured with degraded collagen. Cell Tissue Res 2003, 311:393-399.
11. Oesser S., Adam M., Babel W., Seifert J. Oral administration of (14)C labeled gelatin hydrolysate leads to an accumulation of radioactivity in cartilage of mice (C57/BL). J Nutr 1999, 129:1891-1895.
12. Oesser S., Raabe A., Schunck M. Orally administered collagen hydrolysate halts the progression of osteoarthritis in STR/ort mice. Osteoarthritis Cartilage 2007, 15(Suppl C):94-95.
13. Oesser S., Proksch E., Schunck M. Prophylactic treatment with a special collagen hydrolysate decreases cartilage tissue degeneration in the knee joints. Osteoarthritis Cartilage 2008, 16(Suppl 4):S45.
14. Moskowitz R.W. Role of collagen hydrolysate in bone and joint disease. Semin Arthritis Rheum 2000, 30:87-99.
15. Altman R., Asch E., Bloch D., Bole G., Borenstein D., Brandt K., et al. Development of criteria for the classification and reporting of osteoarthritis. Classification of osteoarthritis of the knee. Diagnostic and Therapeutic Criteria Committee of the American Rheumatism Association. Arthritis Rheum 1986, 29:1039-1049.
16. Tiderius C., Hori M., Williams A., Sharma L., Prasad P.V., Finnell M., et al. dGEMRIC as a function of BMI. Osteoarthritis Cartilage 2006, 14:1091-1097.
17. Buckland-Wright C. Protocols for precise radio-anatomical positioning of the tibiofemoral and patellofemoral compartments of the knee. Osteoarthritis Cartilage 1995, 3(Suppl A):71-80.