Tonic inhibition of allergic itch signaling by the descending noradrenergic system in mice

Journal of Pharmacological Sciences

Volumn 115, Issue 3, 2011, Pages 417-420

  Gotoh, Yoshikazu ^a   Omori, Yu ^a   Andoh, Tsugunobu ^a   Kuraishi, Yasushi ^a  

^a UNIVERSITY OF TOYAMA   (Japan)

Author keywords

Allergic itch; Clonidine; Descending noradrenergic system

Indexed keywords

5,7 DIHYDROXYTRYPTAMINE; ALLERGEN; ALPHA 2 ADRENERGIC RECEPTOR; CLONIDINE; NORADRENALIN; OXIDOPAMINE; PHENTOLAMINE; YOHIMBINE;

ADRENERGIC RECEPTOR BLOCKING; ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ARTICLE; BITE; CONTROLLED STUDY; FOREFOOT; HINDLIMB; INHIBITION KINETICS; INSECT ALLERGY; MALE; MOSQUITO; MOUSE; NONHUMAN; NORADRENERGIC SYSTEM; PRURITUS; SIGNAL TRANSDUCTION; SPINAL CORD;

EID: 79952808679     PISSN: 13478613     EISSN: 13478648     Source Type: Journal    
DOI: 10.1254/jphs.10305SC     Document Type: Article

References (15)

1. Stander S, Steinhoff M, Schmelz M, Weisshaar E, Metze D, Luger T. Neurophysiology of pruritus: cutaneous elicitation of itch. Arch Dermatol. 2003;139:1463-1470. (Pubitemid 37441284)
2. Handwerker HO. Microneurography of pruritus. Neurosci Lett. 2010;470:193-196.
3. Sun YG, Zhao ZQ, Meng XL, Yin J, Liu XY, Chen ZF. Cellular basis of itch sensation. Science. 2009;325:1531-1534.
4. 2-adrenoceptors in the spinal cord in mice. Eur J Pharmacol. 2011;650:215-219.
5. 2 receptors in mice. Neurosci Res. 1999;35:77-83.
6. Kuraishi Y, Ohtsuka E, Nakano T, Kawai S, Andoh T, Nojima H, et al. Possible involvement of 5-lipoxygenase metabolite in itch-associated response of mosquito allergy in mice. J Pharmacol Sci. 2007;105:41-47. (Pubitemid 47463523)
7. Nakano T, Andoh T, Tayama M, Kosaka M, Lee JB, Kuraishi Y. Effects of topical application of tacrolimus on acute itch-associated responses in mice. Biol Pharm Bull. 2008;31:752-754. (Pubitemid 351500498)
8. Nakano T, Andoh T, Lee JB, Kuraishi Y. Different dorsal horn neurons responding to histamine and allergic itch stimuli. Neuroreport. 2008;19:723-726. (Pubitemid 351555989)
9. Kuraishi Y, Hirota N, Sato Y, Kaneko S, Satoh M, Takagi H. Noradrenergic inhibition of the release of substance P from the primary afferents in the rabbit spinal dorsal horn. Brain Res. 1985;359:177-182. (Pubitemid 16185330)
10. Sugimoto M, Kuraishi Y, Satoh M, Takagi H. Involvement of medullary opioid-peptidergic and spinal noradrenergic systems in the regulation of formalin-induced persistent pain. Neuropharmacology. 1986;25:481-485. (Pubitemid 16036362)
11. Ohtsuka E, Kawai S, Ichikawa T, Nojima H, Kitagawa K, Shirai Y, et al. Roles of mast cells and histamine in mosquito bite-induced allergic itch-associated responses in mice. Jpn J Pharmacol. 2001;86:97-105.
12. Omori Y, Andoh T, Shirakawa H, Ishida H, Hachiga T, Kuraishi Y. Itch-related responses of dorsal horn neurons to cutaneous allergic stimulation in mice. Neuroreport. 2009;20:478-481.
13. Nakazawa T, Yamanishi Y, Kaneko T. A comparative study of monoaminergic involvement in the antinociceptive action of E-2078, morphine and U-50,488E. J Pharmacol Exp Ther. 1991; 257:748-753.
14. Kuraishi Y, Yageta Y, Konno M, Andoh T, Yamaguchi-Miyamoto T, Nojima H. Intracisternal, but not intrathecal, injection of naloxone inhibits cutaneous itch-related response in mice. Biol Pharm Bull. 2008;31:2143-2145.
15. Fairbanks CA, Wilcox GL. Spinal antinociceptive synergism between morphine and clonidine persists in mice made acutely or chronically tolerant to morphine. J Pharmacol Exp Ther. 1999;288:1107-1116. (Pubitemid 29254148)